Anticonvulsant and depressant effects of aqueous extracts of Carum copticum seeds in male rats

Epilepsy and Behavior

Volumn 22, Issue 2, 2011, Pages 220-225

  Rezvani, Mohammad Ebrahim ^a   Roohbakhsh, Ali ^b   Mosaddegh, Mohammad Hossein ^a   Esmailidehaj, Mansour ^a   Khaloobagheri, Fatemeh ^b   Esmaeili, Hossein ^b  

^a SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Anxiety; Carum copticum; Folk medicine; Herbal medicine; Kindling; Locomotor activity; Seizure

Indexed keywords

ALKALOID; ANTHRAQUINONE; ANTICONVULSIVE AGENT; ANXIOLYTIC AGENT; CARUM COPTICUM EXTRACT; FLAVONOID; PENTETRAZOLE; PLANT EXTRACT; SAPONIN; SEDATIVE AGENT; TANNIN; UNCLASSIFIED DRUG;

AFTERDISCHARGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BASOLATERAL AMYGDALA; CARAWAY; CARUM COPTICUM; CLONUS; CONTROLLED STUDY; DRUG EFFECT; ELECTRODE; EPILEPSY; HISTOPATHOLOGY; LATENT PERIOD; LOCOMOTION; MALE; MAZE TEST; MEDICINAL PLANT; NONHUMAN; OPEN FIELD TEST; PHYTOCHEMISTRY; PLANT SEED; RAT; REARING; SEDATION;

AMYGDALA; ANALYSIS OF VARIANCE; ANIMALS; ANTICONVULSANTS; CARUM; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; HYPNOTICS AND SEDATIVES; KINDLING, NEUROLOGIC; MALE; MAZE LEARNING; MOTOR ACTIVITY; PENTYLENETETRAZOLE; PHYTOTHERAPY; RATS; RATS, WISTAR; SEEDS; SEIZURES;

EID: 80053383911     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2011.07.017     Document Type: Article

References (45)

