메뉴 건너뛰기




Volumn 15, Issue 12, 2005, Pages 1763-1782

Recent development of monoamine oxidase inhibitors

Author keywords

Alzheimer's disease; Amido propargylamine; Anxiety; Cinnamide; Dementia; Depression; Diterpene; Fluorobenzamide; Imidazole; Isoindole; Isoquinoline; N acylamminoaryl derivative; Oxazole; Parkinson's disease; Phenanthrene; Phthalimide; Pyridine; Pyrrolidine; Thiazole

Indexed keywords

2 PYRROLIDONE DERIVATIVE; 2,3 DIHYDROISOINDOL 1 ONE DERIVATIVE; 3 PHENYLACRYLAMIDE DERIVATIVE; 3 PHENYLPROPIONAMIDE DERIVATIVE; 3 PHENYLPROPYNAMIDE DERIVATIVE; 4 PYRROLIDINOPHENYLBENZYL ETHER DERIVATIVE; ACRYLAMIDE DERIVATIVE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; BENZAMIDE DERIVATIVE; BENZAZEPINE DERIVATIVE; BENZYL DERIVATIVE; CHOLINESTERASE INHIBITOR; DITERPENE; ETHER DERIVATIVE; INDAN DERIVATIVE; ISOINDOLE DERIVATIVE; ISOQUINOLINE DERIVATIVE; MONOAMINE OXIDASE A INHIBITOR; MONOAMINE OXIDASE B INHIBITOR; N ACYLAMINO ACID; NEW DRUG; PHENANTHRENE DERIVATIVE; PHTHALIMIDE DERIVATIVE; PROPARGYLGLYCINE; PROPIONAMIDE DERIVATIVE; PROPYLAMINE; PYRIDINE DERIVATIVE; TETRALIN DERIVATIVE; UNCLASSIFIED DRUG;

EID: 30344432647     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.15.12.1763     Document Type: Review
Times cited : (37)

References (56)
  • 2
    • 0037199441 scopus 로고    scopus 로고
    • Catalytic mechanism of the topa quinone containing copper amine oxidases
    • MURE M, MILLS SA, KLINMAN JP: Catalytic mechanism of the topa quinone containing copper amine oxidases. Biochemistry (2002) 41(30):9269-9278.
    • (2002) Biochemistry , vol.41 , Issue.30 , pp. 9269-9278
    • Mure, M.1    Mills, S.A.2    Klinman, J.P.3
  • 3
    • 0014314486 scopus 로고
    • Some observations upon a new inhibitor of monoamine oxidase in brain tissue
    • JOHNSTON JP: Some observations upon a new inhibitor of monoamine oxidase in brain tissue. Biochem. Pharmacol. (1968) 17:1285-1297.
    • (1968) Biochem. Pharmacol. , vol.17 , pp. 1285-1297
    • Johnston, J.P.1
  • 4
    • 0015274536 scopus 로고
    • Some puzzling pharmacological effects of monoamine oxidase inhibitors
    • KNOLL J, MAGYAR K: Some puzzling pharmacological effects of monoamine oxidase inhibitors. Adv. Biochem. Psychopharmacol. (1972) 5:393-408.
    • (1972) Adv. Biochem. Psychopharmacol. , vol.5 , pp. 393-408
    • Knoll, J.1    Magyar, K.2
  • 5
    • 0024042954 scopus 로고
    • cDNA cloning of human liver monoamine oxidase A and B: Molecular basis of differences in enzymatic properties
    • BACH AW, LAN NC, JOHNSON DL et al.: cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties. Proc. Natl. Acad. Sci. USA (1988) 85:4934-4938.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 4934-4938
    • Bach, A.W.1    Lan, N.C.2    Johnson, D.L.3
  • 6
    • 0031898408 scopus 로고    scopus 로고
    • Structural aspects of of monoamine oxidase and its reversible inhibition
    • WOUTERS J: Structural aspects of of monoamine oxidase and its reversible inhibition. Curr. Med. Chem. (1998) 5:137-162.
