Inhibition of human and rat testicular steroidogenic enzyme activities by bisphenol A

Toxicology Letters

Volumn 207, Issue 2, 2011, Pages 137-142

  Ye, Leping ^a   Zhao, Binghai ^b   Hu, Guoxin ^a   Chu, Yanhui ^b   Ge, Ren Shan ^a,b,c  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b MUDANJIANG MEDICAL UNIVERSITY   (China)

^c POPULATION COUNCIL   (United States)

Author keywords

17 Hydroxysteroid dehydrogenase 3; 3 Hydroxysteroid dehydrogenase; CYP17A1; Leydig cells

Indexed keywords

17BETA HYDROXYSTEROID DEHYDROGENASE 3; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 4,4' ISOPROPYLIDENEDIPHENOL; CYTOCHROME P450; CYTOCHROME P450 17A1; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; LEYDIG CELL; MALE; MICROSOME; NONHUMAN; PRIORITY JOURNAL; RAT; TESTIS;

17-HYDROXYSTEROID DEHYDROGENASES; 3-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; HUMANS; LEYDIG CELLS; MALE; PHENOLS; RATS; RATS, SPRAGUE-DAWLEY; STEROID 17-ALPHA-HYDROXYLASE; TESTIS; TESTOSTERONE;

RATTUS; RODENTIA;

EID: 80053375708     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.09.001     Document Type: Article

References (26)

