Gene expression and cell differentiation in matrix-associated chondrocyte transplantation grafts: A comparative study

Osteoarthritis and Cartilage

Volumn 19, Issue 10, 2011, Pages 1219-1227

  Albrecht, C ^a,b   Tichy, B ^a,b   Nurnberger S ^a,b   Hosiner, S ^a   Zak, L ^a,b   Aldrian, S ^a,b   Marlovits, S ^a,b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Austrian Cluster for Tissue Regeneration ^*  (Austria)

Author keywords

Cartilage; Chondrocyte; Differentiation; Scaffold; Transplantation

Indexed keywords

AGGRECAN; CELL MARKER; COLLAGEN TYPE 1; COLLAGEN TYPE 2; INTERLEUKIN 1BETA; MELANOMA INHIBITORY ACTIVITY PROTEIN; MOLECULAR SCAFFOLD; UNCLASSIFIED DRUG; VERSICAN;

ADULT; ARTICLE; CARTILAGE CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CELL STRUCTURE; CELL TRANSPLANTATION; CHONDROCYTE IMPLANTATION; COMPARATIVE STUDY; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; GENE EXPRESSION; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MATRIX ASSOCIATED CHONDROCYTE TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

BIOLOGICAL MARKERS; CARTILAGE; CELL DIFFERENTIATION; CHONDROCYTES; GENE EXPRESSION; HUMANS; MICROSCOPY, ELECTRON; PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 80052965510     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2011.07.004     Document Type: Article

References (50)

