Factors affecting phase i stereoselective biotransformation of chiral polychlorinated biphenyls by rat cytochrome P-450 2B1 isozyme

Environmental Science and Technology

Volumn 45, Issue 19, 2011, Pages 8298-8305

  Lu, Zhe ^a   Wong, Charles S ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF WINNIPEG   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPISOMERS; BIOTRANSFORMATION KINETICS; CHIRAL POLLUTANTS; CHIRAL POLYCHLORINATED BIPHENYLS; CYTOCHROME P450; DIFFERENT SUBSTRATES; HOMOLOGY MODELING; IN-VITRO; INHIBITORY ACTIVITY; MOLECULAR LEVELS; PHASE I; PREDICTIVE CAPABILITIES; STEREO-SELECTIVE; SUBSTRATE CONCENTRATIONS;

BIOCONVERSION; COMPETITION; ISOENZYMES; ORGANIC POLLUTANTS; RATS; STEREOSELECTIVITY; SUBSTRATES;

POLYCHLORINATED BIPHENYLS;

CYTOCHROME P450 2B1; ISOENZYME; POLYCHLORINATED BIPHENYL; POLYCHLORINATED BIPHENYL 132; POLYCHLORINATED BIPHENYL 45; POLYCHLORINATED BIPHENYL 95; UNCLASSIFIED DRUG;

BIOTRANSFORMATION; CHEMICAL COMPOSITION; CHLORINATION; CYTOCHROME; HOMOLOGY; INHIBITOR; MOLECULAR ANALYSIS; NUMERICAL MODEL; PCB; RACEMIZATION; REACTION KINETICS; RODENT; SUBSTRATE;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BIOTA; BIOTRANSFORMATION; CHIRALITY; CHLORINATION; CONTROLLED STUDY; ENANTIOMER; IN VITRO STUDY; INCUBATION TIME; ISOMER; KINETICS; MOLECULAR DOCKING; NONHUMAN; POLLUTANT; RACEMIC MIXTURE; RAT; STEREOCHEMISTRY;

ANIMALS; BIOTRANSFORMATION; CYTOCHROME P-450 CYP2B1; ISOENZYMES; KINETICS; METABOLIC DETOXICATION, PHASE I; MODELS, MOLECULAR; POLYCHLORINATED BIPHENYLS; RATS; STEREOISOMERISM;

RATTUS; RUMEX;

EID: 80053418635     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es200673q     Document Type: Article

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