메뉴 건너뛰기




Volumn 92, Issue 5, 2011, Pages 366-376

Intestinal epithelium is more susceptible to cytopathic injury and altered permeability than the lung epithelium in the context of acute sepsis

Author keywords

Acute lung injury; Feline; Mitochondria; Multiple organ failure; Sepsis syndrome

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 80052840292     PISSN: 09599673     EISSN: 13652613     Source Type: Journal    
DOI: 10.1111/j.1365-2613.2011.00783.x     Document Type: Article
Times cited : (14)

References (62)
  • 1
    • 0026736486 scopus 로고
    • Human whole blood interleukin-1-b production: kinetics, cell source, and comparison with TNF-a
    • Allen J.N., Herzyk D.J., Allen E.D., Wewers M.D. (1992) Human whole blood interleukin-1-b production: kinetics, cell source, and comparison with TNF-a. J. Lab. Clin. Med. 119, 538-546.
    • (1992) J. Lab. Clin. Med. , vol.119 , pp. 538-546
    • Allen, J.N.1    Herzyk, D.J.2    Allen, E.D.3    Wewers, M.D.4
  • 2
    • 0343893748 scopus 로고    scopus 로고
    • Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network
    • ARDSnetwork
    • ARDSnetwork. (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N. Engl. J. Med. 342, 1301-1308.
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1301-1308
  • 3
    • 33845415089 scopus 로고    scopus 로고
    • Zinc modulates cytokine-induced lung epithelial cell barrier permeability
    • Bao S. and Knoell D.L. (2006) Zinc modulates cytokine-induced lung epithelial cell barrier permeability. Am. J. Physiol. Lung Cell. Mol. Physiol. 291, L1132-L1141.
    • (2006) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.291
    • Bao, S.1    Knoell, D.L.2
  • 4
    • 34447294235 scopus 로고    scopus 로고
    • The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor
    • Bastarache J.A., Wang L., Geiser T. et al. (2007) The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Thorax 62, 608-616.
    • (2007) Thorax , vol.62 , pp. 608-616
    • Bastarache, J.A.1    Wang, L.2    Geiser, T.3
  • 5
    • 36248959309 scopus 로고    scopus 로고
    • Alveolar edema fluid clearance and acute lung injury
    • Berthiaume Y. and Matthay M.A. (2007) Alveolar edema fluid clearance and acute lung injury. Respir. Physiol. Neurobiol. 159, 350-359.
    • (2007) Respir. Physiol. Neurobiol. , vol.159 , pp. 350-359
    • Berthiaume, Y.1    Matthay, M.A.2
  • 6
    • 1042291171 scopus 로고    scopus 로고
    • Actin re-distribution in response to hydrogen peroxide in airway epithelial cells
    • Boardman K.C., Aryal A.M., Miller W.M., Waters C.M. (2004) Actin re-distribution in response to hydrogen peroxide in airway epithelial cells. J. Cell. Physiol. 199, 57-66.
    • (2004) J. Cell. Physiol. , vol.199 , pp. 57-66
    • Boardman, K.C.1    Aryal, A.M.2    Miller, W.M.3    Waters, C.M.4
  • 7
    • 0037142987 scopus 로고    scopus 로고
    • Association between mitochondrial dysfunction and severity and outcome of septic shock
    • Brealey D., Brand M., Hargreaves I. et al. (2002) Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 360, 219-223.
    • (2002) Lancet , vol.360 , pp. 219-223
    • Brealey, D.1    Brand, M.2    Hargreaves, I.3
  • 8
    • 0034886320 scopus 로고    scopus 로고
    • Chronic ethanol ingestion potentiates TNF-α-mediated oxidative stress and apoptosis in rat type II cells
    • Brown L.A., Harris F.L., Guidot D.M. (2001) Chronic ethanol ingestion potentiates TNF-α-mediated oxidative stress and apoptosis in rat type II cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 281, L377-L386.
    • (2001) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.281
    • Brown, L.A.1    Harris, F.L.2    Guidot, D.M.3
  • 9
    • 0030910766 scopus 로고    scopus 로고
    • Endogenous nitric oxide limits cytokine-induced damage of murine lung epithelial cells
    • Burke-Gaffney A. and Hellewell P.G. (1997) Endogenous nitric oxide limits cytokine-induced damage of murine lung epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 272, L707-L713.
