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Volumn 53, Issue 8, 2007, Pages 967-974

Aspartame decreases evoked extracellular dopamine levels in the rat brain: An in vivo voltammetry study

Author keywords

Aspartame; Dopamine; Release; Striatum; Uptake; Voltammetry

Indexed keywords

ASPARTAME; DOPAMINE; OXIDOPAMINE;

EID: 36248935631     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2007.09.009     Document Type: Article
Times cited : (24)

References (51)
  • 1
    • 0023130088 scopus 로고
    • Time course of adaptations in dopamine biosynthesis, metabolism, and release following nigrostriatal lesions: implications for behavioral recovery from brain injury
    • Altar C.A., Marien M.R., and Marshall J.F. Time course of adaptations in dopamine biosynthesis, metabolism, and release following nigrostriatal lesions: implications for behavioral recovery from brain injury. J. Neurochem. 48 (1987) 390-399
    • (1987) J. Neurochem. , vol.48 , pp. 390-399
    • Altar, C.A.1    Marien, M.R.2    Marshall, J.F.3
  • 2
    • 0020356190 scopus 로고
    • Inhibition by l-phenylalanine of tyrosine transport by synaptosomal plasma membrane vesicles: implications in the pathogenesis of phenylketonuria
    • Aragon M.C., Gimenez C., and Valdivieso F. Inhibition by l-phenylalanine of tyrosine transport by synaptosomal plasma membrane vesicles: implications in the pathogenesis of phenylketonuria. J. Neurochem. 39 (1982) 1185-1187
    • (1982) J. Neurochem. , vol.39 , pp. 1185-1187
    • Aragon, M.C.1    Gimenez, C.2    Valdivieso, F.3
  • 3
    • 0035970991 scopus 로고    scopus 로고
    • Partial, graded losses of dopamine terminals in the rat caudate-putamen: an animal model for the study of compensatory adaptation in preclinical parkinsonism
    • Bergstrom B.P., Schertz K.E., Weirick T., Nafziger B., Takacs S.A., Lopes K.O., Massa K.J., Walker Q.D., and Garris P.A. Partial, graded losses of dopamine terminals in the rat caudate-putamen: an animal model for the study of compensatory adaptation in preclinical parkinsonism. J. Neurosci. Methods 106 (2001) 15-28
    • (2001) J. Neurosci. Methods , vol.106 , pp. 15-28
    • Bergstrom, B.P.1    Schertz, K.E.2    Weirick, T.3    Nafziger, B.4    Takacs, S.A.5    Lopes, K.O.6    Massa, K.J.7    Walker, Q.D.8    Garris, P.A.9
  • 4
    • 0025890083 scopus 로고
    • Metabolism of aspartame and its l-phenylalanine methyl ester decomposition product by the porcine gut
    • Burgert S.L., Anderson D.W., Stegink L.D., Takeuchi H., and Schedl H.P. Metabolism of aspartame and its l-phenylalanine methyl ester decomposition product by the porcine gut. Metabolism 40 (1991) 612-618
    • (1991) Metabolism , vol.40 , pp. 612-618
    • Burgert, S.L.1    Anderson, D.W.2    Stegink, L.D.3    Takeuchi, H.4    Schedl, H.P.5
  • 7
    • 0022618206 scopus 로고
    • Neurobiochemical alterations induced by the artificial sweetener aspartame (nutrasweet)
    • Coulombe Jr. R.A., and Sharma R.P. Neurobiochemical alterations induced by the artificial sweetener aspartame (nutrasweet). Toxicol. Appl. Pharmacol. 83 (1986) 79-85
    • (1986) Toxicol. Appl. Pharmacol. , vol.83 , pp. 79-85
    • Coulombe Jr., R.A.1    Sharma, R.P.2
  • 8
    • 0018099290 scopus 로고
    • Catecholamine innervation of the basal forebrain. IV. Topography of the dopamine projection to the basal forebrain and neostriatum
    • Fallon J.H., and Moore R.Y. Catecholamine innervation of the basal forebrain. IV. Topography of the dopamine projection to the basal forebrain and neostriatum. J. Comp. Neurol. 180 (1978) 545-580
    • (1978) J. Comp. Neurol. , vol.180 , pp. 545-580
    • Fallon, J.H.1    Moore, R.Y.2
  • 9
    • 0008058142 scopus 로고
    • Food additives permitted for direct addition to food for human consumption
    • FDA. Food additives permitted for direct addition to food for human consumption. Fed. Regist. 49 (1984) 6672-6682
