-
1
-
-
34250695169
-
-
U.S. Food and Drug Administration (FDA), Accessed 28 September 2010
-
Table of valid genomic biomarkers in the context of approved drug labels. U.S. Food and Drug Administration (FDA).Available at: http://www.fda.gov/Drugs/ScienceResearch/ResearchAreas/Pharmacogenetics/ucm083378.htm. Accessed 28 September 2010.
-
Table of Valid Genomic Biomarkers In the Context of Approved Drug Labels
-
-
-
2
-
-
0027499297
-
Model-guided determination of maximum tolerated dose in phase I clinical trials: Evidence for increased precision
-
Mick R, Ratain MJ. Model-guided determination of maximum tolerated dose in phase I clinical trials: evidence for increased precision. J Natl Cancer Inst 1993;3;85:217-23.
-
(1993)
J Natl Cancer Inst
, vol.3
, Issue.85
, pp. 217-223
-
-
Mick, R.1
Ratain, M.J.2
-
3
-
-
0026758498
-
The clinical pharmacology of 6-mercaptopurine
-
Lennard L. The clinical pharmacology of 6-mercaptopurine. Eur J Clin Pharmacol 1992;43:329-39.
-
(1992)
Eur J Clin Pharmacol
, vol.43
, pp. 329-339
-
-
Lennard, L.1
-
4
-
-
0018822866
-
Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
-
Weinshilboum RM, Sladek SL. Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980;32:651-62.
-
(1980)
Am J Hum Genet
, vol.32
, pp. 651-662
-
-
Weinshilboum, R.M.1
Sladek, S.L.2
-
5
-
-
0035871560
-
Preponderance of thiopurine S-methyltransferase defi ciency and heterozygosity among patients intolerant to mercaptopurine or azathioprine
-
Evans WE, Hon YY, Bomgaars L, Coutre S, Holdsworth M, Janco R, et al. Preponderance of thiopurine S-methyltransferase defi ciency and heterozygosity among patients intolerant to mercaptopurine or azathioprine. J Clin Oncol 2001;19:2293-301.
-
(2001)
J Clin Oncol
, vol.19
, pp. 2293-2301
-
-
Evans, W.E.1
Hon, Y.Y.2
Bomgaars, L.3
Coutre, S.4
Holdsworth, M.5
Janco, R.6
-
6
-
-
0033135738
-
Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia
-
Relling MV, Hancock ML, Boyett JM, Pui CH, Evans WE. Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia. Blood 1999;93:2817-23.
-
(1999)
Blood
, vol.93
, pp. 2817-2823
-
-
Relling, M.V.1
Hancock, M.L.2
Boyett, J.M.3
Pui, C.H.4
Evans, W.E.5
-
7
-
-
20144365645
-
Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia
-
Stanulla M, Schaeffeler E, Flohr T, Cario G, Schrauder A, Zimmermann M, et al. Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia. JAMA 2005;293:1485-9.
-
(2005)
JAMA
, vol.293
, pp. 1485-1489
-
-
Stanulla, M.1
Schaeffeler, E.2
Flohr, T.3
Cario, G.4
Schrauder, A.5
Zimmermann, M.6
-
8
-
-
3242762099
-
Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identifi cation of novel TPMT variants
-
Schaeffeler E, Fischer C, Brockmeier D, Wernet D, Moerike K, Eichelbaum M, et al. Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identifi cation of novel TPMT variants. Pharmacogenetics 2004;14:407-17.
-
(2004)
Pharmacogenetics
, vol.14
, pp. 407-417
-
-
Schaeffeler, E.1
Fischer, C.2
Brockmeier, D.3
Wernet, D.4
Moerike, K.5
Eichelbaum, M.6
-
9
-
-
0032693405
-
Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: Mechanism for TPMT protein defi ciency inherited by TPMT*2, TPMT*3A, TPMT*3B or TPMT*3C
-
Tai HL, Fessing MY, Bonten EJ, Yanishevsky Y, d'Azzo A, Krynetski E Y, et al. Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: mechanism for TPMT protein defi ciency inherited by TPMT*2, TPMT*3A, TPMT*3B or TPMT*3C. Pharmacogenetics 1999;9:641-50.
