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Volumn 169, Issue 1, 2007, Pages 42-52

Differential inhibition of hepatic microsomal alkoxyresorufin O-dealkylation activities by tetrachlorobiphenyls

Author keywords

Alkoxyresorufin O dealkylation; Cytochrome P450; Immunoblot analysis; Tetrachlorobiphenyls

Indexed keywords

2,2',4,4' TETRACHLOROBIPHENYL; 2,2',5,5' TETRACHLOROBIPHENYL; 3 METHYLCHOLANTHRENE; 3,3',4,4' TETRACHLOROBIPHENYL; BENZYLOXYRESORUFIN O DEALKYLASE; ETHOXYRESORUFIN DEETHYLASE; LIVER ENZYME; METHOXYRESORUFIN O DEALKYLASE; PHENOBARBITAL; POLYCHLORINATED BIPHENYL DERIVATIVE; RESORUFIN DERIVATIVE; TETRACHLOROBIPHENYL; UNCLASSIFIED DRUG;

EID: 34447250786     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2007.05.004     Document Type: Article
Times cited : (12)

References (32)
  • 1
    • 0002481616 scopus 로고    scopus 로고
    • Cytochrome P450 enzymes as biomarkers of PCB exposure and modulators of toxicity
    • Robertson L.W., and Hansen L.G. (Eds), University Press of Kentucky, Lexington, KY
    • Bandiera S.M. Cytochrome P450 enzymes as biomarkers of PCB exposure and modulators of toxicity. In: Robertson L.W., and Hansen L.G. (Eds). PCBs: Recent Advances in Environmental Toxicology and Health Effects (2001), University Press of Kentucky, Lexington, KY 185-192
    • (2001) PCBs: Recent Advances in Environmental Toxicology and Health Effects , pp. 185-192
    • Bandiera, S.M.1
  • 2
    • 10844278294 scopus 로고    scopus 로고
    • Metabolism of polychlorinated biphenyls by Gunn rats: identification and serum retention of catechol metabolites
    • Haraguchi K., Kato Y., Koga N., and Degawa M. Metabolism of polychlorinated biphenyls by Gunn rats: identification and serum retention of catechol metabolites. Chem. Res. Toxicol. 17 (2004) 1684-1691
    • (2004) Chem. Res. Toxicol. , vol.17 , pp. 1684-1691
    • Haraguchi, K.1    Kato, Y.2    Koga, N.3    Degawa, M.4
  • 3
    • 0025701991 scopus 로고
    • Effects of molecular substitution patterns on the cytochrome P-450-dependent metabolism of 2,2′,3,5,5′,6- and 2,2′,3,4,4′,6-hexachlorobiphenyl by rat liver microsomal monooxygenases
    • Borlakoglu J.T., Drew M.G., Wilkins J.P., and Dils R.R. Effects of molecular substitution patterns on the cytochrome P-450-dependent metabolism of 2,2′,3,5,5′,6- and 2,2′,3,4,4′,6-hexachlorobiphenyl by rat liver microsomal monooxygenases. Biochim. Biophys. Acta 1036 (1990) 167-175
    • (1990) Biochim. Biophys. Acta , vol.1036 , pp. 167-175
    • Borlakoglu, J.T.1    Drew, M.G.2    Wilkins, J.P.3    Dils, R.R.4
  • 4
    • 0027238758 scopus 로고
    • Metabolism of di-, tri-, tetra-, penta- and hexachlorobiphenyls by hepatic microsomes isolated from control animals and animals treated with Aroclor 1254, a commercial mixture of polychlorinated biphenyls (PCBs)
    • Borlakoglu J.T., and Wilkins J.P. Metabolism of di-, tri-, tetra-, penta- and hexachlorobiphenyls by hepatic microsomes isolated from control animals and animals treated with Aroclor 1254, a commercial mixture of polychlorinated biphenyls (PCBs). Comp. Biochem. Physiol. C 105 (1993) 95-106
    • (1993) Comp. Biochem. Physiol. C , vol.105 , pp. 95-106
    • Borlakoglu, J.T.1    Wilkins, J.P.2
  • 5
    • 0025895904 scopus 로고
    • Metabolism in vitro of 3,4,3′,4′- and 2,5,2′,5′-tetrachlorobiphenyl by rat liver microsomes and highly purified cytochrome P-450
