메뉴 건너뛰기




Volumn 238, Issue 1, 2006, Pages 119-127

YM-201627: An orally active antitumor agent with selective inhibition of vascular endothelial cell proliferation

Author keywords

Angiogenesis; Endothelial cells; Vascular endothelial growth factor (VEGF); YM 201627

Indexed keywords

ANTINEOPLASTIC AGENT; MATRIGEL; UNCLASSIFIED DRUG; YM 201627;

EID: 33744946282     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.06.037     Document Type: Article
Times cited : (52)

References (31)
  • 1
    • 0027970092 scopus 로고
    • Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
    • O'Reilly M.S., Holmgren L., Shing Y., Chen C., Rosenthal R.A., Moses M., et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79 (1994) 315-328
    • (1994) Cell , vol.79 , pp. 315-328
    • O'Reilly, M.S.1    Holmgren, L.2    Shing, Y.3    Chen, C.4    Rosenthal, R.A.5    Moses, M.6
  • 2
    • 0031789314 scopus 로고    scopus 로고
    • Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer
    • Ishigami S., Arii S., Furutani M., Niwano M., Harada T., Mizumoto M., et al. Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer. Br. J. Cancer 78 (1998) 1379-1384
    • (1998) Br. J. Cancer , vol.78 , pp. 1379-1384
    • Ishigami, S.1    Arii, S.2    Furutani, M.3    Niwano, M.4    Harada, T.5    Mizumoto, M.6
  • 4
    • 84975525035 scopus 로고
    • Clinical applications of research on angiogenesis
    • Folkman J. Clinical applications of research on angiogenesis. N. Engl. J. Med. 235 (1995) 1757-1763
    • (1995) N. Engl. J. Med. , vol.235 , pp. 1757-1763
    • Folkman, J.1
  • 5
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285 (1971) 1182-1186
    • (1971) N. Engl. J. Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 6
    • 0030829035 scopus 로고    scopus 로고
    • Enhanced expression of vascular endothelial growth factor in metastatic melanoma
    • Salven P., Heikkila P., and Joensuu H. Enhanced expression of vascular endothelial growth factor in metastatic melanoma. Br. J. Cancer 76 (1997) 930-934
    • (1997) Br. J. Cancer , vol.76 , pp. 930-934
    • Salven, P.1    Heikkila, P.2    Joensuu, H.3
  • 7
    • 0031779403 scopus 로고    scopus 로고
    • Tumor angiogenesis and vascular endothelial growth factor expression in stage I lung adenocarcinoma
    • Shibusa T., Shijubo N., and Abe S. Tumor angiogenesis and vascular endothelial growth factor expression in stage I lung adenocarcinoma. Clin. Cancer Res. 4 (1998) 1483-1487
    • (1998) Clin. Cancer Res. , vol.4 , pp. 1483-1487
    • Shibusa, T.1    Shijubo, N.2    Abe, S.3
  • 8
    • 0031955262 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor correlates with tumor progression in gallbladder cancer clinical studies
    • Okita S., Kondoh S., Shiraishi K., Kaino S., Hatano S., and Okita K. Expression of vascular endothelial growth factor correlates with tumor progression in gallbladder cancer clinical studies. Int. J. Oncol. 12 (1998) 1013-1018
    • (1998) Int. J. Oncol. , vol.12 , pp. 1013-1018
    • Okita, S.1    Kondoh, S.2    Shiraishi, K.3    Kaino, S.4    Hatano, S.5    Okita, K.6
  • 9
    • 0031941942 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression and vascular density as prognostic markers of survival in patients with low-grade astrocytoma
    • Abdulrauf S.I., Edvardsen K., Ho K.L., Yang X.Y., Rock J.P., and Rosenblum M.L. Vascular endothelial growth factor expression and vascular density as prognostic markers of survival in patients with low-grade astrocytoma. J. Neurosurg. 88 (1998) 513-520
    • (1998) J. Neurosurg. , vol.88 , pp. 513-520
    • Abdulrauf, S.I.1    Edvardsen, K.2    Ho, K.L.3    Yang, X.Y.4    Rock, J.P.5    Rosenblum, M.L.6
  • 10
    • 0344109584 scopus 로고    scopus 로고
    • Markers of tumor angiogenesis and proteolysis independently define high- and low-risk subsets of node-negative breast cancer patients
    • Eppenberger U., Kueng W., Schlaeppi J.-M., Roesel J.L., Benz C., Mueller H., et al. Markers of tumor angiogenesis and proteolysis independently define high- and low-risk subsets of node-negative breast cancer patients. J. Clin. Oncol. 16 (1998) 3129-3136
    • (1998) J. Clin. Oncol. , vol.16 , pp. 3129-3136
    • Eppenberger, U.1    Kueng, W.2    Schlaeppi, J.-M.3    Roesel, J.L.4    Benz, C.5    Mueller, H.6
  • 11
    • 0024801035 scopus 로고