    • (1984) Fed. Regist. , vol.49 , pp. 6672-6682
    • FDA1
  • 10
    • 0020527328 scopus 로고
    • Acute effects of aspartame on large neutral amino acids and monoamines in rat brain
    • Fernstrom J.D., Fernstrom M.H., and Gillis M.A. Acute effects of aspartame on large neutral amino acids and monoamines in rat brain. Life Sciences 32 (1983) 1651-1658
    • (1983) Life Sciences , vol.32 , pp. 1651-1658
    • Fernstrom, J.D.1    Fernstrom, M.H.2    Gillis, M.A.3
  • 11
    • 0024595813 scopus 로고
    • Oral aspartame and plasma phenylalanine: pharmacokinetic difference between rodents and man, and relevance to CNS effects of phenylalanine
    • Fernstrom J.D. Oral aspartame and plasma phenylalanine: pharmacokinetic difference between rodents and man, and relevance to CNS effects of phenylalanine. J. Neural Transm. 75 (1989) 159-164
    • (1989) J. Neural Transm. , vol.75 , pp. 159-164
    • Fernstrom, J.D.1
  • 12
    • 0025066434 scopus 로고
    • Acute effects of aspartame on concentrations of brain amines and their metabolites in selected brain regions of fischer 344 and sprague-dawley rats
    • Freeman G., Sobotka T., and Hattan D. Acute effects of aspartame on concentrations of brain amines and their metabolites in selected brain regions of fischer 344 and sprague-dawley rats. Drug Chem. Toxicol. 13 (1990) 113-133
    • (1990) Drug Chem. Toxicol. , vol.13 , pp. 113-133
    • Freeman, G.1    Sobotka, T.2    Hattan, D.3
  • 13
    • 0028300117 scopus 로고
    • Heterogeneity of evoked dopamine overflow within the striatal and striatoamygdaloid regions
    • Garris P.A., Ciolkowski E.L., and Wightman R.M. Heterogeneity of evoked dopamine overflow within the striatal and striatoamygdaloid regions. Neuroscience 59 (1994) 417-427
    • (1994) Neuroscience , vol.59 , pp. 417-427
    • Garris, P.A.1    Ciolkowski, E.L.2    Wightman, R.M.3
  • 14
    • 0037010807 scopus 로고    scopus 로고
    • Modeling fast dopamine neurotransmission in the nucleus accumbens during behavior
    • Garris P.A., and Rebec G.V. Modeling fast dopamine neurotransmission in the nucleus accumbens during behavior. Behav. Brain Res. 137 (2002) 47-63
    • (2002) Behav. Brain Res. , vol.137 , pp. 47-63
    • Garris, P.A.1    Rebec, G.V.2
  • 15
    • 0028144402 scopus 로고
    • Different kinetics govern dopaminergic transmission in the amygdala, prefrontal cortex, and striatum: an in vivo voltammetric study
    • Garris P.A., and Wightman R.M. Different kinetics govern dopaminergic transmission in the amygdala, prefrontal cortex, and striatum: an in vivo voltammetric study. J. Neurosci. 14 (1994) 442-450
    • (1994) J. Neurosci. , vol.14 , pp. 442-450
    • Garris, P.A.1    Wightman, R.M.2
  • 16
    • 0023481972 scopus 로고
    • The neostriatal mosaic: II. Patch- and matrix-directed mesostriatal dopaminergic and non-dopaminergic systems
    • Gerfen C.R., Herkenham M., and Thibault J. The neostriatal mosaic: II. Patch- and matrix-directed mesostriatal dopaminergic and non-dopaminergic systems. J. Neurosci. 7 (1987) 3915-3934
    • (1987) J. Neurosci. , vol.7 , pp. 3915-3934
    • Gerfen, C.R.1    Herkenham, M.2    Thibault, J.3
  • 17
    • 0034604525 scopus 로고    scopus 로고
    • Acute effects of aspartame on aggression and neurochemistry of rats
    • Goerss A.L., Wagner G.C., and Hill W.L. Acute effects of aspartame on aggression and neurochemistry of rats. Life Sci. 67 (2000) 1325-1329
    • (2000) Life Sci. , vol.67 , pp. 1325-1329
    • Goerss, A.L.1    Wagner, G.C.2    Hill, W.L.3
  • 18
    • 0033842481 scopus 로고    scopus 로고
    • The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving
    • Grace A.A. The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving. Addiction 95 suppl. 2 (2000) S119-S128
    • (2000) Addiction , vol.95 , Issue.SUPPL. 2
    • Grace, A.A.1
