Discovery of imidazo[1,2-a]pyridines as potent MCH1R antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 16, 2009, Pages 4589-4593

  Kishino, Hiroyuki ^a   Moriya, Minoru ^a   Sakuraba, Shunji ^a   Sakamoto, Toshihiro ^a   Takahashi, Hidekazu ^a   Suzuki, Takao ^a   Moriya, Ryuichi ^a   Ito, Masahiko ^a   Iwaasa, Hisashi ^a   Takenaga, Norihiro ^a   Ishihara, Akane ^a   Kanatani, Akio ^a   Sato, Nagaaki ^a   Fukami, Takehiro ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Imidazo 1,2 a pyridine; MCH1R antagonists; Melanin concentrating hormone; Obesity

Indexed keywords

IMIDAZO[1,2 A]PYRIDINE DERIVATIVE; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; DRUG PENETRATION; DRUG POTENCY; DRUG RECEPTOR BINDING; NONHUMAN; RAT; RECEPTOR AFFINITY;

ANIMALS; ANTI-OBESITY AGENTS; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DISCOVERY; HUMANS; PYRIDINES; RATS; RECEPTORS, SOMATOSTATIN; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 67651115760     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.101     Document Type: Article

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