    • (1997) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.272
    • Burke-Gaffney, A.1    Hellewell, P.G.2
  • 10
    • 0031923418 scopus 로고    scopus 로고
    • Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons
    • Carraway M.S., Welty-Wolf K.E., Kantrow S.P. et al. (1998) Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons. Am. J. Respir. Crit. Care Med. 157, 938-949.
    • (1998) Am. J. Respir. Crit. Care Med. , vol.157 , pp. 938-949
    • Carraway, M.S.1    Welty-Wolf, K.E.2    Kantrow, S.P.3
  • 11
    • 28044462916 scopus 로고    scopus 로고
    • Functional and morphological changes of the gut barrier during the restitution process after hemorrhagic shock
    • Chang J.X., Chen S., Ma L.P. et al. (2005) Functional and morphological changes of the gut barrier during the restitution process after hemorrhagic shock. World J. Gastroenterol. 11, 5485-5491.
    • (2005) World J. Gastroenterol. , vol.11 , pp. 5485-5491
    • Chang, J.X.1    Chen, S.2    Ma, L.P.3
  • 12
    • 0037012470 scopus 로고    scopus 로고
    • Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis
    • Coopersmith C.M., Stromberg P.E., Dunne W.M. et al. (2002) Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis. JAMA 287, 1716-1721.
    • (2002) JAMA , vol.287 , pp. 1716-1721
    • Coopersmith, C.M.1    Stromberg, P.E.2    Dunne, W.M.3
  • 13
    • 0036006793 scopus 로고    scopus 로고
    • Opposing effect by cytokines on Fas-mediated apoptosis in A549 lung epithelial cells
    • Coulter K.R., Doseff A., Sweeney P. et al. (2002) Opposing effect by cytokines on Fas-mediated apoptosis in A549 lung epithelial cells. Am. J. Respir. Cell Mol. Biol. 26, 58-66.
    • (2002) Am. J. Respir. Cell Mol. Biol. , vol.26 , pp. 58-66
    • Coulter, K.R.1    Doseff, A.2    Sweeney, P.3
  • 14
    • 0018351181 scopus 로고
    • The subcellular pathology of shock in trauma patients: studies using the immediate autopsy
    • Cowley R.A., Mergner W.J., Fisher R.S., Jones R.T., Trump B.F. (1979) The subcellular pathology of shock in trauma patients: studies using the immediate autopsy. Am. Surg. 45, 255-269.
    • (1979) Am. Surg. , vol.45 , pp. 255-269
    • Cowley, R.A.1    Mergner, W.J.2    Fisher, R.S.3    Jones, R.T.4    Trump, B.F.5
  • 16
    • 0036174522 scopus 로고    scopus 로고
    • Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity
    • Crouser E.D., Julian M.W., Blaho D.V., Pfeiffer D.R. (2002a) Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity. Crit. Care Med. 30, 276-284.
    • (2002) Crit. Care Med. , vol.30 , pp. 276-284
    • Crouser, E.D.1    Julian, M.W.2    Blaho, D.V.3    Pfeiffer, D.R.4
  • 17
    • 0036885023 scopus 로고    scopus 로고
    • Cyclosporin A ameliorates mitochondrial ultrastructural injury in the ileum during acute endotoxemia
    • Crouser E.D., Julian M.W., Joshi M.S. et al. (2002b) Cyclosporin A ameliorates mitochondrial ultrastructural injury in the ileum during acute endotoxemia. Crit. Care Med. 30, 2722-2728.
    • (2002) Crit. Care Med. , vol.30 , pp. 2722-2728
    • Crouser, E.D.1    Julian, M.W.2    Joshi, M.S.3
  • 18
    • 0020658389 scopus 로고
    • The risk factors, incidence and prognosis of ARDS following septicemia
    • Fein A.M., Lippmann M., Holtzman H., Eliraz A., Goldberg S.K. (1983) The risk factors, incidence and prognosis of ARDS following septicemia. Chest 83, 40-42.
    • (1983) Chest , vol.83 , pp. 40-42
    • Fein, A.M.1    Lippmann, M.2    Holtzman, H.3    Eliraz, A.4    Goldberg, S.K.5
  • 19
    • 15244341423 scopus 로고    scopus 로고
    • Epithelial barrier dysfunction: a unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level
    • Fink M.P. and Delude R.L. (2005) Epithelial barrier dysfunction: a unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level. Crit. Care Clin. 21, 177-196.
