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Volumn 44, Issue 9, 2011, Pages 883-889

Central chemoreceptors and neural mechanisms of cardiorespiratory control

Author keywords

Cardiorespiratory responses; Chemoreflex; Phrenic nerve activity; Sympathetic nerve activity; Ventrolateral medulla

Indexed keywords

BRAIN STEM; CARDIOVASCULAR FUNCTION; CATECHOLAMINERGIC SYSTEM; CHEMORECEPTOR; CHEMORECEPTOR REFLEX; EXERCISE; HUMAN; HYPERCAPNIA; LUNG FUNCTION; MEDULLA OBLONGATA; NERVE CONDUCTION; NONHUMAN; PHRENIC NERVE; PONTINE NUCLEUS; REVIEW; SYMPATHETIC FUNCTION; SYMPATHETIC NERVE;

EID: 80053321282     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2011007500094     Document Type: Review
Times cited : (21)

References (57)
  • 1
    • 0024818276 scopus 로고
    • Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans
    • Somers VK, Mark AL, Zavala DC, Abboud FM. Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans. J Appl Physiol 1989; 67: 2101-2106.
    • (1989) J Appl Physiol , vol.67 , pp. 2101-2106
    • Somers, V.K.1    Mark, A.L.2    Zavala, D.C.3    Abboud, F.M.4
  • 2
    • 33846909590 scopus 로고    scopus 로고
    • Modelling the respiratory chemoreflex control of acid-base balance
    • Duffin J. Modelling the respiratory chemoreflex control of acid-base balance. Conf Proc IEEE Eng Med Biol Soc 2005; 6: 5836-5839.
    • (2005) Conf Proc IEEE Eng Med Biol Soc , vol.6 , pp. 5836-5839
    • Duffin, J.1
  • 4
    • 33744511429 scopus 로고    scopus 로고
    • Central chemoreception 2005: A brief review
    • Nattie E, Li A. Central chemoreception 2005: a brief review. Auton Neurosci 2006; 126-127: 332-338.
    • (2006) Auton Neurosci , vol.126-127 , pp. 332-338
    • Nattie, E.1    Li, A.2
  • 5
    • 0020335139 scopus 로고
    • Central chemosensitivity and the reaction theory
    • Loeschcke HH. Central chemosensitivity and the reaction theory. J Physiol 1982; 332: 1-24.
    • (1982) J Physiol , vol.332 , pp. 1-24
    • Loeschcke, H.H.1
  • 7
    • 70349167990 scopus 로고    scopus 로고
    • Neurochemistry of bulbospinal presympathetic neurons of the medulla oblongata
    • Stornetta RL. Neurochemistry of bulbospinal presympathetic neurons of the medulla oblongata. J Chem Neuroanat 2009; 38: 222-230.
    • (2009) J Chem Neuroanat , vol.38 , pp. 222-230
    • Stornetta, R.L.1
  • 8
    • 78049414217 scopus 로고    scopus 로고
    • Sympathetic overactivity coupled with active expiration in rats submitted to chronic intermittent hypoxia
    • Zoccal DB, Machado BH. Sympathetic overactivity coupled with active expiration in rats submitted to chronic intermittent hypoxia. Respir Physiol Neurobiol 2010; 174: 98-101.
    • (2010) Respir Physiol Neurobiol , vol.174 , pp. 98-101
    • Zoccal, D.B.1    McHado, B.H.2
  • 9
    • 79956224544 scopus 로고    scopus 로고
    • Coupling between respiratory and sympathetic activities as a novel mechanism underpinning neurogenic hypertension
    • Zoccal DB, Machado BH. Coupling between respiratory and sympathetic activities as a novel mechanism underpinning neurogenic hypertension. Curr Hypertens Rep 2011; 13: 229-236.