    • (1998) Curr. Med. Chem. , vol.5 , pp. 137-162
    • Wouters, J.1
  • 7
    • 0028278443 scopus 로고
    • Structure-activity relationships in the oxidation of benzylamine analogues by bovine liver mitochondrial monoamine oxidase B
    • WALKER MC, EDMONDSON DE: Structure-activity relationships in the oxidation of benzylamine analogues by bovine liver mitochondrial monoamine oxidase B. Biochemistry (1994) 33:7088-7098.
    • (1994) Biochemistry , vol.33 , pp. 7088-7098
    • Walker, M.C.1    Edmondson, D.E.2
  • 8
    • 0033550070 scopus 로고    scopus 로고
    • Structure-activity relationships in the oxidation of para-substituted benzylamine analogues by recombinant human liver monoamine oxidase A
    • MILLER JR, EDMONDSON DE: Structure-activity relationships in the oxidation of para-substituted benzylamine analogues by recombinant human liver monoamine oxidase A. Biochemistry (1999) 38:13670-13683.
    • (1999) Biochemistry , vol.38 , pp. 13670-13683
    • Miller, J.R.1    Edmondson, D.E.2
  • 9
    • 0000897452 scopus 로고
    • A mechanism for mitochondrial monoamine oxidase catalyzed amine oxidation
    • SILVERMAN RB, HOFFMAN SJ, CATUS WB: A mechanism for mitochondrial monoamine oxidase catalyzed amine oxidation. J. Am. Chem. Soc. (1980) 102:7126-7128.
    • (1980) J. Am. Chem. Soc. , vol.102 , pp. 7126-7128
    • Silverman, R.B.1    Hoffman, S.J.2    Catus, W.B.3
  • 10
    • 0001532593 scopus 로고
    • Mechanistic analysis of the 3-methyllumiflavin-promoted oxidative deamination of benzylamine. A potential model for monoamine oxidase catalysis
    • KIM JM, BOGDAN MA, MARIANO PS: Mechanistic analysis of the 3-methyllumiflavin-promoted oxidative deamination of benzylamine. A potential model for monoamine oxidase catalysis. J. Am. Chem. Soc. (1993) 115:10591-10595.
    • (1993) J. Am. Chem. Soc. , vol.115 , pp. 10591-10595
    • Kim, J.M.1    Bogdan, M.A.2    Mariano, P.S.3
  • 11
    • 0042835703 scopus 로고    scopus 로고
    • Inactivation of mitochondrial monoamine oxidase B by methylthio-substituted benzylamines
    • LU X, RODRÌGUEZ M, GU W, SILVERMAN RB: Inactivation of mitochondrial monoamine oxidase B by methylthio-substituted benzylamines. Bioorg. Med. Chem. (2003) 11(20):4423-4430.
    • (2003) Bioorg. Med. Chem. , vol.11 , Issue.20 , pp. 4423-4430
    • Lu, X.1    Rodrìguez, M.2    Gu, W.3    Silverman, R.B.4
  • 12
    • 0026520063 scopus 로고
    • The new generation of monoamine oxidase inhibitors
    • CESURA AM, PLETSCHER A: The new generation of monoamine oxidase inhibitors. Prog. Drug Res. (1992) 38:171-257.
    • (1992) Prog. Drug Res. , vol.38 , pp. 171-257
    • Cesura, A.M.1    Pletscher, A.2
  • 13
    • 0028145566 scopus 로고
    • Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography
    • SAURA J, LUQUE JM, CESURA AM et al.: Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography. Neuroscience (1994) 62:15-30.
    • (1994) Neuroscience , vol.62 , pp. 15-30
    • Saura, J.1    Luque, J.M.2    Cesura, A.M.3
  • 14
    • 0032609787 scopus 로고    scopus 로고
    • Moclobemide in patients with dementia and depression
    • AMREIN R, MARTIN JR, CAMERON AM: Moclobemide in patients with dementia and depression. Adv. Neurol. (1999) 80:509-519.
