Testosterone suppresses oxidative stress via androgen receptor-independent pathway in murine cardiomyocytes

Molecular Medicine Reports

Volumn 4, Issue 6, 2011, Pages 1183-1188

  Zhang, Li ^a   Wu, Saizhu ^a   Ruan, Yunjun ^b   Hong, Lei ^a   Xing, Xiaowen ^c   Lai, Wenyan ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

^c GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Androgen receptor; Cardiomyocyte; Castration; Oxidative stress; Testosterone

Indexed keywords

ANDROGEN RECEPTOR; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; SUPEROXIDE DISMUTASE; TESTOSTERONE; TESTOSTERONE PROPIONATE;

ANDROGEN DEFICIENCY; ANDROGEN THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CASTRATION; CONTROLLED STUDY; DRUG DOSE REGIMEN; ENZYME ACTIVITY; FEMALE; GENE DELETION; HEART LEFT VENTRICLE; HEART MUSCLE CELL; MALE; MITOCHONDRIAL DNA DEPLETION; MOUSE; NONHUMAN; OXIDATIVE STRESS; SINGLE DRUG DOSE; TESTICULAR FEMINIZATION; TESTOSTERONE BLOOD LEVEL;

ANDROGENS; ANIMALS; DNA, MITOCHONDRIAL; GLUTATHIONE PEROXIDASE; MALE; MALONDIALDEHYDE; MICE; MYOCYTES, CARDIAC; OXIDATIVE STRESS; RECEPTORS, ANDROGEN; SUPEROXIDE DISMUTASE; TESTOSTERONE;

MAMMALIA; MURINAE; MUS;

EID: 80053126234     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.539     Document Type: Article

References (35)