    • (2011) Curr Hypertens Rep , vol.13 , pp. 229-236
    • Zoccal, D.B.1    McHado, B.H.2
  • 10
    • 33745712914 scopus 로고    scopus 로고
    • The sympathetic control of blood pressure
    • Guyenet PG. The sympathetic control of blood pressure. Nat Rev Neurosci 2006; 7: 335-346.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 335-346
    • Guyenet, P.G.1
  • 11
    • 53849126814 scopus 로고    scopus 로고
    • Identification of neurotransmitters and colocalization of transmitters in brainstem respiratory neurons
    • Stornetta RL. Identification of neurotransmitters and colocalization of transmitters in brainstem respiratory neurons. Respir Physiol Neurobiol 2008; 164: 18-27.
    • (2008) Respir Physiol Neurobiol , vol.164 , pp. 18-27
    • Stornetta, R.L.1
  • 12
    • 0023003816 scopus 로고
    • Role of ventrolateral medulla in regulation of respiratory and cardiovascular systems
    • Millhorn DE, Eldridge FL. Role of ventrolateral medulla in regulation of respiratory and cardiovascular systems. J Appl Physiol 1986; 61: 1249-1263.
    • (1986) J Appl Physiol , vol.61 , pp. 1249-1263
    • Millhorn, D.E.1    Eldridge, F.L.2
  • 13
    • 12344264797 scopus 로고    scopus 로고
    • Autonomic cardiovascular responses to hypercapnia in conscious rats: The roles of the chemo-and baroreceptors
    • Oikawa S, Hirakawa H, Kusakabe T, Nakashima Y, Hayashida Y. Autonomic cardiovascular responses to hypercapnia in conscious rats: the roles of the chemo-and baroreceptors. Auton Neurosci 2005; 117: 105-114.
    • (2005) Auton Neurosci , vol.117 , pp. 105-114
    • Oikawa, S.1    Hirakawa, H.2    Kusakabe, T.3    Nakashima, Y.4    Hayashida, Y.5
  • 15
    • 0024582416 scopus 로고
    • Central respiratory modulation of medullary sympathoexcitatory neurons in rat
    • Haselton JR, Guyenet PG. Central respiratory modulation of medullary sympathoexcitatory neurons in rat. Am J Physiol 1989; 256: R739-R750.
    • (1989) Am J Physiol , vol.256
    • Haselton, J.R.1    Guyenet, P.G.2
  • 16
    • 0023162356 scopus 로고
    • Central respiratory modulation of subretrofacial bulbospinal neurones in the cat
    • McAllen RM. Central respiratory modulation of subretrofacial bulbospinal neurones in the cat. J Physiol 1987; 388: 533-545.
    • (1987) J Physiol , vol.388 , pp. 533-545
    • McAllen, R.M.1
  • 17
    • 0027196083 scopus 로고
    • Ventrolateral medulla and sympathetic chemoreflex in the rat
    • Koshiya N, Huangfu D, Guyenet PG. Ventrolateral medulla and sympathetic chemoreflex in the rat. Brain Res 1993; 609: 174-184.
    • (1993) Brain Res , vol.609 , pp. 174-184
    • Koshiya, N.1    Huangfu, D.2    Guyenet, P.G.3
  • 18
    • 58349092325 scopus 로고    scopus 로고
    • Modulation of the sympathetic response to acute hypoxia by the caudal ventrolateral medulla in rats
    • Mandel DA, Schreihofer AM. Modulation of the sympathetic response to acute hypoxia by the caudal ventrolateral medulla in rats. J Physiol 2009; 587: 461-475.
    • (2009) J Physiol , vol.587 , pp. 461-475
    • Mandel, D.A.1    Schreihofer, A.M.2
  • 19
    • 0028890526 scopus 로고
    • NMDA receptor-mediated sympathetic chemoreflex excitation of RVL-spinal vasomotor neurones in rats
    • Sun MK, Reis DJ. NMDA receptor-mediated sympathetic chemoreflex excitation of RVL-spinal vasomotor neurones in rats. J Physiol 1995; 482 (Part 1): 53-68.
