Increased 3-nitrotyrosine levels in mitochondrial membranes and impaired respiratory chain activity in brain regions of adult female rats submitted to daily vitamin A supplementation for 2 months

Brain Research Bulletin

Volumn 86, Issue 3-4, 2011, Pages 246-253

  De Oliveira, Marcos Roberto ^a   Lorenzi, Rodrigo ^a   Schnorr, Carlos Eduardo ^a   Morrone, Maurílio ^a   Moreira, José Cláudio Fonseca ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Central nervous system; Female rats; Low doses; Nitrosative stress; Respiratory chain activity; Vitamin A supplementation

Indexed keywords

3 NITROTYROSINE; ADVANCED GLYCATION END PRODUCT RECEPTOR; ALPHA SYNUCLEIN; AMINE OXIDASE (FLAVIN CONTAINING); AMYLOID BETA PROTEIN; BETA SYNUCLEIN; COPPER ZINC SUPEROXIDE DISMUTASE; DOPAMINE 2 RECEPTOR; GLUCOSE REGULATED PROTEIN 78; GLUTATHIONE TRANSFERASE; MANGANESE SUPEROXIDE DISMUTASE; RETINOL PALMITATE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN REGION; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ACTIVITY; ESTRUS CYCLE; FEMALE; FRONTAL CORTEX; HIPPOCAMPUS; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN; VITAMIN SUPPLEMENTATION;

AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; BRAIN CHEMISTRY; ELECTRON TRANSPORT; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESTROUS CYCLE; FEMALE; GLYCOSYLATION END PRODUCTS, ADVANCED; MITOCHONDRIAL DISEASES; MITOCHONDRIAL MEMBRANES; MONOAMINE OXIDASE; OXIDATIVE STRESS; RATS; RATS, WISTAR; RECEPTORS, DOPAMINE D2; SUCCINATE DEHYDROGENASE; SUPEROXIDE DISMUTASE; SYNUCLEINS; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE; UBIQUINONE; VITAMIN A; VITAMINS;

EID: 80053279079     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2011.08.006     Document Type: Article

References (37)

