P2y5/LPA 6 attenuates LPA 1-mediated VE-cadherin translocation and cellcell dissociation through G 12/13 proteinSrcRap1

Cardiovascular Research

Volumn 92, Issue 1, 2011, Pages 149-158

  Kimura, Takao ^a,b   Mogi, Chihiro ^a   Sato, Koichi ^a   Tomura, Hideaki ^a   Ohta, Hideo ^c   Im, Doon Soon ^d   Kuwabara, Atsushi ^e   Kurose, Hitoshi ^f   Murakami, Masami ^b   Okajima, Fumikazu ^a  

^a GUNMA UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c KYOWA HAKKO KOGYO CO LTD   (Japan)

^d Pusan National University   (South Korea)

^e TAKASAKI UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^f KYUSHU UNIVERSITY   (Japan)

Author keywords

Endothelial cell; Lysophosphatidic acid; p2y5 LPA 6; Vascular endothelial cadherin

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; CADHERIN; G 12 PROTEIN; G 13 PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; KI 16198; LACTIC ACID; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHATIDIC ACID RECEPTOR 1; LYSOPHOSPHATIDIC ACID RECEPTOR 6; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PERTUSSIS TOXIN; RAP1 PROTEIN; RHO FACTOR; SMALL INTERFERING RNA; STEROID RECEPTOR COACTIVATOR 1; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; CELL DISRUPTION; CELL INTERACTION; CELL LEVEL; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIMB INJURY; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIGENS, CD; CADHERINS; CELLS, CULTURED; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; GTPASE-ACTIVATING PROTEINS; HUMANS; LYSOPHOSPHOLIPIDS; MALE; MAP KINASE KINASE 4; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN TRANSPORT; RATS; RATS, WISTAR; RECEPTORS, LYSOPHOSPHATIDIC ACID; RECEPTORS, PURINERGIC P2; SRC-FAMILY KINASES;

EID: 80052885398     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvr154     Document Type: Article

References (42)