  • 19
    • 0021920211 scopus 로고
    • Partial lesions of the nigrostriatal pathway in the rat. Acceleration of transmitter synthesis and release of surviving dopaminergic neurones by drugs
    • Hefti F., Enz A., and Melamed E. Partial lesions of the nigrostriatal pathway in the rat. Acceleration of transmitter synthesis and release of surviving dopaminergic neurones by drugs. Neuropharmacology 24 (1985) 19-23
    • (1985) Neuropharmacology , vol.24 , pp. 19-23
    • Hefti, F.1    Enz, A.2    Melamed, E.3
  • 20
    • 0022342966 scopus 로고
    • Differences between the release of radiolabelled and endogenous dopamine from superfused rat brain slices: effects of depolarizing stimuli, amphetamine and synthesis inhibition
    • Herdon H., Strupish J., and Nahorski S.R. Differences between the release of radiolabelled and endogenous dopamine from superfused rat brain slices: effects of depolarizing stimuli, amphetamine and synthesis inhibition. Brain Res. 348 (1985) 309-320
    • (1985) Brain Res. , vol.348 , pp. 309-320
    • Herdon, H.1    Strupish, J.2    Nahorski, S.R.3
  • 22
    • 0014083681 scopus 로고
    • Phenylalanine as substrate and inhibitor of tyrosine hydroxylase
    • Ikeda M., Levitt M., and Udenfriend S. Phenylalanine as substrate and inhibitor of tyrosine hydroxylase. Arch. Biochem. Biophys. 120 (1967) 420-427
    • (1967) Arch. Biochem. Biophys. , vol.120 , pp. 420-427
    • Ikeda, M.1    Levitt, M.2    Udenfriend, S.3
  • 23
    • 0027413103 scopus 로고
    • Aspartame use in Parkinson's disease
    • Karstaedt P.J., and Pincus J.H. Aspartame use in Parkinson's disease. Neurology 43 (1993) 611-613
    • (1993) Neurology , vol.43 , pp. 611-613
    • Karstaedt, P.J.1    Pincus, J.H.2
  • 24
    • 0026458521 scopus 로고
    • Regulation of transient dopamine concentration gradients in the microenvironment surrounding nerve terminals in the rat striatum
    • Kawagoe K.T., Garris P.A., Wiedemann D.J., and Wightman R.M. Regulation of transient dopamine concentration gradients in the microenvironment surrounding nerve terminals in the rat striatum. Neuroscience 51 (1992) 55-64
    • (1992) Neuroscience , vol.51 , pp. 55-64
    • Kawagoe, K.T.1    Garris, P.A.2    Wiedemann, D.J.3    Wightman, R.M.4
  • 25
    • 0022568852 scopus 로고
    • Acute effects of aspartame on systolic blood pressure in spontaneously hypertensive rats
    • Kiritsy P.J., and Maher T.J. Acute effects of aspartame on systolic blood pressure in spontaneously hypertensive rats. J. Neural Transm. 66 (1986) 121-128
    • (1986) J. Neural Transm. , vol.66 , pp. 121-128
    • Kiritsy, P.J.1    Maher, T.J.2
  • 26
    • 0025755805 scopus 로고
    • Effect of aspartame-derived phenylalanine on neutral amino acid uptake in human brain: a positron emission tomography study
    • Koeppe R.A., Shulkin B.L., Rosenspire K.C., Shaw L.A., Betz A.L., Mangner T., Price J.C., and Agranoff B.W. Effect of aspartame-derived phenylalanine on neutral amino acid uptake in human brain: a positron emission tomography study. J. Neurochem. 56 (1991) 1526-1535
    • (1991) J. Neurochem. , vol.56 , pp. 1526-1535
    • Koeppe, R.A.1    Shulkin, B.L.2    Rosenspire, K.C.3    Shaw, L.A.4    Betz, A.L.5    Mangner, T.6    Price, J.C.7    Agranoff, B.W.8
  • 27
    • 0022454066 scopus 로고
    • In vivo comparison of the regulation of releasable dopamine in the caudate nucleus and the nucleus accumbens of the rat brain
    • Kuhr W.G., Bigelow J.C., and Wightman R.M. In vivo comparison of the regulation of releasable dopamine in the caudate nucleus and the nucleus accumbens of the rat brain. J. Neurosci. 6 (1986) 974-982
    • (1986) J. Neurosci. , vol.6 , pp. 974-982
    • Kuhr, W.G.1    Bigelow, J.C.2    Wightman, R.M.3
  • 28
    • 0026705246 scopus 로고
    • Effect of dietary aspartame on plasma concentrations of phenylalanine and tyrosine in normal and homozygous phenylketonuric patients