    • (2005) Crit. Care Clin. , vol.21 , pp. 177-196
    • Fink, M.P.1    Delude, R.L.2
  • 22
    • 1642582148 scopus 로고    scopus 로고
    • Increased iNOS activity is essential for pulmonary epithelial tight junction dysfunction in endotoxemic mice
    • Han X., Fink M.P., Uchiyama T., Yang R., Delude R.L. (2004) Increased iNOS activity is essential for pulmonary epithelial tight junction dysfunction in endotoxemic mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 286, L259-L267.
    • (2004) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.286
    • Han, X.1    Fink, M.P.2    Uchiyama, T.3    Yang, R.4    Delude, R.L.5
  • 23
    • 0025214103 scopus 로고
    • Histologic and ultrastructural changes in nonpulmonary organs during early hyperdynamic sepsis
    • Hersch M., Gnidec A.A., Bersten A.D., Troster M., Rutledge F.S., Sibbald W.J. (1990) Histologic and ultrastructural changes in nonpulmonary organs during early hyperdynamic sepsis. Surgery 107, 397-410.
    • (1990) Surgery , vol.107 , pp. 397-410
    • Hersch, M.1    Gnidec, A.A.2    Bersten, A.D.3    Troster, M.4    Rutledge, F.S.5    Sibbald, W.J.6
  • 24
    • 0032770246 scopus 로고    scopus 로고
    • Apoptotic cell death in patients with sepsis, shock and multiple organ dysfunction
    • Hotchkiss R.S., Swanson P.E., Freeman B.D. et al. (1999) Apoptotic cell death in patients with sepsis, shock and multiple organ dysfunction. Crit. Care Med. 27, 1230-1251.
    • (1999) Crit. Care Med. , vol.27 , pp. 1230-1251
    • Hotchkiss, R.S.1    Swanson, P.E.2    Freeman, B.D.3
  • 25
    • 84860709016 scopus 로고    scopus 로고
    • Quantitative analysis of mitochondrial membrane potential measurements with JC-1
    • Huang M., Camara A.K., Stowe D.F., Qi F., Beard D.A. (2007) Quantitative analysis of mitochondrial membrane potential measurements with JC-1. FASEB J. 21, 946.
    • (2007) FASEB J. , vol.21 , pp. 946
    • Huang, M.1    Camara, A.K.2    Stowe, D.F.3    Qi, F.4    Beard, D.A.5
  • 26
    • 0037384023 scopus 로고    scopus 로고
    • Role of intestinal epithelial apoptosis in survival
    • Husain K.D. and Coopersmith C.M. (2003) Role of intestinal epithelial apoptosis in survival. Curr. Opin. Crit. Care 9, 159-163.
    • (2003) Curr. Opin. Crit. Care , vol.9 , pp. 159-163
    • Husain, K.D.1    Coopersmith, C.M.2
  • 28
    • 0034485383 scopus 로고    scopus 로고
    • Digital imaging analysis for the study of endotoxin-induced mitochondrial ultrastructure injury
    • Joshi M.S., Crouser E.D., Julian M.W., Schanbacher B.L., Bauer J.A. (2000) Digital imaging analysis for the study of endotoxin-induced mitochondrial ultrastructure injury. Anal. Cell. Pathol. 21, 41-48.
    • (2000) Anal. Cell. Pathol. , vol.21 , pp. 41-48
    • Joshi, M.S.1    Crouser, E.D.2    Julian, M.W.3    Schanbacher, B.L.4    Bauer, J.A.5
  • 30
    • 2142823694 scopus 로고    scopus 로고
    • Reducing atelectasis attenuates bacterial growth and translocation in experimental pneumonia
    • van Kaam A.H., Lachmann R.A., Herting E. et al. (2004) Reducing atelectasis attenuates bacterial growth and translocation in experimental pneumonia. Am. J. Respir. Crit. Care Med. 169, 1046-1053.
    • (2004) Am. J. Respir. Crit. Care Med. , vol.169 , pp. 1046-1053
    • van Kaam, A.H.1    Lachmann, R.A.2    Herting, E.3
  • 31
    • 67650507043 scopus 로고    scopus 로고
    • Zinc-deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis
    • Knoell D.L., Julian M.W., Bao S. et al. (2009) Zinc-deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis. Crit. Care Med. 37, 1380-1388.
