Silencing of Rac1 modifies lung cancer cell migration, invasion and actin cytoskeleton rearrangements and enhances chemosensitivity to antitumor drugs

International Journal of Molecular Medicine

Volumn 28, Issue 5, 2011, Pages 769-776

  Chen, Qing Yong ^a   Xu, Li Qun ^a   Jiao, De Min ^a   Yao, Qing Hua ^b   Wang, Yan Yi ^c   Hu, Hui Zhen ^a   Wu, Yu Quan ^a   Song, Jia ^d   Yan, Jie ^a   Wu, Li Jun ^a  

^a The 117th Hospital of Chinese PLA   (China)

^b ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

^c GUIZHOU UNIVERSITY   (China)

^d NONE

Author keywords

Actin cytoskeleton; Chemosensitivity; Lung cancer cells; Migration and invasion; Rac1; RNA interference

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; ACTIN; ANTINEOPLASTIC AGENT; P21 ACTIVATED KINASE 1; RAC1 PROTEIN;

ADULT; AGED; ARTICLE; CANCER CELL; CANCER INCIDENCE; CANCER INHIBITION; CANCER INVASION; CANCER STAGING; CARCINOMA CELL; CELL DIFFERENTIATION; CELL FUNCTION; CELL MIGRATION; CHEMOSENSITIVITY; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; CYTOSKELETON; DISEASE SEVERITY; DOWN REGULATION; FEMALE; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; GENE THERAPY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LAMELLIPODIUM; LUNG PARENCHYMA; LUNG SMALL CELL CANCER; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MOLECULARLY TARGETED THERAPY; PHENOTYPE; PRIORITY JOURNAL; RNA INTERFERENCE;

ACTIN CYTOSKELETON; ADULT; AGED; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; ORGANOPLATINUM COMPOUNDS; RAC1 GTP-BINDING PROTEIN; YOUNG ADULT;

EID: 80053096031     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.775     Document Type: Article

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