    • (1999) Adv. Neurol. , vol.80 , pp. 509-519
    • Amrein, R.1    Martin, J.R.2    Cameron, A.M.3
  • 15
    • 0021276089 scopus 로고
    • Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase
    • CHIBA K, TREVOR A, CASTAGNOLI N: Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase. Biochem. Biophys. Res. Commun. (1984) 120:574-578.
    • (1984) Biochem. Biophys. Res. Commun. , vol.120 , pp. 574-578
    • Chiba, K.1    Trevor, A.2    Castagnoli, N.3
  • 16
    • 0021864767 scopus 로고
    • Metabolism of the neurotoxin in MPTP by human liver monoamine oxidase B
    • FRITZ RR, ABELL CW, PATEL NT, GESSNER W, BROSSI A: Metabolism of the neurotoxin in MPTP by human liver monoamine oxidase B. FEBS Lett. (1985) 186:224-228.
    • (1985) FEBS Lett. , vol.186 , pp. 224-228
    • Fritz, R.R.1    Abell, C.W.2    Patel, N.T.3    Gessner, W.4    Brossi, A.5
  • 17
    • 84984766381 scopus 로고    scopus 로고
    • Increased stress response and β-phenylethylamine in MAOB-deficient mice
    • GRIMSBY J, TOTH M, CHEN K et al.: Increased stress response and β-phenylethylamine in MAOB-deficient mice. Nat. Genet. (1997) 17:206-210.
    • (1997) Nat. Genet. , vol.17 , pp. 206-210
    • Grimsby, J.1    Toth, M.2    Chen, K.3
  • 18
    • 0035933061 scopus 로고    scopus 로고
    • Pro-apoptotic gene expression mediated by the p38 mitogen-activated protein kinase signal transduction pathway
    • DE ZUTTER GS, DAVIS RJ: Pro-apoptotic gene expression mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Proc. Natl. Acad. Sci. USA (2001) 98:6168-6173.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6168-6173
    • De Zutter, G.S.1    Davis, R.J.2
  • 19
    • 0008001201 scopus 로고
    • Antitubercular substances. II. Substitution products of isonicotinic hydrazide
    • MCMILLAN FH, LEONARD F, MELTZER RI, KING JA: Antitubercular substances. II. Substitution products of isonicotinic hydrazide. J. Am. Pharm. Assoc. (1953) 42:457-464.
    • (1953) J. Am. Pharm. Assoc. , vol.42 , pp. 457-464
    • Mcmillan, F.H.1    Leonard, F.2    Meltzer, R.I.3    King, J.A.4
  • 20
    • 0019798422 scopus 로고
    • The acetylenic monoamine oxidase inhibitors clorgyline, deprenyl, pargyline and J-508: Their properties and applications
    • FOWLER CJ, ORELAND L, CALLINGHAM BA: The acetylenic monoamine oxidase inhibitors clorgyline, deprenyl, pargyline and J-508: their properties and applications. J. Pharm. Pharmacol. (1981) 33:341-347.
    • (1981) J. Pharm. Pharmacol. , vol.33 , pp. 341-347
    • Fowler, C.J.1    Oreland, L.2    Callingham, B.A.3
  • 22
    • 0019462668 scopus 로고
    • Tyramine antagonistic properties of AGN 1135, an irreversible inhibitor of monoamine oxidase type B
    • FINBERG J P, TENNE M, YOUDIM MB: Tyramine antagonistic properties of AGN 1135, an irreversible inhibitor of monoamine oxidase type B. Br. J. Pharmacol. (1981) 73(1):65-74.
