In vivo cytokine modulatory effects of cinnamaldehyde, the major constituent of leaf essential oil from Cinnamomum osmophloeum Kaneh.

Phytotherapy Research

Volumn 25, Issue 10, 2011, Pages 1511-1518

  Lin, Shih Shen Chou ^a   Lu, Tsong Ming ^a   Chao, Pei Chun ^a,b   Lai, Ya Yun ^a   Tsai, Hsiu Ting ^a   Chen, Chung Shih ^c   Lee, Yi Pang ^a   Chen, Shu Chen ^d   Chou, Ming Chih ^a   Yang, Chi Chiang ^a,b  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHAOYANG UNIVERSITY OF TECHNOLOGY   (Taiwan)

^d CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

cinnamaldehyde; Cinnamomum osmophloeum Kaneh.; cytokine; in vivo; toxicity

Indexed keywords

3 PHENYLPROPIONALDEHYDE; BENZALDEHYDE; CINNAMALDEHYDE; CYTOKINE; ESSENTIAL OIL; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; OVALBUMIN; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; BODY WEIGHT; CINNAMOMUM; CINNAMOMUM OSMOPHLOEUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOMODULATION; IN VIVO STUDY; KIDNEY FUNCTION; LIVER FUNCTION; MASS FRAGMENTOGRAPHY; MOUSE; NONHUMAN; PLANT LEAF; TOXICITY TESTING;

ACROLEIN; ALDEHYDES; ANIMALS; BENZALDEHYDES; CINNAMOMUM; CYTOKINES; FEMALE; IMMUNOLOGIC FACTORS; MICE; MICE, INBRED BALB C; MODELS, ANIMAL; OILS, VOLATILE; OVALBUMIN; PLANT EXTRACTS; PLANT LEAVES;

ANIMALIA; CINNAMOMUM OSMOPHLOEUM; MURINAE; MUS;

EID: 80053359013     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3419     Document Type: Article

References (45)

