The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2

Cancer Research

Volumn 62, Issue 17, 2002, Pages 4890-4893

  Leung, Ka Man ^a   Po, Lai See ^a   Tsang, Fan Cheung ^a   Siu, Wai Yi ^a   Lau, Anita ^a   Ho, Horace T B ^a   Poon, Randy Y C ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; PROTEIN ING1B; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY;

BINDING, COMPETITIVE; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE PROTEINS; CELL DIVISION; DNA-BINDING PROTEINS; GENES, TUMOR SUPPRESSOR; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG NEOPLASMS; NUCLEAR PROTEINS; PROTEIN ISOFORMS; PROTEINS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0036733697     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Surfing the p53 network
2. Signaling to p53: Breaking the MDM2-p53 circuit
3. Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation
4. p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1
5. A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis
6. The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control
7. Adenovirus-mediated transfer of p33ING1 with p53 drastically augments apoptosis in gliomas
8. DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53
9. Recombination and mutagenesis of DNA sequences using PCR
10. MDM2 and MDMX bind and stabilize the p53-related protein p73
11. Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2
12. Degradation of cyclin A does not require its phosphorylation by CDC2 and cyclin-dependent kinase 2
13. A possible role of p73 on the modulation of p53 level through MDM2
14. Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex
15. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
16. Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
17. Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
18. RB regulates the stability and the apoptotic function of p53 via MDM2
19. The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation