메뉴 건너뛰기




Volumn 290, Issue 1, 2011, Pages 7-26

Spatio-temporal modelling of the NF-κB intracellular signalling pathway: The roles of diffusion, active transport, and cell geometry

Author keywords

Active transport; Cell geometry; Diffusion; NF B; Spatio temporal model

Indexed keywords

I KAPPA B ALPHA; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

EID: 80052826648     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2011.08.036     Document Type: Article
Times cited : (21)

References (57)
  • 4
    • 0034633702 scopus 로고    scopus 로고
    • Generation of oscillations by the p53-mdm2 feedback loop: a theoretical and experimental study
    • Bar-Or R.L., Maya R., Segel L., Alon U., Levine A., Oren M. Generation of oscillations by the p53-mdm2 feedback loop: a theoretical and experimental study. Proc. Natl. Acad. Sci. USA 2000, 97:11250-11255.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11250-11255
    • Bar-Or, R.L.1    Maya, R.2    Segel, L.3    Alon, U.4    Levine, A.5    Oren, M.6
  • 5
    • 77956238040 scopus 로고    scopus 로고
    • A model of yeast cell-cycle regulation based on multisite phosphorylation
    • Barik D., Baumann W.T., Paul M.R., Novak B., Tyson J.J. A model of yeast cell-cycle regulation based on multisite phosphorylation. Mol. Sys. Biol. 2010, 6:405.
    • (2010) Mol. Sys. Biol. , vol.6 , pp. 405
    • Barik, D.1    Baumann, W.T.2    Paul, M.R.3    Novak, B.4    Tyson, J.J.5
  • 6
    • 56049089849 scopus 로고    scopus 로고
    • Stochastic simulation of enzyme-catalyzed reactions with disparate timescales
    • Barik D., Paul M.R., Baumann W.T., Cao Y., Tyson J.J. Stochastic simulation of enzyme-catalyzed reactions with disparate timescales. Biophys. J. 2008, 95:3563-3574.
    • (2008) Biophys. J. , vol.95 , pp. 3563-3574
    • Barik, D.1    Paul, M.R.2    Baumann, W.T.3    Cao, Y.4    Tyson, J.J.5
  • 8
    • 0032864252 scopus 로고    scopus 로고
    • Spatial gradients of cellular phospho-proteins
    • Brown G., Kholodenko B. Spatial gradients of cellular phospho-proteins. FEBS Lett. 1999, 457:452-454.
    • (1999) FEBS Lett. , vol.457 , pp. 452-454
    • Brown, G.1    Kholodenko, B.2
  • 9
    • 0034731365 scopus 로고    scopus 로고
    • Dynamic shuttling of nuclear factor κB between the nucleus and cytoplasm as a consequence of inhibitor dissociation
    • Carlotti F., Dower S., Qwarnstrom E. Dynamic shuttling of nuclear factor κB between the nucleus and cytoplasm as a consequence of inhibitor dissociation. J. Biol. Chem. 2000, 275:41028-41034.
    • (2000) J. Biol. Chem. , vol.275 , pp. 41028-41034
    • Carlotti, F.1    Dower, S.2    Qwarnstrom, E.3
  • 10
    • 35349011081 scopus 로고    scopus 로고
    • Triptolide inhibits tumor promoter-induced uPAR expression via blocking NF-κB signaling in human gastric AGS cells
    • Chang H., Kim M., Baek M., Park J., Chung I., Shin B., Ahn B., Jung Y. Triptolide inhibits tumor promoter-induced uPAR expression via blocking NF-κB signaling in human gastric AGS cells. Anticancer Res. 2007, 27:3411-3417.
    • (2007) Anticancer Res. , vol.27 , pp. 3411-3417
    • Chang, H.1    Kim, M.2    Baek, M.3    Park, J.4    Chung, I.5    Shin, B.6    Ahn, B.7    Jung, Y.8
  • 11
    • 43249116959 scopus 로고    scopus 로고
    • Understanding NF-κB signaling via mathematical modeling
    • Cheong R., Hoffmann A., Levchenko A. Understanding NF-κB signaling via mathematical modeling. Mol. Syst. Biol. 2008, 4.
    • (2008) Mol. Syst. Biol. , vol.4
    • Cheong, R.1    Hoffmann, A.2    Levchenko, A.3
  • 13
    • 33646516400 scopus 로고    scopus 로고
    • Transport of messenger RNA from the nucleus to the cytoplasm
    • Cole C., Scarcelli J. Transport of messenger RNA from the nucleus to the cytoplasm. Curr. Opin. Cell Biol. 2006, 18:299-306.
    • (2006) Curr. Opin. Cell Biol. , vol.18 , pp. 299-306
    • Cole, C.1    Scarcelli, J.2
  • 15
    • 33845444174 scopus 로고    scopus 로고
    • A complex oscillating network of signaling genes underlies the mouse segmentation clock
