6-Substituted imidazo[1,2-a]pyridines: Synthesis and biological activity against colon cancer cell lines HT-29 and Caco-2

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4573-4583

  Dahan Farkas, Nurit ^a   Langley, Candice ^b   Rousseau, Amanda L ^b   Yadav, Dharmendra B ^b   Davids, Hajierah ^a,c   De Koning, Charles B ^b  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^c NELSON MANDELA METROPOLITAN UNIVERSITY   (South Africa)

Author keywords

6 substituted imidazo 1,2 a pyridines; Apoptosis; Caspases; Colon cancer; HT 29 and Caco 2; Multicomponent coupling reactions

Indexed keywords

2 (2,4 BIS(BENZYLOXY)PHENYL) 3 (CYCLOHEXYLAMINO)IMIDAZO[1,2 A]PYRIDINE 6 CARBOXAMIDE; 2 (2,4 DIMETHOXYPHENYL) N (2,6 DIMETHLYPHENYL) 6 NITROIMIDAZO[1,2 A]PYRIDINE 3 AMINE; 6 BROMO 2 (2,4 DIMETHOXYPHENYL) N (2,6 DIMETHYLPHENYL)IMIDAZO[1,2 A]PYRIDINE 3 AMIN; [2 (3,4 DIMETHOXY PHENYL) 6 METHYL IMIDAZO[1,2 A]PYRIDIN 3 YL](2.6 DIMETHYLPHENYL)AMINE; [2 (3,4 DIMETHOXY PHENYL) 6 PHENYL IMIDAZO[1,2 A]PYRIDIN 3 YL](2,6 DIMETHYL PHENYL)AMINE; [6 BROMO 2 (3,4 DIMETHOXY PHENYL) IMIDAZO[1,2 A]PYRIDIN 3 YL](2,6 DIMETHYLPHENYL)AMINE; BENZYL [6 BROMO 2 (2,5 DIMETHOXY PHENYL) IMIDAZO[1,2 A]PYRIDIN 3 YL]AMINE; CAMPTOTHECIN; CASPASE 3; CASPASE 8; CYTOCHROME C; IMIDAZO[1,2 A]PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN CACO 2; CELL VIABILITY; COLON CANCER; CONTROLLED STUDY; CROSS COUPLING REACTION; CYTOSOL; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKOCYTE; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

CACO-2 CELLS; CELL PROLIFERATION; HT29 CELLS; HUMANS; HYDROLYSIS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PYRIDINES;

EID: 80052951745     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.07.036     Document Type: Article

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