-
1
-
-
34250779802
-
Natalizumab for multiple sclerosis
-
DOI 10.1056/NEJMct071462
-
Ransohoff RM. Natalizumab for multiple sclerosis. N Engl J Med 2007; 356: 2622-2629. (Pubitemid 46961007)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.25
, pp. 2622-2629
-
-
Ransohoff, R.M.1
-
2
-
-
33646347357
-
NZB effects on immune cell responses in multiple sclerosis
-
Niino M, Bodner C, Simard ML, Alatab S, Gano D, Kim HJ, et al. NZB effects on immune cell responses in multiple sclerosis. Ann Neurol 2006; 59: 748-755.
-
(2006)
Ann Neurol
, vol.59
, pp. 748-755
-
-
Niino, M.1
Bodner, C.2
Simard, M.L.3
Alatab, S.4
Gano, D.5
Kim, H.J.6
-
3
-
-
74249097818
-
Monoclonal antibodies in MS: Mechanisms of action
-
Bielekova B and Becker BL. Monoclonal antibodies in MS: mechanisms of action. Neurology 2010; 74(Suppl 1): S31-S40.
-
(2010)
Neurology
, vol.74
, Issue.SUPPL. 1
-
-
Bielekova, B.1
Becker, B.L.2
-
4
-
-
61449227381
-
Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to NZB
-
Del Pilar Martin M, Cravens PD, Winger R, Frohman EM, Racke MK, Eagar TN, et al. Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to NZB. Arch Neurol 2008; 65: 1596-1603.
-
(2008)
Arch Neurol
, vol.65
, pp. 1596-1603
-
-
Del Pilar Martin, M.1
Cravens, P.D.2
Winger, R.3
Frohman, E.M.4
Racke, M.K.5
Eagar, T.N.6
-
5
-
-
33646347610
-
Immune surveillance in multiple sclerosis patients treated with natalizumab
-
DOI 10.1002/ana.20858
-
Stüve O, Marra CM, Jerome KR, Cook L, Cravens PD, Cepok S, et al. Immune surveillance in multiple sclerosis patients treated with NZB. Ann Neurol 2006; 59: 743-747. (Pubitemid 43673151)
-
(2006)
Annals of Neurology
, vol.59
, Issue.5
, pp. 743-747
-
-
Stuve, O.1
Marra, C.M.2
Jerome, K.R.3
Cook, L.4
Cravens, P.D.5
Cepok, S.6
Frohman, E.M.7
Phillips, T.8
Arendt, G.9
Hemmer, B.10
Monson, N.L.11
Racke, M.K.12
-
6
-
-
0029076191
-
Role of the VLA-4 molecule in T cell costimulation. Identification of the tyrosine phosphorylation pattern induced by the ligation of VLA-4
-
Sato T, Tachibana K, Nojima Y, D'Avirro N and Morimoto C. Role of the VLA-4 molecule in T cell costimulation. Identification of the tyrosine phosphorylation pattern induced by the ligation of VLA-4. J Immunol 1995; 155: 2938-2947.
-
(1995)
J Immunol
, vol.155
, pp. 2938-2947
-
-
Sato, T.1
Tachibana, K.2
Nojima, Y.3
D'avirro, N.4
Morimoto, C.5
-
7
-
-
33644584352
-
AFFIRM Investigators. A randomized, placebo-controlled trial of NZB for relapsing multiple sclerosis
-
Polman CH, O'Connor PW, Havrdova E, Hutchinson M, Kappos L, Miller DH, et al. AFFIRM Investigators. A randomized, placebo-controlled trial of NZB for relapsing multiple sclerosis. N Engl J Med 2006; 354: 899-910.
-
(2006)
N Engl J Med
, vol.354
, pp. 899-910
-
-
Polman, C.H.1
O'connor, P.W.2
Havrdova, E.3
Hutchinson, M.4
Kappos, L.5
Miller, D.H.6
-
8
-
-
33644608613
-
SENTINEL Investigators. NZB plus interferon beta-1a for relapsing multiple sclerosis
-
Rudick RA, Stuart WH, Calabresi PA, Confavreux C, Galetta SL, Radue EW, et al. SENTINEL Investigators. NZB plus interferon beta-1a for relapsing multiple sclerosis. N Engl J Med 2006; 354: 911-923.