    • Dequeant M., Glynn E., Gaudenz K., Wahl M., Chen J., Mushegian A., Pourquie O. A complex oscillating network of signaling genes underlies the mouse segmentation clock. Science 2006, 314:1595-1598.
    • (2006) Science , vol.314 , pp. 1595-1598
    • Dequeant, M.1    Glynn, E.2    Gaudenz, K.3    Wahl, M.4    Chen, J.5    Mushegian, A.6    Pourquie, O.7
  • 18
    • 70349549913 scopus 로고    scopus 로고
    • Exploring mechanisms of oscillations in p53 and nuclear factor-κB systems
    • Hat B., Puszynski K., Lipniacki T. Exploring mechanisms of oscillations in p53 and nuclear factor-κB systems. IET Syst. Biol. 2009, 3:342-355.
    • (2009) IET Syst. Biol. , vol.3 , pp. 342-355
    • Hat, B.1    Puszynski, K.2    Lipniacki, T.3
  • 19
    • 0037174669 scopus 로고    scopus 로고
    • Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop
    • Hirata H., Yoshiura S., Ohtsuka T., Bessho Y., Harada T., Yoshikawa K. Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science 2002, 298:840-843.
    • (2002) Science , vol.298 , pp. 840-843
    • Hirata, H.1    Yoshiura, S.2    Ohtsuka, T.3    Bessho, Y.4    Harada, T.5    Yoshikawa, K.6
  • 20
    • 0037044575 scopus 로고    scopus 로고
    • The IκB-NF-κB signaling module: temporal control and selective gene activation
    • Hoffmann A., Levchenko A., Scott M., Baltimore D. The IκB-NF-κB signaling module: temporal control and selective gene activation. Science 2002, 298:1241-1245.
    • (2002) Science , vol.298 , pp. 1241-1245
    • Hoffmann, A.1    Levchenko, A.2    Scott, M.3    Baltimore, D.4
  • 22
    • 33644524741 scopus 로고    scopus 로고
    • Cell-signalling dynamics in time and space
    • Kholodenko B. Cell-signalling dynamics in time and space. Nat. Rev. Mol. Cell Biol. 2006, 7:165-174.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 165-174
    • Kholodenko, B.1
  • 26
    • 18244372714 scopus 로고    scopus 로고
    • Model reduction and analysis of robustness for the Wnt/Β-catenin signal transduction pathway
    • Kruger R., Heinrich R. Model reduction and analysis of robustness for the Wnt/Β-catenin signal transduction pathway. Genome Inf. 2004, 15:138-148.
    • (2004) Genome Inf. , vol.15 , pp. 138-148
    • Kruger, R.1    Heinrich, R.2
  • 28
    • 0034730713 scopus 로고    scopus 로고
    • Failure to regulate TNF-induced NF-κB and cell death responses in A20-deficient mice
    • Lee E., Boone D., Chai S., Libby S., Chien M., Lodolce J., Ma A. Failure to regulate TNF-induced NF-κB and cell death responses in A20-deficient mice. Science 2000, 289(5488):2350-2354.
    • (2000) Science , vol.289 , Issue.5488 , pp. 2350-2354
    • Lee, E.1    Boone, D.2    Chai, S.3    Libby, S.4    Chien, M.5    Lodolce, J.6    Ma, A.7
  • 30
    • 76449087408 scopus 로고    scopus 로고
    • Dynamics of nonmembranous cell components: role of active transport along microtubules
    • Lomakin A., Nadezhdina E. Dynamics of nonmembranous cell components: role of active transport along microtubules. Biochemistry (Mosc) 2010, 75:7-18.
    • (2010) Biochemistry (Mosc) , vol.75 , pp. 7-18
    • Lomakin, A.1    Nadezhdina, E.2
  • 31
    • 33749165927 scopus 로고    scopus 로고
    • Microtubules are required for NF-κB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc
    • Mackenzie G., Keen C., Oteiza P. Microtubules are required for NF-κB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc. J. Neurochem. 2006, 99:402-415.
    • (2006) J. Neurochem. , vol.99 , pp. 402-415
    • Mackenzie, G.1    Keen, C.2    Oteiza, P.3
  • 32
    • 41449104141 scopus 로고    scopus 로고
    • Direct measurement of protein dynamics inside cells using a rationally designed photoconvertible protein
    • Matsuda T., Miyawaki A., Nagai T. Direct measurement of protein dynamics inside cells using a rationally designed photoconvertible protein. Nat. Methods 2008, 5:339-345.
    • (2008) Nat. Methods , vol.5 , pp. 339-345
    • Matsuda, T.1    Miyawaki, A.2    Nagai, T.3
  • 33
    • 33750619877 scopus 로고    scopus 로고
