Effects of a single large dose of vitamin A, given during the postpartum period to HIV-positive women and their infants, on child HIV infection, HIV-free survival, and mortality

Journal of Infectious Diseases

Volumn 193, Issue 6, 2006, Pages 860-871

  Humphrey, Jean H ^a   Iliff, Peter J ^a   Marinda, Edmore T ^a   Mutasa, Kuda ^a   Moulton, Lawrence H ^a   Chidawanyika, Henry ^a   Ward, Brian J ^a   Nathoo, Kusum J ^a   Malaba, Lucie C ^a   Zijenah, Lynn S ^a   Zvandasara, Partson ^a   Ntozini, Robert ^a   Mzengeza, Faith ^a   Mahomva, Agnes I ^a   Ruff, Andrea J ^a   Mbizvo, Michael T ^a   Zunguza, Clare O ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

RETINOL;

ADULT; ARTICLE; BREAST FEEDING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE TRANSMISSION; FEMALE; HIGH RISK INFANT; HIGH RISK PREGNANCY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; MAJOR CLINICAL STUDY; MALE; MATERNAL SERUM; MORTALITY; MOTHER CHILD RELATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PUERPERIUM; RANDOMIZED CONTROLLED TRIAL; SEROPREVALENCE; SURVIVAL; VITAMIN SUPPLEMENTATION;

DIETARY SUPPLEMENTS; DISEASE TRANSMISSION, VERTICAL; FEMALE; HIV INFECTIONS; HIV SERONEGATIVITY; HUMANS; INFANT; INFANT MORTALITY; INFANT, NEWBORN; MILK, HUMAN; POSTPARTUM PERIOD; PREGNANCY; VITAMIN A; VITAMIN A DEFICIENCY;

EID: 33644895392     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/500366     Document Type: Article

References (52)