1. Curl W.W., Krome J., Gordon E.S., Rushing J., Smith B.P., Poehling G.G. Cartilage injuries: a review of 31,516 knee arthroscopies. Arthroscopy 1997, 13:456-460.
2. Gelber A.C., Hochberg M.C., Mead L.A., Wang N.Y., Wigley F.M., Klag M.J. Joint injury in young adults and risk for subsequent knee and hip osteoarthritis. Ann Intern Med 2000, 133:321-328.
3. Saris D.B., Vanlauwe J., Victor J., Almqvist K.F., Verdonk R., Bellemans J., et al. Treatment of symptomatic cartilage defects of the knee: characterized chondrocyte implantation results in better clinical outcome at 36 months in a randomized trial compared to microfracture. Am J Sports Med 2009, 37(Suppl 1):10S-19S.
4. Knutsen G., Engebretsen L., Ludvigsen T.C., Drogset J.O., Grontvedt T., Solheim E., et al. Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial. J Bone Joint Surg Am 2004, 86-A:455-464.
5. Hunziker E.B. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage 2002, 10:432-463.
6. Marlovits S., Hombauer M., Tamandl D., Vecsei V., Schlegel W. Quantitative analysis of gene expression in human articular chondrocytes in monolayer culture. Int J Mol Med 2004, 13:281-287.
7. Schlegel W., Albrecht C., Eckl P., Freudenthaler H., Berger A., Vecsei V., et al. Dedifferentiation of human articular chondrocytes is associated with alterations in expression patterns of GDF-5 and its receptors. J Cell Mol Med 2009, 13:3398-3404.
8. Schnabel M., Marlovits S., Eckhoff G., Fichtel I., Gotzen L., Vecsei V., et al. Dedifferentiation-associated changes in morphology and gene expression in primary human articular chondrocytes in cell culture. Osteoarthritis Cartilage 2002, 10:62-70.
9. Albrecht C., Schlegel W., Bartko P., Eckl P., Jagersberger T., Vecsei V., et al. Changes in the endogenous BMP expression during redifferentiation of chondrocytes in 3D cultures. Int J Mol Med 2010, 26:317-323.
10. Schlegel W., Nurnberger S., Hombauer M., Albrecht C., Vecsei V., Marlovits S. Scaffold-dependent differentiation of human articular chondrocytes. Int J Mol Med 2008, 22:691-699.
11. Kurz B., Domm C., Jin M., Sellckau R., Schunke M. Tissue engineering of articular cartilage under the influence of collagen I/III membranes and low oxygen tension. Tissue Eng 2004, 10:1277-1286.
12. Malda J., van Blitterswijk C.A., van Geffen M., Martens D.E., Tramper J., Riesle J. Low oxygen tension stimulates the redifferentiation of dedifferentiated adult human nasal chondrocytes. Osteoarthritis Cartilage 2004, 12:306-313.
13. Kawanishi M., Oura A., Furukawa K., Fukubayashi T., Nakamura K., Tateishi T., et al. Redifferentiation of dedifferentiated bovine articular chondrocytes enhanced by cyclic hydrostatic pressure under a gas-controlled system. Tissue Eng 2007, 13:957-964.
14. Schulz R.M., Bader A. Cartilage tissue engineering and bioreactor systems for the cultivation and stimulation of chondrocytes. Eur Biophys J 2007, 36:539-568.
15. Chubinskaya S., Segalite D., Pikovsky D., Hakimiyan A.A., Rueger D.C. Effects induced by BMPS in cultures of human articular chondrocytes: comparative studies. Growth Factors 2008, 26:275-283.
16. van Osch G.J., van der Veen S.W., Verwoerd-Verhoef H.L. In vitro redifferentiation of culture-expanded rabbit and human auricular chondrocytes for cartilage reconstruction. Plast Reconstr Surg 2001, 107:433-440.
17. Marlovits S., Zeller P., Singer P., Resinger C., Vecsei V. Cartilage repair: generations of autologous chondrocyte transplantation. Eur J Radiol 2006, 57:24-31.
18. Cherubino P., Grassi F.A., Bulgheroni P., Ronga M. Autologous chondrocyte implantation using a bilayer collagen membrane: a preliminary report. J Orthop Surg (Hong Kong) 2003, 11:10-15.
19. Hendrickson D.A., Nixon A.J., Grande D.A., Todhunter R.J., Minor R.M., Erb H., et al. Chondrocyte-fibrin matrix transplants for resurfacing extensive articular cartilage defects. J Orthop Res 1994, 12:485-497.
20. Hoemann C.D., Sun J., McKee M.D., Chevrier A., Rossomacha E., Rivard G.E., et al. Chitosan-glycerol phosphate/blood implants elicit hyaline cartilage repair integrated with porous subchondral bone in microdrilled rabbit defects. Osteoarthritis Cartilage 2007, 15:78-89.
21. Pavesio A., Abatangelo G., Borrione A., Brocchetta D., Hollander A.P., Kon E., et al. Hyaluronan-based scaffolds (Hyalograft C) in the treatment of knee cartilage defects: preliminary clinical findings. Novartis Found Symp 2003, 249:203-217. discussion 29-33, 34-8, 39-41.
22. Selmi T.A., Verdonk P., Chambat P., Dubrana F., Potel J.F., Barnouin L., et al. Autologous chondrocyte implantation in a novel alginate-agarose hydrogel: outcome at two years. J Bone Joint Surg Br 2008, 90:597-604.
23. Vinatier C., Magne D., Moreau A., Gauthier O., Malard O., Vignes-Colombeix C., et al. Engineering cartilage with human nasal chondrocytes and a silanized hydroxypropyl methylcellulose hydrogel. J Biomed Mater Res A 2007, 80:66-74.
24. Munirah S., Kim S.H., Ruszymah B.H., Khang G. The use of fibrin and poly(lactic-co-glycolic acid) hybrid scaffold for articular cartilage tissue engineering: an in vivo analysis. Eur Cell Mater 2008, 15:41-52.