    • Mackey S.A., and Berlin C.M. Effect of dietary aspartame on plasma concentrations of phenylalanine and tyrosine in normal and homozygous phenylketonuric patients. Clin. Pediatr. 31 7 (1992) 394-399
    • (1992) Clin. Pediatr. , vol.31 , Issue.7 , pp. 394-399
    • Mackey, S.A.1    Berlin, C.M.2
  • 29
    • 24944491512 scopus 로고
    • Absorption of peptides, amino acids and their methylated derivatives
    • Stegink L.D., and Filer Jr. L.J. (Eds), Marcel Dekker, New York
    • Matthews D.M. Absorption of peptides, amino acids and their methylated derivatives. In: Stegink L.D., and Filer Jr. L.J. (Eds). Aspartame: Physiology and Biochemistry (1984), Marcel Dekker, New York 29-46
    • (1984) Aspartame: Physiology and Biochemistry , pp. 29-46
    • Matthews, D.M.1
  • 30
    • 0023612687 scopus 로고
    • Possible neurologic effects of aspartame, a widely used food additive
    • Maher T.J., and Wurtman R.J. Possible neurologic effects of aspartame, a widely used food additive. Environ. Health Perspect. 75 (1987) 53-57
    • (1987) Environ. Health Perspect. , vol.75 , pp. 53-57
    • Maher, T.J.1    Wurtman, R.J.2
  • 31
    • 0019314187 scopus 로고
    • Functional and pharmacological significance of brain dopamine and norepinephrine storage pools
    • McMillen B.A., German D.C., and Shore P.A. Functional and pharmacological significance of brain dopamine and norepinephrine storage pools. Biochem. Pharmacol. 29 (1980) 3045-3050
    • (1980) Biochem. Pharmacol. , vol.29 , pp. 3045-3050
    • McMillen, B.A.1    German, D.C.2    Shore, P.A.3
  • 32
    • 0032161884 scopus 로고    scopus 로고
    • Color images for fast-scan CV measurements in biological systems
    • Michael D., Travis E.R., and Wightman R.M. Color images for fast-scan CV measurements in biological systems. Anal. Chem. 70 (1998) 586A-592A
    • (1998) Anal. Chem. , vol.70
    • Michael, D.1    Travis, E.R.2    Wightman, R.M.3
  • 38
    • 0025284644 scopus 로고
    • Plasma and brain kinetics of large neutral amino acids and of striatum monoamines in rats given aspartame
    • Romano M., Diomede L., Guiso G., Caccia S., Perego C., and Salmona M. Plasma and brain kinetics of large neutral amino acids and of striatum monoamines in rats given aspartame. Food Chem. Toxicol. 28 (1990) 317-321
    • (1990) Food Chem. Toxicol. , vol.28 , pp. 317-321
    • Romano, M.1    Diomede, L.2    Guiso, G.3    Caccia, S.4    Perego, C.5    Salmona, M.6
  • 39
    • 0031867046 scopus 로고    scopus 로고
    • Predictive reward signal of dopamine neurons
    • Schultz W. Predictive reward signal of dopamine neurons. J. Neurophysiol. 80 (1998) 1-27
    • (1998) J. Neurophysiol. , vol.80 , pp. 1-27
    • Schultz, W.1
  • 40
    • 0023389017 scopus 로고
    • Effects of repeated doses of aspartame on serotonin and its metabolite in various regions of the mouse brain
    • Sharma R.P., and Coulombe Jr. R.A. Effects of repeated doses of aspartame on serotonin and its metabolite in various regions of the mouse brain. Food Chem. Toxicol. 25 (1987) 565-568
    • (1987) Food Chem. Toxicol. , vol.25 , pp. 565-568
    • Sharma, R.P.1    Coulombe Jr., R.A.2
  • 41
    • 0023634699 scopus 로고
    • Kinetics of neutral amino acid transport across the blood brain barrier
    • Smith Q.R., Momma S., Aoyagi M., and Rapoport S.I. Kinetics of neutral amino acid transport across the blood brain barrier. J. Neurochem. 49 (1987) 1651-1658
    • (1987) J. Neurochem. , vol.49 , pp. 1651-1658
    • Smith, Q.R.1    Momma, S.2    Aoyagi, M.3    Rapoport, S.I.4
  • 42
    • 0022602592 scopus 로고
    • Dietary aspartame with protein on plasma and brain amino acids, brain monoamine and behavior in rats
    • Torii K., Mimura T., Takasaki Y., and Ichimura M. Dietary aspartame with protein on plasma and brain amino acids, brain monoamine and behavior in rats. Physiol. Behav. 36 (1986) 765-771
