Effects of insulin resistance and hepatic lipid accumulation on hepatic mRNA expression levels of apoB, MTP and L-FABP in non-alcoholic fatty liver disease

Experimental and Therapeutic Medicine

Volumn 2, Issue 6, 2011, Pages 1077-1081

  Higuchi, Nobito ^a   Kato, Masaki ^a   Tanaka, Masatake ^a   Miyazaki, Masayuki ^a   Takao, Shinichiro ^a   Kohjima, Motoyuki ^a   Kotoh, Kazuhiro ^a   Enjoji, Munechika ^b   Nakamuta, Makoto ^c   Takayanagi, Ryoichi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b FUKUOKA UNIVERSITY   (Japan)

^c NATIONAL HOSPITAL ORGANIZATION   (Japan)

Author keywords

Apolipoprotein B; Fatty acid binding protein; Homeostasis model assessment of insulin resistance; Microsomal triglyceride transfer protein; Non alcoholic fatty liver disease; Very low density lipoprotein

Indexed keywords

APOLIPOPROTEIN B; FATTY ACID BINDING PROTEIN; MESSENGER RNA; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; INSULIN RESISTANCE; LIPID LIVER LEVEL; LIPID STORAGE; LIVER BIOPSY; MALE; NONALCOHOLIC FATTY LIVER; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA ANALYSIS;

EID: 80052765066     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2011.328     Document Type: Article

References (29)

1. Angulo P: Nonalcoholic fatty liver disease. N Engl J Med 346: 1221-1231, 2002.
2. Fabbrini E, Sullivan S and Klein S: Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 51: 679-689, 2010.
3. Tiniakos DG, Vos MB and Brunt EM: Nonalcoholic fatty liver disease: pathology and pathogenesis. Annu Rev Pathol 5: 145-171, 2010.
4. Jaworski K, Sarkadi-Nagy E, Duncan RE, Ahmadian M and Sul HS: Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue. Am J Physiol Gastrointest Liver Physiol 293: G1-G4, 2007.
5. Iizuka K and Horikawa Y: ChREBP: a glucose-activated transcription factor involved in the development of metabolic syndrome. Endocr J 55: 617-624, 2008.
6. Higuchi N, Kato M, Shundo Y, Tajiri H, Tanaka M, Yamashita N, Kohjima M, Kotoh K, Nakamuta M, Takayanagi R and Enjoji M: Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease. Hepatol Res 38: 1122-1129, 2008.
7. Kato M, Higuchi N and Enjoji M: Reduced hepatic expression of adipose tissue triglyceride lipase and CGI-58 may contribute to the development of non-alcoholic fatty liver disease in patients with insulin resistance. Scand J Gastroenterol 43: 1018-1019, 2008.
8. Meshkani R and Adeli K: Hepatic insulin resistance, metabolic syndrome and cardiovascular disease. Clin Biochem 42: 1331-1346, 2009.
9. Shelness GS and Sellers JA: Very-low-density lipoprotein assembly and secretion. Curr Opin Lipidol 12: 151-157, 2001.
10. Sparks JD and Sparks CE: Overindulgence and metabolic syndrome: is FoxO1 a missing link? J Clin Invest 118: 2012-2015, 2008.
11. Raabe M, Veniant MM, Sullivan MA, Zlot CH, Bjorkegren J, Nielsen LB, Wong JS, Hamilton RL and Young SG: Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice. J Clin Invest 103: 1287-1298, 1999.
12. Binas B and Erol E: FABPs as determinants of myocellular and hepatic fuel metabolism. Mol Cell Biochem 299: 75-84, 2007.
13. Sladek FM: Orphan receptor HNF-4 and liver-specific gene expression. Receptor 3: 223-232, 1993.
14. Sheena V, Hertz R, Nousbeck J, Berman I, Magenheim J and Bar-Tana J: Transcriptional regulation of human microsomal triglyceride transfer protein by hepatocyte nuclear factor-4alpha. J Lipid Res 46: 328-341, 2005.
15. Ladias JA, Hadzopoulou-Cladaras M, Kardassis D, Cardot P, Cheng J, Zannis V and Cladaras C: Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, and ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3. J Biol Chem 267: 15849-15860, 1992.
16. Hertz R, Magenheim J, Berman I and Bar-Tana J: Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4alpha. Nature 392: 512-516, 1998.
17. Jump DB: Dietary polyunsaturated fatty acids and regulation of gene transcription. Curr Opin Lipidol 13: 155-164, 2002.
18. Yoon M: The role of PPARalpha in lipid metabolism and obesity: focusing on the effects of estrogen on PPARalpha actions. Pharmacol Res 60: 151-159, 2009.
19. Ameen C, Edvardsson U, Ljungberg A, Asp L, Akerblad P, Tuneld A, Olofsson SO, Linden D and Oscarsson J: Activation of peroxisome proliferator-activated receptor alpha increases the expression and activity of microsomal triglyceride transfer protein in the liver. J Biol Chem 280: 1224-1229, 2005.
20. Landrier JF, Thomas C, Grober J, Duez H, Percevault F, Souidi M, Linard C, Staels B and Besnard P: Statin induction of liver fatty acid-binding protein (L-FABP) gene expression is peroxisome proliferator-activated receptor-alpha-dependent. JBiol Chem 279: 45512-45518, 2004.
21. Au WS, Kung HF and Lin MC: Regulation of microsomal triglyceride transfer protein gene by insulin in HepG2 cells: roles of MAPKerk and MAPKp38. Diabetes 52: 1073-1080, 2003.
22. Kamagate A, Qu S, Perdomo G, Su D, Kim DH, Slusher S, Meseck M and Dong HH: FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice. J Clin Invest 118: 2347-2364, 2008.
23. Wei Y, Wang D, Topczewski F and Pagliassotti MJ: Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am J Physiol Endocrinol Metab 291: E275-E281, 2006.
24. Roebuck KA: Oxidant stress regulation of IL-8 and ICAM-1 gene expression: differential activation and binding of the transcription factors AP-1 and NF-κB (Review). Int J Mol Med 4: 223-230, 1999.
25. Gius D, Botero A, Shah S and Curry HA: Intracellular oxidation/reduction status in the regulation of transcription factors NF-kappa B and AP-1. Toxicol Lett 106: 93-106, 1999.
26. Liu H, Colavitti R, Rovira II and Finkel T: Redox-dependent transcriptional regulation. Circ Res 97: 967-974, 2005.
27. George DK, Goldwurm S, MacDonald GA, Cowley LL, Walker NI, Ward PJ, Jazwinska EC and Powell LW: Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis. Gastroenterology 114: 311-318, 1998.
28. Mantena SK, King AL, Andringa KK, Eccleston HB and Bailey SM: Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol-and obesity-induced fatty liver diseases. Free Radic Biol Med 44: 1259-1272, 2008.
29. Mitsuyoshi H, Yasui K, Harano Y, Endo M, Tsuji K, Minami M, Itoh Y, Okanoue T and Yoshikawa T: Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease. Hepatol Res 39: 366-373, 2009.