    • (1981) Br. J. Pharmacol. , vol.73 , Issue.1 , pp. 65-74
    • Finberg, J.P.1    Tenne, M.2    Youdim, M.B.3
  • 23
    • 0034525115 scopus 로고    scopus 로고
    • TV3326, a novel neuroprotective drug with cholinesterase and monoamine oxidase inhibitory activities for the treatment of Alzheimer's disease
    • WEINSTOCK M, BEJAR C, WANG RH et al.: TV3326, a novel neuroprotective drug with cholinesterase and monoamine oxidase inhibitory activities for the treatment of Alzheimer's disease. J. Neural Transm. (2000) Suppl.60:157-169.
    • (2000) J. Neural Transm. , Issue.SUPPL. 60 , pp. 157-169
    • Weinstock, M.1    Bejar, C.2    Wang, R.H.3
  • 24
    • 0016816484 scopus 로고
    • The nature of inhibition of cat brain mitochondrial monoamine oxidase by clorgyline
    • YOUDIM M B, HOLMAN B: The nature of inhibition of cat brain mitochondrial monoamine oxidase by clorgyline. J. Neural Tranm. (1975) 37(1):11-24.
    • (1975) J. Neural Tranm. , vol.37 , Issue.1 , pp. 11-24
    • Youdim, M.B.1    Holman, B.2
  • 25
    • 0027082365 scopus 로고
    • A reversible monoamine oxidase inhibitor, toloxatone: Structural and electronic properties
    • MOUREAU F, WOUTERS J, VERCAUTEREN DP et al.: A reversible monoamine oxidase inhibitor, toloxatone: structural and electronic properties. Eur. J. Med. Chem. (1992) 27:939-948.
    • (1992) Eur. J. Med. Chem. , vol.27 , pp. 939-948
    • Moureau, F.1    Wouters, J.2    Vercauteren, D.P.3
  • 26
    • 0028220831 scopus 로고
    • A reversible monoamine oxidase inhibitor, toloxatone: Spectrophotometric and molecular orbital studies of the interaction with flavin adenine dinucleotide (FAD)
    • MOUREAU F, WOUTERS J, VERCAUTEREN DP et al.: A reversible monoamine oxidase inhibitor, toloxatone: spectrophotometric and molecular orbital studies of the interaction with flavin adenine dinucleotide (FAD). Eur. J. Med. Chem. (1994) 29:269-277.
    • (1994) Eur. J. Med. Chem. , vol.29 , pp. 269-277
    • Moureau, F.1    Wouters, J.2    Vercauteren, D.P.3
  • 27
    • 0028806711 scopus 로고
    • A reversible monoamine oxidase inhibitor, toloxatone: Comparison of its physicochemical properties with those of other inhibitors including brofaromine, harmine, R40519 and moclobemide
    • MOUREAU F, WOUTERS J, DEPAS M et al.: A reversible monoamine oxidase inhibitor, toloxatone: comparison of its physicochemical properties with those of other inhibitors including brofaromine, harmine, R40519 and moclobemide. Eur. J. Med. Chem. (1995) 30:823-838.
    • (1995) Eur. J. Med. Chem. , vol.30 , pp. 823-838
    • Moureau, F.1    Wouters, J.2    Depas, M.3
  • 28
    • 0032696321 scopus 로고    scopus 로고
    • Befloxatone (MD-370503): Antidepressant, MAO-A [monoamine oxidase A] inhibitor
    • RABASSEDA X, SORBERA LA, CASTANER J: Befloxatone (MD-370503): antidepressant, MAO-A [monoamine oxidase A] inhibitor. Drugs Fut. (1999) 24:1057-1067.
    • (1999) Drugs Fut. , vol.24 , pp. 1057-1067
    • Rabasseda, X.1    Sorbera, L.A.2    Castaner, J.3
  • 29
    • 0032802065 scopus 로고    scopus 로고
    • A reversible monoamine oxidase A inhibitor, befloxatone: Structural approach of its mechanism of action
    • WOUTERS J, MOUREAU F, EVRARD G et al.: A reversible monoamine oxidase A inhibitor, befloxatone: structural approach of its mechanism of action. Bioorg. Med. Chem. (1999) 7:1683-1693.
