Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid-induced seizures in rats

Journal of Neuroscience Research

Volumn 87, Issue 16, 2009, Pages 3687-3696

  Morales Garcia, Jose A ^a   Luna Medina, Rosario ^a   Martinez, Ana ^b,d   Santos, Angel ^c   Perez Castillo, Ana ^a  

^a CSIC   (Spain)

^b Neuropharma SA   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

Excitotoxicity; Hippocampus; Kainic acid; Neuroprotection; Status epilepticus

Indexed keywords

CALCIUM; CALCIUM ANTAGONIST; CALCIUM CHANNEL L TYPE; KAINIC ACID; NP 04634; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; DRUG POTENTIATION; DRUG STRUCTURE; EPILEPTIC STATE; EXCITOTOXICITY; GLIOSIS; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; LATENT PERIOD; MALE; MORTALITY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; TREATMENT RESPONSE;

ANALYSIS OF VARIANCE; ANIMALS; ANTICONVULSANTS; ASTROCYTES; BENZAMIDES; CALCIUM; CALCIUM CHANNEL BLOCKERS; CELLS, CULTURED; CYTOPROTECTION; GLIOSIS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; KAINIC ACID; MALE; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; SEIZURES; TIME FACTORS;

EID: 71249160060     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22165     Document Type: Article

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