1. Allen L.H., Haskell M. Estimating the potential for vitamin A toxicity in women and young children. J. Nutr. 2002, 132:2907S-2919S.
2. Bánhegyi G., Mandl J., Csala M. Redox-based endoplasmic reticulum dysfunction in neurological disease. J. Neurochem. 2008, 107:20-34.
3. Bjelakovic G., Nikolova D., Gluud L.L., Simonetti R.G., Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systemic review and meta-analysis. J. Am. Med. Assoc. 2007, 297:842-857.
4. Bjelakovic G., Nikolova D., Gluud L., Simonetti R., Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst. Rev. 2008, 2. CD007176.
5. Calabrese V., Mancuso C., Calvani M., Rizzarelli E., Butterfield D.A., Stella A.M.G. Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity. Nat. Rev. Neurosci. 2007, 8:766-775.
6. De Oliveira M.R., Silvestrin R.B., Mello e Souza T., Moreira J.C.F. Oxidative stress in the hippocampus, anxiety-like behavior and decreased locomotory and exploratory activity of adult rats: effects of sub acute vitamin A supplementation at therapeutic doses. Neurotoxicology 2007, 28:1191-1199.
7. De Oliveira M.R., Pasquali M.A.B., Silvestrin R.B., Mello e Souza T., Moreira J.C.F. Vitamin A supplementation induces a prooxidative state in the striatum and impairs locomotory and exploratory activity of adult rats. Brain Res. 2007, 1169:112-119.
8. De Oliveira M.R., Moreira J.C.F. Impaired redox state and respiratory chain enzyme activities in the cerebellum of vitamin A-treated rats. Toxicology 2008, 253:125-130.
9. De Oliveira M.R., Oliveira M.W.S., Lorenzi R., Da Rocha R.F., Moreira J.C.F. Short-term vitamin A supplementation at therapeutic doses induces a pro-oxidative state in the hepatic environment and facilitates calcium-ion-induced oxidative stress in rat liver mitochondria independently from permeability transition pore formation. Cell Biol. Toxicol. 2008, 25:545-560.
10. De Oliveira M.R., Oliveira M.W.S., Behr G.A., Hoff M.L.M., Da Rocha R.F., Moreira J.C.F. Evaluation of the effects of vitamin A supplementation on adult rat substantia nigra and striatum redox and bioenergetics states: mitochondrial impairment, increased 3-nitrotyrosine and α-synuclein, but decreased D2 receptors contents. Prog. Neuro-Psychopharmacol. Biol. Psychiatr. 2009, 33:353-362.
11. De Oliveira M.R., Oliveira M.W.S., Behr G.A., Moreira J.C.F. Vitamin A supplementation at clinical doses induces a dysfunction in the redox and bioenergetics states, but did not change neither caspases activities nor TNF-α levels in the frontal cortex of adult Wistar rats. J. Psychiatr. Res. 2009, 43:754-762.
12. De Oliveira M.R., Oliveira M.W.S., Hoff M.L.M., Behr G.A., Da Rocha R.F., Moreira J.C.F. Evaluation of redox and bioenergetics states in the liver of vitamin A-treated rats. Eur. J. Pharmacol. 2009, 610:99-105.
13. Draper H.H., Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol. 1990, 186:421-431.
14. Fischer J.C., Ruitenbeek W., Berden J.Á., Trijbels J.M., Veerkamp J.H., Stadhouders M., Sengers R.C., Janssen A.J. Differential investigation of the capacity of succinate oxidation in human skeletal muscle. Clin. Chim. Acta 1985, 153:23-36.
15. Greiner T. Vitamins and minerals for women: recent programs and intervention trials. Nutr. Res. Pract. 2011, 5:3-10.
16. Grivennikova V.G., Vinogradov A.D. Generation of superoxide by the mitochondrial complex I. Biochim. Biophys. Acta 2006, 1757:553-561.
17. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferases: the first enzymatic step in mercapturic acid formation. J. Biol. Chem. 1974, 249:7130-7139.
18. Halliwell B. Oxidative stress and neurodegeneration: where are we now?. J. Neurochem. 2006, 97:1634-1658.
19. Humphrey J.H., Iliff P.J., Marinda E.T., Mutasa K., Moulton L.H., Chidawanyika H., Ward B.J., Nathoo K.J., Malaba L.C., Zijenah L.S., Zvandasara P., Ntozini R., Mzengeva F., Mahomva A.I., Ruff A.J., Mbizvo M.T., Zunzuga C.D. Effects of a single large dose of vitamin A, given during postpartum period to HIV-positive women and their infants, on child HIV infection, HIV-free survival, and mortality. J. Infect. Dis. 2006, 193:860-871. ZVITAMBO Study Group.
20. Klamt F., De Oliveira M.R., Moreira J.C.F. Retinol induces permeability transition and cytochrome c release from rat liver mitochondria. Biochim. Biophys. Acta 2005, 1726:14-20.
21. Lowry O.H., Rosebrough A.L., Randal R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
22. Mactier H., Weaver L.T. Vitamin A and preterm infants: what we know, what we don't know, and what we need to know. Arch. Dis. Child Fetal Neonatal Educ. 2005, 90:103-108.
23. Malhotra J.D., Kaufman R.J. Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?. Antioxid. Redox Signal 2007, 9:2277-2293.
24. Marcondes F.K., Biachi F.J., Tanno A.P. Determination of the estrous cycle phases of rats: some helpful considerations. Braz. J. Biol. 2002, 62:609-614.
25. Misra H.P., Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol. Chem. 1972, 247:3170-3175.
26. Myhre A.M., Carlsen M.H., Bohn S.K., Wold H.L., Laake P., Blomhoff R. Water-miscible, emulsified, and solid forms of retinol supplements are more toxic than oil-based preparations. Am. J. Clin. Nutr. 2003, 78:1152-1159.
27. Napoli J.L. Interactions of retinoids binding proteins and enzymes in retinoids metabolism. Biochim. Biophys. Acta 1999, 1440:139-162.
28. O'Reilly K., Bailey S.J., Lane M.A. Retinoid-mediated regulation of mood: possible cellular mechanisms. Exp. Biol. Med. 2008, 233:251-258.
29. Palace V.P., Khaper P., Qin Q., Singal P.K. Antioxidant potential of vitamin A and carotenoids and their relevance to heart disease. Free Radic. Biol. Med. 1999, 26:746-761.
30. Poderoso J.J., Carreras M.C., Lisdero C., Riobo N., Schopfer F., Boveris A. Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles. Arch. Biochem. Biophys. 1996, 328:85-92.
31. Rustin P., Chretien D., Bourgeron T., Gérard B., Rötig A., Saudubray J.M., Munnich A. Biochemical and molecular investigations in respiratory chain deficiencies. Clin. Chim. Acta 1994, 228:35-51.
32. Shapira A.H., Mann V.M., Cooper J.M., Dexter D., Daniel S.E., Jenner P., Clark J.B., Marsden C.D. Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease. J. Neurochem. 1990, 55:2142-2145.
33. Souza J.M., Peluffo G., Radi R. Protein tyrosine nitration - functional alteration or just a biomarker?. Free Radic. Biol. Med. 2008, 45:357-366.
34. Strassburger M., Bloch W., Sulyok S., Schuller J., Keist A.F., Schmidt A., Wenk J., Peters T., Wlaschek M., Krieg T., Hafner M., Kümin A., Werner S., Müller W., Scharffetter-Kochanek K. Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. Free Radic. Biol. Med. 2005, 38:1458-1470.
35. Tsunati H., Iwasaki H., Kawai Y., Tanaka T., Ueda T., Uchida M., Nakamura T. Reduction of leukemia cell growth in a patient with acute promyelocytic leukemia treated by retinol palmitate. Leuk. Res. 1990, 14:595-600.
36. Tsunati H., Ueda T., Uchida M., Nakamura T. Pharmacological studies of retinol palmitate and its clinical effect in patients with acute non-lymphocytic leukemia. Leuk. Res. 1991, 15:463-471.
37. Weissbach H., Smith T.E., Daly J.W., Witkop B., Udenfriend S. A rapid spectrophotometric assay of monoamine oxidase based on the rate of disappearance of kynuramine. J. Biol. Chem. 1960, 235:1160-1163.