Modelling of bet v 1 binding to lipids

Scandinavian Journal of Immunology

Volumn 70, Issue 2, 2009, Pages 116-124

  Mattila, K ^a,b   Renkonen, R ^a,c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b CSC Scientific Computing Ltd   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BET V 1 PROTEIN; CERAMIDE; GANGLIOSIDE; GLYCOLIPID; LIPID; PROTEIN; SPHINGOMYELIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CAVEOLA; COMPUTER MODEL; EPITHELIUM; HYDROPHOBICITY; LIPID RAFT; MOLECULAR MODEL; POLLEN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LIPID INTERACTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT;

ALGORITHMS; ANTIGENS, PLANT; BETULA; CAVEOLAE; HUMANS; LIPIDS; MODELS, IMMUNOLOGICAL; POLLEN; PROTEIN CONFORMATION;

EID: 67651248247     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2009.02277.x     Document Type: Article

References (28)

1. Averbeck M, Gebhardt C, Emmrich F, Treudler R, Simon JC. Immunologic principles of allergic disease. J Dtsch Dermatol Ges 2007 5 : 1015 28.
2. Bohle B. The impact of pollen-related food allergens on pollen allergy. Allergy 2007 62 : 3 10.
3. D'Amato G, Cecchi L, Bonini S et al. Allergenic pollen and pollen allergy in Europe. Allergy 2007 62 : 976 90.
4. Larche M, Akdis CA, Valenta R. Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol 2006 6 : 761 71.
5. Valenta R, Niederberger V. Recombinant allergens for immunotherapy. J Allergy Clin Immunol 2007 119 : 826 30.
6. Renkonen J, Mattila P, Lehti S et al. Birch pollen allergen Bet v 1 binds to and is transported through conjunctival epithelium in allergic patients. Allergy 2009 64 : 868 75.
7. Joenväärä S, Mattila P, Renkonen J et al. Caveolar traffic through nasal epithelium of birch pollen allergen Bet v 1 in allergic patients. J Allergy Clin Immunol Apr 1 2009 (Epub ahead of print).
8. Schenk MF, Gilissen LJ, Esselink GD, Smulders MJ. Seven different genes encode a diverse mixture of isoforms of Bet v 1, the major birch pollen allergen. BMC Genomics 2006 7 : 168.
9. Mirza O, Henriksen A, Ipsen H et al. Dominant epitopes and allergic cross-reactivity: complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen Bet v 1. J Immunol 2000 165 : 331 8.
10. Swoboda I, Hoffmann-Sommergruber K, Scheiner O, Heberle-Bors E, Vicente O. Bet v 1 proteins, the major birch pollen allergens and members of a family of conserved pathogenesis-related proteins, show ribonucease activity in vitro. Physiol Plant 1996 96 : 433 8.
11. Mogensen JE, Wimmer R, Larsen JN, Spangfort MD, Otzen DE. The major birch allergen, Bet v 1, shows affinity for a broad spectrum of physiological ligands. J Biol Chem 2002 277 : 23684 92.
12. Markovic-Housley Z, Degano M, Lamba D et al. Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier. J Mol Biol 2003 325 : 123 33.
13. Mogensen JE, Ferreras M, Wimmer R, Petersen SV, Enghild JJ, Otzen DE. The major allergen from birch tree pollen, Bet v 1, binds and permeabilizes membranes. Biochemistry 2007 46 : 3356 65.
14. Gajhede M, Osmark P, Poulsen FM et al. X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy. Nat Struct Biol 1996 3 : 1040 5.
15. Spangfort MD, Mirza O, Ipsen H, Van Neerven RJ, Gajhede M, Larsen JN. Dominating IgE-binding epitope of Bet v 1, the major allergen of birch pollen, characterized by X-ray crystallography and site-directed mutagenesis. J Immunol 2003 171 : 3084 90.
16. Saraste M, Sibbald PR, Wittinghofer A. The P-loop - a common motif in ATP- and GTP-binding proteins. Trends Biochem Sci 1990 15 : 430 4.
17. Ponting CP, Aravind L. START: a lipid-binding domain in StAR, HD-ZIP and signalling proteins. Trends Biochem Sci 1999 24 : 130 2.
18. Yaworsky DC, Baker BY, Bose HS et al. pH-dependent interactions of the carboxyl-terminal helix of steroidogenic acute regulatory protein with synthetic membranes. J Biol Chem 2005 280 : 2045 54.
19. Roderick SL, Chan WW, Agate DS et al. Structure of human phosphatidylcholine transfer protein in complex with its ligand. Nat Struct Biol 2002 9 : 507 11.
20. Tsujishita Y, Hurley JH. Structure and lipid transport mechanism of a StAR-related domain. Nat Struct Biol 2000 7 : 408 14.
21. Wu G, Robertson DH, Brooks CL 3rd., Vieth M. Detailed analysis of grid-based molecular docking: a case study of CDOCKER-A CHARMm-based MD docking algorithm. J Comput Chem 2003 24 : 1549 62.
22. Protein Database in Europe (PDBe). http://www.ebi.ac.uk/pdbe/ (last accessed January 2009).
23. Murcia M, Faraldo-Gomez JD, Maxfield FR, Roux B. Modeling the structure of the StART domains of MLN64 and StAR proteins in complex with cholesterol. J Lipid Res 2006 47 : 2614 30.
24. Erickson JA, Jalaie M, Robertson DH, Lewis RA, Vieth M. Lessons in molecular recognition: the effects of ligand and protein flexibility on molecular docking accuracy. J Med Chem 2004 47 : 45 55.
25. Lascombe MB, Ponchet M, Venard P, Milat ML, Blein JP, Prange T. The 1.45 A resolution structure of the cryptogein-cholesterol complex: a close-up view of a sterol carrier protein (SCP) active site. Acta Crystallogr D Biol Crystallogr 2002 58 : 1442 7.
26. Swiss-Prot Protein knowledgebase, UniProtKB/Swiss-Prot Release 57.3 of 26-May-2009. http://ca.expasy.org/sprot/.
27. Fujimoto Y, Nagata R, Fukasawa H et al. Purification and cDNA cloning of cytokinin-specific binding protein from mung bean (Vigna radiata). Eur J Biochem 1998 258 : 794 802.
28. Atshavaes BP, Jefferson JR, McIntosh AL et al. Effect of sterol carrier protein-2 expression on sphingolipid distribution in plasma membrane lipid rafts/caveolae. Lipids 2007 42 : 871 84.