Design, synthesis and determination of antifungal activity of 5(6)-substituted benzotriazoles

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2214-2222

  Patel, Pallav D ^a   Patel, Maulik R ^a   Kocsis, Bela ^b   Kocsis, Erika ^b   Graham, Steven M ^a   Warren, Andrew R ^a   Nicholson, Stacia M ^a   Billack, Blase ^a   Fronczek, Frank R ^c   Talele, Tanaji T ^a  

^a ST JOHN'S UNIVERSITY   (United States)

^b UNIVERSITY OF PÉCS   (Hungary)

^c LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

Antifungal activity; Benzotriazole; Docking; Regioisomer; X ray crystallography

Indexed keywords

2 (2,4 DIFLUOROPHENYL) 1 (1H BENZO[D][1,2,3]TRIAZOL 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (3H [1,2,3]TRIAZOLO[4,5 B]PYRIDIN 3 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (5 CHLORO 1H BENZO[D][1,2,3]TRIAZOL 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (5 FLUORO 1H BENZO[D][1,2,3]TRIAZOL 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (5 METHOXY 1H BENZO[D][1,2,3]TRIAZOL 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (5 METHYL 1H BENZO[D][1,2,3]TRIAZOL 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (5 NITRO 1H BENZO[D][1,2,3]TRIAZOL 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (5,6 DIMETHYL 1H BENZO[D][1,2,3] TRIAZOL 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (5,6 DIMETHYL 2H BENZO[D][1,2,3] TRIAZOL 2 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (6 CHLORO 1H BENZO[D][1,2,3]TRIAZOL 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (6 FLUORO 1H BENZO[D][1,2,3]TRIAZOL 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (6 METHYL 1H BENZO[D][1,2,3]TRIAZOL 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (6 NITRO 1H BENZO[D][1,2,3]TRIAZOL 1 YL) 3 (1H 1,2,4-TRIAZOL 1 YL)PROPAN 2 OL; ANTIFUNGAL AGENT; BENZOTRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS NIGER; CANDIDA; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; MOLECULAR DOCKING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANTIFUNGAL AGENTS; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; FUNGI; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; TRIAZOLES;

EID: 77950861936     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.062     Document Type: Article

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