Anticancer and radio-sensitizing evaluation of some new thiazolopyrane and thiazolopyranopyrimidine derivatives bearing a sulfonamide moiety

European Journal of Medicinal Chemistry

Volumn 46, Issue 10, 2011, Pages 5120-5126

  Ghorab, Mostafa M ^a   Ragab, Fatma A ^b   Heiba, Helmy I ^c   El Hazek, Reham M ^c  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b CAIRO UNIVERSITY   (Egypt)

^c NATIONAL CENTER FOR RADIATION RESEARCH AND TECHNOLOGY   (Egypt)

Author keywords

Anticancer; Radio sensitizer; Sulfonamide; Thiazolopyrane; Thiazolopyranopyrimidine

Indexed keywords

2 CHLORO N [7 (4 CHLOROPHENYL) 6 CYANO 2 (4 SULFAMOYLPHENYLAMINO) 7H THIAZOLO[4,5 B]PYRANE 5 YL]ACETAMIDE; 4 [5 (4 CHLOROBENZYLIDENEAMINO) 7 (4 CHLOROPHENYL) 6 CYANO 7H THIAZOLO[4,5 B]PYRANE 2 YLAMINO]BENZENESULFONAMIDE; 4 [5 (BENZYLIDENEAMINO) 7 (4 CHLOROPHENYL) 6 CYANO 7H THIAZOLO[4,5 B]PYRANE 2 YLAMINO]BENZENESULFONAMIDE; 4 [5 AMINO 7 (4 CHLOROPHENYL) 6 CYANO 7H THIAZOLO[4,5 B]PYRANE 2 YL AMINO]BENZENESULFONAMIDE; 4 [7 (4 CHLOROPHENYL) 6 CYANO 5 (4 METHYLBENZYLIDENEAMINO) 7H THIAZOLO[4,5 B]PYRANE 2 YLAMINO]BENZENESULFONAMIDE; 4 [7 (4 CHLOROPHENYL) 6 CYANO 5 UREIDO 7H THIAZOLO[4,5 B]PYRANE 2 YL AMINO]BENZENESULFONAMIDE; 4 [8 AMINO 9 (4 CHLOROPHENYL) 6 OXO 5,9 DIHYDROTHIAZOLO[4,5 B]PYRANO[2,3 D]PYRIMIDINE 2 YL AMINO)BENZENESULFONAMIDE; 4 [8 AMINO 9 (4 CHLOROPHENYL) 6 THIOXO 5,9 DIHYDROTHIAZOLO[4,5 B]PYRANO[2,3 D]PYRIMIDINE 2 YL AMINO]BENZENESULFONAMIDE; 4 [8 AMINO 9 (4 CHLOROPHENYL) 9H THIAZOLO[4,5 B]PYRANO[2,3 D]PYRIMIDINE 2 YLAMINO]BENZENESULFONAMIDE; 4 [9 (4 CHLOROPHENYL) 8 OXO 7, 9DIHYDROTHIAZOLO[4,5 B]PYRANO[2,3 D]PYRIMIDIN 2 YLAMINO]BENZENESULFONAMIDE; 5 AMINO 7 (4 CHLOROPHENYL) 2 (4 SULFAMOYLPHENYLAMINO) 7H THIAZOLO[4,5 B]PYRANE 6 CARBOXAMIDE; BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE; DOXORUBICIN; N [7 (4 CHLOROPHENYL) 6 CYANO 2 (4 SULFAMOYLPHENYLAMINO) 7H THIAZOLO[4,5 B]PYRANE 5 YL]ACETAMIDE; N ACETYL N [7 (4 CHLOROPHENYL) 6 CYANO 2 (4 SULFAMOYLPHENYLAMINO) 7H THIAZOLO[4,5 B]PYRANE 5 YL]ACETAMIDE; PYRAN DERIVATIVE; PYRIMIDINE DERIVATIVE; RADIOSENSITIZING AGENT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL KILLING; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; GAMMA RADIATION; HUMAN; HUMAN CELL; IC 50; INFRARED SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; RADIATION DOSE; RADIOSENSITIZATION;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GAMMA RAYS; HUMANS; PYRANS; PYRIMIDINES; RADIATION-SENSITIZING AGENTS; SULFONAMIDES; THIAZOLES;

EID: 80053211227     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.08.026     Document Type: Article

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