-
(1999)
Pharmacogenetics
, vol.9
, pp. 641-650
-
-
Tai, H.L.1
Fessing, M.Y.2
Bonten, E.J.3
Yanishevsky, Y.4
D'Azzo, A.5
Krynetski, E.Y.6
-
10
-
-
33747168764
-
Cost-effectiveness of pharmacogenomics in clinical practice: A case study of thiopurine methyltransferase genotyping in acute lymphoblastic leukemia in Europe
-
van den Akker-van Marle ME, Gurwitz D, Detmar SB, Enzing CM, Hopkins MM, Gutierrez de Mesa E, et al. Cost-effectiveness of pharmacogenomics in clinical practice: a case study of thiopurine methyltransferase genotyping in acute lymphoblastic leukemia in Europe. Pharmacogenomics 2006;7:783-92.
-
(2006)
Pharmacogenomics
, vol.7
, pp. 783-792
-
-
van den Akker-van Marle, M.E.1
Gurwitz, D.2
Detmar, S.B.3
Enzing, C.M.4
Hopkins, M.M.5
de Mesa, E.G.6
-
11
-
-
0025331198
-
Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia
-
Lennard L, Lilleyman JS, Van Loon J, Weinshilboum RM. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia. Lancet 1990;336:225-9.
-
(1990)
Lancet
, vol.336
, pp. 225-229
-
-
Lennard, L.1
Lilleyman, J.S.2
van Loon, J.3
Weinshilboum, R.M.4
-
12
-
-
0032917646
-
The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations
-
Collie-Duguid ES, Pritchard SC, Powrie RH, Sludden J, Collier DA, Li T, et al. The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations. Pharmacogenetics 1999;9:37-42.
-
(1999)
Pharmacogenetics
, vol.9
, pp. 37-42
-
-
Collie-Duguid, E.S.1
Pritchard, S.C.2
Powrie, R.H.3
Sludden, J.4
Collier, D.A.5
Li, T.6
-
13
-
-
0037328448
-
Genetic determinants of the thiopurine methyltransferase intermediate activity phenotype in British Asians and Caucasians
-
Marinaki AM, Arenas M, Khan ZH, Lewis CM, Shobowale-Bakre el-M, Escuredo E, et al. Genetic determinants of the thiopurine methyltransferase intermediate activity phenotype in British Asians and Caucasians. Pharmacogenetics 2003;13:97-105.
-
(2003)
Pharmacogenetics
, vol.13
, pp. 97-105
-
-
Marinaki, A.M.1
Arenas, M.2
Khan, Z.H.3
Lewis, C.M.4
Shobowale-Bakre, M.5
Escuredo, E.6
-
14
-
-
0034162687
-
Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2
-
Humerickhouse R, Lohrbach K, Li L, Bosron WF, Dolan ME. Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2. Cancer Res 2000;60:1189-92.
-
(2000)
Cancer Res
, vol.60
, pp. 1189-1192
-
-
Humerickhouse, R.1
Lohrbach, K.2
Li, L.3
Bosron, W.F.4
Dolan, M.E.5
-
15
-
-
38449109707
-
Translation of pharmacogenetic knowledge into cancer therapeutics
-
Yong WP, Innocenti F. Translation of pharmacogenetic knowledge into cancer therapeutics. Clin Adv Hematol Oncol 2007;5:698-706.
-
(2007)
Clin Adv Hematol Oncol
, vol.5
, pp. 698-706
-
-
Yong, W.P.1
Innocenti, F.2
-
16
-
-
0030030762
-
Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome
-
Monaghan G, Ryan M, Seddon R, Hume R, Burchell B. Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome. Lancet 1996;347:578-81.
-
(1996)
Lancet
, vol.347
, pp. 578-581
-
-
Monaghan, G.1
Ryan, M.2
Seddon, R.3
Hume, R.4
Burchell, B.5
-
17
-
-
0031719562
-
Neonatal hyperbilirubinemia and mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene: A common missense mutation among Japanese, Koreans and Chinese
-
Akaba K, Kimura T, Sasaki A, Tanabe S, Ikegami T, Hashimoto M, et al. Neonatal hyperbilirubinemia and mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene: a common missense mutation among Japanese, Koreans and Chinese. Biochem Mol Biol Int 1998;46:21-6.
-
(1998)
Biochem Mol Biol Int
, vol.46
, pp. 21-26
-
-
Akaba, K.1
Kimura, T.2
Sasaki, A.3
Tanabe, S.4
Ikegami, T.5
Hashimoto, M.6
-
19
-
-
2342459714
-
Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan
-
Innocenti F, Undevia SD, Iyer L, Chen PX, Das S, Kocherginsky M, et al. Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. J Clin Oncol 2004;22:1382-8.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1382-1388
-
-
Innocenti, F.1
Undevia, S.D.2
Iyer, L.3
Chen, P.X.4
Das, S.5
Kocherginsky, M.6
-
20
-
-
33751103939
-
Adding pharmacogenetics information to drug labels: Lessons learned
-
Haga SB, Thummel KE, Burke W. Adding pharmacogenetics information to drug labels: lessons learned. Pharmacogenet Genomics 2006;16:847-54.