1. Marsh JD, Lehmann MH, Ritchie RH, Gwathmey JK, Green GE and Schiebinger RJ: Androgen receptor mediate hypertrophy in cardiac myocytes. Circulation 98: 256-261, 1998. (Pubitemid 28337617)
2. Golden KL, Marsh JD, Jiang Y and Moulden J: Gonadectomy alters myosin heavy chain composition in isolated cardiac myocytes. Endocrine 24: 137-140, 2004. (Pubitemid 41271165)
3. Marin DP, Bolin AP, Dos Santos Rde C, Curi R and Otton R: Testosterone suppresses oxidative stress in human neutrophils. Cell Biochem Funct 28: 394-402, 2010.
4. Malkin CJ, Pugh PJ, West JN, Van Beek EJ, Jones TH and Channer KS: Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial. Eur Heart J 27: 57-64, 2006. (Pubitemid 41785933)
5. Li ZB, Wang J, Wang JX, Chen XM and Jiang SS: Testosterone therapy improves cardiac function of male rats with right heart failure. Zhanghua Nan Ke Xue 15: 994-1000, 2009.
6. Singal PK, Khaper N, Palace V and Kumar D: The role of oxidative stress in the genesis of heart disease. Cardiovasc Res 40: 426-432, 1998. (Pubitemid 28557280)
7. Bernhard D and Laufer G: The aging cardiomyocyte: a mini-review. Gerontology 54: 24-31, 2008. (Pubitemid 351650654)
8. Ma YS, Wu SB, Lee WY, Cheng JS and Wei YH: Response to the increase of oxidative stress and mutation of mitochondrial DNA in aging. Biochim Biophys Acta 1790: 1021-1029, 2009.
9. Wei YH: Mitochondrial DNA alterations as ageing-associated molecular events. Mutat Res 275: 145-155, 1992.
10. Richter C: Oxidative damage to mitochondrial DNA and its relationship to ageing. Int J Biochem Cell Biol 27: 647-653, 1995.
11. Békési G, Kakucs R, Várbíró S, Rácz K, Sprintz D, Fehér J and Székács B: In vitro effects of different steroid hormones on superoxide anion production of human neutrophil granulocytes. Steroids 65: 889-894, 2000.
12. Alonso-Alvarez C, Bertrand S, Faivre B, Chastel O and Sorci G: Testosterone and oxidative stress: the oxidation handicap hypothesis. Proc Biol Sci 274: 819-825, 2007. (Pubitemid 47056761)
13. Ahlbom E, Prins GS and Ceccatelli S: Testosterone protects cerebellar granule cells from oxidative stress-induced cell death through a receptor mediated mechanism. Brain Res 892: 255-262, 2001. (Pubitemid 32141211)
14. He WW, Kumar MV and Tindall DJ: A frame-shift mutation in the androgen receptor gene causes complete androgen insensitivity in the testicularfeminized mouse. Nucleic Acids Res 19: 2373-2378, 1991. (Pubitemid 21902973)
15. Jones RD, Pugh PJ, Hall J, Channer KS and Jones TH: Altered circulating hormone levels, endothelial function and vascular reactivity in the testicular feminised mouse. Eur J Endocrinol 148: 111-120, 2003. (Pubitemid 36176011)
16. Leri A, Liu Y, Wang X, Kajstura J, Malhotra A, Meggs LG and Anversa P: Overexpression of insulin-like growth factor-1 attenuates the myocyte renin- angiotensin system in transgenic mice. Circ Res 84: 752-762, 1999. (Pubitemid 29181482)
17. Yagi K: Assay for blood plasma or serum. Methods Enzymol 105: 328-331, 1984.
18. Brossas JY, Barreau E, Courtois Y and Tréton J: Multiple deletions in mitochondrial DNA are present in senescent mouse brain. Biochem Biophys Res Commun 202: 654-659, 1994. (Pubitemid 24259264)
19. Wang E, Wong A and Cortopassi G: The rate of mitochondrial mutagenesis is faster in mice than humans. Mutat Res 377: 157-166, 1997. (Pubitemid 27290601)
20. Zeng Z, Zhang Z, Yu H, Corbley MJ, Tang Z and Tong T: Mitochondrial DNA deletions are associated with ischemia and aging in Balb/c mouse brain. J Cell Biochem 73: 545-553, 1999. (Pubitemid 29256943)
21. Nettleship JE, Jones TH, Channer KS and Jones RD: Physiological testosterone replacement therapy attenuates fatty streak and improves high-density lipoprotein cholesterol in the Tfm mouse: an effect that is independent of the classic androgen receptor. Circulation 116: 2427-2434, 2007. (Pubitemid 350145077)
22. Park CJ, Park SA, Yoon TG, Lee SJ, Yum KW and Kim HJ: Bupivacaine induces apoptosis via ROS in the Schwann cell line. J Dent Res 84: 852-857, 2005. (Pubitemid 43827820)
23. Meydan S, Kus I, Tas U, et al: Effects of testosterone on orchiectomy-induced oxidative damage in the rat hippocampus. J Chem Neuroanat 40: 281-285, 2010.
24. Barp J, Araújo ASR, Rigatto KV, Llesuy S, Belló-Klein A and Singal P: Myocardial antioxidant and oxidative stress changes due to sex hormones. Braz J Med Biol Res 35: 1075-1081, 2002. (Pubitemid 35476806)
25. Kłapciñska B, Jagsz S, Sadowska-Krepa E, Górski J, Kempa K and Langfort J: Effects of castration and testosterone replacement on the antioxidant defense system in rat left ventricle. J Physiol Sci 58: 173-177, 2008. (Pubitemid 351846446)
26. Ji LL, Dillon D and Wu E: Myocardial aging: antioxidant enzyme systems and related biochemical properties. Am J Physiol 261: R386-R392, 1991.
27. Judge S, Jang YM, Smith A, Hagen T and Leeuwenburgh C: Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging. FASEB J 19: 419-421, 2005. (Pubitemid 40316536)
28. Sreelatha Kumari KT, Menon VP and Leelamma S: Testosterone and lipid peroxide metabolism in orchidectomised rats. Indian J Exp Biol 31: 323-326, 1993.
29. Biliñska B, Wiszniewska B, Kosiniak-Kamysz K, et al: Hormonal status of male reproductive system: androgens and estrogens in the testis and epididymis. In vivo and in vitro approaches. Reprod Biol 6 (Suppl 1): S43-S58, 2006.
30. Huh K, Shin US, Choi JW and Lee SI: Effect of sex hormones on lipid peroxidation in rat liver. Arch Pharm Res 17: 109-114, 1994.
31. Guzman DC, Mejia GB, Vazquez IE, Garcia EH, Del Angel DS and Olguín HJ: Effect of testosterone and steroids homologues on indolamines and lipid peroxidation in rat brain. J Steroid Biochem Mol Biol 94: 369-373, 2005. (Pubitemid 40602477)
32. Shigenaga MK, Hagen TM and Ames BN: Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci USA 91: 10771-10778, 1994. (Pubitemid 24349567)
33. Izzotti A, Cartiglia C, Taningher M, De Flora S and Balansky R: Age-related increases of 8-hydroxy-2′-deoxyguanosine and DNA- protein crosslinks in mouse organs. Mutat Res 446: 215-223, 1999.
34. Tanhauser SM and Laipis PJ: Multiple deletions are detectable in mitochondrial DNA of aging mice. J Biol Chem 270: 24769-24775, 1995.
35. Lin H, Lu JP, Laflamme P, et al: Inter-related in vitro effects of androgens, fatty acids and oxidative stress in prostate cancer: a mechanistic model supporting prevention strategies. Int J Oncol 37: 761-766, 2010.