1. Beissert S, Schwarz A, Schwarz T,. 2006. Regulatory T cells. J Invest Dermatol 126: 15-24. (Pubitemid 43336089)
2. Billiau A,. 1996. Interferon-gamma: biology and role in pathogenesis. Adv Immunol 62: 61-130.
3. Cabello CM, Bair WB 3rd, Lamore SD, et al., 2009. The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth. Free Radic Biol Med 46: 220-231.
4. Chang ST, Chen PF, Chang SC,. 2001. Antibacterial activity of leaf essential oils and their constituents from Cinnamomum osmophloeum. J Ethnopharmacol 77: 123-127.
5. Chang ST, Cheng SS,. 2002. Antitermitic activity of leaf essential oils and components from Cinnamomum osmophleum. J Agric Food Chem 50: 1389-1392.
6. Chen PF, Chang ST,. 2002. Application of essential oils from wood on the manufacture of environment-friendly antimicrobial paper products. Q J Chin For 35: 69-74.
7. Chen PF, Chang ST, Wu HH,. 2002. Antimite activity of essential oils and their components from Cinnamomum osmophloeum. Q J Chin For 35: 397-404.
8. Cheng SS, Liu JY, Tsai KH, Chen WJ, Chang ST,. 2004. Chemical composition and mosquito larvicidal activity of essential oils from leaves of different Cinnamomum osmophloeum provenances. J Agric Food Chem 52: 4395-4400.
9. Debattista J, Timms P, Allan J, Allan J,. 2002. Reduced levels of gamma-interferon secretion in response to chlamydial 60 kDa heat shock protein amongst women with pelvic inflammatory disease and a history of repeated Chlamydia trachomatis infections. Immunol Lett 81: 205-210. (Pubitemid 34310226)
10. Dunn DE, Herold KC, Otten GR, et al,. 1987. Interleukin 2 and concanavalin A stimulate interferon-gamma production in a murine cytolytic T cell clone by different pathways. J Immunol 139: 3942-3948. (Pubitemid 18013681)
11. Friedman M, Kozukue N, Harden LA,. 2000. Cinnamaldehyde content in foods determined by gas chromatography-mass spectrometry. J Agric Food Chem 48: 5702-5709.
12. Guo JY, Huo HR, Zhao BS, et al., 2006. Cinnamaldehyde reduces IL-1beta-induced cyclooxygenase-2 activity in rat cerebral microvascular endothelial cells. Eur J Pharmacol 537: 174-180.
13. Ho CC, Lin SS, Chou MY, et al., 2005. Effects of CAPE-like compounds on HIV replication in vitro and modulation of cytokines in vivo. J Antimicrob Chemother 56: 372-379.
14. Höglund CO, Axén J, Kemi C, et al., 2006. Changes in immune regulation in response to examination stress in atopic and healthy individuals. Clin Exp Allergy 36: 982-992. (Pubitemid 44166617)
15. Hu TW, Lin YT, Ho CK,. 1985. Natural variation of chemical components of the leaf oil of Cinnamomum osmophloeum Kaneh. Bull Taiwan For Res Inst Eng 78: 18.
16. Huang TH, Yang CC, Ding SJ, Yen M, Kao CT, Chou MY,. 2005. Inflammatory cytokines reaction elicited by root-end filling materials. J Biomed Mater Res 72B: 123-128. (Pubitemid 40478267)
17. Jayaprakasha GK, Jagan Mohan Rao L, Sakariah KK,. 2003. Volatile constituents from Cinnamomum zeylanicum fruit stalks and their antioxidant activities. J Agric Food Chem 51: 4344-4348.
18. Karrow NA, Leffel EK, Guo TL, et al., 2001. Dermal exposure to cinnamaldehyde alters lymphocyte subpopulations, number of interferon-gamma- producing cells, and expression of B7 costimulatory molecules and cytokine messenger RNAs in auricular lymph nodes of B6C3F1 mice. Am J Contact Dermat 12: 6-17. (Pubitemid 32194977)
19. Kidd P,. 2003. Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Altern Med Rev 8: 223-246. (Pubitemid 37099886)
20. Kim DH, Kim CH, Kim MS, et al., 2007. Suppression of age-related inflammatory NF-kappaB activation by cinnamaldehyde. Biogerontology 8: 545-554. (Pubitemid 47365342)
21. Lee CW, Lee SH, Lee JW, et al,. 2007. 2-Hydroxycinnamaldehyde inhibits SW620 colon cancer cell growth through AP-1 inactivation. J Pharmacol Sci 104: 19-28.
22. Levings MK, Bacchetta R, Schulz U, Roncarolo MG,. 2002. The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells. Int Arch Allergy Immunol 129: 263-276.
23. Liao BC, Hsieh CW, Liu YC, Tzeng TT, Sun YW, Wung BS,. 2008. Cinnamaldehyde inhibits the tumor necrosis factor-alpha-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-kappaB activation: effects upon IkappaB and Nrf2. Toxicol Appl Pharmacol 229: 161-171.