    • Potential for control of signaling pathways via cell size and shape
    • Meyers J., Craig J., Odde D. Potential for control of signaling pathways via cell size and shape. Curr. Biol. 2006, 16:1685-1693.
    • (2006) Curr. Biol. , vol.16 , pp. 1685-1693
    • Meyers, J.1    Craig, J.2    Odde, D.3
  • 34
    • 39549091696 scopus 로고    scopus 로고
    • Transcription factor NF-κB is transported to the nucleus via cytoplasmic dynein/dynactin motor complex in hippocampal neurons
    • Mikenberg I., Widera D., Kaus A., Kaltschmidt B., Kaltschmidt C. Transcription factor NF-κB is transported to the nucleus via cytoplasmic dynein/dynactin motor complex in hippocampal neurons. PLoS ONE 2007, 2(7):e589.
    • (2007) PLoS ONE , vol.2 , Issue.7
    • Mikenberg, I.1    Widera, D.2    Kaus, A.3    Kaltschmidt, B.4    Kaltschmidt, C.5
  • 35
    • 0043180477 scopus 로고    scopus 로고
    • Oscillatory expression of Hes1, p53, and NF-κB driven by transcriptional time delays
    • Monk N. Oscillatory expression of Hes1, p53, and NF-κB driven by transcriptional time delays. Curr. Biol. 2003, 13:1409-1413.
    • (2003) Curr. Biol. , vol.13 , pp. 1409-1413
    • Monk, N.1
  • 36
    • 0037426670 scopus 로고    scopus 로고
    • NF-κB is constitutively activated in high-grade squamous intraepithelial lesions and squamous cell carcinomas of the human uterine cervix
    • Nair A., Venkatraman M., Maliekal T., Nair B., Karunagaran D. NF-κB is constitutively activated in high-grade squamous intraepithelial lesions and squamous cell carcinomas of the human uterine cervix. Oncogene 2003, 22:50-58.
    • (2003) Oncogene , vol.22 , pp. 50-58
    • Nair, A.1    Venkatraman, M.2    Maliekal, T.3    Nair, B.4    Karunagaran, D.5
  • 39
    • 0034647693 scopus 로고    scopus 로고
    • Signal-dependent and -independent degradation of free and NF-κB-boundIκBα
    • Pando M., Verma I. Signal-dependent and -independent degradation of free and NF-κB-boundIκBα. J. Biol. Chem. 2000, 275:21278-21286.
    • (2000) J. Biol. Chem. , vol.275 , pp. 21278-21286
    • Pando, M.1    Verma, I.2
  • 40
    • 61449205308 scopus 로고    scopus 로고
    • Resveratrol inhibits tumor cell adhesion to endothelial cells by blocking ICAM-1 expression
    • Park J., Kim K., Kim M., Chang H., Baek M., Kim S., Jung Y. Resveratrol inhibits tumor cell adhesion to endothelial cells by blocking ICAM-1 expression. Anticancer Res. 2009, 29:355-362.
    • (2009) Anticancer Res. , vol.29 , pp. 355-362
    • Park, J.1    Kim, K.2    Kim, M.3    Chang, H.4    Baek, M.5    Kim, S.6    Jung, Y.7
  • 41
    • 33845768987 scopus 로고    scopus 로고
    • Integrating cell-signalling pathways with NF-κB and IKK function
    • Perkins N. Integrating cell-signalling pathways with NF-κB and IKK function. Nat. Rev. Mol. Cell Biol. 2007, 8:49-62.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 49-62
    • Perkins, N.1
  • 43
    • 2442464889 scopus 로고    scopus 로고
    • Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks
    • Pommier Y., Sordet O., Antony S., Hayward R., Kohn K. Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks. Oncogene 2004, 23:2934-2949.
    • (2004) Oncogene , vol.23 , pp. 2934-2949
    • Pommier, Y.1    Sordet, O.2    Antony, S.3    Hayward, R.4    Kohn, K.5
  • 44
    • 70349556035 scopus 로고    scopus 로고
    • Crosstalk between p53 and NF-κB systems: pro- and anti-apoptotic functions of NF-κB
    • Puszynski K., Bertolusso R., Lipniacki T. Crosstalk between p53 and NF-κB systems: pro- and anti-apoptotic functions of NF-κB. IET Syst. Biol. 2009, 3:356-367.
    • (2009) IET Syst. Biol. , vol.3 , pp. 356-367
    • Puszynski, K.1    Bertolusso, R.2    Lipniacki, T.3
  • 45
    • 0035869022 scopus 로고    scopus 로고
    • Kinetic analysis of translocation through nuclear pore complexes
    • Ribbeck K., Gorlich D. Kinetic analysis of translocation through nuclear pore complexes. EMBO J. 2001, 20:1320-1330.
    • (2001) EMBO J. , vol.20 , pp. 1320-1330
