Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats

Journal of Toxicological Sciences

Volumn 36, Issue 5, 2011, Pages 507-514

  Nemoto, Kiyomitsu ^a   Tanaka, Takahiro ^a   Ikeda, Ayaka ^a   Ito, Sei ^a   Mizukami, Masanori ^a   Hikida, Tokihiro ^a   Gamou, Toshie ^b   Habano, Wataru ^b   Ozawa, Shogo ^b   Inoue, Kaoru ^c   Yoshida, Midori ^c   Nishikawa, Akiyoshi ^c   Degawa, Masakuni ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b IWATE MEDICAL UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Hepatocellular hypertrophy; Liver tumor promoter; Nmda receptor; Non genotoxic hepatocarcinogen

Indexed keywords

CLOFIBRATE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHENOBARBITAL; PIPERONYL BUTOXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; GENE; GENE EXPRESSION PROFILING; GRIN2C GENE; LIVER CELL; LIVER HYPERTROPHY; LIVER WEIGHT; MALE; NONHUMAN; RAT; REAL TIME POLYMERASE CHAIN REACTION;

RATTUS;

EID: 80053477651     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.36.507     Document Type: Article

References (27)

1. Bullock, W.M., Cardon, K., Bustillo, J., Roberts, R.C. and Perrone-Bizzozero, N.I. (2008): Altered expression of genes involved in GABAergic transmission and neuromodulation of granule cell activity in the cerebellum of schizophrenia patients. Am. J. Psychiatry, 165, 1594-1603.
2. Cook, J.C. and Hodgson, E. (1985): The induction of cytochrome P-450 by isosafrole and related methylenedioxyphenyl compounds. Chem. Biol. Interact., 54, 299-315.
3. Crampton, R.F., Gray, T.J., Grasso, P. and Parke, D.V. (1977): Longterm studies on chemically induced liver enlargement in the rat. I. Sustained induction of microsomal enzymes with absence of liver damage on feeding phenobarbitone or butylated hydroxytoluene. Toxicology, 7, 289-306.
4. Elrick, M.M., Kramer, J.A., Alden, C.L., Blomme, E.A., Bunch, R.T., Cabonce, M.A., Curtiss, S.W., Kier, L.D., Kolaja, K.L., Rodi, C.P. and Morris, D.L. (2005): Differential display in rat livers treated for 13 weeks with phenobarbital implicates a role for metabolic and oxidative stress in nongenotoxic carcinogenicity. Toxicol. Pathol., 33, 118-126.
5. Fujitani, T., Ando, H., Fujitani, K., Ikeda, T., Kojima, A., Kubo, Y., Ogata, A., Oishi, S., Takahashi, H., Takahashi, O. and Yoneyama, M. (1992): Sub-acute toxicity of piperonyl butoxide in F344 rats. Toxicology, 72, 291-298.
6. Hagiwara, A., Miyata, E., Tamano, S., Sano, M., Masuda, C., Funae, Y., Ito, N., Fukushima, S. and Shirai, T. (1999): Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats. Food Chem. Toxicol., 37, 869-879.
7. Hess, R., Stäubli, W. and Riess, W. (1965): Nature of the hepatomegalic effect produced by ethyl-chlorophenoxy-isobutyrate in the rat. Nature, 208, 856-858.
8. Hinoi, E., Takarada, T., Ueshima, T., Tsuchihashi, Y. and Yoneda, Y. (2004): Glutamate signaling in peripheral tissues. Eur. J. Biochem., 271, 1-13.
9. Huang, W., Zhang, J., Washington, M., Liu, J., Parant, J.M., Lozano, G. and Moore, D.D. (2005): Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. Mol. Endocrinol., 19, 1646-1653.
10. Kalia, L.V., Kalia, S.K. and Salter, M.W. (2008): NMDA receptors in clinical neurology: excitatory times ahead. Lancet Neurol., 7, 742-755.
