Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 3986-3995

  Zhang, Zhanbin ^a,b   Lu, Xiaoxia ^a   Xu, Jinbin ^a   Rothfuss, Justin ^a   MacH, Robert H ^a   Tu, Zhude ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BEIJING NORMAL UNIVERSITY   (China)

Author keywords

CNS; PDE10A; Schizophrenia

Indexed keywords

1 (3 FLUORO 4 METHOXYBENZYL) 6 (2 FLUOROETHOXY) 7 METHOXYISOQUINOLINE OXALATE; 1 [3 (2 FLUOROETHOXY) 4 METHOXYBENZYL] 6,7 DIMETHOXYISOQUINOLINE; 1 [4 (2 FLUOROETHOXY) 3 METHOXYBENZYL] 6,7 DIMETHOXYISOQUINOLINE OXALATE; 1 [4 [2 (2 FLUOROETHOXY)ETHOXY] 3 METHOXYBENZYL] 6,7 DIMETHOXYISOQUINOLINE; 6 (2 FLUOROETHOXY) 7 METHOXY 1 (4 METHOXY 3 METHYLBENZYL)ISOQUINOLINE OXALATE; 6,7 DIMETHOXY 4 (4 METHOXYBENZYL)QUINAZOLINE OXALATE; ISOQUINOLINE DERIVATIVE; PAPAVERINE; PHOSPHODIESTERASE; PHOSPHODIESTERASE 10A; PHOSPHODIESTERASE 3A; PHOSPHODIESTERASE 3B; PHOSPHODIESTERASE III; PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; CYCLIZATION; DRUG CROSS REACTIVITY; DRUG SELECTIVITY; ENZYME INHIBITION; HYDROGENOLYSIS; IC 50; IN VITRO STUDY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

DRUG EVALUATION, PRECLINICAL; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES;

EID: 80052918961     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.05.072     Document Type: Article

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