Gαq-protein carboxyl terminus imitation polypeptide GCIP-27 attenuates proliferation of vascular smooth muscle cells and vascular remodeling in spontaneously hypertensive rats

Biological and Pharmaceutical Bulletin

Volumn 34, Issue 10, 2011, Pages 1527-1532

  Zhang, Hai Gang ^a   Cheng, Yi Qun ^a   Liu, Ya ^a   Zhou, Jian Zhi ^a   Jia, Yi ^a   Wang, Xiu Qin ^a   Li, Xiao Hui ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Gq protein; Hypertension; Polypeptide drug; Vascular remodeling; Vascular smooth muscle cell

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CALCIUM ION; CARDIOVASCULAR AGENT; COLLAGEN; G ALPHA Q CARBOXYL TERMINUS IMITATION POLYPEPTIDE 27; LEUCINE; LOSARTAN; PHOSPHOLIPASE C; THYMIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL WALL THICKNESS; ARTERY DIAMETER; ARTICLE; BLOOD PRESSURE MEASUREMENT; CALCIUM CELL LEVEL; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; ESSENTIAL HYPERTENSION; IN VITRO STUDY; MALE; MITOSIS INHIBITION; NONHUMAN; PROTEIN CONTENT; RAT; SMOOTH MUSCLE FIBER; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; VASCULAR DISEASE; VASCULAR SMOOTH MUSCLE; VASODILATATION;

3T3 CELLS; ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; AORTA; BLOOD PRESSURE; BLOOD PRESSURE DETERMINATION; CALCIUM; CARDIOTONIC AGENTS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HYPERTENSION; HYPERTROPHY; LOSARTAN; MALE; MICE; MOLECULAR TARGETED THERAPY; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PEPTIDES; RANDOM ALLOCATION; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RATS, WISTAR; TETRAZOLIUM SALTS; THIAZOLES; TYPE C PHOSPHOLIPASES; VASOCONSTRICTOR AGENTS;

EID: 80053519408     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.34.1527     Document Type: Article

References (31)

1. Erami C., Zhang H., Ho J. G., French D. M., Faber J. E., Am. J. Physiol. Heart Circ. Physiol., 283, H1577-H1587 (2002).
2. Wang X., Ohnishi M., Wada A., Tsutamoto T., Sawaki M., Fujii M., Matsumoto T., Yamamoto T., Kurokawa K., Yamada H., Kinoshita M., Life Sci., 69, 2477-2488 (2001).
3. Kuo L. E., Abe K., Zukowska Z., Peptides, 28, 435-440 (2007).
4. Schiffrin E. L., Touyz R. M., Am. J. Physiol. Heart Circ. Physiol., 287, H435-H446 (2004).
5. Willianms B., Am. J. Cardiol., 87, 10C-17C (2001).
6. Zhang H., Cotecchia S., Thomas S. A., Tanoue A., Tsujimoto G., Faber J. E., Am. J. Physiol. Heart Circ. Physiol., 287, H2106-H2114 (2004).
7. Mitrovic V., Willenbrock R., Miric M., Seferovic P., Spinar J., Dabrowski M., Kiowski W., Marks D. S., Alegria E., Dukát A., Lenz K., Arens H. A., Am. Heart J., 145, E14 (2003).
8. Anderson L. L., Marshall G. R., Crocker E., Smith S. O., Baranski T. J., J. Biol. Chem., 280, 31019-31026 (2005).
9. Kostenis E., Martini L., Ellis J., Waldhoer M., Heydorn A., Rosenkilde M. M., Norregaard P. K., Jorgensen R., Whistler J. L., Milligan G., J. Pharmacol. Exp. Ther., 313, 78-87 (2005).
10. Lambright D. G., Sondek J., Bohm A., Skiba N. P., Hamm H. E., Sigler P. B., Nature (London), 379, 311-319 (1996).
11. Zhou J. Z., Li X. H., Zhang H. G., Tang Y., Wang X. Q., Acta Pharmacol. Sin., 24, 1108-1112 (2003).
12. Wang X. Q., Zhang H. G., Cheng Y. Q., Li X. H., Clin. Exp. Pharmacol. Physiol., 35, 1215-1221 (2008).
13. Yang D. L., Zhang H. G., Xu Y. L., Gao Y. H., Yang X. J., Hao X. Q., Su M., Wang X. Q., Li X. H., Biol. Pharm. Bull., 32, 376-381 (2009).
14. Zhang H. G., Li X. H., Zhou J. Z., Liu Y., Jia Y., Yuan Z. B., Clin. Exp. Pharmacol. Physiol., 34, 1276-1281 (2007).
15. Kim Y. S., Ki M. S., Ha H., Park J., Kim H. J., Park K., Surg. Today, 32, 230-235 (2002).
16. Bunkenburg B., van Amelsvoort T., Rogg H., Wood J. M., Hypertension, 20, 746-754 (1992).
17. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J., J. Biol. Chem., 193, 265-275 (1951).
18. Ling S. H., Dai A. Z., Guo Z. X., Yan X. J., Komesaroff P. A., Clin. Exp. Pharmacol. Physiol., 32, 571-578 (2005).
19. Zheng Y., Song H. J., Kim C. H., Kim H. S., Kim E. G., Sachinidis A., Ahn H. Y., J. Cardiovasc. Pharmacol., 43, 200-208 (2004).
20. Chu W. F., Sun H. L., Dong D. L., Qiao G. F., Yang B. F., Basic Clin. Pharmacol. Toxicol., 98, 104-109 (2006).
21. Yao H. W., Zhu J. P., Zhao M. H., Lu Y., Respiration, 73, 236-242 (2006).
22. Yu J. X., Yin X. X., Shen J. P., Qiu J., Yin H. L., Jiang S. J., Clin. Exp. Pharmacol. Physiol., 33, 1231-1238 (2006).
23. Schnabel P., Gäs H., Nohr T., Camps M., Böhm M., J. Mol. Cell. Cardiol., 28, 2419-2427 (1996).
24. Schnabel P., Nohr T., Nickenig G., Paul M., Böhm M., Hypertension, 30, 1356-1361 (1997).
25. Belmadani S., Zerfaoui M., Boulares H. A., Palen D. I., Matrougui K., Am. J. Physiol. Heart Circ. Physiol., 295, H69-H76 (2008).
26. Li C., Xu Q., Cell. Signal., 12, 435-445 (2000).
27. Xiong C., Mou Y., Zhang J., Fu M., Chen Y. E., Akinbami M. A., Cui T., Life Sci., 77, 3037-3048 (2005).
28. Mervaala E. M., Müller D. N., Park J. K., Schmidt F., Löhn M., Breu V., Dragun D., Ganten D., Haller H., Luft F. C., Hypertension, 33, 389-395 (1999).
29. Rizzoni D., Castellano M., Porteri E., Bettoni G., Muiesan M. L., Agabiti-Rosei E., Am. J. Hypertens., 7, 193-200 (1994).
30. John St., Sutton M., Ferrari V. A., Curr. Treat. Options Cardiovasc. Med., 4, 97-108 (2002).
31. Vanhoutte P. M., Circ. J., 73, 595-601 (2009).