Curcumin reverses chemoresistance of human gastric cancer cells by downregulating the NF-κB transcription factor

Oncology Reports

Volumn 26, Issue 5, 2011, Pages 1197-1203

  Yu, Liang Liang ^a   Wu, Jia Guo ^a   Dai, Ning ^a   Yu, Hong Gang ^b   Si, Jian Min ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

Chemotherapy; Curcumin; Gastric cancer cell; NF B

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CURCUMIN; DOXORUBICIN; ETOPOSIDE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; PROTEIN BCL 2; PROTEIN BCL XL; TRANSCRIPTION FACTOR RELA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER RESISTANCE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG POTENTIATION; GEL MOBILITY SHIFT ASSAY; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; INTRACELLULAR SIGNALING; MONOTHERAPY; NICK END LABELING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; STOMACH CANCER; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BCL-X PROTEIN; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CURCUMIN; DNA, NEOPLASM; DOWN-REGULATION; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; ETOPOSIDE; HUMANS; I-KAPPA B PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; NF-KAPPA B; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; STOMACH NEOPLASMS; TRANSCRIPTION FACTOR RELA;

EID: 80053162298     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1410     Document Type: Article

References (32)

1. Edderkaoui M, Odinokova I, Ohno I, et al: Ellagic acid induces apoptosis through inhibition of nuclear factor kappa B in pancreatic cancer cells. World J Gastroenterol 14: 3672-3680, 2008.
2. Vega MI, Martínez-Paniagua M, Huerta-Yepez S, González- Bonilla C, Uematsu N and Bonavida B: Dysregulation of the cell survival/anti-apoptotic NF-kappaB pathway by the novel humanized BM-ca anti-CD20 mAb: implication in chemosensitization. Int J Oncol 35: 1289-1296, 2009.
3. Bhardwaj A, Sethi G, Vadhan-Raj S, et al: Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood 109: 2293-2302, 2007. (Pubitemid 46425866)
4. Gangadharan C, Thoh M and Manna SK: Inhibition of constitutive activity of nuclear transcription factor kappaB sensitizes doxorubicin-resistant cells to apoptosis. J Cell Biochem 107: 203-213, 2009.
5. Ammann JU, Haag C, Kasperczyk H, Debatin KM and Fulda S: Sensitization of neuroblastoma cells for TRAIL-induced apoptosis by NF-kappaB inhibition. Int J Cancer 124: 1301-1311, 2009.
6. Yu LL, Dai N, Yu HG, Sun LM and Si JM: Akt associates with nuclear factor kappaB and plays an important role in chemoresistance of gastric cancer cells. Oncol Rep 24: 113-119, 2010.
7. Tas SW, Vervoordeldonk MJ and Tak PP: Gene therapy targeting nuclear factor-kappaB: towards clinical application in inflammatory diseases and cancer. Curr Gene The 9: 160-170, 2009.
8. Delgado JS, Mustafi R, Yee J, et al: Sorafenib triggers anti-proliferative and pro-apoptotic signals in human esophageal adenocarcinoma cells. Dig Dis Sci 53: 3055-3064, 2008.
9. Arlt A, Gehrz A, Müerköster S, et al: Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene 22: 3243-3251, 2003. (Pubitemid 36712936)
10. Kamat AM, Tharakan ST, Sung B and Aggarwal BB: Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors. Cancer Res 69: 8958-8966, 2009.
11. Kunnumakkara AB, Anand P and Aggarwal BB: Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett 269: 199-225, 2008.
12. Hussain AR, Ahmed M, Al-Jomah NA, et al: Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines. Mol Cancer Ther 7: 3318-3329, 2008.
13. Campbell KJ, Witty JM, Rocha S and Perkins ND: Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappaB transactivation. Cancer Res 66: 929-935, 2006. (Pubitemid 43165960)
14. Wong BC, Jiang X, Fan XM, et al: Suppression of RelA/p65 nuclear translocation independent of IκBα degradation by cyclooxygenase-2 inhibitor in gastric cancer. Oncogene 22: 1189-1197, 2003. (Pubitemid 36363382)
15. Sosic D, Richardson JA, Yu K, Ornitz DM and Olson EN: Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Cell 112: 169-180, 2003. (Pubitemid 36144107)
16. Samanta AK, Huang HJ, Le XF, et al: MEKK3 expression correlates with nuclear factor kappa B activity and with expression of antiapoptotic genes in serous ovarian carcinoma. Cancer 115: 3897-3908, 2009.
17. Lee TL, Yeh J, Friedman J, et al: A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas. Int J Cancer 122: 1987-1998, 2008. (Pubitemid 351441187)
18. Sung B, Kunnumakkara AB, Sethi G, Anand P, Guha S and Aggarwal BB: Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model. Mol Cancer Ther 8: 959-970, 2009.
19. Aggarwal BB, Kumar A and Bharti AC: Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 23: 363-398, 2003. (Pubitemid 36361976)
20. Mustonen H, Puolakkainen P, Kemppainen E, Kiviluoto T and Kivilaakso E: Taurocholate potentiates ethanol-induced NF-kappaB activation and inhibits caspase-3 activity in cultured rat gastric mucosal cells. Dig Dis Sci 54: 928-936, 2009.
21. Nishida T, Yabe Y, Fu HY, et al: Geranylgeranylacetone induces cyclooxygenase-2 expression in cultured rat gastric epithelial cells through NF-kappaB. Dig Dis Sci 52: 1890-1896, 2007. (Pubitemid 47024672)
22. Karin M: Nuclear factor-kappaB in cancer development and progression. Nature 441: 431-436, 2006.
23. Beg AA and Baltimore D: An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 274: 782-784, 1996. (Pubitemid 26398258)
24. Wang CY, Mayo MW and Baldwin AS Jr: TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science 274: 784-787, 1996. (Pubitemid 26398259)
25. Van Antwerp DJ, Martin SJ, Kafri T, Green DR and Verma IM: Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science 274: 787-789, 1996.
26. Wang CY, Mayo MW, Korneluk RG, Goeddel DV and Baldwin AS Jr: NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281: 1680-1683, 1998.
27. Santos-Silva MC, Sampaio de Freitas M and Assreuy J: Killing of lymphoblastic leukemia cells by nitric oxide and taxol: involvement of NF-kappaB activity. Cancer Lett 173: 53-61, 2001. (Pubitemid 32907509)
28. Segev DL, Hoshiya Y, Stephen AE, et al: Mullerian inhibiting substance regulates NFkappaB signaling and growth of mammary epithelial cells in vivo. J Biol Chem 276: 26799-26806, 2001.
29. Segev DL, Ha TU, Tran TT, et al: Mullerian inhibiting substance inhibits breast cancer cell growth through an NFkappa B-mediated pathway. J Biol Chem 275: 28371-28379, 2000.
30. Boland MP, Foster SJ and O'Neill LA: Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells. J Biol Chem 272: 12952-12960, 1997. (Pubitemid 27216711)
31. Kalivendi SV, Kotamraju S, Zhao H, Joseph J and Kalyanaraman B: Doxorubicin-induced apoptosis is associated with increased transcription of endothelial nitric-oxide synthase. Effect of antiapoptotic antioxidants and calcium. J Biol Chem 276: 47266-47276, 2001.
32. Bengmark S, Mesa MD and Gil A: Plant-derived health: the effects of turmeric and curcuminoids. Nutr Hosp 24: 273-281, 2009.