1. Murray T.F., Zhang G., Franklin P.H. Manipulation of endogenous adenosine affects seizure susceptibility. Drug Dev Res 1993, 28:410-415.
2. Goddard G.V., McIntyre D.C., Leech C.K. Permanent change in brain function resulting from daily electrical stimulation. Exp Neurol 1969, 25:295-330.
3. Becker A., Grecksch G., Rüthrich H.L., Pohle W., Marx B., Matthies H. Kindling and its consequences on learning in rats. Behav Neural Biol 1992, 57:37-43.
4. Raza M., Choudhary M.I. Medicinal plants with anticonvulsant activities. Part 3, Bioactive Natural Products (part C) 2000, vol. 22:507-553. Elsevier. Atta-ur-Rahman (Ed.).
5. Zargari A. Medicinal plants (Vol. 2) 1988, Tehran University Publications, Tehran, Iran.
6. Devasankaraiah G., Hanin I., Haranath P.S., Ramanamurthy P.S. Cholinomimetic effects of aqueous extracts from Carum copticum seeds. Br J Pharmacol 1974, 52:613-614.
7. Vasudevan K., Vembar S., Veeraraghavan K., Haranath P.S. Influence of intragastric perfusion of aqueous spice extracts on acid secretion in anesthetized albino rats. Indian J Gastroenterol 2000, 19:53-56.
8. Gilani A.H., Jabeen Q., Ghayur M.N., Janbaz K.H., Akhtar M.S. Studies on the antihypertensive, antispasmodic, bronchodilator and hepatoprotective activities of the Carum copticum seed extract. J Ethnopharmacol 2005, 98:127-135.
9. Boskabady M.H., Shaikhi J. Inhibitory effect of Carum copticum on histamine (H1) receptors of isolated guinea-pig tracheal chains. J Ethnopharmacol 2000, 69:217-227.
10. Dashti-Rahmatabadi M.H., Hejazian S.H., Morshedi A., Rafati A. The analgesic effect of Carum copticum extract and morphine on phasic pain in mice. J Ethnopharmacol 2007, 109:226-228.
11. Olfert E.D., Cross B.M., McWilliam A.A. Guide to the care and use of experimental animals 1993, Canadian Council on Animal Care, Ottawa.
12. Gupta Y.K., Veerendra Kumar M.H., Srivastava A.K. Effect of Centella asiatica on pentylenetetrazole-induced kindling, cognition and oxidative stress in rats. Pharmacol Biochem Behav 2003, 74:579-585.
13. Rezvani M.E., Roohbakhsh A., Allahtavakoli M., Shamsizadeh A. Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: possible involvement of adenosine. J Ethnopharmacol 2010, 127:313-318.
14. Mora S., Diaz-Veliz G., Lungenstrass H., et al. Central nervous system activity of the hydroalcoholic extract of Casimiroa edulis in rats and mice. J Ethnopharmacol 2005, 97:191-197.
15. Miller L.C., Tainter M.L. Estimation of LD50 and its error by means of log-probit graph paper. Proc Soc Exp Biol Med 1944, 57:261-264.
16. Kaur G.J., Arora D.S. Antibacterial and phytochemical screening of Anethum graveolens, Foeniculum vulgare and Trachyspermum ammi. BMC Complement Altern Med 2009, 9:30.
17. Sato M. Intractability of complex partial seizure with secondary generalization: kindling studies in cats. Tohoku J Exp Med 1990, 161(Suppl):253-271.
18. Ramanjaneyulu R., Ticku M.K. Interactions of pentamethylenetetrazole and tetrazole analogues with the picrotoxinin site of the benzodiazepine-GABA receptor-ionophore complex. Eur J Pharmacol 1984, 98:337-345.
19. Leonard B.E. Fundamentals of psychopharmacology 2000, 173-187. John Wiley and Sons Ltd., Chichester. Second ed.
20. Corda M.G., Orlandi M., Lecca D., Giorgi O. Decrease in GABAergic function induced by pentylenetetrazol kindling in rats: antagonism by MK-801. J Pharmacol Exp Ther 1992, 262:792-800.
21. Corda M.G., Giorgi O., Longoni B., Orlandi M., Biggio G. Decrease in the function of the gamma-aminobutyric acid-coupled chloride channel produced by the repeated administration of pentylenetetrazol to rats. J Neurochem 1990, 55:1216-1221.
22. Titulaer M.N., Ghijsen W.E., Kamphuis W., De Rijk T.C., Lopes da Silva F.H. Opposite changes in GABAA receptor function in the CA1-3 area and fascia dentata of kindled rat hippocampus. J Neurochem 1995, 64:2615-2621.
23. Suzuki K., Omura S., Ohashi Y., et al. FK506 facilitates chemical kindling induced by pentylenetetrazole in rats. Epilepsy Res 2001, 46:279-282.
24. Uma Pradeep K., Geervani P., Eggum B.O. Common Indian spices: nutrient composition, consumption and contribution to dietary value. Plant Foods Hum Nutr 1993, 44:137-148.
25. Gao X., Chang Y. Enhancement of benzodiazepine receptor binding by L-lysine is chloride-dependent and due to increase in binding affinity. Eur J Pharmacol 1989, 173:197-200.
26. Chang Y., Gao X., Chen J. Correlation between enhancement of [3H]flunitrazepam binding and suppression of pentylenetetrazol-induced seizures by L-lysine. Eur J Pharmacol 1991, 193:239-247.
27. Ticku M.K., Maksay G. Convulsant/depressant site of action at the allosteric benzodiazepine-GABA receptor-ionophore complex. Life Sci 1983, 33:2363-2375.
28. Vezzani A., Wu H.Q., Stasi M.A., Angelico P., Samanin R. Effect of various calcium channel blockers on three different models of limbic seizures in rats. Neuropharmacology 1988, 27:451-458.
29. Navidpour L., Shafaroodi H., Miri R., Dehpour A.R., Shafiee A. Lipophilic 4-imidazoly-1, 4-dihydropyridines: synthesis, calcium channel antagonist activity and protection against pentylenetetrazole-induced seizure. Farmaco 2004, 59:261-269.
30. Shitak R., Sahai A.K., Hota D., Chakrabarti A. Anti-seizure efficacy of nimodipine in pentylenetetrazole and kainic acid combined seizure models in mice. Indian J Physiol Pharmacol 2006, 50:265-272.
31. Morales-Garcia J.A., Luna-Medina R., Martinez A., Santos A., Perez-Castillo A. Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid-induced seizures in rats. J Neurosci Res 2009, 87:3687-3696.
32. Kamei C., Ishizawa K., Kakinoki H., Fukunaga M. Histaminergic mechanisms in amygdaloid-kindled seizures in rats. Epilepsy Res 1998, 30:187-194.
33. Chen Z., Li Z., Sakurai E., et al. Chemical kindling induced by pentylenetetrazol in histamine H1 receptor gene knockout mice (H1KO), histidine decarboxylase-deficient mice (HDC-/-) and mast cell-deficient W/Wv mice. Brain Res 2003, 968:162-166.
34. Fujii Y., Tanaka T., Harada C., Hirai T., Kamei C. Epileptogenic activity induced by histamine H1 antagonists in amygdala-kindled rats. Brain Res 2003, 991:258-261.
35. Kakinoki H., Ishizawa K., Fukunaga M., Fujii Y., Kamei C. The effects of histamine H3-receptor antagonists on amygdaloid kindled seizures in rats. Brain Res Bull 1998, 46:461-465.
36. Harada C., Fujii Y., Hirai T., Shinomiya K., Kamei C. Inhibitory effect of iodophenpropit, a selective histamine H3 antagonist, on amygdaloid kindled seizures. Brain Res Bull 2004, 63:143-146.
37. Medina J.H., Viola H., Wolfman C., et al. Overview-flavonoids-a new family of benzodiazepine receptor ligands. Neurochem Res 1997, 22:419-425.
38. Ren L., Wang F., Xu Z., Chan W.M., Zhao C., Xue H. GABA(A) receptor subtype selectivity underlying anxiolytic effect of 6-hydroxyflavone. Biochem Pharmacol 2010, 79(9):1337-1344.
39. Schroeter H., Bahia P., Spencer J.P.E., et al. (-) Epicatechin stimulates ERK-dependent cyclic AMP response element activity and upregulates GLUR2 in cortical neurons. J Neurochem 2007, 101:1596-1606.
40. Gottesmann C. GABA mechanisms and sleep. Neuroscience 2002, 111:231-239.
41. Dawson G.R., Tricklebank M.D. Use of the elevated plus maze in the search for novel anxiolytic agents. Trends Pharmacol Sci 1995, 16:33-36.
42. Lister R.G. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology 1987, 92:180-185.
43. File S.E. Behavioural detection of anxiolytic action. Experimental approaches to anxiety and depression 1992, 25-44. John Wiley and Sons, Ltd., Chichester, UK. J.M. Elliot, D.J. Heal, C.A. Marsden (Eds.).
44. Ramos A., Berton O., Mormede P., Chaouloff F. A multiple-test study of anxiety-related behaviours in six inbred rat strains. Behav Brain Res 1997, 85:57-69.
45. Rodgers R.J., Johnson J.T. Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety. Pharmacol Biochem Behav 1995, 52:297-303.