VEGF receptor mRNA expression by ACL fibroblasts is associated with functional healing of the ACL

Knee Surgery, Sports Traumatology, Arthroscopy

Volumn 19, Issue 10, 2011, Pages 1675-1682

  Vavken, Patrick ^a   Saad, Fawzy A ^a   Fleming, Braden C ^b   Murray, Martha M ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

ACL repair; Biomechanics; Tissue engineering; VEGF

Indexed keywords

MESSENGER RNA; TISSUE SCAFFOLD; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

AGE; ANIMAL; ANTERIOR CRUCIATE LIGAMENT; ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION; ARTICLE; BIOMECHANICS; BLOOD; DISEASE MODEL; FEMALE; FIBROBLAST; GENETICS; INJURY; INSTRUMENTATION; KNEE INJURY; METABOLISM; METHODOLOGY; MULTIVARIATE ANALYSIS; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SWINE; TISSUE ENGINEERING; WEIGHT BEARING; WOUND HEALING;

AGE FACTORS; ANIMALS; ANTERIOR CRUCIATE LIGAMENT; ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION; BIOMECHANICS; DISEASE MODELS, ANIMAL; FEMALE; FIBROBLASTS; KNEE INJURIES; MULTIVARIATE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SWINE; TISSUE ENGINEERING; TISSUE SCAFFOLDS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; WEIGHT-BEARING; WOUND HEALING;

EID: 80052877902     PISSN: 09422056     EISSN: 14337347     Source Type: Journal    
DOI: 10.1007/s00167-011-1443-y     Document Type: Article

References (40)

