Unrepairable DNA double-strand breaks initiate cytotoxicity with HSV-TK/ganciclovir

Cancer Gene Therapy

Volumn 18, Issue 10, 2011, Pages 751-759

  Ladd, B ^a   O'Konek, J J ^a   Ostruszka, L J ^b   Shewach, D S ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b Accuri Cytometers   (United States)

Author keywords

g H2AX; ganciclovir; gene therapy; HSV TK

Indexed keywords

1 BETA ARABINOFURANOSYL THYMINE; ATM PROTEIN; ATR PROTEIN; CHECKPOINT KINASE 1; GANCICLOVIR; HISTONE H2AX; HISTONE H2AX GAMMA; RAD51 PROTEIN; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVATION; HERPES SIMPLEX VIRUS; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL SURVIVAL; DNA BREAKS, DOUBLE-STRANDED; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GANCICLOVIR; HISTONES; HUMANS; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; RAD51 RECOMBINASE; SIMPLEXVIRUS; THYMIDINE KINASE; TUMOR SUPPRESSOR PROTEINS;

SIMPLEXVIRUS;

EID: 80052969956     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2011.51     Document Type: Article

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