    • (1995) J Physiol , vol.482 , Issue.PART 1 , pp. 53-68
    • Sun, M.K.1    Reis, D.J.2
  • 20
    • 0029744858 scopus 로고    scopus 로고
    • Monosynaptic projections from the nucleus tractus solitarii to C1 adrenergic neurons in the rostral ventrolateral medulla: Comparison with input from the caudal ventrolateral medulla
    • Aicher SA, Saravay RH, Cravo S, Jeske I, Morrison SF, Reis DJ, et al. Monosynaptic projections from the nucleus tractus solitarii to C1 adrenergic neurons in the rostral ventrolateral medulla: comparison with input from the caudal ventrolateral medulla. J Comp Neurol 1996; 373: 62-75.
    • (1996) J Comp Neurol , vol.373 , pp. 62-75
    • Aicher, S.A.1    Saravay, R.H.2    Cravo, S.3    Jeske, I.4    Morrison, S.F.5    Reis, D.J.6
  • 21
    • 0033837666 scopus 로고    scopus 로고
    • Neural structures that mediate sympathoexcitation during hypoxia
    • Guyenet PG. Neural structures that mediate sympathoexcitation during hypoxia. Respir Physiol 2000; 121: 147-162.
    • (2000) Respir Physiol , vol.121 , pp. 147-162
    • Guyenet, P.G.1
  • 24
    • 79551529524 scopus 로고    scopus 로고
    • Ventrolateral medulla mechanisms involved in cardiorespiratory responses to central chemoreceptor activation in rats
    • Takakura AC, Colombari E, Menani JV, Moreira TS. Ventrolateral medulla mechanisms involved in cardiorespiratory responses to central chemoreceptor activation in rats. Am J Physiol Regul Integr Comp Physiol 2011; 300: R501-R510.
    • (2011) Am J Physiol Regul Integr Comp Physiol , vol.300
    • Takakura, A.C.1    Colombari, E.2    Menani, J.V.3    Moreira, T.S.4
  • 26
    • 33749509940 scopus 로고    scopus 로고
    • Expression of Phox2b by brainstem neurons involved in chemosensory integration in the adult rat
    • Stornetta RL, Moreira TS, Takakura AC, Kang BJ, Chang DA, West GH, et al. Expression of Phox2b by brainstem neurons involved in chemosensory integration in the adult rat. J Neurosci 2006; 26: 10305-10314.
    • (2006) J Neurosci , vol.26 , pp. 10305-10314
    • Stornetta, R.L.1    Moreira, T.S.2    Takakura, A.C.3    Kang, B.J.4    Chang, D.A.5    West, G.H.6
  • 27
    • 45249119097 scopus 로고    scopus 로고
    • Selective lesion of retrotrapezoid Phox2bexpressing neurons raises the apnoeic threshold in rats
    • Takakura AC, Moreira TS, Stornetta RL, West GH, Gwilt JM, Guyenet PG. Selective lesion of retrotrapezoid Phox2bexpressing neurons raises the apnoeic threshold in rats. J Physiol 2008; 586: 2975-2991.
    • (2008) J Physiol , vol.586 , pp. 2975-2991
    • Takakura, A.C.1    Moreira, T.S.2    Stornetta, R.L.3    West, G.H.4    Gwilt, J.M.5    Guyenet, P.G.6
  • 28
    • 78650915227 scopus 로고    scopus 로고
    • + by inhibition of a Kir4.1-Kir5.1-like current and may contribute to chemoreception by a purinergic mechanism
    • + by inhibition of a Kir4.1-Kir5.1-like current and may contribute to chemoreception by a purinergic mechanism. J Neurophysiol 2010; 104: 3042-3052.
    • (2010) J Neurophysiol , vol.104 , pp. 3042-3052
    • Wenker, I.C.1    Kreneisz, O.2    Nishiyama, A.3    Mulkey, D.K.4
  • 29
    • 25644441731 scopus 로고    scopus 로고
    • Regulation of ventral surface chemoreceptors by the central respiratory pattern generator
    • Guyenet PG, Mulkey DK, Stornetta RL, Bayliss DA. Regulation of ventral surface chemoreceptors by the central respiratory pattern generator. J Neurosci 2005; 25: 8938-8947.
