Reduced platelet concentration does not harm PRP effectiveness for ACL repair in a porcine in vivo model

Journal of Orthopaedic Research

Volumn 29, Issue 7, 2011, Pages 1002-1007

  Mastrangelo, Ashley N ^a   Vavken, Patrick ^a   Fleming, Braden C ^b   Harrison, Sophia L ^a   Murray, Martha M ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

ACL; collagen; fibroblast; ligament; scaffold; tissue regeneration

Indexed keywords

COLLAGEN; TISSUE SCAFFOLD;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION; ARTICLE; CELL DENSITY; CELL SHAPE; CONTROLLED STUDY; EXPERIMENTAL PIG; FEMALE; FIBROBLAST; IN VIVO STUDY; JOINT LAXITY; KNEE FUNCTION; LIGAMENT MATURITY INDEX SCORE; MALE; MINIPIG; MUSCULOSKELETAL SYSTEM PARAMETERS; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; SCORING SYSTEM; SUTURE; TENSILE STRENGTH; THROMBOCYTE; THROMBOCYTE RICH PLASMA; TISSUE REPAIR; WOUND HEALING;

ANIMALS; ANTERIOR CRUCIATE LIGAMENT; BIOMECHANICS; BLOOD PLATELETS; COLLAGEN; FEMALE; KNEE JOINT; MALE; MODELS, ANIMAL; ORTHOPEDIC PROCEDURES; PLATELET COUNT; PLATELET-RICH PLASMA; RECOVERY OF FUNCTION; SWINE; SWINE, MINIATURE; TISSUE SCAFFOLDS; WOUND HEALING;

EID: 79955905494     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21375     Document Type: Article

References (21)

1. Kocher MS, Saxon HS, Hovis WD, et al. 2002. Management and complications of anterior cruciate ligament injuries in skeletally immature patients: survey of the Herodicus Society and The ACL Study Group. J Pediatr Orthop 22: 452-457. (Pubitemid 34686480)
2. Koman S,. 1999. Valgus deformity after reconstruction of the anterior cruciate ligament in a skeletally immature patient. A case report. J Bone Joint Surg Am 81: 711-715.
3. Mohtadi N, Grant J,. 2006. Managing anterior cruciate ligament deficiency in the skeletally immature individual: a systematic review of the literature. Clin J Sport Med 16: 457-464. (Pubitemid 44900728)
4. Borchers JR, Pedroza A, Kaeding C,. 2009. Activity level and graft type as risk factors for anterior cruciate ligament graft failure: a case-control study. Am J Sports Med 37: 2362-2367.
5. Murray MM, Spindler KP, Abreu E, et al. 2007. Collagen-platelet rich plasma hydrogel enhances primary repair of the porcine anterior cruciate ligament. J Orthop Res 25: 81-91. (Pubitemid 46070734)
6. Fleming BC, Spindler KP, Palmer MP, et al. 2009. Collagen-platelet composites improve the biomechanical properties of healing anterior cruciate ligament grafts in a porcine model. Am J Sports Med 37: 1554-1563.
7. Cenni E, Avnet S, Fotia C, et al. 2010. Platelet-rich plasma impairs osteoclast generation from human precursors of peripheral blood. J Orthop Res 28: 792-797.
8. Fresno L, Fondevila D, Bambo O, et al. 2010. Effects of platelet-rich plasma on intestinal wound healing in pigs. Vet J 185: 322-327.
9. Murray MM, Magarian E, Zurakowski D, et al. 2010. Bone-to-bone fixation enhances functional healing of the porcine anterior cruciate ligament using a collagen-platelet composite. Arthroscopy 26: S49-S57.
10. Fleming BC, Magarian EM, Harrison SL, et al. 2010. Collagen scaffold supplementation does not improve the functional properties of the repaired anterior cruciate ligament. J Orthop Res 28: 703-709.
11. Murray MM, Magarian EM, Harrison SL, et al. 2010. The effect of skeletal maturity on functional healing of the anterior cruciate ligament. J Bone Joint Surg Am 92: 2039-2049.
12. Murray MM, Spindler KP, Ballard P, et al. 2007. Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffold. J Orthop Res 25: 1007-1017. (Pubitemid 47233077)
13. Joshi SM, Mastrangelo AN, Magarian EM, et al. 2009. Collagen-platelet composite enhances biomechanical and histologic healing of the porcine anterior cruciate ligament. Am J Sports Med 37: 2401-2410.
14. Vavken P, Murray MM,. 2010. Translational studies in anterior cruciate ligament repair. Tissue Eng Part B Rev 16: 5-11.
15. Spindler KP, Murray MM, Carey JL, et al. 2009. The use of platelets to affect functional healing of an anterior cruciate ligament (ACL) autograft in a caprine ACL reconstruction model. J Orthop Res 27: 631-638.
16. Mastrangelo AN, Haus BM, Vavken P, et al. 2010. Immature animals have higher cellular density in the healing anterior cruciate ligament than adolescent or adult animals. J Orthop Res 28: 1100-1106.
17. Mastrangelo AN, Magarian EM, Palmer MP, et al. 2010. The effect of skeletal maturity on the regenerative function of intrinsic ACL cells. J Orthop Res 28: 644-651.
18. Bosch G, van Schie HT, de Groot MW, et al. 2010. Effects of platelet-rich plasma on the quality of repair of mechanically induced core lesions in equine superficial digital flexor tendons: a placebo-controlled experimental study. J Orthop Res 28: 211-217.
19. Thomopoulos S, Das R, Silva MJ, et al. 2009. Enhanced flexor tendon healing through controlled delivery of PDGF-BB. J Orthop Res 27: 1209-1215.
20. Thomopoulos S, Kim HM, Das R, et al. 2010. The effects of exogenous basic fibroblast growth factor on intrasynovial flexor tendon healing in a canine model. J Bone Joint Surg Am 92: 2285-2293.
21. Murray MM, Magarian EM, Harrison SL, et al. 2010. The effect of skeletal maturity on functional healing of the anterior cruciate ligament. J Bone Joint Surg AM 92: 2039-2049.