Quinonoid and phenazine compounds: Synthesis and evaluation against H 37Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4521-4529

  Carneiro, Paula F ^a   Pinto, Maria Do Carmo F R ^a   Coelho, Tatiane S ^b   Cavalcanti, Bruno C ^c   Pessoa, Cláudia ^c   De Simone, Carlos A ^d,e   Nunes, Isabelle K C ^d,e   De Oliveira, Nathalia M ^f   De Almeida, Renata G ^f   Pinto, Antonio V ^a   De Moura, Kelly C G ^a   Da Silva, Pedro A ^b   Da Silva Júnior, Eufrânio N ^f  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE   (Brazil)

^c FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^d FEDERAL UNIVERSITY OF ALAGOAS   (Brazil)

^e UNIVERSITY OF SÃO PAULO   (Brazil)

^f FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Antitubercular; Lapachol; Mycobacterium tuberculosis; Phenazines

Indexed keywords

2 (5 OXO 6 PROPYL 1,2,3,4,5,6 HEXAHYDROBENZO[A]PHENAZIN 6 YLOXY) 3 PROPYL 5,6,7,8 TETRAHYDRONAPHTHALENE 1,4 DIONE; 2 (5 OXO 6 PROPYL 5,6 DIHYDROBENZO[A]PHENAZIN 6 YLOXY) 3 PROPYLNAPHTHALENE 1,4 DIONE; 2 ALLYL 3 (6 ALLYL 5 OXO 5,6 DIHYDROBENZO[A]PHENAZIN 6 YLOXY)NAPHTHALENE 1,4 DIONE; 2 ALLYL 3 HYDROXYNAPHTHALENE 1,4 DIONE; 2 HYDROXY 3 ISOBUTYLNAPHTHALENE 1,4 DIONE; 2 HYDROXY 3 ISOPENTYL 5,6,7,8 TETRAHYDRONAPHTHALENE 1,4 DIONE; 2 HYDROXY 3 ISOPENTYLNAPHTHALENE 1,4 DIONE; 2 HYDROXY 3 PROPYL 5,6,7,8 TETRAHYDRONAPHTHALENE 1,4 DIONE; 2 ISOBUTYL 3 (6 ISOBUTYL 5 OXO 1,2,3,4,5,6 HEXAHYDROBENZO[A]PHENAZIN 6 YLOXY) 5,6,7,8 TETRAHYDRONAPHTHALENE 1,4 DIONE; 2 ISOBUTYL 3 (6 ISOBUTYL 5 OXO 5,6 DIHYDROBENZO[A]PHENAZIN 6 YLOXY)NAPHTHALENE 1,4 DIONE; 2 ISOPENTYL 3 (6 ISOPENTYL 5 OXO 1,2,3,4,5,6 HEXAHYDROBENZO[A]PHENAZIN 6 YLOXY) 5,6,7,8 TETRAHYDRONAPHTHALENE 1,4 DIONE; 2 ISOPENTYL 3 (6 ISOPENTYL 5 OXO 5,6 DIHYDROBENZO[A]PHENAZIN 6 YLOXY)NAPHTHALENE 1,4 DIONE; 6 (2 METHYLPROP 1 ENYL)BENZO[A]PHENAZIN 5(7H)ONE; 6 ALLYLBENZO[A]PHENAZIN 5(7H)ONE; 6 ISOBUTYL 1,2,3,4 TETRAHYDROBENZO[A]PHENAZIN 5(7H)ONE; 6 ISOBUTYLBENZO[A]PHENAZIN 5(7H)ONE; 6 ISOPENTYL 1,2,3,4 TETRAHYDROBENZO[A]PHENAZIN 5(7H)ONE; 6 PROPYL 1,2,3,4 TETRAHYDROBENZO[A]PHENAZIN 5(7H)ONE; DOXORUBICIN; ISONIAZID; LAPACHOL; NOR LAPACHOL; PHENAZINE DERIVATIVE; QUINONE DERIVATIVE; RIFAMPICIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL;

ANTITUBERCULAR AGENTS; CELLS, CULTURED; DRUG RESISTANCE, MICROBIAL; ISONIAZID; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; PHENAZINES; QUINONES; RIFAMPIN; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED; X-RAY DIFFRACTION;

EID: 80052948173     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.07.026     Document Type: Article

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