-
(2006)
Pharmacogenet Genomics
, vol.16
, pp. 847-854
-
-
Haga, S.B.1
Thummel, K.E.2
Burke, W.3
-
21
-
-
34548598459
-
UGT1A1*28 genotype and irinotecan-induced neutropenia: Dose matters
-
Hoskins JM, Goldberg RM, Qu P, Ibrahim JG, McLeod HL. UGT1A1*28 genotype and irinotecan-induced neutropenia: dose matters. J Natl Cancer Inst 2007;99:1290-5.
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 1290-1295
-
-
Hoskins, J.M.1
Goldberg, R.M.2
Qu, P.3
Ibrahim, J.G.4
McLeod, H.L.5
-
22
-
-
33745972934
-
The role of UGT1A1*28 polymorphism in the pharmacodynamics and pharmacokinetics of irinotecan in patients with metastatic colorectal cancer
-
Toffoli G, Cecchin E, Corona G, Russo A, Buonadonna A, D'Andrea M, et al. The role of UGT1A1*28 polymorphism in the pharmacodynamics and pharmacokinetics of irinotecan in patients with metastatic colorectal cancer. J Clin Oncol 2006;24:3061-8.
-
(2006)
J Clin Oncol
, vol.24
, pp. 3061-3068
-
-
Toffoli, G.1
Cecchin, E.2
Corona, G.3
Russo, A.4
Buonadonna, A.5
D'andrea, M.6
-
23
-
-
34250202527
-
Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: Roles of UGT1A1*6 and *28
-
Minami H, Sai K, Saeki M, Saito Y, Ozawa S, Suzuki K, et al. Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28. Pharmacogenet Genomics 2007;17:497-504.
-
(2007)
Pharmacogenet Genomics
, vol.17
, pp. 497-504
-
-
Minami, H.1
Sai, K.2
Saeki, M.3
Saito, Y.4
Ozawa, S.5
Suzuki, K.6
-
24
-
-
65349181626
-
UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients
-
Onoue M, Terada T, Kobayashi M, Katsura T, Matsumoto S, Yanagihara K, et al. UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients. Int J Clin Oncol 2009;14:136-42.
-
(2009)
Int J Clin Oncol
, vol.14
, pp. 136-142
-
-
Onoue, M.1
Terada, T.2
Kobayashi, M.3
Katsura, T.4
Matsumoto, S.5
Yanagihara, K.6
-
25
-
-
59849117793
-
Recommendations from the EGAPP Working Group: Can UGT1A1 genotyping reduce morbidity and mortality in patients with metastatic colorectal cancer treated with irinotecan?
-
Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group
-
Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group. Recommendations from the EGAPP Working Group: can UGT1A1 genotyping reduce morbidity and mortality in patients with metastatic colorectal cancer treated with irinotecan? Genet Med 2009;11:15-20.
-
(2009)
Genet Med
, vol.11
, pp. 15-20
-
-
-
26
-
-
85173409294
-
-
Pharmaceuticals and medical devices safety information No 248, July 2008, Accessed 13 February 2011
-
Pharmaceuticals and medical devices safety information No 248, July 2008, Revision of precautions for irinotecan hydrochlorides. Available at: http://www.pmda.go.jp/english/service/pdf/precautions/PMDSI-248. pdf. Accessed 13 February 2011.
-
Revision of Precautions For Irinotecan Hydrochlorides
-
-
-
27
-
-
3242743744
-
Rapid detection of UGT1A1 gene polymorphisms by newly developed Invader assay
-
Hasegawa Y, Sarashina T, Ando M, Kitagawa C, Mori A, Yoneyama M, et al. Rapid detection of UGT1A1 gene polymorphisms by newly developed Invader assay. Clin Chem 2004;50:1479-80.
-
(2004)
Clin Chem
, vol.50
, pp. 1479-1480
-
-
Hasegawa, Y.1
Sarashina, T.2
Ando, M.3
Kitagawa, C.4
Mori, A.5
Yoneyama, M.6
-
28
-
-
0023187085
-
Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile
-
Heggie GD, Sommadossi JP, Cross DS, Huster WJ, Diasio RB. Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile. Cancer Res 1987;47:2203-6.