1. Wallez Y, Huber P. Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis. Biochim Biophys Acta 2008;1778:794-809. (Pubitemid 351317803)
2. Vestweber D, Winderlich M, Cagna G, Nottebaum AF. Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player. Trends Cell Biol 2009;19:8-15.
3. Gavard J. Breaking the VE-cadherin bonds. FEBS Lett 2009;583:1-6.
4. SiessW, Zangl KJ, Essler M, Bauer M, Brandl R, Corrinth C et al. Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions. Proc Natl Acad Sci USA 1999;96:6931-6936. (Pubitemid 29274987)
5. Neidlinger NA, Larkin SK, Bhagat A, Victorino GP, Kuypers FA. Hydrolysis of phosphatidylserine-exposing red blood cells by secretory phospholipase A2 generates lysophosphatidic acid and results in vascular dysfunction. J Biol Chem 2006;281: 775-781.
6. van Nieuw Amerongen GP, Vermeer MA, van Hinsbergh VW. Role of RhoA and Rho kinase in lysophosphatidic acid-induced endothelial barrier dysfunction. Arterioscler Thromb Vasc Biol 2000;20:127-133.
7. Napoli C, Quehenberger O, De Nigris F, Abete P, Glass CK, Palinski W. Mildly oxidized low density lipoprotein activates multiple apoptotic signaling pathways in human coronary cells. FASEB J 2000;14:1996-2007.
8. Minnear FL, Patil S, Bell D, Gainor JP, Morton CA. Platelet lipid(s) bound to albumin increases endothelial electrical resistance: mimicked by LPA. Am J Physiol Lung Cell Mol Physiol 2001;281:L1337-L1344.
9. Yin F, Watsky MA. LPA and S1P increase corneal epithelial and endothelial cell transcellular resistance. Invest Ophthalmol Vis Sci 2005;46:1927-1933.10.
10. van Meeteren LA, Ruurs P, Stortelers C, Bouwman P, van Rooijen MA, Pradere JP et al. Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. Mol Cell Biol 2006;26:5015-5022. (Pubitemid 43955815)
11. Tanaka M, Okudaira S, Kishi Y, Ohkawa R, Iseki S, Ota M et al. Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. J Biol Chem 2006;281:25822-25830. (Pubitemid 44401970)
12. Teo ST, Yung YC, Herr DR, Chun J. Lysophosphatidic acid in vascular development and disease. IUBMB Life 2009;61:791-799.
13. Pasternack SM, von Kügelgen I, Aboud KA, Lee YA, Rüschendorf F, Voss K et al. G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. Nat Genet 2008;40:329-334. (Pubitemid 351311768)
14. Shimomura Y,Wajid M, Ishii Y, Shapiro L, Petukhova L, Gordon D et al. Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair. Nat Genet 2008;40:335-339. (Pubitemid 351311759)
15. Yanagida K, Masago K, Nakanishi H, Kihara Y, Hamano F, Tajima Y et al. Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6. J Biol Chem 2009;284:17731-17741.
16. Ohta H, Sato K, Murata N, Damirin A, Malchinkhuu E, Kon J et al. Ki16425, a subtypeselective antagonist for EDG-family lysophosphatidic acid receptors. Mol Pharmacol 2003;64:994-1005. (Pubitemid 37153068)
17. Kimura T, Watanabe T, Sato K, Kon J, Tomura H, Tamama K et al. Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3. Biochem J 2000;348:71-76. (Pubitemid 30312132)
18. Cote M, Payet MD, Dufour MN, Guillon G, Gallo-Payet N. Association of the G protein aq/a11-subunit with cytoskeleton in adrenal glomerulosa cells: role in receptor-effector coupling. Endocrinology 1997;138:3299-3307. (Pubitemid 27345682)
19. Maruyama Y, Nishida M, Sugimoto Y, Tanabe S, Turner JH, Kozasa T et al. Ga12/13 mediates a1-adrenergic receptor-induced cardiac hypertrophy. Circ Res 2002;91: 961-969.
20. Fukuhara S, Sakurai A, Sano H, Yamagishi A, Somekawa S, Takakura N et al. Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Mol Cell Biol 2005;25:136-146. (Pubitemid 40039806)
21. Arai K, Maruyama Y, Nishida M, Tanabe S, Takagahara S, Kozasa T et al. Differential requirement of Ga12, Ga13, Gaq, and Gbg for endothelin-1-induced c-Jun NH2-terminal kinase and extracellular signal-regulated kinase activation. Mol Pharmacol 2003;63:478-488.
22. Kimura T, Tomura H, Mogi C, Kuwabara A, Ishiwara M, Shibasawa K et al. Sphingosine 1-phosphate receptors mediate stimulatory and inhibitory signalings for expression of adhesion molecules in endothelial cells. Cell Signal 2006;18:841-850. (Pubitemid 43208937)
23. Malchinkhuu E, Sato K, Horiuchi Y, Mogi C, Ohwada S, Ishiuchi S et al. Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells. Oncogene 2005;24: 6676-6688. (Pubitemid 41486798)
24. Yamada T, Sato K, Komachi M, Malchinkhuu E, Tobo M, Kimura T et al. Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1. J Biol Chem 2004;279:6595-6605. (Pubitemid 38248796)
25. Sato K, Tomura H, Igarashi Y, Ui M, Okajima F. Possible involvement of cell surface receptors in sphingosine 1-phosphate-induced activation of extracellular signalregulated kinase in C6 glioma cells. Mol Pharmacol 1999;55:126-133. (Pubitemid 29042530)
26. Ishida H, Nakayasu H, Nukaya H, Tsuji K. Study of the pharmacological effect of the bile salt, sodium scymnol sulfate, from Rhizoprionodon acutus. III. Protective effect of scymnol against vascular endothelial cell damage in a rat peripheral arterial occlusion model. Biol Pharm Bull 1999;22:822-827. (Pubitemid 29436793)
27. Nwariaku FE, Liu Z, Zhu X, Nahari D, Ingle C, Wu RF et al. NADPH oxidase mediates vascular endothelial cadherin phosphorylation and endothelial dysfunction. Blood 2004;104:3214-3220. (Pubitemid 39507137)
28. Tremblay PL, Auger FA, Huot J. Regulation of transendothelial migration of colon cancer cells by E-selectin-mediated activation of p38 and ERK MAP kinases. Oncogene 2006;25:6563-6573. (Pubitemid 44646184)
29. Khanna P, Yunkunis T, Muddana HS, Peng HH, August A, Dong C. p38 MAP kinase is necessary for melanoma-mediated regulation of VE-cadherin disassembly. Am J Physiol Cell Physiol 2010;298:C1140-C1150.
30. Kim S, Jin J, Kunapuli SP. Relative contribution of G-protein-coupled pathways to protease-activated receptor-mediated Akt phosphorylation in platelets. Blood 2006; 107:947-954. (Pubitemid 43156291)
31. Bunda S, Wang Y, Mitts TF, Liu P, Arab S, Arabkhari M et al. Aldosterone stimulates elastogenesis in cardiac fibroblasts via mineralocorticoid receptor-independent action involving the consecutive activation of Ga13, c-Src, the insulin-like growth factor-I receptor, and phosphatidylinositol 3-kinase/Akt. J Biol Chem 2009;284: 16633-16647.
32. Gong H, Shen B, Flevaris P, Chow C, Lam SC, Voyno-Yasenetskaya TA et al. G protein subunit Ga13 binds to integrin aIIbb3 and mediates integrin 'outside-in' signaling. Science 2010;327:340-343.
33. Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL. Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors. Biochim Biophys Acta 2009;1788:790-796.
34. Williams JR, Khandoga AL, Goyal P, Fells JI, Perygin DH, Siess W et al. Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. J Biol Chem 2009;284:17304-17319.
35. Offermanns S, Mancino V, Revel JP, Simon MI. Vascular system defects and impaired cell chemokinesis as a result of Ga13 deficiency. Science 1997;275:533-536. (Pubitemid 27051909)
36. Mills GB, Moolenaar WH. The emerging role of lysophosphatidic acid in cancer. Nat Rev Cancer 2003;3:582-591. (Pubitemid 37328830)
37. Gavard J, Gutkind JS. VEGF controls endothelial-cell permeability by promoting the b-arrestin-dependent endocytosis of VE-cadherin. Nat Cell Biol 2006;8:1223-1234. (Pubitemid 44660587)
38. Monaghan-Benson E, Burridge K. The regulation of vascular endothelial growth factor-induced microvascular permeability requires Rac and reactive oxygen species. J Biol Chem 2009;284:25602-25611.
39. Knezevic II, Predescu SA, Neamu RF,Gorovoy MS, KnezevicNM, EasingtonCet al. Tiam1 and Rac1 are required for platelet-activating factor-induced endothelial junctional disassembly and increase in vascular permeability. J Biol Chem2009;284:5381-5394.
40. Spindler V, Schlegel N, Waschke J. Role of GTPases in control of microvascular permeability. Cardiovasc Res 2010;87:243-253.
41. Schmitt JM, Stork PJ. PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1. Mol Cell 2002;9:85-94. (Pubitemid 34127773)
42. Fukuyama T, Ogita H, Kawakatsu T, Inagaki M, Takai Y. Activation of Rac by cadherin through the c-Src-Rap1-phosphatidylinositol 3-kinase-Vav2 pathway. Oncogene 2006;25:8-19. (Pubitemid 43049999)