    • (2009) Crit. Care Med. , vol.37 , pp. 1380-1388
    • Knoell, D.L.1    Julian, M.W.2    Bao, S.3
  • 32
    • 0034777484 scopus 로고    scopus 로고
    • Acidosis promotes the permeability transition in energized mitochondria: implications for reperfusion injury
    • Kristian T., Bernardi P., Siesjo B.K. (2001) Acidosis promotes the permeability transition in energized mitochondria: implications for reperfusion injury. J. Neurotrauma 18, 1059-1074.
    • (2001) J. Neurotrauma , vol.18 , pp. 1059-1074
    • Kristian, T.1    Bernardi, P.2    Siesjo, B.K.3
  • 33
    • 0033958436 scopus 로고    scopus 로고
    • Attenuation of intestinal ischemia/reperfusion injury with sodium nitroprusside: studies on mitochondrial function and lipid changes
    • Madesh M., Ramachandran A., Pulimood A., Vadranam M., Balasubramanian K.A. (2000) Attenuation of intestinal ischemia/reperfusion injury with sodium nitroprusside: studies on mitochondrial function and lipid changes. Biochim. Biophys. Acta 1500, 204-216.
    • (2000) Biochim. Biophys. Acta , vol.1500 , pp. 204-216
    • Madesh, M.1    Ramachandran, A.2    Pulimood, A.3    Vadranam, M.4    Balasubramanian, K.A.5
  • 34
    • 0028786481 scopus 로고
    • The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications
    • Meunier V., Bourrie M., Berger Y., Fabre G. (1995) The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications. Cell Biol. Toxicol. 11, 187-194.
    • (1995) Cell Biol. Toxicol. , vol.11 , pp. 187-194
    • Meunier, V.1    Bourrie, M.2    Berger, Y.3    Fabre, G.4
  • 35
    • 0030046074 scopus 로고    scopus 로고
    • The role of chronic alcohol abuse in the development of acute respiratory distress syndrome in adults
    • Moss M., Bucher B., Moore F.A., Moore E.E., Parsons P.E. (1996) The role of chronic alcohol abuse in the development of acute respiratory distress syndrome in adults. JAMA 275, 50-54.
    • (1996) JAMA , vol.275 , pp. 50-54
    • Moss, M.1    Bucher, B.2    Moore, F.A.3    Moore, E.E.4    Parsons, P.E.5
  • 37
    • 0032863001 scopus 로고    scopus 로고
    • Impact of immunomodulating therapy on morbidity in patients with severe sepsis
    • Pittet D., Harbarth S., Suter P.M. et al. (1999) Impact of immunomodulating therapy on morbidity in patients with severe sepsis. Am. J. Respir. Crit. Care Med. 160, 852-857.
    • (1999) Am. J. Respir. Crit. Care Med. , vol.160 , pp. 852-857
    • Pittet, D.1    Harbarth, S.2    Suter, P.M.3
  • 38
    • 0025830873 scopus 로고
    • J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential
    • Reers M., Smith T.W., Chen L.B. (1991) J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential. Biochemistry 30, 4480-4486.
    • (1991) Biochemistry , vol.30 , pp. 4480-4486
    • Reers, M.1    Smith, T.W.2    Chen, L.B.3
  • 39
    • 0033756118 scopus 로고    scopus 로고
    • Impacts and patterns of disturbed gastrointestinal function in critically ill patients
    • Ritz M., Fraser R., Tam W., Dent J. (2000) Impacts and patterns of disturbed gastrointestinal function in critically ill patients. Am. J. Gastroenterol. 95, 3044-3052.
    • (2000) Am. J. Gastroenterol. , vol.95 , pp. 3044-3052
    • Ritz, M.1    Fraser, R.2    Tam, W.3    Dent, J.4
  • 40
    • 0028227589 scopus 로고
    • Inducible nitric oxide synthase is increased in murine lung epithelial cells by cytokine stimulation
    • Robbins R.A., Springall D.R., Warren J.B. et al. (1994) Inducible nitric oxide synthase is increased in murine lung epithelial cells by cytokine stimulation. Biochem. Biophys. Res. Commun. 198, 835-843.