-
(1987)
Cancer Res
, vol.47
, pp. 2203-2206
-
-
Heggie, G.D.1
Sommadossi, J.P.2
Cross, D.S.3
Huster, W.J.4
Diasio, R.B.5
-
29
-
-
0018894446
-
Degradation of pyrimidines and pyrimidines analogs- pathways and mutual infl uences
-
Wasternack C. Degradation of pyrimidines and pyrimidines analogs- pathways and mutual infl uences. Pharmacol Ther 1980;8:629-51.
-
(1980)
Pharmacol Ther
, vol.8
, pp. 629-651
-
-
Wasternack, C.1
-
30
-
-
0035234651
-
Clinical implications of dihydropyrimidine dehydrogenase on 5-FU pharmacology
-
Diasio RB. Clinical implications of dihydropyrimidine dehydrogenase on 5-FU pharmacology. Oncology 2001;15:21-6.
-
(2001)
Oncology
, vol.15
, pp. 21-26
-
-
Diasio, R.B.1
-
32
-
-
15144351973
-
Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer
-
Ridge SA, Sludden J, Wei X, Sapone A, Brown O, Hardy S, et al. Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer. Br J Cancer 1998;77:497-500.
-
(1998)
Br J Cancer
, vol.77
, pp. 497-500
-
-
Ridge, S.A.1
Sludden, J.2
Wei, X.3
Sapone, A.4
Brown, O.5
Hardy, S.6
-
33
-
-
0029973215
-
Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity
-
Wei X, McLeod HL, McMurrough J, Gonzalez FJ, Fernandez-Salguero P. Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity. J Clin Invest 1996;98:610-5.
-
(1996)
J Clin Invest
, vol.98
, pp. 610-615
-
-
Wei, X.1
McLeod, H.L.2
McMurrough, J.3
Gonzalez, F.J.4
Fernandez-Salguero, P.5
-
34
-
-
0034808681
-
Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5′-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls
-
Raida M, Schwabe W, Hausler P, Van Kuilenburg AB, Van Gennip AH, Behnke D, et al. Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5′-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls. Clin Cancer Res 2001;7:2832-9.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 2832-2839
-
-
Raida, M.1
Schwabe, W.2
Hausler, P.3
van Kuilenburg, A.B.4
van Gennip, A.H.5
Behnke, D.6
-
35
-
-
0036798968
-
High prevalence of the IVS14 + 1G→A mutation in the dihydropyrimidine dehydrogenase gene of patients with severe 5-fluorouracil-associated toxicity
-
van Kuilenburg AB, Meinsma R, Zoetekouw L, Van Gennip AH. High prevalence of the IVS14 + 1G→A mutation in the dihydropyrimidine dehydrogenase gene of patients with severe 5-fluorouracil-associated toxicity. Pharmacogenetics 2002;12:555-8.
-
(2002)
Pharmacogenetics
, vol.12
, pp. 555-558
-
-
van Kuilenburg, A.B.1
Meinsma, R.2
Zoetekouw, L.3
van Gennip, A.H.4
-
36
-
-
0034901306
-
Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: Frequency of the common IVS14+1G→A mutation causing DPD deficiency
-
van Kuilenburg AB, Muller EW, Haasjes J, Meinsma R, Zoetekouw L, Waterham HR, et al. Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G→A mutation causing DPD deficiency. Clin Cancer Res 2001;7:1149-53.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1149-1153
-
-
van Kuilenburg, A.B.1
Muller, E.W.2
Haasjes, J.3
Meinsma, R.4
Zoetekouw, L.5
Waterham, H.R.6
-
37
-
-
0035074119
-
Germline mutation of dihydropyrimidine dehydrogenese gene among a Japanese population in relation to toxicity to 5-Fluorouracil
-
Yamaguchi K, Arai Y, Kanda Y, Akagi K. Germline mutation of dihydropyrimidine dehydrogenese gene among a Japanese population in relation to toxicity to 5-Fluorouracil. Jpn J Cancer Res 2001;92:337-42.
-
(2001)
Jpn J Cancer Res
, vol.92
, pp. 337-342
-
-
Yamaguchi, K.1
Arai, Y.2
Kanda, Y.3
Akagi, K.4
-
39
-
-
0025243534
-
Structural and functional analysis of the human thymidylate synthase gene
-
Kaneda S, Nalbantoglu J, Takeishi K, Shimizu K, Gotoh O, Seno T, et al. Structural and functional analysis of the human thymidylate synthase gene. J Biol Chem 1990; 265:20277-84.