1. Dushimimana A, Graham NMH, Humphrey JH, et al. Maternal vitamin A levels and HIV-related birth outcome in Rwanda [abstract Poc4221]. In: Program and abstracts of the 8th International Conference on AIDS/3rd STD World Congress (Amsterdam). Amsterdam: International AIDS Society, 1992.
2. Semba RD, Miotti PG, Chiphangwi JD, et al. Maternal vitamin A deficiency and mother-to-child transmission of HIV-1. Lancet 1994; 343:1593-7.
3. Greenberg BL, Semba RD, Vink PE, et al. Vitamin A deficiency and maternal-infant transmission of HIV in two metropolitan areas in the United States. AIDS 1997; 11:325-32.
4. Nduati RW, John GC, Richardson BA, et al. Human immunodeficiency virus type 1-infected cells in breast milk: association with immunosuppression and vitamin A deficiency. J Infect Dis 1995; 172:1461-8.
5. Ross AC. The relationship between immunocompetence and vitamin A status. In: Sommer A, West KP Jr. Vitamin A deficiency: health, survival, and vision. New York: Oxford University Press, 1996:251-73.
6. Semba RD. Overview of the potential role of vitamin A in mother to child transmission of HIV. Acta Paediatr Suppl 1997; 421:107-12.
7. Fawzi W Nutritional factors and vertical transmission of HIV-1: epidemiology and potential mechanisms. Ann N Y Acad Sci 2000; 918:99-114.
8. Fawzi WW, Msamanga GI, Spiegelman D, Urassa EJ, Hunter DJ. Rationale and design of the Tanzania vitamin and HIV infection trial. Control Clin Trials 1999; 20:75-90.
9. Coutsoudis A, Pillay K, Spooner E, Kuhn L, Coovadia HM. Randomized trial testing the effect of vitamin A supplementation on pregnancy outcomes and early mother-to-child HIV-1 transmission in Durban, South Africa. AIDS 1999; 13:1517-24.
10. Kumwenda N, Miotti PG, Taha TE, et al. Antenatal vitamin A supplementation increases birth weight and decreases anemia among infants born to human immunodeficiency virus-infected women in Malawi. Clin Infect Dis 2002;35:618-24.
11. Fawzi WW, Msamanga G, Hunter D, et al. Randomized trial of vitamin supplements in relation to vertical transmission of HIV-1 in Tanzania. J Acquir Immune Defic Syndr 2000; 23:246-54.
12. Fawzi WW, Msamanga GI, Hunter D, et al. Randomized trial of vitamin supplements in relation to transmission of HIV-1 through breast-feeding and early child mortality. AIDS 2002; 16:1935-44.
13. WHO/UNICEF/IVACG Task Force. Vitamin A supplements: a guide to their use in the treatment and prevention of vitamin A deficiency and xerophthalmia. Geneva: WHO, 1998.
14. Stoltzfus RJ, Hakimi M, Miller KW, et al. High dose vitamin A supplementation of breast feeding Indonesian mothers: effects on the vitamin A status of mother and infant. J Nutr 1993; 123:666-75.
15. Rice AL, Stoltzfus RJ, de Francisco A, Chakraborty J, Kjolhede CL, Wahed MA. Maternal vitamin A or β-carotene supplementation in lactating Bangladeshi women benefits mothers and infants but does not prevent subclinical deficiency. J Nutr 1999; 129:356-65.
16. Basu S, Sengupta B, Roy Paladhi PK. Single megadose vitamin A supplementation of Indian mothers and morbidity in breastfed young infants. Postgrad Med J 2003; 79:397-402.
17. de Benoist B, Martines J, Goodman T. Vitamin A supplementation and the control of vitamin A deficiency: conclusions. Food Nutr Bull 2001;22:335-7.
18. Ross DA. Recommendations for vitamin A supplementation. J Nutr 2002; 132:29025-65.
19. Humphrey JH, Agoestina T, Wu L, et al. Impact of neonatal vitamin A supplementation on infant morbidity and mortality. J Pediatr 1996; 128:489-96.
20. Rahmathullah L, Tielsch JM, Thulasiraj RD, et al. Impact of supplementing newborn infants with vitamin A on early infant mortality: community-based randomized trial in southern India. BMJ 2003; 327:254-7.
21. Beaton GH, Martorell R, Aronson KJ, et al. Effectiveness of vitamin A supplementation in the control of young child morbidity and mortality in developing countries. Standing Committee on Nutrition of the United Nations Administrative Committee (ACC/SCN) State of the Art Series Nutrition Policy Discussion Paper no. 13. Geneva: World Health Organization, 1993.
22. Coutsoudis A, Bobat RA, Coovadia HM, Kuhn L, Tsai W-Y, Stein ZA. The effects of vitamin A supplementation on the morbidity of children born to HIV-infected women. Am J Public Health 1995; 85:1076-81.
23. Semba RD, Ndugwa C, Perry RT, et al. Effect of periodic vitamin A supplementation on mortality and morbidity of human immunodeficiency virus-infected children in Uganda: controlled clinical trial. Nutrition 2005; 21:25-31.
24. Hussey G, Hughes J, Potgieter S, et al. Vitamin A status and supplementation and its effect on immunity in children with AIDS. In: Program and abstracts of the 17th International Vitamin A Consultative Group meeting (Guatemala City, Guatemala). Washington, DC: International Life Sciences Institute, 1996:81.
25. Fawzi WW, Mbise RL, Hertzmark E, et al. A randomized trial of vitamin A supplements in relation to mortality among human immunodeficiency virus-infected and uninfected children in Tanzania. Pediatr Infect Dis J 1999; 18:127-33.
26. Ministry of Health and Child Welfare. Report of the national survey on vitamin A, iron, and iodine. Harare, Zimbabwe: Ministry of Health and Child Welfare, 11-31 October 1999.