    • Ishida C., Koga N., Hanioka N., Saeki H.K., and Yoshimura H. Metabolism in vitro of 3,4,3′,4′- and 2,5,2′,5′-tetrachlorobiphenyl by rat liver microsomes and highly purified cytochrome P-450. J. Pharmacobiodyn. 14 (1991) 276-284
    • (1991) J. Pharmacobiodyn. , vol.14 , pp. 276-284
    • Ishida, C.1    Koga, N.2    Hanioka, N.3    Saeki, H.K.4    Yoshimura, H.5
  • 6
    • 0027179679 scopus 로고
    • Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochromes P4501A2 and 2B, respectively, in the rat and mouse
    • Nerurkar P.V., Park S.S., Thomas P.E., Nims R.W., and Lubet R.A. Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochromes P4501A2 and 2B, respectively, in the rat and mouse. Biochem. Pharmacol. 46 (1993) 933-943
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 933-943
    • Nerurkar, P.V.1    Park, S.S.2    Thomas, P.E.3    Nims, R.W.4    Lubet, R.A.5
  • 7
    • 0020582855 scopus 로고
    • Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats. A study of structure-activity relationships
    • Parkinson A., Safe S.H., Robertson L.W., Thomas P.E., Ryan D.E., Reik L.M., and Levin W. Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats. A study of structure-activity relationships. J. Biol. Chem. 258 (1983) 5967-5976
    • (1983) J. Biol. Chem. , vol.258 , pp. 5967-5976
    • Parkinson, A.1    Safe, S.H.2    Robertson, L.W.3    Thomas, P.E.4    Ryan, D.E.5    Reik, L.M.6    Levin, W.7
  • 8
    • 0020601426 scopus 로고
    • Differential effects of phenobarbitone and 3-methylcholanthrene induction on the hepatic microsomal metabolism and cytochrome P-450-binding of phenoxazone and a homologous series of its n-alkyl ethers (alkoxyresorufins)
    • Burke M.D., and Mayer R.T. Differential effects of phenobarbitone and 3-methylcholanthrene induction on the hepatic microsomal metabolism and cytochrome P-450-binding of phenoxazone and a homologous series of its n-alkyl ethers (alkoxyresorufins). Chem. Biol. Interact. 45 (1983) 243-258
    • (1983) Chem. Biol. Interact. , vol.45 , pp. 243-258
    • Burke, M.D.1    Mayer, R.T.2
  • 9
    • 0030200826 scopus 로고    scopus 로고
    • The regulation by gender, strain, dose, and feeding status of the induction of multiple forms of cytochrome P450 isozymes in rat hepatic microsomes by 2,4,5,2′,4′,5′-hexachlorobiphenyl
    • Ikegwuonu F.I., Ganem L.G., Larson M.C., Shen X., and Jefcoate C.R. The regulation by gender, strain, dose, and feeding status of the induction of multiple forms of cytochrome P450 isozymes in rat hepatic microsomes by 2,4,5,2′,4′,5′-hexachlorobiphenyl. Toxicol. Appl. Pharmacol. 139 (1996) 33-41
    • (1996) Toxicol. Appl. Pharmacol. , vol.139 , pp. 33-41
    • Ikegwuonu, F.I.1    Ganem, L.G.2    Larson, M.C.3    Shen, X.4    Jefcoate, C.R.5
  • 10
    • 26844462359 scopus 로고    scopus 로고
    • Responses of prepubertal female rats to environmental PCBs with high and low dioxin equivalencies
    • Li M., and Hansen L.G. Responses of prepubertal female rats to environmental PCBs with high and low dioxin equivalencies. Fundam. Appl. Toxicol. 33 (1996) 282-293
    • (1996) Fundam. Appl. Toxicol. , vol.33 , pp. 282-293
    • Li, M.1    Hansen, L.G.2
  • 11
    • 0037494678 scopus 로고    scopus 로고
    • Inhibition of CYP 1A2-dependent MROD activity in rat liver microsomes: an explanation of the hepatic sequestration of a limited subset of halogenated aromatic hydrocarbons
    • Chen J.J., Chen G.S., and Bunce N.J. Inhibition of CYP 1A2-dependent MROD activity in rat liver microsomes: an explanation of the hepatic sequestration of a limited subset of halogenated aromatic hydrocarbons. Environ. Toxicol. 18 (2003) 115-119