-
(1990)
J Biol Chem
, vol.265
, pp. 20277-20284
-
-
Kaneda, S.1
Nalbantoglu, J.2
Takeishi, K.3
Shimizu, K.4
Gotoh, O.5
Seno, T.6
-
40
-
-
0035671827
-
Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression
-
Kawakami K, Salonga D, Park JM, Danenberg KD, Uetake H, Brabender J, et al. Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression. Clin Cancer Res 2001;7:4096-101.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 4096-4101
-
-
Kawakami, K.1
Salonga, D.2
Park, J.M.3
Danenberg, K.D.4
Uetake, H.5
Brabender, J.6
-
41
-
-
0035750549
-
Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy
-
Pullarkat ST, Stoehlmacher J, Ghaderi V, Xiong YP, Ingles SA, Sherrod A, et al. Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy. Pharmacogenomics J 2001;1:65-70.
-
(2001)
Pharmacogenomics J
, vol.1
, pp. 65-70
-
-
Pullarkat, S.T.1
Stoehlmacher, J.2
Ghaderi, V.3
Xiong, Y.P.4
Ingles, S.A.5
Sherrod, A.6
-
42
-
-
4444339951
-
Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy
-
Lecomte T, Ferraz JM, Zinzindohoue F, Loriot MA, Tregouet DA, Landi B, et al. Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. Clin Cancer Res 2004;10:5880-8.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 5880-5888
-
-
Lecomte, T.1
Ferraz, J.M.2
Zinzindohoue, F.3
Loriot, M.A.4
Tregouet, D.A.5
Landi, B.6
-
43
-
-
0035522659
-
Thymidylate synthase pharmacogenetics in colorectal cancer
-
Marsh S, McLeod HL. Thymidylate synthase pharmacogenetics in colorectal cancer. Clin Colorectal Cancer 2001;1:175-8.
-
(2001)
Clin Colorectal Cancer
, vol.1
, pp. 175-178
-
-
Marsh, S.1
McLeod, H.L.2
-
44
-
-
0035430487
-
Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer
-
Marsh S, McKay JA, Cassidy J, McLeod HL. Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer. Int J Oncol 2001;19:383-6.
-
(2001)
Int J Oncol
, vol.19
, pp. 383-386
-
-
Marsh, S.1
McKay, J.A.2
Cassidy, J.3
McLeod, H.L.4
-
45
-
-
0141507954
-
Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene
-
Kawakami K, Watanabe G. Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene. Cancer Res 2003; 63:6004-7.
-
(2003)
Cancer Res
, vol.63
, pp. 6004-6007
-
-
Kawakami, K.1
Watanabe, G.2
-
46
-
-
0037567591
-
A novel single nucleotide polymorphism within the 5′-tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity
-
Mandola M V, Stoehlmacher J, Muller-Weeks S, Cesarone G, Yu MC, Lenz HJ, et al. A novel single nucleotide polymorphism within the 5′-tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity. Cancer Res 2003;63:2898-904.
-
(2003)
Cancer Res
, vol.63
, pp. 2898-2904
-
-
Mandola, M.V.1
Stoehlmacher, J.2
Muller-Weeks, S.3
Cesarone, G.4
Yu, M.C.5
Lenz, H.J.6
-
48
-
-
43749114271
-
Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: A Prospective Clinical Trial by the German 5-FU Toxicity Study Group
-
Schwab M, Zanger UM, Marx C, Schaeffeler E, Klein K, Dippon J, et al. Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: A Prospective Clinical Trial by the German 5-FU Toxicity Study Group. J Clin Oncol 2008;26:2131-8.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2131-2138
-
-
Schwab, M.1
Zanger, U.M.2
Marx, C.3
Schaeffeler, E.4
Klein, K.5
Dippon, J.6
-
49
-
-
0346602691
-
Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine
-
Stearns V, Johnson MD, Rae JM, Morocho A, Novielli A, Bhargava P, et al. Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. J Natl Cancer Inst 2003;95:1758-64.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 1758-1764
-
-
Stearns, V.1
Johnson, M.D.2
Rae, J.M.3
Morocho, A.4
Novielli, A.5
Bhargava, P.6
-
50
-
-
0038697813
-
Quantification of tamoxifen and three metabolites in plasma by high-performance liquid chromatography with fluorescence detection: Application to a clinical trial
-
Lee KH, Ward BA, Desta Z, Flockhart DA, Jones DR. Quantification of tamoxifen and three metabolites in plasma by high-performance liquid chromatography with fluorescence detection: application to a clinical trial. J Chromatogr B Analyt Technol Biomed Life Sci 2003;791:245-53.