    • (2005) J Neurosci , vol.25 , pp. 8938-8947
    • Guyenet, P.G.1    Mulkey, D.K.2    Stornetta, R.L.3    Bayliss, D.A.4
  • 30
    • 79959354634 scopus 로고    scopus 로고
    • Intermittent hypoxia-induced sensitization of central chemoreceptors contributes to sympathetic nerve activity during late expiration in rats
    • Molkov YI, Zoccal DB, Moraes DJ, Paton JF, Machado BH, Rybak IA. Intermittent hypoxia-induced sensitization of central chemoreceptors contributes to sympathetic nerve activity during late expiration in rats. J Neurophysiol 2011; 105: 3080-3091.
    • (2011) J Neurophysiol , vol.105 , pp. 3080-3091
    • Molkov, Y.I.1    Zoccal, D.B.2    Moraes, D.J.3    Paton, J.F.4    McHado, B.H.5    Rybak, I.A.6
  • 31
    • 33748879744 scopus 로고    scopus 로고
    • Afferent and efferent connections of the rat retrotrapezoid nucleus
    • Rosin DL, Chang DA, Guyenet PG. Afferent and efferent connections of the rat retrotrapezoid nucleus. J Comp Neurol 2006; 499: 64-89.
    • (2006) J Comp Neurol , vol.499 , pp. 64-89
    • Rosin, D.L.1    Chang, D.A.2    Guyenet, P.G.3
  • 32
    • 65949119125 scopus 로고    scopus 로고
    • Photostimulation of retrotrapezoid nucleus phox2b-expressing neurons in vivo produces long-lasting activation of breathing in rats
    • Abbott SB, Stornetta RL, Fortuna MG, Depuy SD, West GH, Harris TE, et al. Photostimulation of retrotrapezoid nucleus phox2b-expressing neurons in vivo produces long-lasting activation of breathing in rats. J Neurosci 2009; 29: 5806-5819.
    • (2009) J Neurosci , vol.29 , pp. 5806-5819
    • Abbott, S.B.1    Stornetta, R.L.2    Fortuna, M.G.3    Depuy, S.D.4    West, G.H.5    Harris, T.E.6
  • 34
    • 21844455769 scopus 로고    scopus 로고
    • ATP is a mediator of chemosensory transduction in the central nervous system
    • Gourine AV, Llaudet E, Dale N, Spyer KM. ATP is a mediator of chemosensory transduction in the central nervous system. Nature 2005; 436: 108-111.
    • (2005) Nature , vol.436 , pp. 108-111
    • Gourine, A.V.1    Llaudet, E.2    Dale, N.3    Spyer, K.M.4
  • 35
    • 0022416091 scopus 로고
    • Impulse conduction properties of noradrenergic locus coeruleus axons projecting to monkey cerebrocortex
    • Aston-Jones G, Foote SL, Segal M. Impulse conduction properties of noradrenergic locus coeruleus axons projecting to monkey cerebrocortex. Neuroscience 1985; 15: 765-777.
    • (1985) Neuroscience , vol.15 , pp. 765-777
    • Aston-Jones, G.1    Foote, S.L.2    Segal, M.3
  • 36
  • 37
    • 0021220966 scopus 로고
    • Ventilation and arousal responses to hypercapnia in normal sleeping humans
    • Berthon-Jones M, Sullivan CE. Ventilation and arousal responses to hypercapnia in normal sleeping humans. J Appl Physiol 1984; 57: 59-67.
    • (1984) J Appl Physiol , vol.57 , pp. 59-67
    • Berthon-Jones, M.1    Sullivan, C.E.2
  • 39
    • 0019375059 scopus 로고
    • Hypercapnia and hypoxia: Chemoreceptor-mediated control of locus coeruleus neurons and splanchnic, sympathetic nerves
    • Elam M, Yao T, Thoren P, Svensson TH. Hypercapnia and hypoxia: chemoreceptor-mediated control of locus coeruleus neurons and splanchnic, sympathetic nerves. Brain Res 1981; 222: 373-381.