    • (2003) Environ. Toxicol. , vol.18 , pp. 115-119
    • Chen, J.J.1    Chen, G.S.2    Bunce, N.J.3
  • 12
    • 0032942357 scopus 로고    scopus 로고
    • Competitive inhibition by inducer as a confounding factor in the use of the ethoxyresorufin-O-deethylase (EROD) assay to estimate exposure to dioxin-like compounds
    • Petrulis J.R., and Bunce N.J. Competitive inhibition by inducer as a confounding factor in the use of the ethoxyresorufin-O-deethylase (EROD) assay to estimate exposure to dioxin-like compounds. Toxicol. Lett. 105 (1999) 251-260
    • (1999) Toxicol. Lett. , vol.105 , pp. 251-260
    • Petrulis, J.R.1    Bunce, N.J.2
  • 13
    • 0035075653 scopus 로고    scopus 로고
    • Application of the ethoxyresorufin-O-deethylase (EROD) assay to mixtures of halogenated aromatic compounds
    • Petrulis J.R., Chen G., Benn S., LaMarre J., and Bunce N.J. Application of the ethoxyresorufin-O-deethylase (EROD) assay to mixtures of halogenated aromatic compounds. Environ. Toxicol. 16 (2001) 177-184
    • (2001) Environ. Toxicol. , vol.16 , pp. 177-184
    • Petrulis, J.R.1    Chen, G.2    Benn, S.3    LaMarre, J.4    Bunce, N.J.5
  • 14
    • 17444397464 scopus 로고    scopus 로고
    • Inhibition of human and rat CYP1A2 by TCDD and dioxin-like chemicals
    • Staskal D.F., Diliberto J.J., Devito M.J., and Birnbaum L.S. Inhibition of human and rat CYP1A2 by TCDD and dioxin-like chemicals. Toxicol. Sci. 84 (2005) 225-231
    • (2005) Toxicol. Sci. , vol.84 , pp. 225-231
    • Staskal, D.F.1    Diliberto, J.J.2    Devito, M.J.3    Birnbaum, L.S.4
  • 15
    • 0344442736 scopus 로고    scopus 로고
    • Spectral interactions of tetrachlorobiphenyls with hepatic microsomal cytochrome P450 enzymes
    • Hrycay E.G., and Bandiera S.M. Spectral interactions of tetrachlorobiphenyls with hepatic microsomal cytochrome P450 enzymes. Chem. Biol. Interact. 146 (2003) 285-296
    • (2003) Chem. Biol. Interact. , vol.146 , pp. 285-296
    • Hrycay, E.G.1    Bandiera, S.M.2
  • 16
    • 0030582448 scopus 로고    scopus 로고
    • ® on hepatic expression of cytochrome P450 2B in rats
    • ® on hepatic expression of cytochrome P450 2B in rats. Biochem. Pharmacol. 52 (1996) 735-742
    • (1996) Biochem. Pharmacol. , vol.52 , pp. 735-742
    • Wong, A.1    Bandiera, S.M.2
  • 18
    • 78651165715 scopus 로고
    • The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
    • Omura T., and Sato R. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem. 239 (1964) 2370-2378
    • (1964) J. Biol. Chem. , vol.239 , pp. 2370-2378
    • Omura, T.1    Sato, R.2
  • 19
    • 0016333916 scopus 로고
    • Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene
    • Burke M.D., and Mayer R.T. Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene. Drug Metab. Dispos. 2 (1974) 583-588
    • (1974) Drug Metab. Dispos. , vol.2 , pp. 583-588
    • Burke, M.D.1    Mayer, R.T.2
  • 20
    • 0017795019 scopus 로고
    • Purification and properties of NADPH-cytochrome P-450 reductase
    • Strobel H.W., and Dignam J.D. Purification and properties of NADPH-cytochrome P-450 reductase. Meth. Enzymol. 52 (1978) 89-96
    • (1978) Meth. Enzymol. , vol.52 , pp. 89-96
    • Strobel, H.W.1    Dignam, J.D.2
  • 21
    • 0025139447 scopus 로고
    • Purification and characterization of hepatic microsomal cytochrome P-450
    • Ryan D.E., and Levin W. Purification and characterization of hepatic microsomal cytochrome P-450. Pharmacol. Ther. 45 (1990) 153-239