-
(2006)
N Engl J Med
, vol.354
, pp. 911-923
-
-
Rudick, R.A.1
Stuart, W.H.2
Calabresi, P.A.3
Confavreux, C.4
Galetta, S.L.5
Radue, E.W.6
-
9
-
-
39149138486
-
Induction of systemic TNFα in Natalizumab-treated multiple sclerosis
-
DOI 10.1111/j.1468-1331.2007.02037.x
-
Khademi M, Stol D, Olsson T and Wallström E. Induction of systemic TNFalpha in NZB-treated multiple sclerosis. Eur J Neurol 2008; 15: 309-312. (Pubitemid 351257912)
-
(2008)
European Journal of Neurology
, vol.15
, Issue.3
, pp. 309-312
-
-
Khademi, M.1
Stol, D.2
Olsson, T.3
Wallstrom, E.4
-
10
-
-
67650032747
-
NZB treatment is associated with peripheral sequestration of proinflammatory T cells
-
Kivisäkk P, Healy BC, Viglietta V, Quintana FJ, Hootstein MA, Weiner HL, et al. NZB treatment is associated with peripheral sequestration of proinflammatory T cells. Neurology 2009; 72: 1922-1930.
-
(2009)
Neurology
, vol.72
, pp. 1922-1930
-
-
Kivisäkk, P.1
Healy, B.C.2
Viglietta, V.3
Quintana, F.J.4
Hootstein, M.A.5
Weiner, H.L.6
-
11
-
-
53749105749
-
Effects of NZB treatment on Foxp3+ T regulatory cells
-
Stenner MP, Waschbisch A, Buck D, Doerck S, Einsele H, Toyka KV, et al. Effects of NZB treatment on Foxp3+ T regulatory cells. PLoS One 2008; 3: e3319.
-
(2008)
PLoS One
, vol.3
-
-
Stenner, M.P.1
Waschbisch, A.2
Buck, D.3
Doerck, S.4
Einsele, H.5
Toyka, K.V.6
-
12
-
-
5144235394
-
Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: From pipe dreams to (therapeutic) pipelines
-
DOI 10.1073/pnas.0404874101
-
Hohlfeld R and Wekerle H. Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines. Proc Natl Acad Sci USA 2004; 101(Suppl. 2): 14599-14606. (Pubitemid 39346730)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.SUPPL. 2
, pp. 14599-14606
-
-
Hohlfeld, R.1
Wekerle, H.2
-
13
-
-
0033546663
-
The effect of anti-α4 integrin antibody on brain lesion activity in MS
-
Tubridy N, Behan PO, Capildeo R, Chaudhuri A, Forbes R, Hawkins CP, et al. The effect of anti-alpha4 integrin antibody on brain lesion activity in MS. The UK Antegren Study Group. Neurology 1999; 53: 466-472. (Pubitemid 29382036)
-
(1999)
Neurology
, vol.53
, Issue.3
, pp. 466-472
-
-
Tubridy, N.1
Behan, P.O.2
Capildeo, R.3
Chaudhuri, A.4
Forbes, R.5
Hawkins, C.P.6
Hughes, R.A.C.7
Palace, J.8
Sharrack, B.9
Swingler, R.10
Young, C.11
Moseley, I.F.12
MacManus, D.G.13
Donoghue, S.14
Miller, D.H.15
-
14
-
-
41549130359
-
Postwithdrawal rebound increase in T2 lesional activity in natalizumab-treated MS patients
-
DOI 10.1212/01.wnl.0000265393.03231.e5, PII 0000611420080325100002
-
Vellinga MM, Castelijns JA, Barkhof F, Uitdehaag BM and Polman CH. Postwithdrawal rebound increase in T2 lesional activity in natalizumab-treated MS patients. Neurology 2008; 70: 1150-1151. (Pubitemid 351464749)
-
(2008)
Neurology
, vol.70
, Issue.13 PART 2
, pp. 1150-1151
-
-
Vellinga, M.M.1
Castelijns, J.A.2
Barkhof, F.3
Uitdehaag, B.M.J.4
Polman, C.H.5
-
15
-
-
77956385153
-
Natalizumab drug holiday in multiple sclerosis: Poorly Tolerated
-
Killestein J, Vennegoor A, Strijbis EM, Seewann A, van Oosten BW, Uitdehaag BM, et al. Natalizumab drug holiday in multiple sclerosis: Poorly Tolerated. Ann Neurol 2010; 68: 392-395.
