Synthesis, antimicrobial activity and possible mechanism of action of 9-bromo-substituted indolizinoquinoline-5,12-dione derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4625-4633

  Wu, Xi Wei ^a   Wu, Zu Ping ^a   Wang, Lu Xia ^b   Zhang, Hong Bin ^b   Chen, Jian Wen ^a   Zhang, Wei ^a   Gu, Lian Quan ^a   Huang, Zhi Shu ^a   An, Lin Kun ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Guangzhou Liuhuaqiao Hospital   (China)

Author keywords

9 bromo substituted indolizinoquinoline 5,12 dione derivatives; Antimicrobial activity; DNA gyrase; DNA topoisomerase IV; Methicillin resistant Staphylococcus aureus

Indexed keywords

2 FLUOROETHYL 9 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXYLATE; 2,2,2 TRIFLUOROETHYL 9 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXYLATE; 6 (4 ACETYLPIPERAZINE 1 CARBONYL) 9 BROMOINDOLIZINO[2,3 G]QUINOLINE 5,12 DIONE; 9 BROMO 6 (4 METHYLPIPERAZINE 1 CARBONYL)INDOLIZINO[2,3 G]QUINOLINE 5,12 DIONE; 9 BROMO 6 (MORPHOLINE 4 CARBONYL)INDOLIZINO[2,3 G]QUINOLINE 5,12 DIONE; 9 BROMO 6 (PYRROLIDINE 1 CARBONYL)INDOLIZINO[2,3 G]QUINOLINE 5,12 DIONE; 9 BROMO 6 (THIOMORPHOLINE 4 CARBONYL)INDOLIZINO[2,3 G]QUINOLINE 5,12 DIONE; 9 BROMO SUBSTITUTED INDOLIZINOQUINOLINE 5,12 DIONE DERIVATIVE; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE IV; ETHYL 9 BROMO 5,12DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXYLATE; METHYL 9 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXYLATE; N (2 MORPHOLINOETHYL) 9 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N (3 MORPHOLINOPROPYL) 9 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N [2 (DIETHYLAMINO)ETHYL] 9 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N [2 (DIMETHYLAMINO)ETHYL] 9 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N [2 (PIPERIDIN 1 YL)ETHYL] 9 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N [2 (PYRROLIDIN 1 YL)ETHYL] 9 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N [3 (DIETHYLAMINO)PROPYL] 9 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N [3 (DIMETHYLAMINO)PROPYL] 9 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N [3 (PIPERIDIN 1 YL)PROPYL] 9 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N [3 (PYRROLIDIN 1 YL)PROPYL] 9 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N BENZYL 9 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N BUTYL 9 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N ISOPROPYL 9 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N PROPYL 9 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N,N DIETHYL 9 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BETA HEMOLYTIC STREPTOCOCCUS; CANDIDA ALBICANS; CONTROLLED STUDY; DNA SUPERCOILING; DRUG SCREENING; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; SALMONELLA PARATYPHI; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

ANTI-BACTERIAL AGENTS; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; QUINOLINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 80052925382     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.07.042     Document Type: Article

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