    • (1990) Pharmacol. Ther. , vol.45 , pp. 153-239
    • Ryan, D.E.1    Levin, W.2
  • 23
    • 32544433014 scopus 로고    scopus 로고
    • Generation of specific antibodies and their use to characterize sex differences in four rat P450 3A enzymes following vehicle and pregnenolone 16α-carbonitrile treatment
    • Jan Y.-H., Mishin V., Busch C.M., and Thomas P.E. Generation of specific antibodies and their use to characterize sex differences in four rat P450 3A enzymes following vehicle and pregnenolone 16α-carbonitrile treatment. Arch. Biochem. Biophys. 446 (2006) 101-110
    • (2006) Arch. Biochem. Biophys. , vol.446 , pp. 101-110
    • Jan, Y.-H.1    Mishin, V.2    Busch, C.M.3    Thomas, P.E.4
  • 24
    • 0022357068 scopus 로고
    • Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450
    • Burke M.D., Thompson S., Elcombe C.R., Halpert J., Haaparanta T., and Mayer R.T. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450. Biochem. Pharmacol. 34 (1985) 3337-3345
    • (1985) Biochem. Pharmacol. , vol.34 , pp. 3337-3345
    • Burke, M.D.1    Thompson, S.2    Elcombe, C.R.3    Halpert, J.4    Haaparanta, T.5    Mayer, R.T.6
  • 25
    • 0029042181 scopus 로고
    • Effect of cytochrome P450 inducers on liver microsomal metabolism of tetrachlorobiphenyls in rats, guinea pigs and hamsters
    • Koga N., Kikuichi-Nishimura N., and Yoshimura H. Effect of cytochrome P450 inducers on liver microsomal metabolism of tetrachlorobiphenyls in rats, guinea pigs and hamsters. Biol. Pharm. Bull. 18 (1995) 705-710
    • (1995) Biol. Pharm. Bull. , vol.18 , pp. 705-710
    • Koga, N.1    Kikuichi-Nishimura, N.2    Yoshimura, H.3
  • 26
    • 0032868570 scopus 로고    scopus 로고
    • Oxidative inactivation of cytochrome P-450 1A (CYP1A) stimulated by 3,3′,4,4′-tetrachlorobiphenyl: production of reactive oxygen by vertebrate CYP1As
    • Schlezinger J.J., White R.D., and Stegeman J.J. Oxidative inactivation of cytochrome P-450 1A (CYP1A) stimulated by 3,3′,4,4′-tetrachlorobiphenyl: production of reactive oxygen by vertebrate CYP1As. Mol. Pharmacol. 56 (1999) 588-597
    • (1999) Mol. Pharmacol. , vol.56 , pp. 588-597
    • Schlezinger, J.J.1    White, R.D.2    Stegeman, J.J.3
  • 27
    • 0031904697 scopus 로고    scopus 로고
    • Low inducibility of CYP1A activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): characterization of the Ah receptor and the role of CYP1A inhibition
    • Besselink H.T., Denison M.S., Hahn M.E., Karchner S.I., Vethaak A.D., Koeman J.H., and Brouwer A. Low inducibility of CYP1A activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): characterization of the Ah receptor and the role of CYP1A inhibition. Toxicol. Sci. 43 (1998) 161-171
    • (1998) Toxicol. Sci. , vol.43 , pp. 161-171
    • Besselink, H.T.1    Denison, M.S.2    Hahn, M.E.3    Karchner, S.I.4    Vethaak, A.D.5    Koeman, J.H.6    Brouwer, A.7
  • 31
    • 0030749297 scopus 로고    scopus 로고
    • Substrate docking algorithms and prediction of the substrate specificity of cytochrome P450cam and its L244A mutant
    • DeVoss J.J., Sibbesen O., Zhang Z., and Ortiz de Montellano P.R. Substrate docking algorithms and prediction of the substrate specificity of cytochrome P450cam and its L244A mutant. J. Am. Chem. Soc. 119 (1997) 5480-5498
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 5480-5498
    • DeVoss, J.J.1    Sibbesen, O.2    Zhang, Z.3    Ortiz de Montellano, P.R.4


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