Nitric oxide synthesis and biological functions of nitric oxide released from ruthenium compounds

Brazilian Journal of Medical and Biological Research

Volumn 44, Issue 9, 2011, Pages 947-957

  Pereira, A C ^a   Paulo, M ^a   Araujo A V ^a   Rodrigues, G J ^a   Bendhack, L M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Conduit vessel; Nitric oxide; NO synthase; Resistance artery; Ruthenium complex; Vasodilatation

Indexed keywords

4 AMINOPYRIDINE; ACETYLCHOLINE; AMYL NITRITE; CYCLIC GMP DEPENDENT PROTEIN KINASE; GLYCERYL TRINITRATE; GUANYLATE CYCLASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; RUTHENIUM DERIVATIVE;

ANGINA PECTORIS; BIOAVAILABILITY; BIOTRANSFORMATION; BLOOD VESSEL TONE; CALCIUM SIGNALING; CYTOPLASM; DRUG MECHANISM; DRUG MEGADOSE; DRUG STRUCTURE; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; ENZYME RELEASE; ENZYME SYNTHESIS; HUMAN; HYPERTENSION; REVIEW; SMOOTH MUSCLE FIBER; UNSPECIFIED SIDE EFFECT; VASCULAR DISEASE; VASODILATATION;

EID: 80053308094     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2011007500084     Document Type: Review

References (60)