-
(2010)
Ann Neurol
, vol.68
, pp. 392-395
-
-
Killestein, J.1
Vennegoor, A.2
Strijbis, E.M.3
Seewann, A.4
Van Oosten, B.W.5
Uitdehaag, B.M.6
-
16
-
-
33749462336
-
PSTAT1, pSTAT3, and T-bet expression in peripheral blood mononuclear cells from relapsing-remitting multiple sclerosis patients correlates with disease activity
-
DOI 10.1002/jnr.20995
-
Frisullo G, Angelucci F, Caggiula M, Nociti V, Iorio R, Patanella AK, et al. pSTAT1, pSTAT3, and T-bet expression in peripheral blood mononuclear cells from relapsing-remitting multiple sclerosis patients correlates with disease activity. J Neurosci Res 2006; 84: 1027-1036. (Pubitemid 44521047)
-
(2006)
Journal of Neuroscience Research
, vol.84
, Issue.5
, pp. 1027-1036
-
-
Frisullo, G.1
Angelucci, F.2
Caggiula, M.3
Nociti, V.4
Iorio, R.5
Patanella, A.K.6
Sancricca, C.7
Mirabella, M.8
Tonali, P.A.9
Batocchi, A.P.10
-
17
-
-
34547841656
-
Glucocorticoid treatment reduces T-bet and pSTAT1 expression in mononuclear cells from relapsing remitting multiple sclerosis patients
-
DOI 10.1016/j.clim.2007.05.011, PII S1521661607012193
-
Frisullo G, Nociti V, Iorio R, Patanella AK, Bianco A, Caggiula M, et al. Glucocorticoid treatment reduces T-bet and pSTAT1 expression in mononuclear cells from relapsing remitting multiple sclerosis patients. Clin Immunol 2007; 124: 284-293. (Pubitemid 47247610)
-
(2007)
Clinical Immunology
, vol.124
, Issue.3
, pp. 284-293
-
-
Frisullo, G.1
Nociti, V.2
Iorio, R.3
Katia Patanella, A.4
Bianco, A.5
Caggiula, M.6
Sancricca, C.7
Tonali, P.A.8
Mirabella, M.9
Batocchi, A.P.10
-
18
-
-
66549093255
-
Regulatory T cells fail to suppress CD4T+-bet+ T cells in relapsing multiple sclerosis patients
-
Frisullo G, Nociti V, Iorio R, Patanella AK, Caggiula M, Marti A, et al. Regulatory T cells fail to suppress CD4T+-bet+ T cells in relapsing multiple sclerosis patients. Immunology 2009; 127: 418-428.
-
(2009)
Immunology
, vol.127
, pp. 418-428
-
-
Frisullo, G.1
Nociti, V.2
Iorio, R.3
Patanella, A.K.4
Caggiula, M.5
Marti, A.6
-
19
-
-
0034955141
-
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the diagnosis of multiple sclerosis
-
McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001; 50: 121-127.
-
(2001)
Ann Neurol
, vol.50
, pp. 121-127
-
-
McDonald, W.I.1
Compston, A.2
Edan, G.3
Goodkin, D.4
Hartung, H.P.5
Lublin, F.D.6
-
20
-
-
55449137632
-
Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis
-
Krumbholz M, Meinl I, Kümpfel T, Hohlfeld R and Meinl E. Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis. Neurology 2008; 71: 1350-1354.
-
(2008)
Neurology
, vol.71
, pp. 1350-1354
-
-
Krumbholz, M.1
Meinl, I.2
Kümpfel, T.3
Hohlfeld, R.4
Meinl, E.5
-
21
-
-
77951954050
-
Effects of natalizumab on circulating B cells, T regulatory cells and natural killer cells
-
Putzki N, Baranwal MK, Tettenborn B, Limmroth V and Kreuzfelder E. Effects of natalizumab on circulating B cells, T regulatory cells and natural killer cells. Eur Neurol 2010; 63: 311-317.
-
(2010)
Eur Neurol
, vol.63
, pp. 311-317
-
-
Putzki, N.1
Baranwal, M.K.2
Tettenborn, B.3
Limmroth, V.4
Kreuzfelder, E.5
-
22
-
-
70149122373
-
Pathogenic CD8(+) T cells in multiple sclerosis
-
Friese MA and Fugger L. Pathogenic CD8(+) T cells in multiple sclerosis. Ann Neurol 2009; 66: 132-141.
-
(2009)
Ann Neurol
, vol.66
, pp. 132-141
-
-
Friese, M.A.1
Fugger, L.2
-
23
-
-
0034677646
-
A novel transcription factor, T-bet, directs Th1 lineage commitment
-
Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG and Glimcher LH. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000; 100: 655-669.