    • (1994) Biochem. Biophys. Res. Commun. , vol.198 , pp. 835-843
    • Robbins, R.A.1    Springall, D.R.2    Warren, J.B.3
  • 41
    • 20044371666 scopus 로고    scopus 로고
    • The Caco-2 cell line as a model of the intestinal barrier: influence of cell culture and culture-related factors on Caco-2 cell functional characteristics
    • Sambuy Y., De Angelis I., Ranaldi G., Scarino M.L., Stammati A., Zucco F. (2005) The Caco-2 cell line as a model of the intestinal barrier: influence of cell culture and culture-related factors on Caco-2 cell functional characteristics. Cell Biol. Toxicol. 21, 1-26.
    • (2005) Cell Biol. Toxicol. , vol.21 , pp. 1-26
    • Sambuy, Y.1    De Angelis, I.2    Ranaldi, G.3    Scarino, M.L.4    Stammati, A.5    Zucco, F.6
  • 42
    • 14844295769 scopus 로고    scopus 로고
    • Mitochondrial dysfunction occurs before transport of tight junction deficits in biliary epithelial cells exposed to bile from methylenedianiline-treated rats
    • Santa Cruz V., Dugas T.R., Kanz M.F. (2005) Mitochondrial dysfunction occurs before transport of tight junction deficits in biliary epithelial cells exposed to bile from methylenedianiline-treated rats. Toxicol. Sci. 84, 129-138.
    • (2005) Toxicol. Sci. , vol.84 , pp. 129-138
    • Santa Cruz, V.1    Dugas, T.R.2    Kanz, M.F.3
  • 43
    • 0026453362 scopus 로고
    • Hyperdynamic sepsis in baboons: II. Relation of organ damage to severity of sepsis evaluated by a newly developed morphological scoring system
    • Schlag G., Redl H., van Vuuren C.J., Davies J. (1992) Hyperdynamic sepsis in baboons: II. Relation of organ damage to severity of sepsis evaluated by a newly developed morphological scoring system. Circ. Shock 38, 253-263.
    • (1992) Circ. Shock , vol.38 , pp. 253-263
    • Schlag, G.1    Redl, H.2    van Vuuren, C.J.3    Davies, J.4
  • 44
    • 32344446760 scopus 로고    scopus 로고
    • Role of Caco-2 cell monolayers in prediction of intestinal drug absorption
    • Shah P., Jogani V., Bagchi T., Misra A. (2006) Role of Caco-2 cell monolayers in prediction of intestinal drug absorption. Biotechnol. Prog. 22, 186-198.
    • (2006) Biotechnol. Prog. , vol.22 , pp. 186-198
    • Shah, P.1    Jogani, V.2    Bagchi, T.3    Misra, A.4
  • 45
    • 0029870085 scopus 로고    scopus 로고
    • Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid
    • Smith J.J., Travis S.M., Greenberg E.P., Welsh M.J. (1996) Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 85, 229-236.
    • (1996) Cell , vol.85 , pp. 229-236
    • Smith, J.J.1    Travis, S.M.2    Greenberg, E.P.3    Welsh, M.J.4
  • 46
    • 0035053279 scopus 로고    scopus 로고
    • Inhibition of Na+, K+-ATPase by interferon gamma down-regulates intestinal epithelial transport and barrier function
    • Sugi K., Musch M.W., Field M., Chang E.B. (2001) Inhibition of Na+, K+-ATPase by interferon gamma down-regulates intestinal epithelial transport and barrier function. Gastroenterology 120, 1393-1403.
    • (2001) Gastroenterology , vol.120 , pp. 1393-1403
    • Sugi, K.1    Musch, M.W.2    Field, M.3    Chang, E.B.4
  • 47
    • 0032162008 scopus 로고    scopus 로고
    • The influence of intestinal ischemia and reperfusion on bidirectional intestinal barrier permeability, membrane integrity, proteinase inhibitors, and cell death in rats
    • Sun Z., Wang X., Deng X. et al. (1998) The influence of intestinal ischemia and reperfusion on bidirectional intestinal barrier permeability, membrane integrity, proteinase inhibitors, and cell death in rats. Shock 10, 203-212.
    • (1998) Shock , vol.10 , pp. 203-212
    • Sun, Z.1    Wang, X.2    Deng, X.3
  • 48
    • 0029935286 scopus 로고    scopus 로고
    • Role of the gut in multiple organ failure: bacterial translocation and permeability changes
    • Swank G.M. and Deitch E.A. (1996) Role of the gut in multiple organ failure: bacterial translocation and permeability changes. World J. Surg. 20, 411-417.