24. Lin SJ, Chen CS, Ho CC, et al., 2006. In vitro anti-microbial and in vivo cytokines modulation effects of different prepared Chinese herbal medicines. Food Chem Toxicol 44: 2078-2085.
25. Lin SJ, Tsai JH, Tsai CH, et al., 2004. The in vivo effects of cytokines modulation for balb/c mice fed with a combined Chinese herb-soaked solution, Yifei-Ruennhou tea. Immunopharacol Immunotoxicol 26: 435-444.
26. Lin SJ, Tsai JH, Tsai CH, et al., 2005a. The in vivo effects of cytokine modulation for Balb/C mice given Canavalia ensiformis (L.) seeds with different heat treatment. Food Chem 91: 139-145.
27. Lin SS, Chou MY, Ho CC, et al., 2005b. Study of the viral infections and cytokines associated with recurrent aphthous ulceration. Microb Infect 7: 635-644.
28. Luo JP, Zhang ZS, Tian C, Li XM,. 2000. Determination of cinnamaldehyde in Guizhi by HPLC. Zhongguo Zhong Yao Za Zhi 25: 544-545.
29. Ma YY, Huo HR, Li CH, et al., 2008. Effects of cinnamaldehyde on PGE2 release and TRPV4 expression in mouse cerebral microvascular endothelial cells induced by interleukin-1beta. Biol Pharm Bull 31: 426-430.
30. MacNeil IA, Suda T, Moore KW, Mosmann TR, Zlotnik A,. 1990. IL-10, a novel growth cofactor for mature and immature T cells. J Immunol 145: 4167-4173.
31. Marcelletti JF, Katz DH,. 1991. Elicitation of antigen-induced primary and secondary murine IgE antibody responses in vitro. Cell Immunol 135: 471-489.
32. Matan N, Rimkeeree H, Mawson AJ, Chompreeda P, Haruthaithanasan V, Parker M,. 2006. Antimicrobial activity of cinnamon and clove oils under modified atmosphere conditions. Int J Food Microbiol 107: 180-185. (Pubitemid 43339776)
33. Napolitani G, Acosta-Rodriguez EV, Lanzavecchia A, Sallusto F,. 2009. Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-gamma production by memory CD4+ T cells. Eur J Immunol 39: 1301-1312.
34. Park JH, Lee JK, Kim HS, et al., 2004. Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice. Int Immunopharmacol 4: 429-436. (Pubitemid 38375975)
35. Redwine LS, Mills PJ, Hong S, et al., 2007. Cardiac-related hospitalization and/or death associated with immune dysregulation and symptoms of depression in heart failure patients. Psychosom Med 69: 23-29. (Pubitemid 46148361)
36. Schroder K, Hertzog PJ, Ravasi T, Hume DA,. 2004. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 75: 163-189. (Pubitemid 38174573)
37. Seder RA, Paul WE,. 1994. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol 12: 635-673. (Pubitemid 24140427)
38. Shirai T, Inui N, Suda T, Chida K,. 2006. Correlation between peripheral blood T-cell profiles and airway inflammation in atopic asthma. J Allergy Clin Immunol 118: 622-626. (Pubitemid 44301390)
39. Szodoray P, Timar O, Veres K, et al,. 2006. TH1/TH2 imbalance, measured by circulating and intracytoplasmic inflammatory cytokines-immunological alterations in acute coronary syndrome and stable coronary artery disease. Scand J Immunol 64: 336-344. (Pubitemid 44215124)
40. Taga K, Chretien J, Cherney B, Diaz L, Brown M, Tosato G,. 1994. Interleukin-10 inhibits apoptotic cell death in infectious mononucleosis T cells. J Clin Invest 94: 251-260. (Pubitemid 24218099)
41. Teloni R, Giannoni F, Rossi P, Nisini R, Gagliardi MC,. 2007. Interleukin-4 inhibits cyclo-oxygenase-2 expression and prostaglandin E production by human mature dendritic cells. Immunology 120: 83-89.
42. Tsai CH, Tsai HH, Yang YY, et al., 2000. The in vivo effects of cytokines modulation in Balb/C mice fed with Canavalia ensiformis seeds. J Biomed Lab Sci 12: 31-34.
43. Viardot A, Grey ST, Mackay F, Chisholm D,. 2007. Potential antiinflammatory role of insulin via the preferential polarization of effector T cells toward a T helper 2 phenotype. Endocrinology 148: 346-353. (Pubitemid 46021467)
44. Wang SY, Chen PF, Chang ST,. 2005. Antifungal activities of essential oils and their constituents from indigenous cinnamon (Cinnamomum osmophleum) leaf against wood decay fungi. Bioresource Technol 96: 813-818.
45. Yang WZ, Ametaj BN, Benchaar C, He ML, Beauchemin KA,. 2010. Cinnamaldehyde in feedlot cattle diets: intake, growth performance, carcass characteristics, and blood metabolites. J Anim Sci 88: 1082-1092.