Ventrolateral medulla mechanisms involved in cardiorespiratory responses to central chemoreceptor activation in rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 300, Issue 2, 2011, Pages

  Takakura, Ana C ^a   Colombari, Eduardo ^a   Menani, José V ^a   Moreira, Thiago S ^b  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Chemoreflex; Phrenic nerve; Sympathetic activity

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 6,7 DINITRO QUINOXALINE 2,3 DIONE; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; CARBON DIOXIDE; MUSCIMOL; PROTEIN BOTZINGER; QUINOXALINE DERIVATIVE; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; BRAIN REGION; BREATHING; CARBON DIOXIDE TENSION; CHEMORECEPTOR; HEART; HYPERCAPNIA; MALE; NONHUMAN; PHRENIC NERVE; PRIORITY JOURNAL; RAT; RETROTRAPEZOID NUCLEUS; SYMPATHETIC NERVE; SYMPATHETIC TONE;

2-AMINO-5-PHOSPHONOVALERATE; ANIMALS; BLOOD PRESSURE; CARDIOVASCULAR PHYSIOLOGICAL PROCESSES; CHEMORECEPTOR CELLS; EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; HYPERCAPNIA; HYPERTENSION; MALE; MEDULLA OBLONGATA; MODELS, NEUROLOGICAL; MUSCIMOL; PHRENIC NERVE; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; RESPIRATORY PHYSIOLOGICAL PROCESSES; SODIUM CYANIDE; SPLANCHNIC NERVES; VAGOTOMY;

EID: 79551529524     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00220.2010     Document Type: Article

References (44)