25. Nicodemus G.D., Villanueva I., Bryant S.J. Mechanical stimulation of TMJ condylar chondrocytes encapsulated in PEG hydrogels. J Biomed Mater Res A 2007, 83:323-331.
26. Vinatier C., Mrugala D., Jorgensen C., Guicheux J., Noel D. Cartilage engineering: a crucial combination of cells, biomaterials and biofactors. Trends Biotechnol 2009, 27:307-314.
27. Ma Z., Mao Z., Gao C. Surface modification and property analysis of biomedical polymers used for tissue engineering. Colloids Surf B Biointerfaces 2007, 60:137-157.
28. Vasita R., Shanmugam I.K., Katt D.S. Improved biomaterials for tissue engineering applications: surface modification of polymers. Curr Top Med Chem 2008, 8:341-353.
29. Lao L., Tan H., Wang Y., Gao C. Chitosan modified poly(L-lactide) microspheres as cell microcarriers for cartilage tissue engineering. Colloids Surf B Biointerfaces 2008, 66:218-225.
30. Bryant S.J., Cuy J.L., Hauch K.D., Ratner B.D. Photo-patterning of porous hydrogels for tissue engineering. Biomaterials 2007, 28:2978-2986.
31. Woodfield T.B., Malda J., de Wijn J., Peters F., Riesle J., van Blitterswijk C.A. Design of porous scaffolds for cartilage tissue engineering using a three-dimensional fiber-deposition technique. Biomaterials 2004, 25:4149-4161.
32. Nuernberger S., Cyran N., Albrecht C., Redl H., Vecsei V., Marlovits S. The influence of scaffold architecture on chondrocyte distribution and behavior in matrix-associated chondrocyte transplantation grafts. Biomaterials 2011, 32:1032-1040.
33. Basad E., Ishaque B., Bachmann G., Sturz H., Steinmeyer J. Matrix-induced autologous chondrocyte implantation versus microfracture in the treatment of cartilage defects of the knee: a 2-year randomised study. Knee Surg Sports Traumatol Arthrosc 2010, 18:519-527.
34. Ochs B.G., Muller-Horvat C., Rolauffs B., Fritz J., Weise K., Schewe B. [Treatment of osteochondritis dissecans of the knee: one-step procedure with bone grafting and matrix-supported autologous chondrocyte transplantation]. Z Orthop Unfall 2007, 145:146-151.
35. Schneider U., Andereya S. [First results of a prospective randomized clinical trial on traditional chondrocyte transplantation vs CaReS-technology]. Z Orthop Ihre Grenzgeb 2003, 141:496-497.
36. Foldager C.B., Munir S., Ulrik-Vinther M., Soballe K., Bunger C., Lind M. Validation of suitable house keeping genes for hypoxia-cultured human chondrocytes. BMC Mol Biol 2009, 10:94.
37. Bosserhoff A.K., Buettner R. Establishing the protein MIA (melanoma inhibitory activity) as a marker for chondrocyte differentiation. Biomaterials 2003, 24:3229-3234.
38. Schmid R., Schiffner S., Opolka A., Grassel S., Schubert T., Moser M., et al. Enhanced cartilage regeneration in MIA/CD-RAP deficient mice. Cell Death Dis 2010, 1:e97.
39. Barlic A., Drobnic M., Malicev E., Kregar-Velikonja N. Quantitative analysis of gene expression in human articular chondrocytes assigned for autologous implantation. J Orthop Res 2008, 26:847-853.
40. Darling E.M., Athanasiou K.A. Rapid phenotypic changes in passaged articular chondrocyte subpopulations. J Orthop Res 2005, 23:425-432.
41. Teshima R., Ono M., Yamashita Y., Hirakawa H., Nawata K., Morio Y. Immunohistochemical collagen analysis of the most superficial layer in adult articular cartilage. J Orthop Sci 2004, 9:270-273.
42. Nuernberger S., Cyran N., Albrecht C., Redl H., Vecsei V., Marlovits S. The influence of scaffold architecture on chondrocyte distribution and behavior in matrix-associated chondrocyte transplantation grafts. Biomaterials 2010.
43. Allemann F., Mizuno S., Eid K., Yates K.E., Zaleske D., Glowacki J. Effects of hyaluronan on engineered articular cartilage extracellular matrix gene expression in 3-dimensional collagen scaffolds. J Biomed Mater Res 2001, 55:13-19.
44. Goodstone N.J., Cartwright A., Ashton B. Effects of high molecular weight hyaluronan on chondrocytes cultured within a resorbable gelatin sponge. Tissue Eng 2004, 10:621-631.
45. Albrecht C., Schlegel W., Eckl P., Jagersberger T., Sadeghi K., Berger A., et al. Alterations in CD44 isoforms and HAS expression in human articular chondrocytes during the de- and re-differentiation processes. Int J Mol Med 2009, 23:253-259.
46. Schulze-Tanzil G., de Souza P., Villegas Castrejon H., John T., Merker H.J., Scheid A., et al. Redifferentiation of dedifferentiated human chondrocytes in high-density cultures. Cell Tissue Res 2002, 308:371-379.
47. Watt F.M. Effect of seeding density on stability of the differentiated phenotype of pig articular chondrocytes in culture. J Cell Sci 1988, 89(Pt 3):373-378.
48. Lin Z., Fitzgerald J.B., Xu J., Willers C., Wood D., Grodzinsky A.J., et al. Gene expression profiles of human chondrocytes during passaged monolayer cultivation. J Orthop Res 2008, 26:1230-1237.
49. Campo G.M., Avenoso A., Campo S., D'Ascola A., Nastasi G., Calatroni A. Small hyaluronan oligosaccharides induce inflammation by engaging both toll-like-4 and CD44 receptors in human chondrocytes. Biochem Pharmacol 2010, 80:480-490.
50. Campo G.M., Avenoso A., Campo S., D'Ascola A., Traina P., Calatroni A. Differential effect of molecular size HA in mouse chondrocytes stimulated with PMA. Biochim Biophys Acta 2009, 1790:1353-1367.