α-Adrenergic signal transduction in renin transgenic rats

Hypertension

Volumn 30, Issue 6, 1997, Pages 1356-1361

  Schnabel, Petra ^a   Nohr, Theo ^b   Nickenig, Georg ^b   Paul, Martin ^b   Böhm, Michael ^b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b NONE

Author keywords

Cardiac hypertrophy; G proteins; Phospholipase C; Signal transduction; adrenoceptors

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHOLIPASE C; RENIN;

ADRENERGIC SYSTEM; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART HYPERTROPHY; HEART MUSCLE CONTRACTILITY; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

EID: 0030668725     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.30.6.1356     Document Type: Article

References (25)

1. Berridge MJ. Inositol triphosphate and calcium signalling. Nature. 1993;361:315-325.
2. Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science. 1992;258:607-614.
3. 1-adrenoceptors mediate positive inotropic effect and changes in phosphatidylinositol metabolism: species differences in receptor distribution and the intracellular coupling process in mammalian ventricular myocardium. Circ Res. 1991;68: 1179-1190.
4. 1-adrenergic stimulation of inositol polyphosphates in mammalian heart. Mol Pharmacol. 1992;42:134-140.
5. 1-adrenoceptors: an overview. Pharmacoll Rev. 1993;45:147-175.
6. Schmitz W, Eschenhagen T, Mende U, Müller FU, Scholz H. The role of alpha1-adrenergic and muscarinic receptors in cardiac function. Eur Heart J. 1991;12(suppl F):83-87.
7. Simpson PC. Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alphal adrenergic response. J Clin Invest. 1983;72:732-738.
8. 1-adrenergic stimulation. J Biol Chem. 1994;269:13490-13496.
9. Böhm M, Mende U, Schmitz W, Scholz H. Increased sensitivity to α-adrenoceptor stimulation but intact muscarinergic and purinergic isoprenaline-antagonistic effect in prehypertensive cardiac hypertrophy of spontaneously hypertensive rats. Naunyn Schmiedeberg's Arch Pharmacol. 1986;333:284-289.
10. Kawaguchi H, Sano H, Iizuka K, Okada H, Kudo T, Kageyama K, Muramoto S, Murakami T, Okamoto H, Mochizuki N, Kitabatake A. Phosphatidylinositol metabolism in hypertrophic rat heart. Circ Res. 1993;72:966-972.
11. Ivorra D, Gascon S, Vila E, Badia A. α-Adrenoceptor subtypes and inositol phosphate production in heart ventricles of spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1993;21:931-936.
12. Mullins JJ, Peters J, Ganten D. Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature. 1990; 344:541-544.
13. Böhm M, Moll M, Schmid B, Paul M, Ganten D, Castellano M, Erdmann E. β-adrenergic neuroeffector mechanisms in cardiac hypertrophy of renin transgenic rats. Hypertension. 1994;24:653-662.
14. Tawfik-Schlieper H, Moll M, Schmid B, Schwinger RHG, Paul M, Ganten D, Böhm M. Alterations of cardiac α- and β-adrenoceptors and inotropic responsiveness in hypertensive transgenic rats harbouring the mouse renin gene (TGR(mREN2)27). Clin Exp Hypertens. 1995;17:631-648.
15. Schnabel P, Schreck R, Schiller DL, Camps M, Gierschik P. Stimulation of phospholipase C by a mutationally activated G protein α16 subunit. Biochem Biophys Res Commun. 1992;188:1018-1023.
16. Schnabel P, Gäs H, Nohr T, Camps M, Böhm M. Identification and characterization of G protein-regulated phospholipase C in human myocardium. J Mol Cell Cardiol. 1996;28:2419-2427.
17. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
18. Wilkie TM, Scherle PA, Strathmann MP, Slepak VZ, Simon MI. Characterization of G-protein α subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines. Proc Natl Acad Sci U S A. 1991;88:10049-10053.
19. Shimohama S, Matsushima H, Fujimoto S, Takenawa T, Taniguchi T, Kameyama M, Kimura J. Differential involvement of phospholipase C in Alzheimer's disease. Gerontology. 1995;41:13-19.
20. Richardson R, Ali H, Tomhave ED, Haribabu B, Snyderman R. Cross-desensitization of chemoattractant receptors at multiple levels: evidence for a role for inhibition of phospholipase C activity. J Biol Chem. 1995;270:27829-27833.
21. 1-Adrenergic receptors in nonfailing and failing human heart. J Pharmacol Exp Ther. 1988;247:1039-1045.
22. Böhm M, Diet F, Feiler G, Kemkes B, Kreuzer E, Weinhold C, Erdmann E. Subsensitivity of the failing human heart to isoprenaline and milrinone is related to beta-adrenoceptor downregulation. J Cardiovasc Pharmacol. 1988;14:726-732.
23. 2-adrenoceptor-mediated positive inotropic effects in human end-stage heart failure. Br J Pharmacol. 1992;105:463-469.
24. Böhm M, Castellano M, Paul M, Erdmann E. Cardiac norepinephrine, β-adrenoceptors, and Giα-proteins in prehypertensive and hypertensive spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1994;23:980-987.
25. Ganten D, Lindpaintner K, Ganten U, Peters J, Zimmermann F, Bader M, Mullins J. Transgenic rats: new animal models in hypertension research. Hypertension. 1991;17:843-855.