1. Abbott SB, Stornetta RL, Fortuna MG, Depuy SD, West GH, Harris TE, Guyenet PG. Photostimulation of retrotrapezoid nucleus phox2b-expressing neurons in vivo produces long-lasting activation of breathing in rats. J Neurosci 29: 5806-5819, 2009.
2. Aicher SA, Saravay RH, Cravo S, Jeske I, Morrison SF, Reis DJ, Milner TA. Monosynaptic projections from the nucleus tractus solitarii to C1 adrenergic neurons in the rostral ventrolateral medulla: Comparison with input from the caudal ventrolateral medulla. J Comp Neurol 373: 62-75, 1996.
3. Allen NJ, Barres BA. Neuroscience: Glia - more than just brain glue. Nature 457: 675-677, 2009.
4. Antunes VR, Brailoiu GC, Kwok EH, Scruggs P, Dun NJ. Orexins/hypocretins excite rat sympathetic preganglionic neurons in vivo and in vitro. Am J Physiol Regul Integr Comp Physiol 281: R1801-R1807, 2001.
5. Brabet I, Mary S, Bockaert J, Pin JP. Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses. Neuropharmacology 34: 895-903, 1995.
6. Brown DL, Guyenet PG. Electrophysiological study of cardiovascular neurons in the rostral ventrolateral medulla in rats. Circ Res 56: 359-369, 1985.
7. Conn PJ, Pin JP. Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 37: 205-237, 1997.
8. 2 decreases membrane conductance and depolarizes neurons in the nucleus tractus solitarii. Exp Brain Res 76: 656-661, 1989.
9. Deng BS, Nakamura A, Zhang W, Yanagisawa M, Fukuda Y, Kuwaki T. Contribution of orexin in hypercapnic chemoreflex: evidence from genetic and pharmacological disruption and supplementation studies in mice. J Appl Physiol 103: 1772-1779, 2007.
10. de Paula PM, Branco LG. Glutamatergic receptors of the rostral ventrolateral medulla are involved in the ventilatory response to hypoxia. Respir Physiol Neurobiol 146: 125-134, 2005.
11. Dun NJ, Le Dun S, Chen CT, Hwang LL, Kwok EH, Chang JK. Orexins: a role in medullary sympathetic outflow. Regul Pept 96: 65-70, 2000.
12. Feldman JL, Ellenberger HH. Central coordination of respiratory and cardiovascular control in mammals. Annu Rev Physiol 50: 593-606, 1988.
13. Feldman JL, Del Negro CA. Looking for inspiration: new perspectives on respiratory rhythm. Nat Rev Neurosci 7: 232-242, 2006.
14. Gourine AV, Llaudet E, Dale N, Spyer KM. ATP is a mediator of chemosensory transduction in the central nervous system. Nature 436: 108-111, 2005.
15. Guyenet PG, Darnall RA, Riley TA. Rostral ventrolateral medulla and sympathorespiratory integration in rats. Am J Physiol Regul Integr Comp Physiol 259: R1063-R1074, 1990.
16. Guyenet PG. Neural structures that mediate sympathoexcitation during hypoxia. Respir Physiol 121: 147-162, 2000.
17. Guyenet PG. The sympathetic control of blood pressure. Nat Rev Neurosci 7: 335-346, 2006.
18. 2 response of sympathetic preganglionic neurons. J Auton Nerv Syst 3: 421-435, 1981.
19. Haselton JR, Guyenet PG. Central respiratory modulation of medullary sympathoexcitatory neurons in rat. Am J Physiol Regul Integr Comp Physiol 256: R739-R750, 1989.
20. + responses in primary cell culture. J Appl Physiol 105: 1301-1311, 2008.
21. Koshiya N, Huangfu D, Guyenet PG. Ventrolateral medulla and sympathetic chemoreflex in the rat. Brain Res 609: 174-184, 1993.
22. Koshiya N, Guyenet PG. Tonic sympathetic chemoreflex after blockade of respiratory rhythmogenesis in the rat. J Physiol London 491: 859-869, 1996.
23. Kumar NN, Ferguson J, Padley JR, Pilowsky PM, Goodchild AK. Differential muscarinic receptor gene expression levels in the ventral medulla of spontaneously hypertensive and Wistar-Kyoto rats: role in sympathetic baroreflex function. J Hypertens 27: 1001-1008, 2009.
24. Lioy F, Hanna BD, Polosa C. Cardiovascular control by medullary surface chemoreceptors. J Auton Nerv Syst 3: 9-24, 1981.
25. Loeschcke HH. Central chemosensitivity and the reaction theory. J Physiol 332: 1-24, 1982.
26. Mandel DA, Schreihofer AM. Central respiratory modulation of barosensitive neurones in rat caudal ventrolateral medulla. J Physiol London 572: 881-896, 2006.
27. Mandel DA, Schreihofer AM. Modulation of the sympathetic response to acute hypoxia by the caudal ventrolateral medulla in rats. J Physiol 587: 461-475, 2009.
28. Millhorn DE. Neural respiratory and circulatory interaction during chemoreceptor stimulation and cooling of ventral medulla in cats. J Physiol London 370: 217-231, 1986.
29. Millhorn DE, Eldridge FL. Role of ventrolateral medulla in regulation of respiratory and cardiovascular systems. J Appl Physiol 61: 1249-1263, 1986.
30. Moreira TS, Takakura AC, Colombari E, Guyenet PG. Central chemoreceptors and sympathetic vasomotor outflow. J Physiol 577: 369-386, 2006.
31. Moreira TS, Takakura AC, Colombari E, West GH, Guyenet PG. Inhibitory input from slowly adapting lung stretch receptors to retrotrapezoid nucleus chemoreceptors. J Physiol 580: 285-300, 2007.
32. Mulkey DK, Stornetta RL, Weston MC, Simmons JR, Parker A, Bayliss DA, Guyenet PG. Respiratory control by ventral surface chemoreceptor neurons in rats. Nat Neurosci 7: 1360-1369, 2004.
33. Nattie EE, Li A. Rat retrotrapezoid nucleus iono- and metabotropic glutamate receptors and the control of breathing. J Appl Physiol 78: 153-163, 1995.
34. 2 dialysis in nucleus tractus solitarius region of rat increases ventilation in sleep and wakefulness. J Appl Physiol 92: 2119-2130, 2002.
35. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates, 4th ed. San Diego, CA: Academic, 1988.
36. 2 and discharge patterns of sympathetic preganglionic neurons. Brain Res 122: 255-267, 1977.
37. Richerson GB. Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis. Nat Rev Neurosci 5: 449-461, 2004.
38. Rosin DL, Chang DA, Guyenet PG. Afferent and efferent connections of the rat retrotrapezoid nucleus. J Comp Neurol 499: 64-89, 2006.
39. Schreihofer AM, Guyenet PG. Identification of C1 presympathetic neurons in rat rostral ventrolateral medulla by juxtacellular labeling in vivo. J Comp Neurol 387: 524-536, 1997.
40. Schreihofer AM, Guyenet PG. Sympathetic reflexes after depletion of bulbospinal catecholaminergic neurons with anti-DβH-saporin. Am J Physiol Regul Integr Comp Physiol 279: R729-R742, 2000.
41. Sun MK, Reis DJ. NMDA receptor-mediated sympathetic chemoreflex excitation of RVL-spinal vasomotor neurones in rats. J Physiol London 482: 53-68, 1995.
42. 2-sensitive neurons in rats. J Physiol London 572: 503-523, 2006.
43. Takakura AC, Moreira TS, Stornetta RL, West GH, Gwilt JM, Guyenet PG. Selective lesions of retrotrapezoid Phox2b-expressing neurons raises the apneic threshold in rats. J Physiol London 586: 2975-2991, 2008.
44. Tsuchihashi T, Liu Y, Kagiyama S, Matsumura K, Abe I, Fujishima M. Metabotropic glutamate receptor subtypes involved in cardiovascular regulation in the rostral ventrolateral medulla of rats. Brain Res Bull 52: 279-283, 2000.