    • Ribbeck, K.1    Gorlich, D.2
  • 46
    • 0027451924 scopus 로고
    • In vivo control of NF-κB activation by IκBα
    • Rice N., Ernst M. In vivo control of NF-κB activation by IκBα. EMBO J. 1993, 12:4685-4695.
    • (1993) EMBO J. , vol.12 , pp. 4685-4695
    • Rice, N.1    Ernst, M.2
  • 47
    • 0031596724 scopus 로고    scopus 로고
    • Nuclear localization of IκBα is mediated by the second ankyrin repeat: the IκBα ankyrin repeats define a novel class of cis-acting nuclear import sequences
    • Sachdev S., Hoffmann A., Hannink M. Nuclear localization of IκBα is mediated by the second ankyrin repeat: the IκBα ankyrin repeats define a novel class of cis-acting nuclear import sequences. Mol. Cell Biol. 1998, 18:2524-2534.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 2524-2534
    • Sachdev, S.1    Hoffmann, A.2    Hannink, M.3
  • 48
    • 77958130354 scopus 로고    scopus 로고
    • Gene copy-number polymorphism in nature
    • Schrider D., Hahn M. Gene copy-number polymorphism in nature. Proc. Roy. Soc. B 2010, 277:3213-3221.
    • (2010) Proc. Roy. Soc. B , vol.277 , pp. 3213-3221
    • Schrider, D.1    Hahn, M.2
  • 49
    • 0030742748 scopus 로고    scopus 로고
    • Translational diffusion of macromolecule-sized solutes in cytoplasm and nucleus
    • Seksek O., Biwersi J., Verkman A.S. Translational diffusion of macromolecule-sized solutes in cytoplasm and nucleus. J. Cell Biol. 1997, 138:131-142.
    • (1997) J. Cell Biol. , vol.138 , pp. 131-142
    • Seksek, O.1    Biwersi, J.2    Verkman, A.S.3
  • 50
    • 0000564581 scopus 로고    scopus 로고
    • The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-κB activation
    • Song H., Rothe M., Goeddel D. The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-κB activation. Proc. Natl. Acad. Sci. USA 1996, 93:6721-6725.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 6721-6725
    • Song, H.1    Rothe, M.2    Goeddel, D.3
  • 51
    • 78650723177 scopus 로고    scopus 로고
    • Spatio-temporal modelling of the Hes1 and p53-Mdm2 intracellular signalling pathways
    • Sturrock M., Terry A., Xirodimas D., Thompson A., Chaplain M. Spatio-temporal modelling of the Hes1 and p53-Mdm2 intracellular signalling pathways. J. Theor. Biol. 2011, 273:15-31.
    • (2011) J. Theor. Biol. , vol.273 , pp. 15-31
    • Sturrock, M.1    Terry, A.2    Xirodimas, D.3    Thompson, A.4    Chaplain, M.5
  • 52
    • 0027168447 scopus 로고
    • NF-κB controls expression of inhibitor IκBα: evidence for an inducible autoregulatory pathway
    • Sun S.C., Ganchi P., Ballard D., Greene W. NF-κB controls expression of inhibitor IκBα: evidence for an inducible autoregulatory pathway. Science 1993, 259:1912-1915.
    • (1993) Science , vol.259 , pp. 1912-1915
    • Sun, S.C.1    Ganchi, P.2    Ballard, D.3    Greene, W.4
  • 53
    • 79952222104 scopus 로고    scopus 로고
    • A spatio-temporal model of Notch signalling in the zebrafish segmentation clock: conditions for synchronised oscillatory dynamics
    • Terry A., Sturrock M., Dale J., Maroto M., Chaplain M. A spatio-temporal model of Notch signalling in the zebrafish segmentation clock: conditions for synchronised oscillatory dynamics. PLoS ONE 2011, 6(2):e16980.
    • (2011) PLoS ONE , vol.6 , Issue.2
    • Terry, A.1    Sturrock, M.2    Dale, J.3    Maroto, M.4    Chaplain, M.5
  • 55
    • 34547664904 scopus 로고    scopus 로고
    • Extended analyses of the Wnt/Β-catenin pathway: robustness and oscillatory behaviour
    • Wawra C., Kuhl M., Kestler H.A. Extended analyses of the Wnt/Β-catenin pathway: robustness and oscillatory behaviour. FEBS Lett. 2007, 581:4043-4048.
    • (2007) FEBS Lett. , vol.581 , pp. 4043-4048
    • Wawra, C.1    Kuhl, M.2    Kestler, H.A.3
  • 56
    • 33845332311 scopus 로고    scopus 로고
    • Garland Science, Taylor & Francis Group
    • Weinberg R. The Biology of Cancer 2007, Garland Science, Taylor & Francis Group.
    • (2007) The Biology of Cancer
    • Weinberg, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.