    • (1999) Bioorg. Med. Chem. , vol.7 , pp. 1683-1693
    • Wouters, J.1    Moureau, F.2    Evrard, G.3
  • 30
    • 0036140732 scopus 로고    scopus 로고
    • Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders
    • BINDA C, NEWTON-VINSON P, HUBALEK F, EDMONDSON DE, MATTEVI A: Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders. Nat. Struct. Biol. (2002) 9:22-26.
    • (2002) Nat. Struct. Biol. , vol.9 , pp. 22-26
    • Binda, C.1    Newton-Vinson, P.2    Hubalek, F.3    Edmondson, D.E.4    Mattevi, A.5
  • 31
    • 0348046389 scopus 로고    scopus 로고
    • The FAD binding sites of human monoamine oxidases A and B
    • EDMONDSON D E, BINDA C, MATTEVI A: The FAD binding sites of human monoamine oxidases A and B. Neurotoxicology (2004) 25:63-72.
    • (2004) Neurotoxicology , vol.25 , pp. 63-72
    • Edmondson, D.E.1    Binda, C.2    Mattevi, A.3
  • 32
    • 24644437716 scopus 로고    scopus 로고
    • Three-dimensional structure of human monoamine oxidase A (MAO A): Relation to the structures of rat MAO A and human MAO B
    • DE COLIBUS L, LI M, BINDA C, LUSTIG A, EDMONDSON DE, MATTEVI A: Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B. (2005) Proc. Natl. Acad. Sci. USA 102(36):12684-12689.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , Issue.36 , pp. 12684-12689
    • De Colibus, L.1    Li, M.2    Binda, C.3    Lustig, A.4    Edmondson, D.E.5    Mattevi, A.6
  • 33
    • 1842474296 scopus 로고    scopus 로고
    • Structure of rat monoamine oxidase A and its specific recognitions for substrates and inhibitors
    • MA J, YOSHIMURA M, YAMASHITA E, NAKAGAWA A, ITO A, TSUKIHARA T: Structure of rat monoamine oxidase A and its specific recognitions for substrates and inhibitors. J. Mol. Biol. (2004) 338:103-114.
    • (2004) J. Mol. Biol. , vol.338 , pp. 103-114
    • Ma, J.1    Yoshimura, M.2    Yamashita, E.3    Nakagawa, A.4    Ito, A.5    Tsukihara, T.6
  • 34
    • 18144423424 scopus 로고    scopus 로고
    • Demonstration of isoleucine 199 as a structural determinant for selective inhibition of human monoamine oxidase B by specific reversibile inhibitors
    • HUBALEK F, BINDA C, KHALIL A et al.: Demonstration of isoleucine 199 as a structural determinant for selective inhibition of human monoamine oxidase B by specific reversibile inhibitors. J. Biol. Chem. (2005) 280(16):15761-15766.
    • (2005) J. Biol. Chem. , vol.280 , Issue.16 , pp. 15761-15766
    • Hubalek, F.1    Binda, C.2    Khalil, A.3
  • 36
    • 5144223126 scopus 로고    scopus 로고
    • Three 5H-indeno[1,2-c]pyridazin-5-one derivatives, potent type-B monoamine oxidase inhibitors
    • FREDERICK R, NORBERG B, DURANT F, OOMS F, WOUTERS J: Three 5H-indeno[1,2-c]pyridazin-5-one derivatives, potent type-B monoamine oxidase inhibitors. Acta Crystallogr. C (2004) 60:623-626.
    • (2004) Acta Crystallogr. C , vol.60 , pp. 623-626
    • Frederick, R.1    Norberg, B.2    Durant, F.3    Ooms, F.4    Wouters, J.5
  • 38
    • 12144289182 scopus 로고    scopus 로고
    • Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class
    • BINDA C, HUBALEK F, LI M, HERZIG Y et al.: Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class. J. Med. Chem. (2004) 47:1767-1774.