-
(2003)
J Chromatogr B Analyt Technol Biomed Life Sci
, vol.791
, pp. 245-253
-
-
Lee, K.H.1
Ward, B.A.2
Desta, Z.3
Flockhart, D.A.4
Jones, D.R.5
-
51
-
-
0025168860
-
Genetic polymorphism of sparteine/debrisoquine oxidation: A reappraisal
-
Lennard MS. Genetic polymorphism of sparteine/debrisoquine oxidation: a reappraisal. Pharmacol Toxicol 1990;67:273-83.
-
(1990)
Pharmacol Toxicol
, vol.67
, pp. 273-283
-
-
Lennard, M.S.1
-
52
-
-
0036124107
-
CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants
-
Bradford LD. CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants. Pharmacogenomics 2002;3:229-43.
-
(2002)
Pharmacogenomics
, vol.3
, pp. 229-243
-
-
Bradford, L.D.1
-
53
-
-
0030432585
-
Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles
-
Aklillu E, Persson I, Bertilsson L, Johansson I, Rodrigues F, Ingelman-Sundberg M. Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles. J Pharmacol ExpTher 1996;278:441-6.
-
(1996)
J Pharmacol ExpTher
, vol.278
, pp. 441-446
-
-
Aklillu, E.1
Persson, I.2
Bertilsson, L.3
Johansson, I.4
Rodrigues, F.5
Ingelman-Sundberg, M.6
-
54
-
-
70349929431
-
Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen
-
Schroth W, Goetz MP, Hamann U, Fasching PA, Schmidt M, Winter S, et al. Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen. JAMA 2009;302:1429-36.
-
(2009)
JAMA
, vol.302
, pp. 1429-1436
-
-
Schroth, W.1
Goetz, M.P.2
Hamann, U.3
Fasching, P.A.4
Schmidt, M.5
Winter, S.6
-
55
-
-
37549006389
-
Tamoxifen pharmacogenomics: The role of CYP2D6 as a predictor of drug response
-
Goetz MP, Kamal A, Ames MM. Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug response. Clin Pharmacol Ther 2008;83:160-6.
-
(2008)
Clin Pharmacol Ther
, vol.83
, pp. 160-166
-
-
Goetz, M.P.1
Kamal, A.2
Ames, M.M.3
-
56
-
-
79959353859
-
Lack of correlation between gene variants in tamoxifen metabolizing enymes with primary end points in the ATAC Trial
-
Presented 9 December 2010
-
Rae JM, Drury S, Hayes DF, Stearns V, Thibert JN, Haynes BP, et al. Lack of correlation between gene variants in tamoxifen metabolizing enymes with primary end points in the ATAC Trial. Procs San Antonio Breast Cancer Symposium: Abstract S1-7. Presented 9 December 2010.
-
Procs San Antonio Breast Cancer Symposium: Abstract S1-7
-
-
Rae, J.M.1
Drury, S.2
Hayes, D.F.3
Stearns, V.4
Thibert, J.N.5
Haynes, B.P.6
-
57
-
-
79959367176
-
Outcome according to CYP2D6 genotype among postmenopausal women with endocrine-responsive early invasive breast cancer randomized in the BIG 1-98 trial
-
Presented 9 December 2010
-
Leyland-Jones B, Regan MM, Bouzyk M, Kammler R, Tang W, Pagani O, et al. Outcome according to CYP2D6 genotype among postmenopausal women with endocrine-responsive early invasive breast cancer randomized in the BIG 1-98 trial. Procs San Antonio Breast Cancer Symposium: Abstracts S1-8. Presented 9 December 2010.
-
Procs San Antonio Breast Cancer Symposium: Abstracts S1-8
-
-
Leyland-Jones, B.1
Regan, M.M.2
Bouzyk, M.3
Kammler, R.4
Tang, W.5
Pagani, O.6
-
59
-
-
38349001998
-
SPORE study provides new guidelines for Tamoxifen use
-
Reynolds S. SPORE study provides new guidelines for Tamoxifen use. NCI Cancer Bulletin 2006;3:1-2.
-
(2006)
NCI Cancer Bulletin
, vol.3
, pp. 1-2
-
-
Reynolds, S.1
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