1. Ackerman L.K., Noonan G.O., Heiserman W.M., Roach J.A., Limm W., Begley T.H. Determination of bisphenol A in U.S. infant formulas: updated methods and concentrations. J. Agric. Food Chem. 2010, 58:2307-2313.
2. Akgul Y., Derk R.C., Meighan T., Rao K.M., Murono E.P. The methoxychlor metabolite, HPTE, directly inhibits the catalytic activity of cholesterol side-chain cleavage (P450scc) in cultured rat ovarian cells. Reprod. Toxicol. 2008, 25:67-75.
3. Akingbemi B.T., Sottas C.M., Koulova A.I., Klinefelter G.R., Hardy M.P. Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells. Endocrinology 2004, 145:592-603.
4. Andersson S., Moghrabi N. Physiology and molecular genetics of 17β-hydroxysteroid dehydrogenases. Steroids 1997, 62:143-147.
5. Ashby J. Increasing the sensitivity of the rodent uterotrophic assay to estrogens, with particular reference to bisphenol A. Environ. Health Perspect. 2001, 109:1091-1094.
6. Bosmann H.B., Hales K.H., Li X., Liu Z., Stocco D.M., Hales D.B. Acute in vivo inhibition of testosterone by endotoxin parallels loss of steroidogenic acute regulatory (StAR) protein in Leydig cells. Endocrinology 1996, 137:4522-4525.
7. Edginton A.N., Ritter L. Predicting plasma concentrations of bisphenol A in children younger than 2 years of age after typical feeding schedules, using a physiologically based toxicokinetic model. Environ. Health Perspect. 2009, 117:645-652.
8. Ge R.S., Gao H.B., Nacharaju V.L., Gunsalus G.L., Hardy M.P. Identification of a kinetically distinct activity of 11beta-hydroxysteroid dehydrogenase in rat Leydig cells. Endocrinology 1997, 138:2435-2442.
9. Ge R.S., Hardy M.P. Variation in the end products of androgen biosynthesis and metabolism during postnatal differentiation of rat Leydig cells. Endocrinology 1998, 139:3787-3795.
10. Ge R.S., Hardy M.P. Regulation of Leydig cells during pubertal development. The Leydig Cell in Health and Disease 2007, 55-70. Humana Press, Totowa. A.H. Payne, M.P. Hardy (Eds.).
11. Geissler W.M., Davis D.L., Wu L., Bradshaw K.D., Patel S., Mendonca B.B., Elliston K.O., Wilson J.D., Russell D.W., Andersson S. Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3. Nat. Genet. 1994, 7:34-39.
12. Hauet T., Liu J., Li H., Gazouli M., Culty M., Papadopoulos V. PBR, StAR, and PKA: partners in cholesterol transport in steroidogenic cells. Endocr. Res. 2002, 28:395-401.
13. Herath C.B., Jin W., Watanabe G., Arai K., Suzuki A.K., Taya K. Adverse effects of environmental toxicants, octylphenol and bisphenol A, on male reproductive functions in pubertal rats. Endocrine 2004, 25:163-172.
14. Hu G.X., Lian Q.Q., Ge R.S., Hardy D.O., Li X.K. Phthalate-induced testicular dysgenesis syndrome: Leydig cell influence. Trends Endocrinol. Metab. 2009, 20:139-145.
15. Hu G.X., Zhou H.Y., Li X.W., Chen B.B., Xiao Y.C., Lian Q.Q., Liang G., Kim H.H., Zheng Z.Q., Hardy D.O., Ge R.S. The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes. J. Steroid Biochem. Mol. Biol. 2009, 115:14-19.
16. Hu Q., Jagusch C., Hille U.E., Haupenthal J., Hartmann R.W. Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer. J. Med. Chem. 2011, 53:5749-5758.
17. Leers-Sucheta S., Stocco D.M., Azhar S. Down-regulation of steroidogenic acute regulatory (StAR) protein in rat Leydig cells: implications for regulation of testosterone production during aging. Mech. Ageing Dev. 1999, 107:197-203.
18. Li D., Zhou Z., Qing D., He Y., Wu T., Miao M., Wang J., Weng X., Ferber J.R., Herrinton L.J., Zhu Q., Gao E., Checkoway H., Yuan W. Occupational exposure to bisphenol-A (BPA) and the risk of self-reported male sexual dysfunction. Hum. Reprod. 2009, 25:519-527.
19. Li D.K., Zhou Z., Miao M., He Y., Qing D., Wu T., Wang J., Weng X., Ferber J., Herrinton L.J., Zhu Q., Gao E., Yuan W. Relationship between urine bisphenol-A level and declining male sexual function. J. Androl. 2010, 31:500-506.
20. Murono E.P., Derk R.C., de Leon J.H. Differential effects of octylphenol, 17beta-estradiol, endosulfan, or bisphenol A on the steroidogenic competence of cultured adult rat Leydig cells. Reprod. Toxicol. 2001, 15:551-560.
21. Nakamura D., Yanagiba Y., Duan Z., Ito Y., Okamura A., Asaeda N., Tagawa Y., Li C., Taya K., Zhang S.Y., Naito H., Ramdhan D.H., Kamijima M., Nakajima T. Bisphenol A may cause testosterone reduction by adversely affecting both testis and pituitary systems similar to estradiol. Toxicol. Lett. 2010, 194:16-25.
22. Payne A.H., Downing J.R., Wong K.L. Luteinizing hormone receptors and testosterone synthesis in two distinct populations of Leydig cells. Endocrinology 1980, 106:1424-1429.
23. Payne A.H., O'Shaughnessy P.J. Structure, function and regulation of steroidogenic enzymes in the Leydig cell. The Leydig Cell 1996, 259-286. Cache River Press, Vienna IL. A.H. Payne, M.P.H.L.D. Russell (Eds.).
24. Sriraman V., Niu E., Matias J.R., Donahoe P.K., MacLaughlin D.T., Hardy M.P., Lee M.M. Mullerian inhibiting substance inhibits testosterone synthesis in adult rats. J. Androl. 2001, 22:750-758.
25. Takahashi O., Oishi S. Testicular toxicity of dietary 2,2-bis(4-hydroxyphenyl)propane (bisphenol A) in F344 rats. Arch. Toxicol. 2001, 75:42-51.
26. Tanaka M., Nakaya S., Katayama M., Leffers H., Nozawa S., Nakazawa R., Iwamoto T., Kobayashi S. Effect of prenatal exposure to bisphenol A on the serum testosterone concentration of rats at birth. Hum. Exp. Toxicol. 2006, 25:369-373.