Engineering and optimization of an allosteric biosensor protein for peroxisome proliferator-activated receptor γ ligands

Biosensors and Bioelectronics

Volumn 29, Issue 1, 2011, Pages 132-139

  Li, Jingjing ^a   Gierach, Izabela ^b   Gillies, Alison R ^c   Warden, Charles D ^d   Wood, David W ^a  

^a The Ohio State University   (United States)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^c Princeton University   (United States)

^d RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Biosensor; Engineered allostery; Fusion protein; Hormone assay; Nuclear hormone receptor; PPAR

Indexed keywords

ALLOSTERIC SIGNAL; ALLOSTERY; BACTERIAL BIOSENSOR; BASAL GROWTH; BIOSENSOR PROTEINS; E. COLI; ESCHERICHIA COLI CELLS; FUSION PROTEIN; FUSION PROTEINS; LIGAND BINDING; LIGAND BINDING DOMAIN; LINKER PEPTIDE; MALTOSE BINDING PROTEINS; MULTI DOMAINS; NUCLEAR HORMONE RECEPTOR; NUCLEAR RECEPTORS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; POTENTIAL DRUG; REPORTER ENZYMES; THYMIDYLATE SYNTHASE;

CYTOLOGY; ESCHERICHIA COLI; LIGANDS; OPTIMIZATION; PROTEINS; SENSORS;

BIOSENSORS;

AMINO ACID; DNA; GLYCINE; HORMONE; HYBRID PROTEIN; INTEIN; MALTOSE BINDING PROTEIN; PEPTIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SERINE; THYMIDYLATE SYNTHASE;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL CELL; BACTERIAL GROWTH; BIOENGINEERING; BIOSENSOR; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA FLANKING REGION; ESCHERICHIA COLI; LIGAND BINDING; NONHUMAN; PHENOTYPE; PROCESS OPTIMIZATION; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MODIFICATION;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; BIOSENSING TECHNIQUES; HUMANS; INTEINS; LIGANDS; MYCOBACTERIUM TUBERCULOSIS; PPAR GAMMA; PROTEIN ENGINEERING; REC A RECOMBINASES; RECOMBINANT FUSION PROTEINS; REPETITIVE SEQUENCES, AMINO ACID;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 80053121542     PISSN: 09565663     EISSN: 18734235     Source Type: Journal    
DOI: 10.1016/j.bios.2011.08.006     Document Type: Article

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