Effects of testosterone on orchiectomy-induced oxidative damage in the rat hippocampus

Journal of Chemical Neuroanatomy

Volumn 40, Issue 4, 2010, Pages 281-285

  Meydan, Sedat ^a   Kus, Ilter ^b   Tas, Ufuk ^c   Ogeturk, Murat ^d   Sancakdar, Enver ^d   Dabak, Durrin Ozlem ^d   Zararsiz, Ismail ^a   Sarsilmaz, Mustafa ^b  

^a MUSTAFA KEMAL UNIVERSITY   (Turkey)

^b BALIKESIR UNIVERSITY   (Turkey)

^c GAZIOSMANPASA UNIVERSITY   (Turkey)

^d FIRAT UNIVERSITY   (Turkey)

Author keywords

Hippocampus; Immunohistochemistry; Orchiectomy; Rat; Testosterone

Indexed keywords

GLUTATHIONE PEROXIDASE; MALONALDEHYDE; SUPEROXIDE DISMUTASE; TESTOSTERONE PROPIONATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; HIPPOCAMPUS; IMMUNOREACTIVITY; MALE; NEUROPROTECTION; NONHUMAN; ORCHIECTOMY; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; MALE; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; ORCHIECTOMY; OXIDATIVE STRESS; RATS; RATS, WISTAR; TESTOSTERONE;

EID: 78549254489     PISSN: 08910618     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchemneu.2010.07.006     Document Type: Article

References (41)

