Comprehensive mutational analysis of LRRK2 reveals variants supporting association with autosomal dominant Parkinson's disease

Journal of Human Genetics

Volumn 56, Issue 9, 2011, Pages 671-675

  Seki, Naomi ^a   Takahashi, Yuji ^a   Tomiyama, Hiroyuki ^b   Rogaeva, Ekaterina ^c   Murayama, Shigeo ^d   Mizuno, Yoshikuni ^b   Hattori, Nobutaka ^b   Marras, Connie ^c   Lang, Anthony E ^c   George Hyslop, Peter St ^c,e   Goto, Jun ^a   Tsuji, Shoji ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

^c TORONTO WESTERN HOSPITAL   (Canada)

^d TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

comprehensive mutational analysis; LRRK2; microarray based resequencing; p.G2385R; Parkinsons disease

Indexed keywords

LEUCINE RICH REPEAT KINASE 2;

ADULT; AGED; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CONTROLLED STUDY; DNA MICROARRAY; EXON; FEMALE; GENE FREQUENCY; GENE IDENTIFICATION; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE;

ADULT; AGED; AMINO ACID SEQUENCE; ANIMALS; ASIAN CONTINENTAL ANCESTRY GROUP; BASE SEQUENCE; CATTLE; COHORT STUDIES; DNA MUTATIONAL ANALYSIS; DOGS; EUROPEAN CONTINENTAL ANCESTRY GROUP; EXONS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MICE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PARKINSONIAN DISORDERS; PEDIGREE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-SERINE-THREONINE KINASES; RATS; SEQUENCE ANALYSIS, DNA;

EID: 80053280323     PISSN: 14345161     EISSN: 1435232X     Source Type: Journal    
DOI: 10.1038/jhg.2011.79     Document Type: Article

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