    • (2004) J. Med. Chem. , vol.47 , pp. 1767-1774
    • Binda, C.1    Hubalek, F.2    Li, M.3    Herzig, Y.4
  • 39
    • 0030891319 scopus 로고    scopus 로고
    • Synthesis, conformational analysis and antidepressant activity of moclobemide new analogues
    • GHANBARPOUR A, HADIZADEH F, PIRI F, RACHIDI-RANJBAR P: Synthesis, conformational analysis and antidepressant activity of moclobemide new analogues. Pharm. Acta Helv. (1997) 72:119-122.
    • (1997) Pharm. Acta Helv. , vol.72 , pp. 119-122
    • Ghanbarpour, A.1    Hadizadeh, F.2    Piri, F.3    Rachidi-Ranjbar, P.4
  • 40
    • 30344483275 scopus 로고
    • Transient gene expression in mammalian cells grown in serum-free suspension culture
    • SCHLAEGER EJ, CHRISTENSEN K: Transient gene expression in mammalian cells grown in serum-free suspension culture. Cytotechnology (1988) 15:1-13.
    • (1988) Cytotechnology , vol.15 , pp. 1-13
    • Schlaeger, E.J.1    Christensen, K.2
  • 41
    • 0031573408 scopus 로고    scopus 로고
    • A one-step fluorometric method for the continuous measurement of monoamine oxidase activity
    • ZHOU M, PANCHUCK-VOLOSHINA N: A one-step fluorometric method for the continuous measurement of monoamine oxidase activity. Anal. Biochem. (1997) 253:169-174.
    • (1997) Anal. Biochem. , vol.253 , pp. 169-174
    • Zhou, M.1    Panchuck-Voloshina, N.2
  • 42
    • 0031003993 scopus 로고    scopus 로고
    • Inhibition of monoamine oxidase A by β carboline derivatives
    • KIM H, SABLIN SO, RAMSAY RR: Inhibition of monoamine oxidase A by β carboline derivatives. Arch. Biochem. Biophys. (1997) 337:137-142.
    • (1997) Arch. Biochem. Biophys. , vol.337 , pp. 137-142
    • Kim, H.1    Sablin, S.O.2    Ramsay, R.R.3
  • 43
    • 0018657040 scopus 로고
    • 3H]Harmaline as a specific ligand of MAO A. I. Properties of the active site of MAO A from rat and bovine brains
    • 3H]Harmaline as a specific ligand of MAO A. I. Properties of the active site of MAO A from rat and bovine brains. J. Neurochem. (1979) 32(6):1817-1827.
    • (1979) J. Neurochem. , vol.32 , Issue.6 , pp. 1817-1827
    • Nelson, D.L.1    Herbert, A.2    Petillot, T.3    Pichat, L.4    Glowinski, J.5    Hamon, M.6
  • 44
    • 0025139357 scopus 로고
    • Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: Racemic and optical active 1,2,3,4-tetrahydro-,3,4-dihydro-, and fully aromatic isoquinoline
    • BEMBENEK ME, ABELL CW, CHRISEY LA, ROZWADOWSKA MD, GESSNER W, BROSSI A: Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optical active 1,2,3,4-tetrahydro-,3,4-dihydro-, and fully aromatic isoquinoline. J. Med. Chem. (1990) 33:147-152.
    • (1990) J. Med. Chem. , vol.33 , pp. 147-152
    • Bembenek, M.E.1    Abell, C.W.2    Chrisey, L.A.3    Rozwadowska, M.D.4    Gessner, W.5    Brossi, A.6
  • 47
    • 12244296145 scopus 로고    scopus 로고
    • Rasagiline: Neurodegeneration, neuroprotection, and mitochondrial permeability transition
    • YOUDIM MB, BAR-AM O, YOGEV-FALACH M et al.: Rasagiline: neurodegeneration, neuroprotection, and mitochondrial permeability transition. J. Neurosci. Res. (2004) 79:172-179.