    • (1996) World J. Surg. , vol.20 , pp. 411-417
    • Swank, G.M.1    Deitch, E.A.2
  • 49
    • 0343484965 scopus 로고    scopus 로고
    • Baboon model of E. coli sepsis: role of phospholipids microparticles in DIC
    • Taylor F.B. (1999) Baboon model of E. coli sepsis: role of phospholipids microparticles in DIC. Sepsis 3, 125-133.
    • (1999) Sepsis , vol.3 , pp. 125-133
    • Taylor, F.B.1
  • 52
    • 0029797843 scopus 로고    scopus 로고
    • Hyperpermeability and ATP depletion induced by chronic hypoxia or glycolytic inhibition in Caco-2BBe monolayers
    • Unno N., Menconi M.J., Salzman A.L. et al. (1996) Hyperpermeability and ATP depletion induced by chronic hypoxia or glycolytic inhibition in Caco-2BBe monolayers. Am. J. Physiol. Gastrointest. Liver Physiol. 270, G1010-G1021.
    • (1996) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.270
    • Unno, N.1    Menconi, M.J.2    Salzman, A.L.3
  • 53
    • 33750522498 scopus 로고    scopus 로고
    • Why do patients who have acute lung injury/acute respiratory distress syndrome die from multiple organ dysfunction syndrome? Implications for management
    • Vincent J. and Zambon M. (2006) Why do patients who have acute lung injury/acute respiratory distress syndrome die from multiple organ dysfunction syndrome? Implications for management. Clin. Chest Med. 27, 725-731.
    • (2006) Clin. Chest Med. , vol.27 , pp. 725-731
    • Vincent, J.1    Zambon, M.2
  • 54
    • 31344461826 scopus 로고    scopus 로고
    • Sepsis in European intensive care units: results of the SOAP study
    • Vincent J.L., Sakr Y., Sprung C.L. et al. (2006) Sepsis in European intensive care units: results of the SOAP study. Crit. Care Med. 34, 344-353.
    • (2006) Crit. Care Med. , vol.34 , pp. 344-353
    • Vincent, J.L.1    Sakr, Y.2    Sprung, C.L.3
  • 55
    • 40949086461 scopus 로고    scopus 로고
    • Cytokine-induced epithelial permeability changes are regulated by the activation of the p38 mitogen-activated protein kinase pathway in cultured Caco-2 cells
    • Wang Q., Guo X., Wells-Byrum D., Noel G., Pritts T.A., Ogle C.K. (2008) Cytokine-induced epithelial permeability changes are regulated by the activation of the p38 mitogen-activated protein kinase pathway in cultured Caco-2 cells. Shock 29, 531-537.
    • (2008) Shock , vol.29 , pp. 531-537
    • Wang, Q.1    Guo, X.2    Wells-Byrum, D.3    Noel, G.4    Pritts, T.A.5    Ogle, C.K.6
  • 57
    • 65649151403 scopus 로고    scopus 로고
    • Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study
    • Watanabe E., Muenzer J.T., Hawkins W.G. et al. (2009) Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study. Lab. Invest. 89, 549-561.
    • (2009) Lab. Invest. , vol.89 , pp. 549-561
    • Watanabe, E.1    Muenzer, J.T.2    Hawkins, W.G.3
  • 60
    • 0026636673 scopus 로고
    • Differentiated structure and function of cultures from human tracheal epithelium
    • Yamaya M., Finkbeiner W.E., Chun S.Y., Widdicombe J.H. (1992) Differentiated structure and function of cultures from human tracheal epithelium. Am. J. Physiol. 262, L713-L724.
    • (1992) Am. J. Physiol. , vol.262
    • Yamaya, M.1    Finkbeiner, W.E.2    Chun, S.Y.3    Widdicombe, J.H.4
  • 61
    • 33846521353 scopus 로고    scopus 로고
    • Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase
    • Zheng B. and Cantley L.C. (2007) Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase. Proc. Natl Acad. Sci. USA 104, 819-822.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 819-822
    • Zheng, B.1    Cantley, L.C.2
  • 62
    • 0026016470 scopus 로고
    • Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial
    • Ziegler E.J., Fisher C.J., Sprung C.L. et al. (1991) Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. N. Engl. J. Med. 324, 429-436.
    • (1991) N. Engl. J. Med. , vol.324 , pp. 429-436
    • Ziegler, E.J.1    Fisher, C.J.2    Sprung, C.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.