    • Vascular permeability factor, an endothelial cell mitogen related to PDGF
    • Keck P.J., Hauser S.D., Krivi G., Sanzo K., Warren T., Feder J., et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246 (1989) 1309-1312
    • (1989) Science , vol.246 , pp. 1309-1312
    • Keck, P.J.1    Hauser, S.D.2    Krivi, G.3    Sanzo, K.4    Warren, T.5    Feder, J.6
  • 12
    • 0027053487 scopus 로고
    • Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro
    • Pepper M.S., Ferrara N., Orci L., and Montesano R. Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochem. Biophys. Res. Commun. 189 (1992) 824-831
    • (1992) Biochem. Biophys. Res. Commun. , vol.189 , pp. 824-831
    • Pepper, M.S.1    Ferrara, N.2    Orci, L.3    Montesano, R.4
  • 13
    • 0026321129 scopus 로고
    • Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells
    • Pepper M.S., Ferrara N., Orci L., and Montesano R. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem. Biophys. Res. Commun. 181 (1991) 902-906
    • (1991) Biochem. Biophys. Res. Commun. , vol.181 , pp. 902-906
    • Pepper, M.S.1    Ferrara, N.2    Orci, L.3    Montesano, R.4
  • 14
    • 0026446859 scopus 로고
    • Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells
    • Unemori E.N., Ferrari N., Bauer E.A., and Amento E.P. Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J. Cell. Physiol. 153 (1992) 557-562
    • (1992) J. Cell. Physiol. , vol.153 , pp. 557-562
    • Unemori, E.N.1    Ferrari, N.2    Bauer, E.A.3    Amento, E.P.4
  • 15
    • 0031870786 scopus 로고    scopus 로고
    • Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro
    • Lamoreaux W.J., Fitzgerald M.E., Reiner A., Hasty K.A., and Charles S.T. Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro. Microvasc. Res. 55 (1998) 29-42
    • (1998) Microvasc. Res. , vol.55 , pp. 29-42
    • Lamoreaux, W.J.1    Fitzgerald, M.E.2    Reiner, A.3    Hasty, K.A.4    Charles, S.T.5
  • 16
    • 3042643346 scopus 로고    scopus 로고
    • Bevacizumab: an angiogenesis inhibitor with efficacy in colorectal and other malignancies
    • Zondor S.D., and Medina P.J. Bevacizumab: an angiogenesis inhibitor with efficacy in colorectal and other malignancies. Ann. Pharmacother. 38 (2004) 1258-1264
    • (2004) Ann. Pharmacother. , vol.38 , pp. 1258-1264
    • Zondor, S.D.1    Medina, P.J.2
  • 17
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • Fong T.A., Shawver L.K., Sun L., Tang C., App H., Powell T.J., et al. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res. 59 (1999) 99-106
    • (1999) Cancer Res. , vol.59 , pp. 99-106
    • Fong, T.A.1    Shawver, L.K.2    Sun, L.3    Tang, C.4    App, H.5    Powell, T.J.6
  • 18
    • 0029134581 scopus 로고
    • Probing molecular interactions with homogeneous techniques based on rare earth cryptates and fluorescence energy transfer
    • Mathis G. Probing molecular interactions with homogeneous techniques based on rare earth cryptates and fluorescence energy transfer. Clin. Chem. 41 (1995) 1391-1397
    • (1995) Clin. Chem. , vol.41 , pp. 1391-1397
    • Mathis, G.1
  • 19
    • 0026495179 scopus 로고
    • A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor
    • Passaniti A., Taylor R.M., Pili R., Guo Y., Long P.V., Haney J.A., et al. A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab. Invest. 67 (1992) 519-528
    • (1992) Lab. Invest. , vol.67 , pp. 519-528
    • Passaniti, A.1    Taylor, R.M.2    Pili, R.3    Guo, Y.4    Long, P.V.5    Haney, J.A.6
  • 20
    • 0042121208 scopus 로고    scopus 로고
    • Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1
    • Nakatsu M.N., Sainson R.C., Aoto J.N., Taylor K.L., Aitkenhead M., Perez-del-Pulgar S., et al. Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1. Microvasc. Res. 66 (2003) 102-112
    • (2003) Microvasc. Res. , vol.66 , pp. 102-112
    • Nakatsu, M.N.1    Sainson, R.C.2    Aoto, J.N.3    Taylor, K.L.4    Aitkenhead, M.5    Perez-del-Pulgar, S.6
  • 21
    • 0842329999 scopus 로고    scopus 로고
    • Angiogenesis inhibitors in clinical development; where are we now and where are we going?
    • Eskens F.A. Angiogenesis inhibitors in clinical development; where are we now and where are we going?. Brit. J. Cancer 90 (2004) 1-7
    • (2004) Brit. J. Cancer , vol.90 , pp. 1-7
    • Eskens, F.A.1
  • 22