1. Oliveira AP, Lunardi CN, Rodrigues GJ, Bendhack LM. Relaxation induced by calcium ionophore is impaired in carotid arteries from 2K-1C rats due to failed effect of nitric oxide on the smooth muscle cells. Vascul Pharmacol 2009; 50: 153-159.
2. Moncada S, Higgs EA. The discovery of nitric oxide and its role in vascular biology. Br J Pharmacol 2006; 147 (Suppl 1): S193-S201.
3. de Gaitani CM, de Melo MC, Lunardi CN, de S Oliveira, da Silva RS, Bendhack LM. Hypotensive effect of the nitrosyl ruthenium complex nitric oxide donor in renal hypertensive rats. Nitric Oxide 2009; 20: 195-199.
4. Bonaventura D, Oliveira FS, da Silva RS, Bendhack LM. Decreased vasodilation induced by a new nitric oxide donor in two kidney, one clip hypertensive rats is due to impaired K channel activation. Clin Exp Pharmacol Physiol 2005; 32: 478-481.
5. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288: 373-376.
6. Rodrigues GJ, Restini CB, Lunardi CN, Neto MA, Moreira JE, Bendhack LM. Decreased number of caveolae in endothelial cells impairs the relaxation induced by acetylcholine in hypertensive rat aortas. Eur J Pharmacol 2010; 627: 251-257.
7. Rodrigues GJ, Restini CB, Lunardi CN, Moreira JE, Lima RG, da Silva RS, et al. Caveolae dysfunction contributes to impaired relaxation induced by nitric oxide donor in aorta from renal hypertensive rats. J Pharmacol Exp Ther 2007; 323: 831-837.
8. Voldstedlund M, Vinten J, Tranum-Jensen J. cav-p60 expression in rat muscle tissues. Distribution of caveolar proteins. Cell Tissue Res 2001; 306: 265-276.
9. Ribeiro MO, Antunes E, de Nucci G, Lovisolo SM, Zatz R. Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension. Hypertension 1992; 20: 298-303.
10. Bernátová I, Pechanova O, Babal P, Kysela S, Stvrtina S, Andriantsitohaina R. Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension. Am J Physiol Heart Circ Physiol 2002; 282: H942-H948.
11. Mittal CK, Murad F. Activation of guanylate cyclase by superoxide dismutase and hydroxyl radical: a physiological regula tor of guanosine 3',5'-monophosphate formation. Proc Natl Acad Sci U S A 1977; 74: 4360-4364.
12. 2+ induces rat aorta relaxation by ultraviolet light irradiation. Nitric Oxide 2005; 13: 170-175.
13. Allardyce CS, Dyson PJ. Ruthenium in medicine: current clinical uses and future prospects. Platinum Metals Rev 2001; 45: 62-69.
14. Bonaventura D, de S Oliveira, Togniolo V, Tedesco AC, da Silva RS, Bendhack LM. A macrocyclic nitrosyl ruthenium complex is a NO donor that induces rat aorta relaxation. Nitric Oxide 2004; 10: 83-91.
15. 3+ complex and its vasodilator activity based on visible light irradiation. Inorg Chem 2006; 359: 2543-2549.
16. Lunardi CN, Vercesi JA, da Silva RS, Bendhack LM. Vasorelaxation induced by the new nitric oxide donor cis-[Ru(Cl)(bpy)(2)(NO)](PF(6) is due to activation of K(Ca) by a cGMP-dependent pathway. Vascul Pharmacol 2007; 47: 139-144.
17. 2+ mediated by phosphate ion: visible light generation of nitric oxide for biological targets. J Phys Chem B 2007; 111: 6962-6968.
18. Rodrigues GJ, Lunardi CN, Lima RG, Santos CX, Laurindo FR, da Silva RS, et al. Vitamin C improves the effect of a new nitric oxide donor on the vascular smooth muscle from renal hypertensive rats. Nitric Oxide 2008; 18: 176-183.
19. Bonaventura D, de Lima RG, Vercesi JA, da Silva RS, Bendhack LM. Comparison of the mechanisms underlying the relaxation induced by two nitric oxide donors: sodium nitroprusside and a new ruthenium complex. Vascul Pharmacol 2007; 46: 215-222.
20. Bonaventura D, Oliveira FS, Lunardi CN, Vercesi JA, da Silva RS, Bendhack LM. Characterization of the mechanisms of action and nitric oxide species involved in the relaxation induced by the ruthenium complex. Nitric Oxide 2006; 15: 387-394.
21. da Rocha ZN, Marchesi MS, Molin JC, Lunardi CN, Miranda KM, Bendhack LM, et al. The inducing NO-vasodilation by chemical reduction of coordinated nitrite ion in cis-[Ru(NO(2) L(bpy)(2)](+) complex. Dalton Trans 2008; 4282-4287.
22. 3: hypotensive effect of endothelium-dependent and-independent vasodilators in different hypertensive animals models. Nitric Oxide 2002; 7: 50-56.
23. Fricker SP, Slade E, Powell NA, Vaughan OJ, Henderson GR, Murrer BA, et al. Ruthenium complexes as nitric oxide scavengers: a potential therapeutic approach to nitric oxidemediated diseases. Br J Pharmacol 1997; 122: 1441-1449.
24. Jia YX, Pan CS, Yang JH, Liu XH, Yuan WJ, Zhao J, et al. Altered L-arginine/nitric oxide synthase/nitric oxide pathway in the vascular adventitia of rats with sepsis. Clin Exp Pharmacol Physiol 2006; 33: 1202-1208.
25. Christensen KL, Mulvany MJ. Location of resistance arteries. J Vasc Res 2001; 38: 1-12.
26. Kang KT, Sullivan JC, Sasser JM, Imig JD, Pollock JS. Novel nitric oxide synthase-dependent mechanism of vasorelaxation in small arteries from hypertensive rats. Hypertension 2007; 49: 893-901.
27. Liu H, Ledingham JM, Mullaney I, Laverty R. Endothelial function in mesenteric resistance arteries from the genetically hypertensive rat. Clin Exp Pharmacol Physiol 2002; 29: 405-411.
28. Christensen FH, Stankevicius E, Hansen T, Jorgensen MM, Valverde VL, Simonsen U, et al. Flow-and acetylcholineinduced dilatation in small arteries from rats with renovascular hypertension-effect of tempol treatment. Eur J Pharmacol 2007; 566: 160-166.
29. White RM, Rivera CO, Davison CB. Differential contribution of endothelial function to vascular reactivity in conduit and resistance arteries from deoxycorticosterone-salt hypertensive rats. Hypertension 1996; 27: 1245-1253.