1. Carmeliet P (2003) Angiogenesis in health and disease. Nat Med 9(6): 653-660.
2. Casteleyn P (1999) Management of anterior cruciate ligament lesions: surgical fashion, personal whim or scientific evidence? Study of medium and long-term results. Acta Orthop Belg 65: 327-339.
3. Cheng M, Wang H, Yoshida R, Murray MM (2009) Platelets and plasma proteins are both required to stimulate collagen gene expression by anterior cruciate ligament cells in three-dimensional culture. Tissue Eng Part A 16(5): 1479-1489.
4. Cohen M, Amaro JT, Ejnisman B, Carvalho RT, Nakano KK, Peccin MS, Teixeira R, Laurino CF, Abdalla RJ (2007) Anterior cruciate ligament reconstruction after 10 to 15 years: association between meniscectomy and osteoarthrosis. Arthroscopy 23(6): 629-634.
5. Dupont WD, Plummer WD (1990) Power and sample size calculations: a review and computer program. Control Clin Trial 11: 116-128.
6. Dupont WD, Plummer WD Jr (1998) Power and sample size calculations for studies involving linear regression. Control Clin Trial 19(6): 589.
7. Everts PA, Knape JT, Weibrich G, Schonberger JP, Hoffmann J, Overdevest EP, Box HA, van Zundert A (2006) Platelet-rich plasma and platelet gel: a review. J Extra Corpor Technol 38(2): 174-187.
8. Fleming BC, Carey JL, Spindler KP, Murray MM (2008) Can suture repair of ACL transection restore normal anteroposterior laxity of the knee? An ex vivo study. J Orthop Res 26(11): 1500-1505.
9. Fleming BC, Magarian EM, Harrison SL, Paller DJ, Murray MM (2010) Collagen scaffold supplementation does not improve the functional properties of the repaired anterior cruciate ligament. J Orthop Res 28(6): 703-709.
10. Fleming BC, Spindler KP, Palmer M, Magarian E, Murray MM (2009) Collagen-platelet composites improve the biomechanical properties of healing ACL grafts in a porcine model. Am J Sports Med 37(8): 1554-1563.
11. Hofstaetter JG, Saad FA, Samuel RE, Wunderlich L, Choi YH, Glimcher MJ (2004) Differential expression of VEGF isoforms and receptors in knee joint menisci under systemic hypoxia. Biochem Biophys Res Commun 324(2): 667-672.
12. Hofstaetter JG, Saad FA, Sunk IG, Bobacz K, Friehs I, Glimcher MJ (2007) Age-dependent expression of VEGF isoforms and receptors in the rabbit anterior cruciate ligament. Biochim Biophys Acta 1770(7): 997-1002.
13. Hofstaetter JG, Wunderlich L, Samuel RE, Saad FA, Choi YH, Glimcher MJ (2005) Systemic hypoxia alters gene expression levels of structural proteins and growth factors in knee joint cartilage. Biochem Biophys Res Commun 330(2): 386-394.
14. Hou Y, Mao Z, Wei X, Lin L, Chen L, Wang H, Fu X, Zhang J, Yu C (2009) Effects of transforming growth factor-beta1 and vascular endothelial growth factor 165 gene transfer on Achilles tendon healing. Matrix Biol 28(6): 324-335.
15. Joshi SM, Mastrangelo AN, Magarian EM, Fleming BC, Murray MM (2009) Collagen-platelet composite enhances biomechanical and histologic healing of the porcine anterior cruciate ligament. Am J Sports Med 37(12): 2401-2410.
16. Kessler MA, Behrend H, Henz S, Stutz G, Rukavina A, Kuster MS (2008) Function, osteoarthritis and activity after ACL-rupture: 11 years follow-up results of conservative versus reconstructive treatment. Knee Surg Sports Traumatol Arthrosc 16(5): 442-448.
17. Kilian O, Alt V, Heiss C, Jonuleit T, Dingeldein E, Flesch I, Fidorra U, Wenisch S, Schnettler R (2005) New blood vessel formation and expression of VEGF receptors after implantation of platelet growth factor-enriched biodegradable nanocrystalline hydroxyapatite. Growth Factors 23(2): 125-133.
18. Lind M, Menhert F, Pedersen AB (2008) The first results from the Danish ACL reconstruction registry: epidemiologic and 2 year follow-up results from 5, 818 knee ligament reconstructions. Knee Surg Sports Traumatol Arthrosc.
19. Lohmander LS, Englund M, Dahl L, Roos EM (2007) The long-term consequence of anterior cruciate ligament and meniscus injuries. Am J Sports Med 35: 1756-1769.
20. Lohmander LS, Ostenberg A, Englund M, Roos H (2004) High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury. Arthritis Rheum 50(10): 3145-3152.
21. Mastrangelo A, Magarian E, Palmer M, Vavken P, Murray M (2009) The effect of skeletal maturity on the regenerative function of intrinsic ACL cells. J Orthop Res 28(5): 644-651.
22. Mastrangelo A, Vavken P, Fleming B, Harrison S, Murray M (2011) Reduced platelet concentration does not harm PRP effectiveness for ACL repair in a porcine in vivo model. J Orthop Res (in press).
23. Mastrangelo AN, Haus BM, Vavken P, Palmer MP, Machan JT, Murray MM (2010) Immature animals have higher cellular density in the healing anterior cruciate ligament than adolescent or adult animals. J Orthop Res 28(8): 1100-1106.
24. Mastrangelo AN, Magarian EM, Palmer MP, Vavken P, Murray MM (2010) The effect of skeletal maturity on the regenerative function of intrinsic ACL cells. J Orthop Res 28(5): 644-651.
25. Murray MM, Magarian EM, Harrison SL, Zurakowski D, Fleming BC (2010) The effect of skeletal maturity on functional healing of the anterior cruciate ligament. J Bone Joint Surg Am 92(11): 2039-2049.
26. Murray MM, Martin SD, Martin TL, Spector M (2000) Histological changes in the human anterior cruciate ligament after rupture. J Bone Joint Surg Am 82(10): 1387-1397.
27. Murray MM, Palmer M, Abreu E, Spindler KP, Zurakowski D, Fleming BC (2009) Platelet-rich plasma alone is not sufficient to enhance suture repair of the ACL in skeletally immature animals: an in vivo study. J Orthop Res 27(5): 639-645.
28. Odorisio T, Schietroma C, Zaccaria M, Cianfarani F, Tiveron C, Tatangelo L, Failla C, Zambruno G (2002) Mice overexpressing placenta growth factor exhibit increased vascularization and vessel permeability. J Cell Sci 115: 2559-2567.
29. Petersen W, Pufe T, Unterhauser F, Zantop T, Mentlein R, Weiler A (2003) The splice variants 120 and 164 of the angiogenic peptide vascular endothelial cell growth factor (VEGF) are expressed during Achilles tendon healing. Arch Orthop Trauma Surg 123(9): 475-480.
30. Petersen W, Unterhauser F, Pufe T, Zantop T, Sudkamp NP, Weiler A (2003) The angiogenic peptide vascular endothelial growth factor (VEGF) is expressed during the remodeling of free tendon grafts in sheep. Arch Orthop Trauma Surg 123(4): 168-174.
31. Petrova T, Makinen T, Alitalo K (1999) Signaling via vascular endothelial growth factor receptors. Exp Cell Res 253(117).
32. Rahimi N (2006) VEGFR-1 and VEGFR-2: two non-identical twins with a unique physiognomy. Front Biosci 11: 818-829.
33. Spindler KP, Murray MM, Carey JL, Zurakowski D, Fleming BC (2009) The use of platelets to affect functional healing of an anterior cruciate ligament (ACL) autograft in a caprine ACL reconstruction model. J Orthop Res 27(5): 631-638.
34. Vavken P, Culen G, Dorotka R (2008) Management of confounding in controlled orthopaedic trials: a cross-sectional study. Clin Orthop Relat Res 466(4): 985-989.
35. Vavken P, Heinrich KM, Koppelhuber C, Rois S, Dorotka R (2009) The use of confidence intervals in reporting orthopaedic research findings. Clin Orthop Relat Res 467(12): 3334-3339.
36. Vavken P, Murray MM (2009) Translational studies in ACL repair. Tissue Eng Part B 16(1): 5-11.
37. Vavken P, Saad F, Murray M (2010) Age-dependence of expression of growth factor receptors in porcine ACL fibroblasts. J Orthop Res 28(8): 1107-1112.
38. Weibrich G, Kleis WK, Hafner G, Hitzler WE (2002) Growth factor levels in platelet-rich plasma and correlations with donor age, sex, and platelet count. J Craniomaxillofac Surg 30(2): 97-102.
39. Yancopoulos G, Davis S, Gale N, Rudge J, Wiegand S, Holash J (2000) Vascular-specific growth factors and blood vessel formation. Nature 407(6801): 242-248.
40. Yoshikawa T, Tohyama H, Katsura T, Kondo E, Kotani Y, Matsumoto H, Toyama Y, Yasuda K (2006) Effects of local administration of vascular endothelial growth factor on mechanical characteristics of the semitendinosus tendon graft after anterior cruciate ligament reconstruction in sheep. Am J Sports Med 34(12): 1918-1925.