    • (1981) Brain Res , vol.222 , pp. 373-381
    • Elam, M.1    Yao, T.2    Thoren, P.3    Svensson, T.H.4
  • 40
    • 0030572887 scopus 로고    scopus 로고
    • The brainstem network involved in coordination of inspiratory activity and cholinergic outflow to the airways
    • Haxhiu MA, Erokwu BO, Cherniack NS. The brainstem network involved in coordination of inspiratory activity and cholinergic outflow to the airways. J Auton Nerv Syst 1996; 61: 155-161.
    • (1996) J Auton Nerv Syst , vol.61 , pp. 155-161
    • Haxhiu, M.A.1    Erokwu, B.O.2    Cherniack, N.S.3
  • 41
    • 21844455769 scopus 로고    scopus 로고
    • ATP is a mediator of chemosensory transduction in the central nervous system
    • Gourine AV, Llaudet E, Dale N, Spyer KM. ATP is a mediator of chemosensory transduction in the central nervous system. Nature 2005; 436: 108-111.
    • (2005) Nature , vol.436 , pp. 108-111
    • Gourine, A.V.1    Llaudet, E.2    Dale, N.3    Spyer, K.M.4
  • 43
    • 78349301247 scopus 로고    scopus 로고
    • Photostimulation of Phox2b medullary neurons activates cardiorespiratory function in conscious rats
    • Kanbar R, Stornetta RL, Cash DR, Lewis SJ, Guyenet PG. Photostimulation of Phox2b medullary neurons activates cardiorespiratory function in conscious rats. Am J Respir Crit Care Med 2010; 182: 1184-1194.
    • (2010) Am J Respir Crit Care Med , vol.182 , pp. 1184-1194
    • Kanbar, R.1    Stornetta, R.L.2    Cash, D.R.3    Lewis, S.J.4    Guyenet, P.G.5
  • 45
    • 0023193686 scopus 로고
    • Afferent and efferent connections of the A5 noradrenergic cell group in the rat
    • Byrum CE, Guyenet PG. Afferent and efferent connections of the A5 noradrenergic cell group in the rat. J Comp Neurol 1987; 261: 529-542.
    • (1987) J Comp Neurol , vol.261 , pp. 529-542
    • Byrum, C.E.1    Guyenet, P.G.2
  • 46
    • 0019995084 scopus 로고
    • Single cell activity in the noradrenergic A-5 region: Responses to drugs and peripheral manipulations of blood pressure
    • Andrade R, Aghajanian GK. Single cell activity in the noradrenergic A-5 region: responses to drugs and peripheral manipulations of blood pressure. Brain Res 1982; 242: 125-135.
    • (1982) Brain Res , vol.242 , pp. 125-135
    • Andrade, R.1    Aghajanian, G.K.2
  • 47
    • 0021257443 scopus 로고
    • Electrophysiological properties of spinally-projecting A5 noradrenergic neurons
    • Byrum CE, Stornetta R, Guyenet PG. Electrophysiological properties of spinally-projecting A5 noradrenergic neurons. Brain Res 1984; 303: 15-29.
    • (1984) Brain Res , vol.303 , pp. 15-29
    • Byrum, C.E.1    Stornetta, R.2    Guyenet, P.G.3
  • 48
    • 0026063350 scopus 로고
    • A5 noradrenergic unit activity and sympathetic nerve discharge in rats
    • Huangfu DH, Koshiya N, Guyenet PG. A5 noradrenergic unit activity and sympathetic nerve discharge in rats. Am J Physiol 1991; 261: R393-R402.
    • (1991) Am J Physiol , vol.261
    • Huangfu, D.H.1    Koshiya, N.2    Guyenet, P.G.3
  • 50
    • 0033537293 scopus 로고    scopus 로고
    • Sympathetic response to stimulation of the pontine A5 region in conscious rabbits
    • Maiorov DN, Wilton ER, Badoer E, Petrie D, Head GA, Malpas SC. Sympathetic response to stimulation of the pontine A5 region in conscious rabbits. Brain Res 1999; 815: 227-236.
