Arsenic inhibits neurite outgrowth by inhibiting the LKB1-AMPK signaling pathway

Environmental Health Perspectives

Volumn 118, Issue 5, 2010, Pages 627-634

  Wang, Xin ^a   Meng, Dan ^b   Chang, Qingshan ^a   Pan, Jingju ^a   Zhang, Zhuo ^a   Chen, Gang ^c   Ke, Zunji ^b   Luo, Jia ^c   Shi, Xianglin ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

AMPK; Arsenic; Developmental neurotoxicity; LKB1; Neurite outgrowth; Neuro 2a neuroblastoma cell; ROS

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACETYLCYSTEINE; ARSENIC; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN KINASE LKB1;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARSENIC POISONING; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; MOUSE; NERVE CELL DIFFERENTIATION; NERVE CELL NECROSIS; NERVE FIBER GROWTH; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

AMP-ACTIVATED PROTEIN KINASES; ARSENIC; CELL DIFFERENTIATION; CELL LINE; ENVIRONMENTAL HEALTH; ENZYME INHIBITORS; HUMANS; NEURITES; NEURONS; OXIDATIVE STRESS; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; WATER POLLUTANTS, CHEMICAL;

EID: 77951700594     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.0901510     Document Type: Article

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