Development and validation of an LC-MS/MS method for the pre-clinical pharmacokinetic investigation of the anticancer candidate AC04 in rodents

Journal of Liquid Chromatography and Related Technologies

Volumn 34, Issue 9, 2011, Pages 744-752

  De Toni Uchôa, Flávia ^a   Haas, Sandra Elisa ^a   Brum Jr , Liberato ^a   Pigatto, Maiara Cássia ^a   Do Carmo Alves De Lima, Maria ^b   Galdino, Suely Lins ^b   Da Rocha Pitta, Ivan ^b   Dalla Costa, Teresa ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

Author keywords

AC04; Acridine; Biological fluid; LC MS MS; Method validation; Pharmacokinetics

Indexed keywords

AC04; ACRIDINE; BIOLOGICAL FLUID; LC-MS/MS; METHOD VALIDATION;

ACETONITRILE; CHROMATOGRAPHY; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; FORMIC ACID; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MAMMALS; MASS SPECTROMETRY;

PHARMACOKINETICS;

5 ACRIDIN 9 YLMETHYLENE 3 (4 METHYLBENZYL)THIAZOLIDINE 2,4 DIONE; ACETONITRILE; ANTINEOPLASTIC AGENT; FORMIC ACID; TERBINAFINE; UNCLASSIFIED DRUG;

ARTICLE; CORRELATION COEFFICIENT; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FOOD AND DRUG ADMINISTRATION; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRECIPITATION; RAT; STANDARD; TANDEM MASS SPECTROMETRY;

RATTUS; RODENTIA;

EID: 79956018897     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826076.2011.563890     Document Type: Article

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