The G2019S LRRK2 mutation is rare in Korean patients with Parkinson's disease

Canadian Journal of Neurological Sciences

Volumn 34, Issue 1, 2007, Pages 53-55

  Cho, Jin Whan ^a,c   Kim, Sung Yeon ^a,d   Park, Sung Sup ^a,d   Kim, Han Jun ^a,d   Ahn, Tae Beom ^a,b   Kim, Jong Min ^a,e   Jeon, Beom Seok ^a,d  

^a Seoul National University   (South Korea)

^b Kyung Hee University   (South Korea)

^c Seoul National University Boramae Hospital   (South Korea)

^d Seoul National University Hospital   (South Korea)

^e Seoul National University Bundang Hospital   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE RICH REPEAT KINASE 2;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FAMILY HISTORY; FEMALE; GENE MUTATION; GENETIC ANALYSIS; HUMAN; KOREA; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; ONSET AGE; PARKINSON DISEASE; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL;

EID: 33947265877     PISSN: 03171671     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0317167100005783     Document Type: Article

References (20)

1. Hofer A, Gasser T. New aspects of genetic contributions to Parkinson's disease. J Mol Neurosci. 2004;24:417-24.
2. Paisan-Ruiz C, Jain S, Evans EW, van der Brug M, de Munain AL, Aparicio S, et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron. 2004;44: 595-600.
3. Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M, Lincoln S, et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron. 2004; 44:601-7.
4. Funayama M, Hasegawa K, Ohta E, Kawashima N, Komiyama M, Kowa H, et al. An LRRK2 mutation as a cause for the Parkinsonism in the original PARK8 family. Ann Neurol. 2005;57:918-21.
5. Aasly JO, Toft M, Fernandez-Mata I, Kachergus J, Hulihan M, White LR, et al. Clinical features of LRRK2-associated Parkinson's disease in central Norway. Ann Neurol. 2005; 57:762-65.
6. Bras JM, Guerreiro RJ, Ribeiro MH, Januario C, Morgadinho A, Oliveira CR, et al. G2019S Dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort. Mov Dis. 2005;20:1653-55.
7. Fonzo AD, Rohe CF, Ferreira J, Chien HF, Vacca L, Stocchi F, et al. A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease. Lancet. 2005;365:412-15.
8. Gilks WP, Abou-Sleiman PM, Gandhi S, Jain S, Singleton A, Lees A, et al. A common LRRK2 mutation in idiopathic Parkinson's disease. Lancet. 2005;365:415-16.
9. Zabetian CP, Samii A, Mosley AD, Roberts JW, Leis BC, Yearout D, et al. A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations. Neurology. 2005;65:741-4.
10. Goldwurm S, Fonzo AD, Simons EJ, Rohe CF, Zini M, Canesi M, et al. The G6055A(G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor. J Med Genet. 2005;42:e65.
11. Kay DM, Zabetian CP, Factor SA, Nutt JG, Samii A, Griffith A, et al. Parkinson's disease and LRRK2: frequency of a common mutation in U.S. movement disorder clinics. Mov Dis.2006; 21:519-23.
12. Mata IF, Taylor JP, Kachergus J, Hulihan M, Huerta C, Lahoz C, et al. LRRK2 R1141G in Spanish patients with Parkinson's disease. Neurosci lett. 2005;382:309-11.
13. Lesage S, Durr A, Tazir M, Lohmann E, Leutenegger AL, Janin S, et al. LRRK2 G2019S as a cause of Parkinson's disease in North African Arabs. N Engl J Med. 2006 Jan 26;354:422-3.
14. Ozelius LJ, Senthil G, Saunder-Pullman R, Ohmann E, Deligtisch A, Tagliati M, et al. LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews. N Engl J Med. 2006; 354:424-5.
15. Infante J, Rodriguez E, Combarros O, Mateo I, Fontalba A, Pascual J, et al. RRK2 G2019S is a common mutation in Spanish patients with late-onset Parkinson's disease. Neurosci Lett 2006; 395:224-6.
16. Lu CS, Simons EJ, Wu-Chou YH, Fonzo AD, Chang HC, Chen RS, et al. The LRRK2 I2012T, G2019S, and I2020T mutations are rare in Taiwanese patients with sporadic Parkinson's disease. Parkinsonism Relat Disord. 2005;11:521-2.
17. Tan EK, Shen H, Tan LCS, Farrer M, Yew K, Chua E, et al. The G2019S LRRK2 mutation in uncommon in an Asian cohort of Parkinson's disease patients. Neurosci lett. 2005;384:327-9.
18. Brice A. Genetics of Parkinson's disease. LRRK2 on the rise. Brain. 2005;128:2760-2.
19. Kachergus J, Mata IF, Hulihan M, Taylor JP, Lincoln S, Aasly J, et al. Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations. Am J Hum Genet. 2005;76: 672-80.
20. Bialecka M, Hui S, Duda GK, Opala G, Tan EK, Drozdzik M. Analysis of LRRK2 G2019S and I2020T mutations in Parkinson's disease. Neurosci letter. 2005;390:1-3.