    • 10744232649 scopus 로고    scopus 로고
    • In vivo assessment of antiangiogenic activity of SU6668 in an experimental colon carcinoma model
    • Marzola P., Degrassi A., Calderan L., Farace P., Crescimanno C., Nicolato E., et al. In vivo assessment of antiangiogenic activity of SU6668 in an experimental colon carcinoma model. Clin. Cancer Res. 10 (2004) 739-750
    • (2004) Clin. Cancer Res. , vol.10 , pp. 739-750
    • Marzola, P.1    Degrassi, A.2    Calderan, L.3    Farace, P.4    Crescimanno, C.5    Nicolato, E.6
  • 23
    • 0036718003 scopus 로고    scopus 로고
    • Results of a phase I dose-escalating study of the antiangiogenic agent, SU5416, in patients with advanced malignancies
    • Stopeck A., Sheldon M., Vahedian M., Cropp G., Gosalia R., and Hannah A. Results of a phase I dose-escalating study of the antiangiogenic agent, SU5416, in patients with advanced malignancies. Clin Cancer Res. 8 (2003) 2798-2805
    • (2003) Clin Cancer Res. , vol.8 , pp. 2798-2805
    • Stopeck, A.1    Sheldon, M.2    Vahedian, M.3    Cropp, G.4    Gosalia, R.5    Hannah, A.6
  • 24
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel D.B., Laird A.D., Xin X., Louie S.G., Christensen J.G., Li G., et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin. Cancer Res. 9 (2003) 327-337
    • (2003) Clin. Cancer Res. , vol.9 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3    Louie, S.G.4    Christensen, J.G.5    Li, G.6
  • 25
    • 3543028023 scopus 로고    scopus 로고
    • PTK787/ZK222584, an inhibitor of vascular endothelial growth factor receptor tyrosine kinases, decreases glioma growth and vascularization
    • Goldbrunner R.H., Bendszus M., Wood J., Kiderlen M., Sasaki M., and Tonn J.C. PTK787/ZK222584, an inhibitor of vascular endothelial growth factor receptor tyrosine kinases, decreases glioma growth and vascularization. Neurosurgery 55 (2004) 426-432
    • (2004) Neurosurgery , vol.55 , pp. 426-432
    • Goldbrunner, R.H.1    Bendszus, M.2    Wood, J.3    Kiderlen, M.4    Sasaki, M.5    Tonn, J.C.6
  • 26
    • 0842289982 scopus 로고    scopus 로고
    • Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy, Clin
    • Ciardiello F., Bianco R., Caputo R., Caputo R., Damiano V., Troiani T., et al. Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy, Clin. Cancer Res. 10 (2004) 784-793
    • (2004) Cancer Res. , vol.10 , pp. 784-793
    • Ciardiello, F.1    Bianco, R.2    Caputo, R.3    Caputo, R.4    Damiano, V.5    Troiani, T.6
  • 28
    • 0025204095 scopus 로고
    • Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumor growth
    • Ingber D., Fujita T., Kishimoto S., Sudo K., Kanamaru T., Brem H., et al. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumor growth. Nature 348 (1990) 555-557
    • (1990) Nature , vol.348 , pp. 555-557
    • Ingber, D.1    Fujita, T.2    Kishimoto, S.3    Sudo, K.4    Kanamaru, T.5    Brem, H.6
  • 29
    • 0032764099 scopus 로고    scopus 로고
    • Induction of G1 arrest and selective growth inhibition by lactacystin in human umbilical vein endothelial cells
    • Kumeda S.I., Deguchi A., Toi M., Omura S., and Umezawa K. Induction of G1 arrest and selective growth inhibition by lactacystin in human umbilical vein endothelial cells. Anticancer Res. 19 (1999) 3961-3968
    • (1999) Anticancer Res. , vol.19 , pp. 3961-3968
    • Kumeda, S.I.1    Deguchi, A.2    Toi, M.3    Omura, S.4    Umezawa, K.5
  • 30
    • 0035347276 scopus 로고    scopus 로고
    • Selective growth inhibition by sangivamycin of human umbilical vein endothelial cells
    • Ohno O., Shima Y., Ikeda Y., Kondo S.I., Kato K., Toi M., et al. Selective growth inhibition by sangivamycin of human umbilical vein endothelial cells. Int. J. Oncol. 18 (2001) 1009-1015
    • (2001) Int. J. Oncol. , vol.18 , pp. 1009-1015
    • Ohno, O.1    Shima, Y.2    Ikeda, Y.3    Kondo, S.I.4    Kato, K.5    Toi, M.6
  • 31
    • 3042818667 scopus 로고    scopus 로고
    • Inhibition of human vascular endothelial cells proliferation by terbinafine
    • Ho P.Y., Liang Y.C., Ho Y.S., Chen C.T., and Lee W.S. Inhibition of human vascular endothelial cells proliferation by terbinafine. Int. J. Cancer 111 (2004) 51-59
    • (2004) Int. J. Cancer , vol.111 , pp. 51-59
    • Ho, P.Y.1    Liang, Y.C.2    Ho, Y.S.3    Chen, C.T.4    Lee, W.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.