Synthesis of some p-toluenesulfonyl-hydrazinothiazoles and hydrazino-bis-thiazoles and their anticancer activity

European Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2010, Pages 5080-5085

  Zaharia, Valentin ^a   Ignat, Adriana ^a   Palibroda, Nicolae ^b   Ngameni, Bathélémy ^a,c   Kuete, Victor ^d   Fokunang, Charles N ^c   Moungang, Marlyse L ^c   Ngadjui, Bonaventure T ^c  

^a IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^b NATIONAL INSTITUTE FOR RESEARCH AND DEVELOPMENT OF ISOTOPIC AND MOLECULAR TECHNOLOGIES   (Romania)

^c UNIVERSITY OF YAOUNDÉ I   (Cameroon)

^d UNIVERSITY OF DSCHANG   (Cameroon)

Author keywords

Cytotoxicity; Hepatocarcinoma; Hydrazino bis thiazoles; p Toluenesulfonyl hydrazinothiazoles; Prostate cancer

Indexed keywords

4 CHLOROMETHYL 2 [2 (2 PHENYL 1,3 THIAZOLO 4 CARBONYL) N ACETYL HYDRAZINO]THIAZOLE; 4 CHLOROMETHYL 2 [2 (2 PHENYL 1,3 THIAZOLO 4 CARBONYL)HYDRAZINO]THIAZOLE; 4 CHLOROMETHYL 2 [2 (PARA TOLUENESULFONYL) N,N DIACETYL HYDRAZINO]THIAZOLE; 4 CHLOROMETHYL 2 [2 (PARA TOLUENESULFONYL)HYDRAZINO]THIAZOLE; 4 ETHYL ACETATE 2 [2 (2 PHENYL 1,3 THIAZOLO 4 CARBONYL)HYDRAZINO]THIAZOLE; 4 ETHYL ACETATE 2 [2 (P TOLUENESULFONYL) N,N DIACETYL HYDRAZINO]THIAZOLE; 4 ETHYL ACETATE 2 [2 (PARA TOLUENESULFONYL)HYDRAZINO]THIAZOLE; 4 ETHYLACETATE 2 [2 (2 PHENYL 1,3 THIAZOLO 4 CARBONYL) N ACETYL HYDRAZINO]THIAZOLE; 4 METHYL 2 [2 (PARA TOLUENESULFONYL) N,N DIACETYL HYDRAZINO]THIAZOLE; 4 METHYL 2 [2 (PARA TOLUENESULFONYL)HYDRAZINO]THIAZOLE; 4 PHENYL 2 [2 (PARA TOLUENESULFONYL) N,N DIACETYL HYDRAZINO]; 4 PHENYL 2 [2 (PARA TOLUENESULFONYL)HYDRAZINO]THIAZOLE; 5 ACETYL 4 METHYL 2 [2 (PARA TOLUENESULFONYL) N,N DIACETYL HYDRAZINO]THIAZOLE; 5 ACETYL 4 METHYL 2 [2 (PARA TOLUENESULFONYL)HYDRAZINO]THIAZOLE; 5 ETHOXYCARBONYL 4 METHYL 2 [2 (PARA TOLUENESULFONYL)HYDRAZINO]THIAZOLE; 5 ETHOXYCARBONYL 4 METHYL 2 [2 (PARA TOLUENSULFONYL) N,N DIACETYL HYDRAZINO]THIAZOLE; ACETIC ANHYDRIDE; ACETONE; ANTINEOPLASTIC AGENT; N,N DIMETHYLFORMAMIDE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ACYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; INFRARED SPECTROSCOPY; LIVER CELL CARCINOMA; MASS SPECTROMETRY; PROSTATE CARCINOMA; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; HYDRAZINES; MAGNETIC RESONANCE SPECTROSCOPY; THIAZOLES; TOSYL COMPOUNDS;

EID: 77957855312     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.08.017     Document Type: Article

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