27. Ministry of Health and Child Welfare. Zimbabwe National HIV and AIDS Estimates. Harare, Zimbabwe: Ministry of Health and Child Welfare, 2003.
28. Malaba L, Iliff PJ, Nathoo KJ, et al. Effect of postpartum maternal or neonatal vitamin A supplementation on infant mortality among infants born to HIV-negative mothers in Zimbabwe. Am J Clin Nutr 2005; 81:454-60.
29. Iliff PJ, Humphrey JH, Mahomva AI, et al. Tolerance of large doses of vitamin A given to mothers and their babies shortly after delivery. Nutr Res 1999; 19:1437-46.
30. Miller MF, Stoltzfus RJ, Mbuya NV, et al. Total body iron in HIV-positive and HIV-negative Zimbabwean newborns strongly predicts anemia throughout infancy and is predicted by maternal hemoglobin concentration. J Nutr 2003; 133:3461-8.
31. Capurro H, Konichezky S, Fonseca D, Caldeyro-Barcia R. A simplified method for diagnosis of gestational age in the newborn infant. J Pediatr 1978; 93:120-2.
32. Gibson RS. Principles of nutritional assessment. New York: Oxford University Press, 1990.
33. Piwoz EG, Iliff PJ, Tavengwa NV, et al. An education and counselling program for preventing breastfeeding-associated HIV transmission in Zimbabwe: design and impact on maternal knowledge and behaviour. J Nutr 2005; 135:950-5.
34. Gavin L, Tavengwa NV, Iliff PJ, Humphrey JH, Nathoo KJ. The development of an intervention to inform women about infant feeding in the context of HIV [poster 269]. In: Program and abstracts of the 2nd Conference on Global Strategies for the Prevention of HIV Transmission from Mothers to Infants (Montreal). 1999.
35. Alioum A, Dabis F, Dequae-Merchadou L, et al. Estimating the efficacy of interventions to prevent mother-to-child transmission of HIV in breast-feeding populations: development of a consensus methodology. Stat Med 2001; 20:3539-56.
36. Turnbull B. The empirical distribution function with arbitrarily grouped, censored, and truncated data. J Royal Statist Soc Ser B 1976; 38:290-5.
37. Hudgens MG, Satten GA, Longini IM Jr. Nonparametric maximum likelihood estimation for competing risks survival data subject to interval censoring and truncation. Biometrics 2001; 57:74-80.
38. WHO. The measurement of overall and cause-specific mortality in infants and children: report of a joint WHO/UNICEF consultation, 15-17 December 1992. Geneva: WHO, 1992.
39. Hammer ES, Gibb D, Havlir D, Mofenson L, Beek IV, Vella S. Scaling up antiretroviral therapy in resource-limited settings: guidelines for a public health approach. Geneva: WHO, 2002.
40. Christian P, West KP Jr, Khatry SK, et al. Night blindness during pregnancy and subsequent mortality among women in Nepal: effects of vitamin A and beta-carotene supplementation. Am J Epidemiol 2000; 152:542-7.
41. Sporn MB, Roberts AB. Interactions of retinoids and transforming growth factor-beta in regulation of cell differentiation and proliferation. Mol Endocrinol 1991; 5:3-7.
42. Hanley TM, Kiefer HL, Schnitzler AC, Marcello JE, Viglianti GA. Retinoid-dependent restriction of human immunodeficiency virus type 1 replication in monocytes/macrophages. J Virol 2004; 78:2819-30.
43. Kiefer HL, Hanley TM, Marcello JE, Karthik AG, Viglianti GA. Retinoic acid inhibition of chromatin remodeling at the human immunodeficiency virus type 1 promoter. J Biol Chem 2004; 279:43604-13.
44. Brown XQ, Hanley TM, Viglianti GA. Interleukin 1β and interleukin 6 potentiate retinoic acid-mediated repression of human immunodeficiency virus type 1 replication in macrophages. AIDS Res Hum Retroviruses 2002; 18:649-56.
45. Poli G, Kinter AL, Justement JS, Bressler P, Kehrl JH, Fauci AS. Retinoic acid mimics transforming growth factor β in the regulation of human immunodeficiency virus expression in monocytic cells. Proc Natl Acad Sci USA 1992;89:2689-93.
46. Maciaszek JW, Coniglio SJ, Talmage DA, Viglianti GA. Retinoid-induced repression of human immunodeficiency virus type 1 core promoter activity inhibits virus replication. J Virol 1998; 72:5862-9.
47. Towers G, Harris J, Lang G, Collins MK, Latchman DS. Retinoic acid inhibits both the basal activity and phorbol ester-mediated activation of the HIV long terminal repeat promoter. AIDS 1995; 9:129-36.
48. Yamaguchi K, Groopman JE, Byrn RA. The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors. AIDS 1994; 8:1675-82.
49. Kitano K, Baldwin GC, Raines MA, Golde DW. Differentiating agents facilitate infection of myeloid leukemia cell lines by monocytotropic HIV-1 strains. Blood 1990; 76:1980-8.
50. Turpin JA, Vargo M, Meltzer MS. Enhanced HIV-1 replication in retinoid-treated monocytes: retinoid effects mediated through mechanisms related to cell differentiation and to a direct transcriptional action on viral gene expression. J Immunol 1992; 148:2539-46.
51. West KP Jr, Katz J, Khatry SK, et al. Double blind, cluster randomised trial of low dose supplementation with vitamin A or β-carotene on mortality related to pregnancy in Nepal. BMJ 1999; 318:570-5.
52. Sommer A. Innocenti Micronutrient Research Report no. 1. International Vitamin A Consultative Group, 2005. Available at: http://ivacg .ilsi.org. Accessed 13 September 2005.