-
(2000)
Cell
, vol.100
, pp. 655-669
-
-
Szabo, S.J.1
Kim, S.T.2
Costa, G.L.3
Zhang, X.4
Fathman, C.G.5
Glimcher, L.H.6
-
25
-
-
65549118531
-
Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin- 12
-
Schulz EG, Mariani L, Radbruch A and Höfer T. Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin- 12. Immunity 2009; 30: 673-683.
-
(2009)
Immunity
, vol.30
, pp. 673-683
-
-
Schulz, E.G.1
Mariani, L.2
Radbruch, A.3
Höfer, T.4
-
26
-
-
0035910037
-
T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells
-
DOI 10.1073/pnas.261570598
-
Lighvani AA, Frucht DM, Jankovic D, Yamane H, Aliberti J, Hissong BD, et al. T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc Natl Acad Sci USA 2001; 98: 15137-15142. (Pubitemid 34013982)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.26
, pp. 15137-15142
-
-
Lighvani, A.A.1
Frucht, D.M.2
Jankovic, D.3
Yamane, H.4
Aliberti, J.5
Hissong, B.D.6
Nguyen, B.V.7
Gadina, M.8
Sher, A.9
Paul, W.E.10
O'Shea, J.J.11
-
27
-
-
40449137091
-
Cutting edge: T-bet and IL-27R are critical for in vivo IFN-gamma production by CD8 T cells during infection
-
Mayer KD, Mohrs K, Reiley W, Wittmer S, Kohlmeier JE, Pearl JE, et al. Cutting edge: T-bet and IL-27R are critical for in vivo IFN-gamma production by CD8 T cells during infection. J Immunol 2008; 180: 693-697.
-
(2008)
J Immunol
, vol.180
, pp. 693-697
-
-
Mayer, K.D.1
Mohrs, K.2
Reiley, W.3
Wittmer, S.4
Kohlmeier, J.E.5
Pearl, J.E.6
-
28
-
-
60549090859
-
Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs
-
Cruz-Guilloty F, Pipkin ME, Djuretic IM, Levanon D, Lotem J, Lichtenheld MG, et al. Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs. J Exp Med 2009; 206: 51-59.
-
(2009)
J Exp Med
, vol.206
, pp. 51-59
-
-
Cruz-Guilloty, F.1
Pipkin, M.E.2
Djuretic, I.M.3
Levanon, D.4
Lotem, J.5
Lichtenheld, M.G.6
-
29
-
-
33846514266
-
T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity
-
Gocke AR, Cravens PD, Ben LH, Hussain RZ, Northrop SC, Racke MK, et al. T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity. J Immunol 2007; 178: 1341-1348. (Pubitemid 46154603)
-
(2007)
Journal of Immunology
, vol.178
, Issue.3
, pp. 1341-1348
-
-
Gocke, A.R.1
Cravens, P.D.2
Ben, L.-H.3
Hussain, R.Z.4
Northrop, S.C.5
Racke, M.K.6
Lovett-Racke, A.E.7
-
30
-
-
77953293952
-
Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis
-
Durant L, Watford WT, Ramos HL, Laurence A, Vahedi G, Wei L, et al. Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity 2010; 32: 605-615.
-
(2010)
Immunity
, vol.32
, pp. 605-615
-
-
Durant, L.1
Watford, W.T.2
Ramos, H.L.3
Laurence, A.4
Vahedi, G.5
Wei, L.6
-
31
-
-
45749101727
-
H17 cells
-
DOI 10.1038/nature07036, PII NATURE07036
-
Bettelli E, Korn T, Oukka M and Kuchroo VK. Induction and effector functions of T(H)17 cells. Nature 2008; 453: 1051-1057. (Pubitemid 351871737)
-
(2008)
Nature
, vol.453
, Issue.7198
, pp. 1051-1057
-
-
Bettelli, E.1
Korn, T.2
Oukka, M.3
Kuchroo, V.K.4
-
32
-
-
18944370055
-
Regulation of IFN-γ production by B effector 1 cells: Essential roles for T-bet and the IFN-γ receptor
-
Harris DP, Goodrich S, Gerth AJ, Peng SL and Lund FE. Regulation of INF-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor. J Immunol 2005; 174: 6781-6790. (Pubitemid 40705641)
-
(2005)
Journal of Immunology
, vol.174
, Issue.11
, pp. 6781-6790
-
-
Harris, D.P.1
Goodrich, S.2
Gerth, A.J.3
Peng, S.L.4
Lund, F.E.5
-
33
-
-
33745699554
-
The T-box transcription factor T-bet in immunity and autoimmunity
-
Peng SL. The T-box transcription factor T-bet in immunity and autoimmunity. Cell Mol Immunol 2006; 3: 87-95.
