Carbon-11 labeled papaverine as a PET tracer for imaging PDE10A: radiosynthesis, in vitro and in vivo evaluation

Nuclear Medicine and Biology

Volumn 37, Issue 4, 2010, Pages 509-516

  Tu, Zhude ^a   Xu, Jinbin ^a   Jones, Lynne A ^a   Li, Shihong ^a   Mach, Robert H ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

C 11; CNS; Papaverine; PDE10A; PET; Phosphodiesterase 10A; Radiotracer

Indexed keywords

METHYL IODIDE; PAPAVERINE C 11; PHOSPHODIESTERASE; PHOSPHODIESTERASE 10A; RADIOLIGAND; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN REGION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORPUS STRIATUM; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG POTENCY; DRUG PURITY; DRUG UPTAKE; IC 50; IMAGE ANALYSIS; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MALE; METHYLATION; MOLECULAR IMAGING; MONKEY; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PUTAMEN; RADIOCHEMISTRY; RAT; RHESUS MONKEY;

ANIMALS; AUTORADIOGRAPHY; BIOLOGICAL TRANSPORT; BRAIN; CARBON RADIOISOTOPES; MALE; PAPAVERINE; PHOSPHORIC DIESTER HYDROLASES; POSITRON-EMISSION TOMOGRAPHY; RADIOACTIVE TRACERS; RADIOCHEMISTRY; RATS;

EID: 77952551015     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2009.12.012     Document Type: Article

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