11. Katsuta, Y., Iida, T., Hasegawa, K., Inomata, S. and Denda, M. (2009): Function of oleic acid on epidermal barrier and calcium infl ux into keratinocytes is associated with N-methyl D-aspartate- type glutamate receptors. Br. J. Dermatol., 160, 69-74.
12. Leung, J.C., Marphis, T., Craver, R.D. and Silverstein, D.M. (2004): Altered NMDA receptor expression in renal toxicity: Protection with a receptor antagonist. Kidney Int., 66, 167-176.
13. Muguruma, M., Unami, A., Kanki, M., Kuroiwa, Y., Nishimura, J., Dewa, Y., Umemura, T., Oishi, Y. and Mitsumori, K. (2007): Possible involvement of oxidative stress in piperonyl butoxide induced hepatocarcinogenesis in rats. Toxicology, 236, 61-75.
14. Nagy, J. (2008): Alcohol related changes in regulation of NMDA receptor functions. Curr. Neuropharmacol., 6, 39-54.
15. Parisi, E., Almadén, Y., Ibarz, M., Panizo, S., Cardús, A., Rodriguez, M., Fernandez, E. and Valdivielso, J.M. (2009): N-methyl-Daspartate receptors are expressed in rat parathyroid gland and regulate PTH secretion. Am. J. Physiol. Renal. Physiol., 296, F1291-1296.
16. Patsouris, D., Mandard, S., Voshol, P.J., Escher, P., Tan, N.S., Havekes, L.M., Koenig, W., März, W., Tafuri, S., Wahli, W., Müller, M. and Kersten, S. (2004): PPARα governs glycerol metabolism. J. Clin. Invest., 114, 94-103.
17. Peters, J.M., Cattley, R.C. and Gonzalez, F.J. (1997): Role of PPARα in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643. Carcinogenesis, 18, 2029-2033.
18. Pitot, H.C. (1977): The natural history of neoplasia. Newer insights into an old problem. Am. J. Pathol., 89, 402-411.
19. Rao, M.S. and Reddy, J.K. (1991): An overview of peroxisome proliferator-induced hepatocarcinogenesis. Environ. Health Perspect., 93, 205-209.
20. Ryu, D.Y., Levi, P.E. and Hodgson, E. (1997): Regulation of hepatic CYP1A isozymes by piperonyl butoxide and acenaphthylene in the mouse. Chem. Biol. Interact., 105, 53-63.
21. Rzeski, W., Turski, L. and Ikonomidou, C. (2001): Glutamate antagonists limit tumor growth. Proc. Natl. Acad. Sci. USA, 98, 6372-6377.
22. Shimizu, Y., Nakatsuru, Y., Ichinose, M., Takahashi, Y., Kume, H., Mimura, J., Fujii-Kuriyama, Y. and Ishikawa, T. (2000): Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. Proc. Natl. Acad. Sci. USA, 97, 779-782.
23. Stepulak, A., Luksch, H., Gebhardt, C., Uckermann, O., Marzahn, J., Sifringer, M., Rzeski, W., Staufner, C., Brocke, K.S., Turski, L. and Ikonomidou C. (2009): Expression of glutamate receptor subunits in human cancers. Histochem. Cell Biol., 132, 435-445.
24. Takahashi, O., Oishi, S., Fujitani, T., Tanaka, T. and Yoneyama, M. (1994): Chronic toxicity studies of piperonyl butoxide in F344 rats: induction of hepatocellular carcinoma. Fundam. Appl. Toxicol., 22, 293-303.
25. Watanabe, K., Kanno, T., Oshima, T., Miwa, H., Tashiro, C. and Nishizaki, T. (2008): The NMDA receptor NR2A subunit regulates proliferation of MKN45 human gastric cancer cells. Biochem. Biophys. Res. Commun., 367, 487-490.
26. Waxman, D.J. (1999): P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. Arch. Biochem. Biophys., 369, 11-23.
27. Yamamoto, Y., Moore, R., Goldsworthy, T.L., Negishi, M. and Maronpot, R.R. (2004): The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice. Cancer Res., 64, 7197-7200.