Osteocalcin: A novel vascular metabolic and osteoinductive factor?

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 31, Issue 10, 2011, Pages 2169-2171

  Kapustin, Alexander N ^a   Shanahan, Catherine M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

calcification; metabolism; signal transduction; vascular biology

Indexed keywords

GLYCEROL 2 PHOSPHATE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; OSTEOCALCIN; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SOX9;

BLOOD VESSEL CALCIFICATION; CELL METABOLISM; CELL PROLIFERATION; ENERGY METABOLISM; GENE OVEREXPRESSION; GENE SILENCING; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; IN VITRO STUDY; IN VIVO STUDY; MINERALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR SMOOTH MUSCLE; VASCULAR SMOOTH MUSCLE CELL; VASCULARIZATION;

ANIMALS; CALCINOSIS; CARTILAGE; GLUCOSE; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; OSTEOCALCIN; VASCULAR DISEASES;

EID: 80053046842     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.111.233601     Document Type: Review

References (16)

1. Idelevich A, Rais Y, Ornan EM. Bone Gla protein increases HIF-1α-dependent glucose metabolism and induces cartilage and vascular calcification. Arterioscler Thromb Vasc Biol. 2011;31:e55-e71.
2. Sage AP, Tintut Y, Demer LL. Regulatory mechanisms in vascular calcification. Nat Rev Cardiol. 2010;7:528-536.
3. Shanahan CM, Proudfoot D, Tyson KL, Cary NR, Edmonds M, Weissberg PL. Expression of mineralisation-regulating proteins in association with human vascular calcification. Z Kardiol. 2000;89(suppl 2):63-68.
4. Shanahan CM, Cary NR, Salisbury JR, Proudfoot D, Weissberg PL, Edmonds ME. Medial localization of mineralization-regulating proteins in association with Monckeberg's sclerosis: evidence for smooth muscle cell-mediated vascular calcification. Circulation. 1999;100:2168-2176.
5. Proudfoot D, Davies JD, Skepper JN, Weissberg PL, Shanahan CM. Acetylated low-density lipoprotein stimulates human vascular smooth muscle cell calcification by promoting osteoblastic differentiation and inhibiting phagocytosis. Circulation. 2002;106:3044-3050. (Pubitemid 35440286)
6. Tyson KL, Reynolds JL, McNair R, Zhang Q, Weissberg PL, Shanahan CM. Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification. Arterioscler Thromb Vasc Biol. 2003;23:489-494. (Pubitemid 36337227)
7. Price PA. Gla-containing proteins of bone. Connect Tissue Res. 1989;21: 51-57; discussion 57-60.
8. Ducy P, Desbois C, Boyce B, Pinero G, Story B, Dunstan C, Smith E, Bonadio J, Goldstein S, Gundberg C, Bradley A, Karsenty G. Increased bone formation in osteocalcin-deficient mice. Nature. 1996;382: 448-452. (Pubitemid 26264860)
9. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007;130:456-469. (Pubitemid 47208519)
10. Ferron M, Wei J, Yoshizawa T, Del Fattore A, DePinho RA, Teti A, Ducy P, Karsenty G. Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell. 2010;142:296-308.
11. Wan C, Shao J, Gilbert SR, Riddle RC, Long F, Johnson RS, Schipani E, Clemens TL. Role of HIF-1α in skeletal development. Ann N YAcad Sci. 2010;1192:322-326.
12. Schipani E, Ryan HE, Didrickson S, Kobayashi T, Knight M, Johnson RS. Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival. Genes Dev. 2001;15:2865-2876. (Pubitemid 33042056)
13. Wang Y, Wan C, Deng L, Liu X, Cao X, Gilbert SR, Bouxsein ML, Faugere MC, Guldberg RE, Gerstenfeld LC, Haase VH, Johnson RS, Schipani E, Clemens TL. The hypoxia-inducible factor a pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest. 2007;117:1616-1626. (Pubitemid 46871346)
14. Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Kurioka S, Yano S, Sugimoto T. Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus. J Clin Endocrinol Metab. 2009;94:45-49.
15. Parker BD, Bauer DC, Ensrud KE, Ix JH. Association of osteocalcin and abdominal aortic calcification in older women: the study of osteoporotic fractures. Calcif Tissue Int. 2010;86:185-191.
16. Seagroves TN, Ryan HE, Lu H, Wouters BG, Knapp M, Thibault P, Laderoute K, Johnson RS. Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells. Mol Cell Biol. 2001;21:3436-3444. (Pubitemid 32381779)