1. Andersen P., Morris R., Amaral D., Bliss T., O'keefe J. The hippocampus book. Hippocampus 2007, 17:1013-1016.
2. Barreto G., Veiga S., Azcoitia I., Garcia-Segura L.M., Garcia-Ovejero D. Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: role of its metabolites, oestradiol and dihydrotestosterone. Eur. J. Neurosci. 2007, 25:3039-3046.
3. Bancroft J. The endocrinology of sexual arousal. J. Endocrinol. 2005, 186:411-427.
4. Celec P., Jani P., Smrekova L., Mrlian A., Kudela M., Hodosy J., et al. Effects of anabolic steroids and antioxidant vitamins on ethanol-induced tissue injury. Life. Sci. 2003, 74:419-434.
5. Elsayed N.M., Bendich A. Dietary antioxidants: potential effects on oxidative products in cigarette smoke. Nutr. Res. 2001, 21:551-567.
6. Esterbauer H., Cheeseman K.H. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hidroxynonenal. Methods Enzymol. 1990, 186:407-421.
7. Estrada M., Varshney A., Ehrlich B.E. Elevated testosterone induces apoptosis in neuronal cells. J. Biol. Chem. 2006, 281:25492-25501.
8. Flück C.E., Miller W.L., Auchus R.J. The 17, 20-lyase activity of cytochrome p450c17 from human fetal testis favors the delta5 steroidogenic pathway. J. Clin. Endocrinol. Metab. 2003, 88:3762-3766.
9. Galea L.A.M., Spritzer M.D., Barker J.M., Pawluski J.L. Gonadal hormone modulation of hippocampal neurogenesis in the adult. Hippocampus 2006, 16:225-232.
10. Gouras G.K., Xu H., Gross R.S., Greenfield J.P., Hai B., Wang R., Greengard P. Testosterone reduces neuronal secretion of Alhzeimer's β-amyloid peptides. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:1202-1205.
11. Guzman D.C., Mejia G.B., Vazquez I.E., Garcia E.H., Del Angel D.S., Olgui{dotless}n H.J. Effect of testosterone and steroids homologues on indolamines and lipid peroxidation in rat brain. J. Steroid. Biochem. Mol. Biol. 2005, 94:369-373.
12. Hammond J., Le Q., Goodyer C., Gelfand M., Trifiro M., LeBlanc A. Testosterone mediated neuroprotection through the androgen receptor in human primary neurons. J. Neurochem. 2001, 77:1319-1326.
13. Huh K., Shin U.S., Choi J.W., Lee S.I. Effect of sex hormones on lipid peroxidation in rat liver. Arch. Pharm. Res. 1994, 17:109-114.
14. Janowsky J.S. Thinking with your gonads: testosterone and cognition. Trends Cogn. Sci. 2006, 10:77-82.
15. Kamal A.A., Gomaa A., El Khafif M., Hammad A.S. Plasma lipid peroxides among workers exposed to silica or asbestos dust. Environ. Res. 1989, 49:173-180.
16. Kandel E.R., Schwartz J.H., Jessel T.M. Principles of Neural Science 2000, Mc Graww-Hill Comp, New York, pp. 1233. 4th ed.
17. Kanter M., Coskun O., Korkmaz A., Oter S. Effects of Nigella sativa on oxidative stress and beta-cell damage in streptozotocin-induced diabetic rats. The Anat. Rec. A. Discov. Mol. Cell. Evol. Biol. 2004, 279:685-691.
18. Karla J., Chaudhary A.K., Prasad K. Increased production of oxygen free radicals in cigarette smokers. Int. J. Exp. Pathol. 1991, 72:1-7.
19. Klapcinska B., Jagsz S., Sadowska-Krepa E., Gorski J., Kempa K., Langfort J. Effects of castration and testosterone replacement on the antioxidant defense system in rat left ventricle. J. Physiol. Sci. 2008, 58:173-177.
20. Leranth C., Petnehazy O., MacLusky N.J. Gonadal hormones affect spine synaptic density in the CA1 hippocampal subfield of male rats. J. Neurosci. 2003, 23:1588-1592.
21. Matsumoto A., Arai Y., Urano A., Hyodo S. Androgen regulates gene expression of cytoskeletal proteins in adult rat motoneurons. Horm. Behav. 1994, 28:357-366.
22. McHugh S.B., Niewoehner B., Rawlins J.N., Bannerman D.M. Dorsal hippocampal N-methyl-d-aspartate receptors underlie spatial working memory performance during non-matching to place testing on the T-maze. Behav. Brain Res. 2008, 186:41-47.
23. Molsa P.K., Marttila R.J., Rinne U.K. Epidemiology of dementia in a Finnish population. Acta. Neurol. Scand. 1982, 65:541-552.
24. Moore K.L., Persaud T.V.N. The Developing Human 1998, WB Saunders Company, Philadelphia, pp. 477. 6th ed.
25. Morimoto S., Mendoza-Rodriguez C.A., Hiriat M., Larrieta M.E., Vital P., Cerbon M.A. Protective effect of testosterone on early apoptotic damage induced by streptozotocin in rat pancreas. J. Endocrinol. 2005, 187:217-224.
26. Ozyurt H., Pekmez H., Parlaktas B.S., Kus I., Ozyurt B., Sarsilmaz M. Oxidative stress in testicular tissues of rats exposed to cigarette smoke and protective effects of caffeic acid phenethyl ester. Asian J. Androl. 2006, 8(2):189-193.
27. Paglia D.E., Valentine W.N. Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 1967, 70:158-169.
28. Paxinos G., Watson C. The Rat Brain: in Stereotaxic Coordinates 2007, Elsevier, London.
29. Rhodes M.E., Frye C.A. Androgens in the hippocampus can alter and be altered by ictal activity. Pharmacol. Biochem. Behav. 2004, 78:483-493.
30. Romeo R.D., Staub D., Jasnow A.M., Karatsoreos I.N., Thornton J.E., McEwen B.S. Dihydrotestosterone increases hippocampal N-methyl-d-aspartate binding but does not affect choline acetyltransferase cell number in the forebrain or choline transporter levels in the CA1 region of adult male rats. Endocrinology 2005, 146:2091-2097.
31. Rubinow D.R., Schmidt P.J. Androgens, brain, and behavior. Am. J. Psychiatry 1996, 153:974-984.
32. Sandstrom N.J., Kim J.H., Wasserman M.A. Testosterone modulates performance on a spatial working memory task in male rats. Horm. Behav. 2006, 50:18-26.
33. Schmidt A.J., Krieg J.C., Vedder H. Differential effects of glucocorticoids and gonadal steroids on glutathione levels in neuronal and glial cell systems. J. Neurosci. Res. 2002, 67:544-550.
34. Schmidt A.J., Krieg J.C., Vedder H. Effects of steroid hormones on catalase activity in neuronal and glial cell systems. Eur. Neuropsychopharmacol. 2005, 15:177-183.
35. Shao C., Roberts K.N., Markesbery W.R., Scheff S.W., Lovell M.A. Oxidative stress in head trauma in aging. Free Radic. Biol. Med. 2006, 41:77-85.
36. Songur A., Ozen O.A., Sarsi{dotless}lmaz M. Hippocampus 2001, T. Klin. J. Med. Sci. 21, 427-431.
37. Stoltzner S.E., Berchtold N.C., Cotman C.W., Pi{dotless}ke C.J. Estrogen regulates bcl-x expression in rat hippocampus. Neuroreport 2001, 12:2797-2800.
38. Sun Y., Oberley L.W., Li Y. A simple method for clinical assay of superoxide dismutase. Clin. Chem. 1988, 34:497-500.
39. Ward G.R., Abdel-Rahman A.A. Orchiectomy or androgen receptor blockade attenuates baroreflex-mediated bradycardia in conscious rats. BMC Pharmacol. 2006, 23(6):1-8.
40. Wilson J.D. Androgens, androgen receptors, and male gender role behavior. Horm. Behav. 2001, 40:358-366.
41. Zararsiz I., Kus I., Ogeturk M., Akpolat N., Kose E., Meydan S., Sarsilmaz M. Melatonin prevents formaldehyde-induced neurotoxicity in prefrontal cortex of rats: an immunohistochemical and biochemical study. Cell Biochem. Funct. 2007, 25:413-418.