Nma111p, the pro-apoptotic HtrA-like nuclear serine protease in Saccharomyces cerevisiae: A short survey

Biochemical Society Transactions

Volumn 39, Issue 5, 2011, Pages 1499-1501

  Fahrenkrog, Birthe ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Apoptosis; High temperature requirement a (HTrA); Nma111p; Programmed cell death; Saccharomyces cerevisiae; Serine protease

Indexed keywords

CYSTEINE; FUNGAL PROTEIN; HYDROGEN PEROXIDE; INHIBITOR OF APOPTOSIS PROTEIN; NMA111P PROTEIN; REACTIVE OXYGEN METABOLITE; SERINE; SERINE PROTEINASE OMI; UNCLASSIFIED DRUG;

AGING; APOPTOSIS; BACULOVIRUS; CELL NUCLEUS; CONFERENCE PAPER; CYTOPLASM; GENE MUTATION; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE; STEADY STATE; SURVIVAL; WILD TYPE; YEAST CELL;

ANIMALS; CELL NUCLEUS; HUMANS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SERINE ENDOPEPTIDASES; SERINE PROTEASES;

SACCHAROMYCES CEREVISIAE;

EID: 80053369271     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0391499     Document Type: Conference Paper

References (32)

1. Strauch, K.L., Johnson, K. and Beckwith, J. (1989) Characterization of degP, a gene required for proteolysis in the cell envelope and essential for growth of Escherichia coli at high temperature. J. Bacteriol. 171, 2689-2696
2. Lipinska, B., Fayet, O., Baird, L. and Georgopoulos, C. (1989) Identification, characterization, and mapping of the Escherichia coli htrA gene, whose product is essential for bacterial growth only at elevated temperatures. J. Bacteriol. 171, 1574-1584 (Pubitemid 19080799)
3. Clausen, T., Southan, C. and Ehrmann, M. (2002) The HtrA family of proteases: implications for protein composition and cell fate. Mol. Cell 10, 443-455 (Pubitemid 35284166)
4. Clausen, T., Kaiser, M., Huber, R. and Ehrmann, M. (2011) HTRA proteases: regulated proteolysis in protein quality control. Nat. Rev. Mol. Cell Biol. 12, 152-162
5. Pallen, M.J. and Wren, B.W. (1997) The HtrA family of serine proteases. Mol. Microbiol. 26, 209-221 (Pubitemid 27483672)
6. Harris, B.Z. and Lim, W.A. (2001) Mechanism and role of PDZ domains in signaling complex assembly. J. Cell Sci. 114, 3219-3231 (Pubitemid 32998900)
7. vande Walle, L., Lamkanfi, M. and vandenabeele, P. (2008) The mitochondrial serine protease HtrA2/Omi: an overview. Cell Death Differ. 15, 453-460 (Pubitemid 351267296)
8. Bulteau, A.L. and Bayot, A. (2011) Mitochondrial proteases and cancer. Biochim. Biophys. Acta 1807, 595-601
9. Bhuiyan, M.S. and Fukunaga, K. (2008) Activation of HtrA2, a mitochondrial serine protease mediates apoptosis: current knowledge on HtrA2 mediated myocardial ischemia/reperfusion injury. Cardiovasc. Ther. 26, 224-232
10. Chien, J., Campioni, M., Shridhar, V. and Baldi, A. (2009) HtrA serine proteases as potential therapeutic targets in cancer. Curr. Cancer Drug Targets 9, 451-468
11. Ponting, C.P. (1997) Evidence for PDZ domains in bacteria, yeast, and plants. Protein Sci. 6, 464-468
12. Fahrenkrog, B., Sauder, U. and Aebi, U. (2004) The S. cerevisiae HtrA-like protein Nma111p is a nuclear serine protease that mediates yeast apoptosis. J. Cell Sci. 117, 115-126 (Pubitemid 38072126)
13. Finkelshtein, A., Shlezinger, N., Bunis, O. and Sharon, A. (2011) Botrytis cinerea BcNma is involved in apoptotic cell death but not in stress adaptation. Fungal Genet. Biol. 48, 621-630
14. Challa, M., Malladi, S., Pellock, B.J., Dresnek, D., Varadarajan, S., Yin, Y.W., White, K. and Bratton, S.B. (2007) Drosophila Omi, a mitochondriallocalized IAP antagonist and proapoptotic serine protease. EMBO J. 26, 3144-3156 (Pubitemid 47057485)
15. Hegde, R., Srinivasula, S.M., Zhang, Z., Wassell, R., Mukattash, R., Cilenti, L., DuBois, G., Lazebnik, Y., Zervos, A.S., Fernandes-Alnemri, T. and Alnemri, E.S. (2002) Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction. J. Biol. Chem. 277, 432-438 (Pubitemid 34952076)