    • (1999) Brain Res , vol.815 , pp. 227-236
    • Maiorov, D.N.1    Wilton, E.R.2    Badoer, E.3    Petrie, D.4    Head, G.A.5    Malpas, S.C.6
  • 51
    • 0021911537 scopus 로고
    • Stimulation by central command of locomotion, respiration and circulation during exercise
    • Eldridge FL, Millhorn DE, Kiley JP, Waldrop TG. Stimulation by central command of locomotion, respiration and circulation during exercise. Respir Physiol 1985; 59: 313-337.
    • (1985) Respir Physiol , vol.59 , pp. 313-337
    • Eldridge, F.L.1    Millhorn, D.E.2    Kiley, J.P.3    Waldrop, T.G.4
  • 52
    • 33645820236 scopus 로고    scopus 로고
    • Point: Supraspinal locomotor centers do contribute significantly to the hyperpnea of dynamic exercise
    • Waldrop TG, Iwamoto GA. Point: supraspinal locomotor centers do contribute significantly to the hyperpnea of dynamic exercise. J Appl Physiol 2006; 100: 1077-1079.
    • (2006) J Appl Physiol , vol.100 , pp. 1077-1079
    • Waldrop, T.G.1    Iwamoto, G.A.2
  • 53
    • 0030575322 scopus 로고    scopus 로고
    • Identification of diencephalic and brainstem cardiorespiratory areas activated during exercise
    • Iwamoto GA, Wappel SM, Fox GM, Buetow KA, Waldrop TG. Identification of diencephalic and brainstem cardiorespiratory areas activated during exercise. Brain Res 1996; 726: 109-122.
    • (1996) Brain Res , vol.726 , pp. 109-122
    • Iwamoto, G.A.1    Wappel, S.M.2    Fox, G.M.3    Buetow, K.A.4    Waldrop, T.G.5
  • 54
    • 33846820107 scopus 로고    scopus 로고
    • Central command regulation of circulatory function mediated by descending pontine cholinergic inputs to sympathoexcitatory rostral ventrolateral medulla neurons
    • Padley JR, Kumar NN, Li Q, Nguyen TB, Pilowsky PM, Goodchild AK. Central command regulation of circulatory function mediated by descending pontine cholinergic inputs to sympathoexcitatory rostral ventrolateral medulla neurons. Circ Res 2007; 100: 284-291.
    • (2007) Circ Res , vol.100 , pp. 284-291
    • Padley, J.R.1    Kumar, N.N.2    Li, Q.3    Nguyen, T.B.4    Pilowsky, P.M.5    Goodchild, A.K.6
  • 55
    • 70450214121 scopus 로고    scopus 로고
    • Activation of the retrotrapezoid nucleus by posterior hypothalamic stimulation
    • Fortuna MG, Stornetta RL, West GH, Guyenet PG. Activation of the retrotrapezoid nucleus by posterior hypothalamic stimulation. J Physiol 2009; 587: 5121-5138.
    • (2009) J Physiol , vol.587 , pp. 5121-5138
    • Fortuna, M.G.1    Stornetta, R.L.2    West, G.H.3    Guyenet, P.G.4
  • 56
    • 0036302061 scopus 로고    scopus 로고
    • The central autonomic nervous system: Conscious visceral perception and autonomic pattern generation
    • Saper CB. The central autonomic nervous system: conscious visceral perception and autonomic pattern generation. Annu Rev Neurosci 2002; 25: 433-469.
    • (2002) Annu Rev Neurosci , vol.25 , pp. 433-469
    • Saper, C.B.1
  • 57
    • 0036159866 scopus 로고    scopus 로고
    • The dorsomedial hypothalamus and the response to stress: Part renaissance, part revolution
    • DiMicco JA, Samuels BC, Zaretskaia MV, Zaretsky DV. The dorsomedial hypothalamus and the response to stress: part renaissance, part revolution. Pharmacol Biochem Behav 2002; 71: 469-480.
    • (2002) Pharmacol Biochem Behav , vol.71 , pp. 469-480
    • DiMicco, J.A.1    Samuels, B.C.2    Zaretskaia, M.V.3    Zaretsky, D.V.4


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