30. Sobey CG, Moffatt JD, Cocks TM. Evidence for selective effects of chronic hypertension on cerebral artery vasodilatation to protease-activated receptor-2 activation. Stroke 1999; 30: 1933-1940.
31. Briones AM, Alonso MJ, Hernanz R, Miguel M, Salaices M. Alterations of the nitric oxide pathway in cerebral arteries from spontaneously hypertensive rats. J Cardiovasc Pharmacol 2002; 39: 378-388.
32. Sampson LJ, Plane F, Garland CJ. Involvement of cyclic GMP and potassium channels in relaxation evoked by the nitric oxide donor, diethylamine NONOate, in the rat small isolated mesenteric artery. Naunyn Schmiedebergs Arch Pharmacol 2001; 364: 220-225.
33. Schubert R, Krien U, Wulfsen I, Schiemann D, Lehmann G, Ulfig N, et al. Nitric oxide donor sodium nitroprusside dilates rat small arteries by activation of inward rectifier potassium channels. Hypertension 2004; 43: 891-896.
34. Shepherd JT, Vanhoutte PM. Role of the venous system in circulatory control. Mayo Clin Proc 1978; 53: 247-255.
35. Greenway CV, Lautt WW. Blood volume, the venous system, preload, and cardiac output. Can J Physiol Pharmacol 1986; 64: 383-387.
36. Szasz T, Thompson JM, Watts SW. A comparison of reactive oxygen species metabolism in the rat aorta and vena cava: focus on xanthine oxidase. Am J Physiol Heart Circ Physiol 2008; 295: H1341-H1350.
37. Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327: 524-526.
38. Vedernikov YP, Graser T, Tiedt N, Vikhert AM. Heterogeneity of the response of venous smooth muscle to arterial endothelium-derived relaxing factor (EDRF) in respect of the role of nitric oxide. Basic Res Cardiol 1988; 83: 122-127.
39. Glick MR, Gehman JD, Gascho JA. Endothelium-derived nitric oxide reduces baseline venous tone in awake instrumented rats. Am J Physiol 1993; 265: H47-H51.
40. Ignarro LJ, Byrns RE, Wood KS. Endothelium-dependent modulation of cGMP levels and intrinsic smooth muscle tone in isolated bovine intrapulmonary artery and vein. Circ Res 1987; 60: 82-92.
41. Bäck M, Norel X, Walch L, Gascard J, Mazmanian G, Dahlen S, et al. Antagonist resistant contractions of the porcine pulmonary artery by cysteinyl-leukotrienes. Eur J Pharmacol 2000; 401: 381-388.
42. Bina S, Hart JL, Sei Y, Muldoon SM. Factors contributing to differences in the regulation of cGMP in isolated porcine pulmonary vessels. Eur J Pharmacol 1998; 351: 253-260.
43. Collier JG, Lorge RE, Robinson BF. Comparison of effects of tolmesoxide (RX71107), diazoxide, hydrallazine, prazosin, glyceryl trinitrate and sodium nitroprusside on forearm arteries and dorsal hand veins of man. Br J Clin Pharmacol 1978; 5: 35-44.
44. Moncada S, Rees DD, Schulz R, Palmer RM. Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. Proc Natl Acad Sci U S A 1991; 88: 2166-2170.
45. Filippov G, Bloch DB, Bloch KD. Nitric oxide decreases stability of mRNAs encoding soluble guanylate cyclase subunits in rat pulmonary artery smooth muscle cells. J Clin Invest 1997; 100: 942-948.
46. Mensinga TT, Speijers GJ, Meulenbelt J. Health implications of exposure to environmental nitrogenous compounds. Toxicol Rev 2003; 22: 41-51.
47. Kleinbongard P, Dejam A, Lauer T, Rassaf T, Schindler A, Picker O, et al. Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radic Biol Med 2003; 35: 790-796.
48. Furchgott RF, Bhadrakom S. Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs. J Pharmacol Exp Ther 1953; 108: 129-143.
49. Ignarro LJ, Lippton H, Edwards JC, Baricos WH, Hyman AL, Kadowitz PJ, et al. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther 1981; 218: 739-749.
50. Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, et al. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med 2003; 9: 1498-1505.
51. Gladwin MT, Raat NJ, Shiva S, Dezfulian C, Hogg N, Kim-Shapiro DB, et al. Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation. Am J Physiol Heart Circ Physiol 2006; 291: H2026-H2035.
52. Lundberg JO, Weitzberg E, Cole JA, Benjamin N. Nitrate, bacteria and human health. Nat Rev Microbiol 2004; 2: 593-602.
53. Lundberg JO, Govoni M. Inorganic nitrate is a possible source for systemic generation of nitric oxide. Free Radic Biol Med 2004; 37: 395-400.
54. Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, et al. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension 2008; 51: 784-790.
55. Zweier JL, Samouilov A, Kuppusamy P. Non-enzymatic nitric oxide synthesis in biological systems. Biochim Biophys Acta 1999; 1411: 250-262.
56. Li H, Cui H, Kundu TK, Alzawahra W, Zweier JL. Nitric oxide production from nitrite occurs primarily in tissues not in the blood: critical role of xanthine oxidase and aldehyde oxidase. J Biol Chem 2008; 283: 17855-17863.
57. Alzawahra WF, Talukder MA, Liu X, Samouilov A, Zweier JL. Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall. Am J Physiol Heart Circ Physiol 2008; 295: H499-H508.
58. Bates JN, Baker MT, Guerra R Jr, Harrison DG. Nitric oxide generation from nitroprusside by vascular tissue. Evidence that reduction of the nitroprusside anion and cyanide loss are required. Biochem Pharmacol 1991; 42 (Suppl): S157-S165.
59. Lunardi CN, Cacciari AL, Silva RS, Bendhack LM. Cytosolic calcium concentration is reduced by photolysis of a nitrosyl ruthenium complex in vascular smooth muscle cells. Nitric Oxide 2006; 15: 252-258.
60. Chen Z, Zhang J, Stamler JS. Identification of the enzymatic mechanism of nitroglycerin bioactivation. Proc Natl Acad Sci U S A 2002; 99: 8306-8311.