-
(2006)
Cell Mol Immunol
, vol.3
, pp. 87-95
-
-
Peng, S.L.1
-
34
-
-
77953988626
-
STAT1-dependent IgG cell-surface expression in a human B cell line derived from a STAT1-deficient patient
-
Najjar I, Deglesne PA, Schischmanoff PO, Fabre EE, Boisson-Dupuis S, Nimmerjahn F, et al. STAT1-dependent IgG cell-surface expression in a human B cell line derived from a STAT1-deficient patient. J Leukoc Biol 2010; 87: 1145-1152.
-
(2010)
J Leukoc Biol
, vol.87
, pp. 1145-1152
-
-
Najjar, I.1
Deglesne, P.A.2
Schischmanoff, P.O.3
Fabre, E.E.4
Boisson-Dupuis, S.5
Nimmerjahn, F.6
-
35
-
-
76149139419
-
B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing longlived antibody responses in humans
-
Avery DT, Deenick EK, Ma CS, Suryani S, Simpson N, Chew GY, et al. B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing longlived antibody responses in humans. J Exp Med 2010; 207: 155-171.
-
(2010)
J Exp Med
, vol.207
, pp. 155-171
-
-
Avery, D.T.1
Deenick, E.K.2
Ma, C.S.3
Suryani, S.4
Simpson, N.5
Chew, G.Y.6
-
36
-
-
44949253997
-
Interferon-β increases BAFF levels in multiple sclerosis: Implications for B cell autoimmunity
-
DOI 10.1093/brain/awn077
-
Krumbholz M, Faber H, Steinmeyer F, Hoffmann LA, Kümpfel T, Pellkofer H, et al. Interferon-beta increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity. Brain 2008; 131: 1455-1463. (Pubitemid 351806460)
-
(2008)
Brain
, vol.131
, Issue.6
, pp. 1455-1463
-
-
Krumbholz, M.1
Faber, H.2
Steinmeyer, F.3
Hoffmann, L.-A.4
Kumpfel, T.5
Pellkofer, H.6
Derfuss, T.7
Ionescu, C.8
Starck, M.9
Hafner, C.10
Hohlfeld, R.11
Meinl, E.12
-
37
-
-
67650433931
-
T-bet is essential for encephalitogenicity of both \hfill Th1 and Th17 cells
-
Yang Y, Weiner J, Liu Y, Smith AJ, Huss DJ, Winger R, et al. T-bet is essential for encephalitogenicity of both \hfill Th1 and Th17 cells. J Exp Med 2009; 206: 1549-1564.
-
(2009)
J Exp Med
, vol.206
, pp. 1549-1564
-
-
Yang, Y.1
Weiner, J.2
Liu, Y.3
Smith, A.J.4
Huss, D.J.5
Winger, R.6
-
38
-
-
70349735887
-
Encephalitogenic T cells that stably express both T-bet and ROR gamma t consistently produce IFNgamma but have a spectrum of IL-17 profiles
-
Abromson-Leeman S, Bronson RT and Dorf ME. Encephalitogenic T cells that stably express both T-bet and ROR gamma t consistently produce IFNgamma but have a spectrum of IL-17 profiles. J Neuroimmunol 2009; 215: 10-24.
-
(2009)
J Neuroimmunol
, vol.215
, pp. 10-24
-
-
Abromson-Leeman, S.1
Bronson, R.T.2
Dorf, M.E.3
-
39
-
-
44449136105
-
Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases
-
Liu X, Lee YS, Yu CR and Egwuagu CE. Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases. J Immunol 2008; 180: 6070-6076.
-
(2008)
J Immunol
, vol.180
, pp. 6070-6076
-
-
Liu, X.1
Lee, Y.S.2
Yu, C.R.3
Egwuagu, C.E.4
-
40
-
-
3142724732
-
Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis
-
DOI 10.1084/jem.20031819
-
Bettelli E, Sullivan B, Szabo SJ, Sobel RA, Glimcher LH and Kuchroo VK. Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J Exp Med 2004; 200: 79-87. (Pubitemid 38924730)
-
(2004)
Journal of Experimental Medicine
, vol.200
, Issue.1
, pp. 79-87
-
-
Bettelli, E.1
Sullivan, B.2
Szabo, S.J.3
Sobel, R.A.4
Glimcher, L.H.5
Kuchroo, V.K.6
-
41
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
DOI 10.1126/science.1079490
-
Hori S, Nomura T and Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-1061. (Pubitemid 36222930)
-
(2003)
Science
, vol.299
, Issue.5609
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
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