16. Igaki, T., Suzuki, Y., Tokushige, N., Aonuma, H., Takahashi, R. and Miura, M. (2007) Evolution of mitochondrial cell death pathway: proapoptotic role of HtrA2/Omi in Drosophila. Biochem. Biophys. Res. Commun. 356, 993-997 (Pubitemid 46529389)
17. Suzuki, Y., Imai, Y., Nakayama, H., Takahashi, K., Takio, K. and Takahashi, R. (2001) A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol. Cell 8, 613-621 (Pubitemid 32946938)
18. Suzuki, Y., Takahashi-Niki, K., Akagi, T., Hashikawa, T. and Takahashi, R. (2004) Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways. Cell Death Differ. 11, 208-216 (Pubitemid 38159645)
19. Verhagen, A.M., Silke, J., Ekert, P.G., Pakusch, M., Kaufmann, H., Connolly, L.M., Day, C.L., Tikoo, A., Burke, R., Wrobel, C. et al. (2002) HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J. Biol. Chem. 277, 445-454 (Pubitemid 34952078)
20. Padmanabhan, N., Fichtner, L., Dickmanns, A., Ficner, R., Schulz, J.B. and Braus, G.H. (2009) The yeast HtrA orthologue Ynm3 is a protease with chaperone activity that aids survival under heat stress. Mol. Biol. Cell 20, 68-77
21. Tong, F., Black, P.N., Bivins, L., Quackenbush, S., Ctrnacta, V. and DiRusso, C.C. (2006) Direct interaction of Saccharomyces cerevisiae Faa1p with the Omi/HtrA protease orthologue Ynm3p alters lipid homeostasis. Mol. Genet. Genomics 275, 330-343
22. Martins, L.M., Iaccarino, I., Tenev, T., Gschmeissner, S., Totty, N.F., Lemoine, N.R., Savopoulos, J., Gray, C.W., Creasy, C.L., Dingwall, C. and Downward, J. (2002) The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. J. Biol. Chem. 277, 439-444 (Pubitemid 34952077)
23. Srinivasula, S.M., Gupta, S., Datta, P., Zhang, Z., Hegde, R., Cheong, N., Fernandes-Alnemri, T. and Alnemri, E.S. (2003) Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2. J. Biol. Chem. 278, 31469-31472 (Pubitemid 37048322)
24. Sekine, K., Hao, Y., Suzuki, Y., Takahashi, R., Tsuruo, T. and Naito, M. (2005) HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells. Biochem. Biophys. Res. Commun. 330, 279-285 (Pubitemid 40394963)
25. Yang, Q.H., Church-Hajduk, R., Ren, J., Newton, M.L. and Du, C. (2003) Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis. Genes Dev. 17, 1487-1496 (Pubitemid 36734706)
26. Jin, S., Kalkum, M., Overholtzer, M., Stoffel, A., Chait, B.T. and Levine, A.J. (2003) CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals. Genes Dev. 17, 359-367 (Pubitemid 36182195)
27. Vaux, D.L. and Silke, J. (2005) IAPs, RINGs and ubiquitylation. Nat. Rev. Mol. Cell Biol. 6, 287-297 (Pubitemid 40516895)
28. Li, F., Flanary, P.L., Altieri, D.C. and Dohlman, H.G. (2000) Cell division regulation by BIR1, a member of the inhibitor of apoptosis family in yeast. J. Biol. Chem. 275, 6707-6711 (Pubitemid 30146205)
29. Uren, A.G., Beilharz, T., O'Connell, M.J., Bugg, S.J., van Driel, R., Vaux, D.L. and Lithgow, T. (1999) Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division. Proc. Natl. Acad. Sci. U.S.A. 96, 10170-10175 (Pubitemid 29422531)
30. Yoon, H.J. and Carbon, J. (1999) Participation of Bir1p, a member of the inhibitor of apoptosis family, in yeast chromosome segregation events. Proc. Natl. Acad. Sci. U.S.A. 96, 13208-13213
31. Walter, D., Wissing, S., Madeo, F. and Fahrenkrog, B. (2006) The inhibitor-of-apoptosis protein Bir1p protects against apoptosis in S. cerevisiae and is a substrate for the yeast homologue of Omi/HtrA2. J. Cell Sci. 119, 1843-1851 (Pubitemid 43811010)
32. Belanger, K.D., Walter, D., Henderson, T.A., Yelton, A.L., O'Brien, T.G., Belanger, K.G., Geier, S.J. and Fahrenkrog, B. (2009) Nuclear localisation is crucial for the proapoptotic activity of the HtrA-like serine protease Nma111p. J. Cell Sci. 122, 3931-3941