    • (1986) Physiol. Behav. , vol.36 , pp. 765-771
    • Torii, K.1    Mimura, T.2    Takasaki, Y.3    Ichimura, M.4
  • 43
    • 0242665791 scopus 로고    scopus 로고
    • Real-time decoding of dopamine concentration changes in the caudate-putamen during tonic and phasic firing
    • Venton B.J., Zhang H., Garris P.A., Phillips P.E.M., Sulzer D., and Wightman R.M. Real-time decoding of dopamine concentration changes in the caudate-putamen during tonic and phasic firing. J. Neurochem. 87 (2003) 1284-1295
    • (2003) J. Neurochem. , vol.87 , pp. 1284-1295
    • Venton, B.J.1    Zhang, H.2    Garris, P.A.3    Phillips, P.E.M.4    Sulzer, D.5    Wightman, R.M.6
  • 45
    • 0024311918 scopus 로고
    • Tyrosine hydroxylase content of residual striatal dopamine nerve terminals following 6-hydroxydopamine administration: a flow cytometric study
    • Wolf M.E., Zigmond M.J., and Kapatos G. Tyrosine hydroxylase content of residual striatal dopamine nerve terminals following 6-hydroxydopamine administration: a flow cytometric study. J. Neurochem. 53 (1989) 879-885
    • (1989) J. Neurochem. , vol.53 , pp. 879-885
    • Wolf, M.E.1    Zigmond, M.J.2    Kapatos, G.3
  • 46
    • 0035882478 scopus 로고    scopus 로고
    • Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission
    • Wu Q., Reith M.E., Kuhar M.J., Carroll F.I., and Garris P.A. Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission. J. Neurosci. 21 (2001) 6338-6347
    • (2001) J. Neurosci. , vol.21 , pp. 6338-6347
    • Wu, Q.1    Reith, M.E.2    Kuhar, M.J.3    Carroll, F.I.4    Garris, P.A.5
  • 47
    • 0035892584 scopus 로고    scopus 로고
    • Determination of release and uptake parameters from electrically evoked dopamine dynamics measured by real-time voltammetry
    • Wu Q., Reith M.E., Wightman R.M., Kawagoe K.T., and Garris P.A. Determination of release and uptake parameters from electrically evoked dopamine dynamics measured by real-time voltammetry. J. Neurosci. Methods 112 (2001) 119-133
    • (2001) J. Neurosci. Methods , vol.112 , pp. 119-133
    • Wu, Q.1    Reith, M.E.2    Wightman, R.M.3    Kawagoe, K.T.4    Garris, P.A.5
  • 48
    • 0020578205 scopus 로고
    • Neurochemical changes following high-dose aspartame with dietary carbohydrates
    • Wurtman R.J. Neurochemical changes following high-dose aspartame with dietary carbohydrates. N. Engl. J. Med. 309 (1983) 429-430
    • (1983) N. Engl. J. Med. , vol.309 , pp. 429-430
    • Wurtman, R.J.1
  • 49
    • 0023281032 scopus 로고
    • Effects of oral aspartame on plasma phenylalanine in humans and experimental rodents
    • Wurtman R.J., and Maher T.J. Effects of oral aspartame on plasma phenylalanine in humans and experimental rodents. J. Neural Transm. 70 (1987) 169-173
    • (1987) J. Neural Transm. , vol.70 , pp. 169-173
    • Wurtman, R.J.1    Maher, T.J.2
  • 50
    • 0022642444 scopus 로고
    • Acute effects of oral or parenteral aspartame on catecholamine metabolism in various regions of rat brain
    • Yokogoshi H., and Wurtman R.J. Acute effects of oral or parenteral aspartame on catecholamine metabolism in various regions of rat brain. J. Nutr. 116 (1986) 356-364
    • (1986) J. Nutr. , vol.116 , pp. 356-364
    • Yokogoshi, H.1    Wurtman, R.J.2
  • 51
    • 0021235482 scopus 로고
    • Neurochemical compensation after nigrostriatal bundle injury in an animal model of preclinical parkinsonism
    • Zigmond M.J., Acheson A.L., Stachowiak M.K., and Stricker E.M. Neurochemical compensation after nigrostriatal bundle injury in an animal model of preclinical parkinsonism. Arch. Neurol. 41 (1984) 856-861
    • (1984) Arch. Neurol. , vol.41 , pp. 856-861
    • Zigmond, M.J.1    Acheson, A.L.2    Stachowiak, M.K.3    Stricker, E.M.4


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