    • (2004) J. Neurosci. Res. , vol.79 , pp. 172-179
    • Youdim, M.B.1    Bar-Am, O.2    Yogev-Falach, M.3
  • 48
    • 11144316146 scopus 로고    scopus 로고
    • Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases
    • YOUDIM MB, FRIDKIN M, ZHENG H: Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases. Mech. Ageing Dev. (2005) 126:317-326.
    • (2005) Mech. Ageing Dev. , vol.126 , pp. 317-326
    • Youdim, M.B.1    Fridkin, M.2    Zheng, H.3
  • 49
    • 17644375125 scopus 로고    scopus 로고
    • CNS target for multifunctional drugs in the treatment of Alzheimer's and Parkinson's disease
    • YOUDIM M B H, BUCCAFUSCO JJ: CNS target for multifunctional drugs in the treatment of Alzheimer's and Parkinson's disease. J. Neural Transm. (2005) 112:519-537.
    • (2005) J. Neural Transm. , vol.112 , pp. 519-537
    • Youdim, M.B.H.1    Buccafusco, J.J.2
  • 50
    • 17844406615 scopus 로고    scopus 로고
    • Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives
    • MANDEL S, WEINREB O, AMIT T, YOUDIM MB: Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives. Brain Res. Rev. (2005) 48:379-387.
    • (2005) Brain Res. Rev. , vol.48 , pp. 379-387
    • Mandel, S.1    Weinreb, O.2    Amit, T.3    Youdim, M.B.4
  • 51
    • 11144245220 scopus 로고    scopus 로고
    • Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders
    • YOUDIM MB, BUCCAFUSCO JJ: Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders. Trends Pharmacol. Sci. (2005) 26:27-35.
    • (2005) Trends Pharmacol. Sci. , vol.26 , pp. 27-35
    • Youdim, M.B.1    Buccafusco, J.J.2
  • 52
    • 0017761725 scopus 로고
    • The pseudoirreversible inhibition of monoamine oxidase by allylamine
    • RANDO RR, EIGNER A: The pseudoirreversible inhibition of monoamine oxidase by allylamine. Mol. Pharmacol. (1977) 13:1005-1013.
    • (1977) Mol. Pharmacol. , vol.13 , pp. 1005-1013
    • Rando, R.R.1    Eigner, A.2
  • 53
    • 0022345028 scopus 로고
    • Inactivation on monoamine oxidase by allylamine does not results in flavin attachment
    • SILVERAMN RB, HIEBERT CK, VASQUEZ ML: Inactivation on monoamine oxidase by allylamine does not results in flavin attachment. J. Biol. Chem. (1985) 260:14648-14652.
    • (1985) J. Biol. Chem. , vol.260 , pp. 14648-14652
    • Silveramn, R.B.1    Hiebert, C.K.2    Vasquez, M.L.3
  • 54
    • 0021330638 scopus 로고
    • (E)-2-(3,4-dimethoxyphenyl)-3-fluoroallylamine: A selective, enzyme activated inhibitor of type B monoamine oxidase
    • BEY P, FOZARD J, LACOSTE JM, McDONALD IA, ZREIKA M, PALFREYMAN MG: (E)-2-(3,4-dimethoxyphenyl)-3-fluoroallylamine: a selective, enzyme activated inhibitor of type B monoamine oxidase. J. Med. Chem. (1984) 27:9-10.
    • (1984) J. Med. Chem. , vol.27 , pp. 9-10
    • Bey, P.1    Fozard, J.2    Lacoste, J.M.3    Mcdonald, I.A.4    Zreika, M.5    Palfreyman, M.G.6
  • 56
    • 0012104203 scopus 로고
    • Screening of analgesics including aspirin type compound based upon the antagonism of chemically induced writhing in mice
    • SIEGMUND EA, CADMUS RA, LU G: Screening of analgesics including aspirin type compound based upon the antagonism of chemically induced writhing in mice. J. Pharmacol. Exp. Therap. (1957) 119:421-425.
    • (1957) J. Pharmacol. Exp. Therap. , vol.119 , pp. 421-425
    • Siegmund, E.A.1    Cadmus, R.A.2    Lu, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.