Fk506 facilitates chemical kindling induced by pentylenetetrazole in rats

Epilepsy Research

Volumn 46, Issue 3, 2001, Pages 279-282

  Suzuki, Katsuaki ^a   Omura, Shinichi ^a   Ohashi, Yutaka ^a   Kawai, Masayoshi ^a   Iwata, Yasuhide ^a   Tani, Kunihiko ^a   Sekine, Yoshimoto ^a   Takei, Noriyoshi ^a   Mori, Norio ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Calcineurin; Fk506; Kindling; Pentylenetetrazole; Rat

Indexed keywords

CALCINEURIN; PENTETRAZOLE; TACROLIMUS;

ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG EFFECT; KINDLING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE;

ANIMALS; CALCINEURIN; CONVULSANTS; IMMUNOSUPPRESSIVE AGENTS; KINDLING, NEUROLOGIC; MALE; PENTYLENETETRAZOLE; RATS; RATS, WISTAR; TACROLIMUS;

EID: 0034881209     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(01)00284-4     Document Type: Article

References (13)

1. Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model
2. Decrease in the function of the gamma-aminobutyric acid-coupled chloride channel produced by the repeated administration of pentylenetetrazol to rats
3. Decrease in GABAergic function induced by pentylenetetrazol kindling in rats: Antagonism by MK-801
4. MK-801 prevents chemical kindling induced by pentylenetetrazole in rats
5. Activation of the dentate gyrus by pentylenetetrazol-evoked seizures induces mossy fiber synaptic reorganization
6. 2+-dependent phosphatase
7. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
8. Calcineurin-mediated LTD of GABAergic inhibition underlies the increased excitability of CA1 neurons associated with LTP
9. Anticonvulsant and antiepileptogenic actions of MK-801 in the kindling and electroshock models
10. Immunosuppressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat
11. Suppression of amygdaloid kindled convulsions following unilateral injections of 2-amino-7-phosphono-heptanoic acid (2-APH) into the substantia innominata of rats
12. Kindling-induced long-lasting changes in synaptic transmission in the basolateral amygdala
13. Opposite changes in GABAA receptor function in the CA1-3 area and fascia dentata of kindled rat hippocampus